LOCUS       NM_001170480             642 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus pleckstrin homology-like domain, family A, member
            2 (Phlda2), transcript variant 2, mRNA.
ACCESSION   NM_001170480
VERSION     NM_001170480.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 642)
  AUTHORS   Tunster,S.J., Creeth,H.D.J. and John,R.M.
  TITLE     The imprinted Phlda2 gene modulates a major endocrine compartment
            of the placenta to regulate placental demands for maternal
            resources
  JOURNAL   Dev Biol 409 (1), 251-260 (2016)
   PUBMED   26476147
REFERENCE   2  (bases 1 to 642)
  AUTHORS   Tunster,S.J., Tycko,B. and John,R.M.
  TITLE     The imprinted Phlda2 gene regulates extraembryonic energy stores
  JOURNAL   Mol Cell Biol 30 (1), 295-306 (2010)
   PUBMED   19884348
REFERENCE   3  (bases 1 to 642)
  AUTHORS   Frank,D., Fortino,W., Clark,L., Musalo,R., Wang,W., Saxena,A.,
            Li,C.M., Reik,W., Ludwig,T. and Tycko,B.
  TITLE     Placental overgrowth in mice lacking the imprinted gene Ipl
  JOURNAL   Proc Natl Acad Sci U S A 99 (11), 7490-7495 (2002)
   PUBMED   12032310
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 3' coding region, which results in a frameshift, compared to
            variant 1. It encodes isoform 2, which has a shorter and distinct
            C-terminus, compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AI029402.1, CB718773.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-369               JAXUCZ010000001.1  208126873-208127241 c
            370-642             JAXUCZ010000001.1  208126302-208126574 c
FEATURES             Location/Qualifiers
     source          1..642
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q42"
     gene            1..642
                     /gene="Phlda2"
                     /note="pleckstrin homology-like domain, family A, member
                     2"
                     /db_xref="GeneID:293637"
                     /db_xref="RGD:1304755"
     exon            1..369
                     /gene="Phlda2"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..385
                     /gene="Phlda2"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="pleckstrin homology-like domain family A member
                     2 isoform 2"
                     /protein_id="NP_001163951.1"
                     /db_xref="GeneID:293637"
                     /db_xref="RGD:1304755"
                     /translation="MASKTVKTSDEILCEGELEKRSDSLFQVWKKKRCVLTADRLRLF
                     SGNSDRPKELYFHSILKVDCVEHTSKYVYFTIVTNFYKEIDFRCTVESCWNAAITMAL
                     IDYQNRRALEEFRRFRDPRE"
     exon            370..642
                     /gene="Phlda2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgcaagct ttcgaaatgg cttcgaaaac cgtgaagact tccgatgaga ttctttgcga
       61 gggcgagctg gagaagcgaa gcgacagcct gttccaggtc tggaagaaga agcgctgcgt
      121 gctcacggcc gatcgcctgc gcctcttctc cggcaacagc gatcggccca aggagctgta
      181 cttccattcc atcctcaagg tggactgcgt ggagcacacc tccaagtacg tgtacttcac
      241 catcgtcacc aacttttaca aggagatcga cttccgctgc acagtcgaga gctgctggaa
      301 cgcggccatc accatggcgc tgatcgacta ccagaaccgt cgggcgctgg aggagtttcg
      361 ccgcttcaga gacccacggg agtagtcgag ccgggaacca gcctacgctg ccgcatcaga
      421 ccggagtcca ggggcccagg agcccagagg atgccccggg tgacgccgcc gctgttcttc
      481 accgaagata ttcccgtgct tgctgagcct tgccccgctg tgcgggtgca ttaacttatt
      541 ggaccgtatt tatattggtt acctgctttc aacccaccat tccgtgttaa tattttttat
      601 accatatttt catcccaaat aaacagtgcc aacttttttt aa
//
