LOCUS       NM_017180               1811 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus pleckstrin homology-like domain, family A, member
            1 (Phlda1), mRNA.
ACCESSION   NM_017180
VERSION     NM_017180.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1811)
  AUTHORS   Sun,L., Gao,G., Wang,X., Zhang,X. and Li,Y.
  TITLE     Protective effect of basic helix-loop-helix family member e40 on
            cerebral ischemia/reperfusion injury: Inhibition of apoptosis via
            repressing the transcription of pleckstrin homology-like domain
            family A, member 1
  JOURNAL   Adv Clin Exp Med 32 (6), 655-666 (2023)
   PUBMED   36881362
  REMARK    GeneRIF: Protective effect of basic helix-loop-helix family member
            e40 on cerebral ischemia/reperfusion injury: Inhibition of
            apoptosis via repressing the transcription of pleckstrin
            homology-like domain family A, member 1.
REFERENCE   2  (bases 1 to 1811)
  AUTHORS   Guo,Y., Jia,P., Chen,Y., Yu,H., Xin,X., Bao,Y., Yang,H., Wu,N.,
            Sun,Y. and Jia,D.
  TITLE     PHLDA1 is a new therapeutic target of oxidative stress and ischemia
            reperfusion-induced myocardial injury
  JOURNAL   Life Sci 245, 117347 (2020)
   PUBMED   31981628
  REMARK    GeneRIF: role in oxidative stress and ischemia reperfusion-induced
            myocardial injury
REFERENCE   3  (bases 1 to 1811)
  AUTHORS   Ono,A., Hirooka,K., Nakano,Y., Nitta,E., Nishiyama,A. and
            Tsujikawa,A.
  TITLE     Gene expression changes in the retina after systemic administration
            of aldosterone
  JOURNAL   Jpn J Ophthalmol 62 (4), 499-507 (2018)
   PUBMED   29713904
REFERENCE   4  (bases 1 to 1811)
  AUTHORS   Wang,J., Wang,F., Zhu,J., Song,M., An,J. and Li,W.
  TITLE     Transcriptome Profiling Reveals PHLDA1 as a Novel Molecular Marker
            for Ischemic Cardiomyopathy
  JOURNAL   J Mol Neurosci 65 (1), 102-109 (2018)
   PUBMED   29736818
  REMARK    GeneRIF: Expression of PHLDA1 was elevated in ischemic
            cardiomyopathy.  Overexpression of PHLDA1 promotes apoptosis of
            cardiac muscle cell.
REFERENCE   5  (bases 1 to 1811)
  AUTHORS   Liu,F., Xu,Z.L., Qian,X.J., Qiu,W.Y. and Huang,H.
  TITLE     Expression of Hsf1, Hsf2, and Phlda1 in cells undergoing
            cryptorchid-induced apoptosis in rat testes
  JOURNAL   Mol Reprod Dev 78 (4), 283-291 (2011)
   PUBMED   21480429
  REMARK    GeneRIF: The expression of Phlda1 mRNA is significantly elevated 3
            days after induction of cryptorchidism.
REFERENCE   6  (bases 1 to 1811)
  AUTHORS   Gomes,I., Xiong,W., Miki,T. and Rosner,M.R.
  TITLE     A proline- and glutamine-rich protein promotes apoptosis in
            neuronal cells
  JOURNAL   J Neurochem 73 (2), 612-622 (1999)
   PUBMED   10428057
REFERENCE   7  (bases 1 to 1811)
  AUTHORS   Park,C.G., Lee,S.Y., Kandala,G., Lee,S.Y. and Choi,Y.
  TITLE     A novel gene product that couples TCR signaling to Fas(CD95)
            expression in activation-induced cell death
  JOURNAL   Immunity 4 (6), 583-591 (1996)
   PUBMED   8673705
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Sep 1, 2009 this sequence version replaced NM_017180.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF192802.1, CK479569.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1248              JAXUCZ010000007.1  48853690-48854937
            1249-1811           JAXUCZ010000007.1  48855332-48855894
FEATURES             Location/Qualifiers
     source          1..1811
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..1811
                     /gene="Phlda1"
                     /gene_synonym="Tdag"
                     /note="pleckstrin homology-like domain, family A, member
                     1"
                     /db_xref="GeneID:29380"
                     /db_xref="RGD:3836"
     exon            1..1248
                     /gene="Phlda1"
                     /gene_synonym="Tdag"
                     /inference="alignment:Splign:2.1.0"
     CDS             2..1222
                     /gene="Phlda1"
                     /gene_synonym="Tdag"
                     /note="PQR protein; proline- and glutamine-rich protein;
                     PQ-rich protein; T-cell death associated"
                     /codon_start=1
                     /product="pleckstrin homology-like domain family A member
                     1"
                     /protein_id="NP_058876.2"
                     /db_xref="GeneID:29380"
                     /db_xref="RGD:3836"
                     /translation="MRRTPAAERLSELGFPPRRGSQEPPFPLGVTRGWGGWPIEKRCE
                     GPRPVPFSERSAEDGREQPAHGSGILWRVRTRLSLCRDPEPPPPPPPLCLLRVSLLCA
                     LRAGGRGSRWSEDSARLLLLPPAGASGSLKAERSSSTPYAGRMLESSGCKALKEGVLE
                     KRSDGLLQLWKKKCCILTEEGLLLIPPKQVQHQQQQQQQQQPGQGTAEPSQPSGPAVT
                     SLEPPAKLKELHFSNMKTVDCVERKGKYMYFTVVMAEGKEIDFRCPQDQGWNAEITLQ
                     MVQYKNRQAILAVKSTRQKQQHLVQQQPPQTQQIQPQPQPQIQPQPQPQIQPQPQPQP
                     QPQPQPQQQPQPQQLHSYPHPHPHLYPHPHPHAHSHPHPHPHPHPHQLQHAHQPLHSQ
                     PQGHRLLRSTSNSA"
     exon            1249..1811
                     /gene="Phlda1"
                     /gene_synonym="Tdag"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatgaggcgt acgccggctg ccgagcgcct ctcggagctg ggttttcccc cgcggcgcgg
       61 gagccaggag ccgccttttc cgctgggtgt cactcggggg tggggagggt ggcccattga
      121 aaagcgctgc gaggggcccc ggccagtgcc cttcagtgag cgctccgcgg aagacggcag
      181 agagcagccc gctcacggct ccgggatctt gtggcgggtc aggactcgcc tgtccctctg
      241 ccgggacccc gagccaccgc cgccaccgcc accgctctgt ctcctgcgag tcagccttct
      301 ctgtgcgctc cgggcaggcg gccgcggaag ccgctggagc gaggacagcg cacggctgct
      361 actgctaccc ccagccggag cgtctggaag cctaaaggcc gagcggagca gcagcacccc
      421 ttatgccgga aggatgctgg agagcagcgg ttgcaaggcg ctgaaggaag gagtgctgga
      481 aaagcgaagc gacgggctgc tgcagctctg gaagaaaaag tgctgcatcc tcactgagga
      541 agggctactg ctcataccgc ccaagcaggt acaacatcag cagcagcaac agcagcagca
      601 acagcccggg caggggacag ccgaaccgtc ccaacctagt ggccccgccg tcaccagcct
      661 tgagccacca gccaagctga aggaattgca cttttccaat atgaagactg tagactgcgt
      721 ggagcgcaag ggcaagtata tgtacttcac tgtggtgatg gcggagggca aagagatcga
      781 ctttcggtgt ccccaggacc agggctggaa cgcagagatc acgttgcaga tggtgcagta
      841 caaaaatcgt caggccatac tggcggtcaa gtctacgagg cagaagcagc agcacctggt
      901 ccagcagcag cctccgcaga cgcagcagat ccaaccccag ccccagccgc agatccaacc
      961 ccagccccag ccgcagatcc agcctcaacc ccaaccccaa ccccaacctc agccccaacc
     1021 ccagcagcag ccccagcccc aacagctcca ctcctacccg cacccgcatc ctcatcttta
     1081 ccctcaccct caccctcacg cgcactcgca cccgcacccg caccctcacc ctcatccaca
     1141 ccaactccag catgcgcacc agcctctcca ctcgcagcca cagggccacc ggcttctccg
     1201 cagcacctcc aactctgcct gaagagggcg gcacccgggc cactcaaggt tttgaggact
     1261 tcgggaagtg ggaagagtgc attactattt aagttcactt ggatcaaaac caacggagtc
     1321 tccccgccct gtgccagatc aagtagtttg gacatcaccc tacggataac gcgcgcttgc
     1381 agttcctcgt agttttttct gcgtaagctt catcacagtg caggaagcga ttttgagtca
     1441 agatgactat ttatgaacct ttggaaggat cacctaacgt aatggacctt gtaggagcaa
     1501 tttatgtact gtaattttat tttaatgtat tttggtttat gattatttat gtttttttaa
     1561 tgcctattct aagacatttc tgaatgtagg ccacctcctc ttccccttct cgccaaaaaa
     1621 aaaaaagaga ctttattttc agaaacctat ttcctagtaa gccctgatct tggaaaagaa
     1681 aaaggggaag aagagtggtg gagtggggca aacatgaaaa atggattcat catccccaga
     1741 acattctcat aaagtcgact ctttttcatt gtatttgaag aagttgaaat taaattctga
     1801 tattactttc a
//
