LOCUS       NM_080584               1836 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus phosphorylase kinase catalytic subunit gamma 2
            (Phkg2), mRNA.
ACCESSION   NM_080584
VERSION     NM_080584.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1836)
  AUTHORS   Brushia,R.J. and Walsh,D.A.
  TITLE     Phosphorylase kinase: the complexity of its regulation is reflected
            in the complexity of its structure
  JOURNAL   Front Biosci 4, D618-D641 (1999)
   PUBMED   10487978
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1836)
  AUTHORS   Burwinkel,B., Shiomi,S., Al Zaben,A. and Kilimann,M.W.
  TITLE     Liver glycogenosis due to phosphorylase kinase deficiency: PHKG2
            gene structure and mutations associated with cirrhosis
  JOURNAL   Hum Mol Genet 7 (1), 149-154 (1998)
   PUBMED   9384616
REFERENCE   3  (bases 1 to 1836)
  AUTHORS   Maichele,A.J., Burwinkel,B., Maire,I., Sovik,O. and Kilimann,M.W.
  TITLE     Mutations in the testis/liver isoform of the phosphorylase kinase
            gamma subunit (PHKG2) cause autosomal liver glycogenosis in the gsd
            rat and in humans
  JOURNAL   Nat Genet 14 (3), 337-340 (1996)
   PUBMED   8896567
REFERENCE   4  (bases 1 to 1836)
  AUTHORS   Calalb,M.B., Fox,D.T. and Hanks,S.K.
  TITLE     Molecular cloning and enzymatic analysis of the rat homolog of
            'PhK-gamma T,' an isoform of phosphorylase kinase catalytic subunit
  JOURNAL   J Biol Chem 267 (3), 1455-1463 (1992)
   PUBMED   1370475
REFERENCE   5  (bases 1 to 1836)
  AUTHORS   Lutaya,G., Sharma,R.J. and Griffiths,J.R.
  TITLE     Glycogenolysis in liver of phosphorylase kinase-deficient rats
            during liver perfusion and ischaemia
  JOURNAL   Biochem J 214 (2), 645-648 (1983)
   PUBMED   6615485
REFERENCE   6  (bases 1 to 1836)
  AUTHORS   Chrisman,T.D., Jordan,J.E. and Exton,J.H.
  TITLE     Purification of rat liver phosphorylase kinase
  JOURNAL   J Biol Chem 257 (18), 10798-10804 (1982)
   PUBMED   6809757
REFERENCE   7  (bases 1 to 1836)
  AUTHORS   Taira,T., Kii,R., Sakai,K., Tabuchi,H., Takimoto,S., Nakamura,S.,
            Takahashi,J., Hashimoto,E., Yamamura,H. and Nishizuka,Y.
  TITLE     Comparison of glycogen phosphorylase kinases of various rat tissues
  JOURNAL   J Biochem 91 (3), 883-888 (1982)
   PUBMED   6281247
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M73808.1.
            
            On Aug 5, 2008 this sequence version replaced NM_080584.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M73808.1, BC128715.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1836
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..1836
                     /gene="Phkg2"
                     /note="phosphorylase kinase catalytic subunit gamma 2"
                     /db_xref="GeneID:140671"
                     /db_xref="RGD:620024"
     exon            1..437
                     /gene="Phkg2"
                     /inference="alignment:Splign:2.1.0"
     CDS             343..1563
                     /gene="Phkg2"
                     /EC_number="2.7.11.19"
                     /note="PHK-gamma-T; phosphorylase kinase subunit gamma-2;
                     phosphorylase kinase gamma subunit 2;
                     serine/threonine-protein kinase PHKG2; PHK-gamma-LT;
                     phosphorylase kinase, gamma 2 (testis)"
                     /codon_start=1
                     /product="phosphorylase b kinase gamma catalytic chain,
                     liver/testis isoform"
                     /protein_id="NP_542151.1"
                     /db_xref="GeneID:140671"
                     /db_xref="RGD:620024"
                     /translation="MTLDVGPEDELPDWAAAKEFYQKYDPKDIIGRGVSSVVRRCVHR
                     ATGDEFAVKIMEVSAERLSLEQLEEVRDATRREMHILRQVAGHPHIITLIDSYESSSF
                     MFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVNFLHVNNIVHRDLKPENIL
                     LDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWA
                     CGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSNTVKDLIAKLLQVDP
                     NARLTAEQALQHPFFERCKGSQPWNLTPRQRFRVAVWTILAAGRVALSSHRLRPLTKN
                     ALLRDPYALRPVRRLIDNCAFRLYGHWVKKGEQQNRAALFQHQPPRPFPIIATDLEGD
                     SSAITEDEVTLVRS"
     exon            438..613
                     /gene="Phkg2"
                     /inference="alignment:Splign:2.1.0"
     exon            614..668
                     /gene="Phkg2"
                     /inference="alignment:Splign:2.1.0"
     exon            669..734
                     /gene="Phkg2"
                     /inference="alignment:Splign:2.1.0"
     exon            735..898
                     /gene="Phkg2"
                     /inference="alignment:Splign:2.1.0"
     exon            899..989
                     /gene="Phkg2"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1143
                     /gene="Phkg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1269
                     /gene="Phkg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1836
                     /gene="Phkg2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcgagaccc cgtccccctc ccagtggacg ccaagtgcgc ttgcgcggta acagccgccc
       61 gcacttgtgc catttccccc ttcttccgag ccacctttcc cccctccctc ccttccctat
      121 ccccttccct gccctgcttc cctcccttcc ccctagactc ttcgttgtgg tcttcccgtt
      181 cctgatcctt cccctacccc acccccaatc cccaggaccc tggcgcccca gccgcaggtg
      241 ctgcgcccac gggagccacg atgtgcgtcc tctcagaacc tgtgggcctc cttgccctca
      301 ctgccctccg tttcctcctc gcaggccccc acatccttca gaatgacgtt ggacgtgggg
      361 ccagaggatg aactcccaga ctgggctgcg gccaaagagt tttaccagaa gtatgacccc
      421 aaggacatca ttggcagagg agtgagctct gtggtccgcc gctgtgtcca tcgagctact
      481 ggtgatgagt ttgcagtgaa gatcatggag gtgtcagctg aacggctgag tcttgagcag
      541 ctggaggagg tgcgggatgc cacacggcga gagatgcaca tccttcgcca ggtcgctggc
      601 cacccccaca tcatcactct catcgattcc tacgagtctt ctagcttcat gttcctggtg
      661 tttgacctga tgcggaaagg agagctgttt gactatctca cagagaaagt ggccctctca
      721 gaaaaggaaa ccaggtccat tatgaggtct ctgctggagg cggtgaactt tcttcatgtc
      781 aacaacattg tacatcgaga cctgaagcct gagaatatcc tcctagatga caatatgcag
      841 atccgccttt cagattttgg gttctcctgc catttggaac ctggcgagaa gcttcgagag
      901 ctgtgtggga ctccgggata tctagcacca gagatcctta aatgctccat ggatgaaacc
      961 cacccaggct acggcaagga agtcgacctc tgggcttgtg gggtaatcct gttcacactt
     1021 ctggctggct cgccaccatt ctggcatcga cgccaaatcc tgatgctacg catgatcatg
     1081 gaaggccaat atcagtttag ttcacccgag tgggatgatc gttcaaacac cgtcaaagac
     1141 ctgatcgcaa agctgctgca ggtggatcct aacgcacgct tgaccgctga gcaagcccta
     1201 cagcacccct tctttgagcg ctgtaaaggc agccagccct ggaacctcac acctcgccag
     1261 cggttccggg tggcagtgtg gacaatactg gctgctggac gagtagcctt aagcagtcac
     1321 cgtttacggc cactaactaa gaatgcactc ttgagagacc cctatgcact gcggccagta
     1381 cggcgcctca ttgacaactg tgccttccgg ctctatggac actgggtgaa gaagggggag
     1441 cagcagaacc gggcggccct cttccagcac cagcctccta ggcctttccc catcattgcc
     1501 actgacctgg aaggagactc cagtgctatc acagaggatg aagttacctt ggtacggagc
     1561 taggaccttc tccctgggca agccacgaag taggactccc caggaggaga ttttcttttt
     1621 ctatcattcc aaccacttgg gactcagatc ttagccctgc cttgccaagt ctacaactga
     1681 gaatgctgct tgtcacagaa accagccctt tacccctacc tacctactct ggacttggag
     1741 atcggggcgg agatggaagg gaacctcttc ccagcattgt gcctggcctt gccatcaccg
     1801 cctgtgctgc atctgaaata aaacctgcta caagcc
//
