LOCUS       NM_001014152            3630 bp    mRNA    linear   ROD 27-FEB-2025
DEFINITION  Rattus norvegicus phosphorylase kinase regulatory subunit beta
            (Phkb), transcript variant 4, mRNA.
ACCESSION   NM_001014152 XM_341657
VERSION     NM_001014152.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3630)
  AUTHORS   Brushia,R.J. and Walsh,D.A.
  TITLE     Phosphorylase kinase: the complexity of its regulation is reflected
            in the complexity of its structure
  JOURNAL   Front Biosci 4, D618-D641 (1999)
   PUBMED   10487978
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3630)
  AUTHORS   Cawley,K.C., Akita,C.G., Wineinger,M.A., Carlsen,R.C., Gorin,F.A.
            and Walsh,D.A.
  TITLE     Coordinated expression of phosphorylase kinase subunits in
            regenerating skeletal muscle
  JOURNAL   J Biol Chem 267 (24), 17287-17295 (1992)
   PUBMED   1512265
REFERENCE   3  (bases 1 to 3630)
  AUTHORS   Kilimann,M.W., Zander,N.F., Kuhn,C.C., Crabb,J.W., Meyer,H.E. and
            Heilmeyer,L.M. Jr.
  TITLE     The alpha and beta subunits of phosphorylase kinase are homologous:
            cDNA cloning and primary structure of the beta subunit
  JOURNAL   Proc Natl Acad Sci U S A 85 (24), 9381-9385 (1988)
   PUBMED   3200826
REFERENCE   4  (bases 1 to 3630)
  AUTHORS   Salsgiver,W.J. and Lawrence,J.C. Jr.
  TITLE     Rat skeletal muscle phosphorylase kinase: turnover and control of
            isozyme levels in culture
  JOURNAL   Am J Physiol 250 (3 Pt 1), C365-C373 (1986)
   PUBMED   3953807
REFERENCE   5  (bases 1 to 3630)
  AUTHORS   Chrisman,T.D., Jordan,J.E. and Exton,J.H.
  TITLE     Purification of rat liver phosphorylase kinase
  JOURNAL   J Biol Chem 257 (18), 10798-10804 (1982)
   PUBMED   6809757
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC085909.1.
            
            On Apr 20, 2005 this sequence version replaced XM_341657.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085909.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3630
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p11"
     gene            1..3630
                     /gene="Phkb"
                     /note="phosphorylase kinase regulatory subunit beta"
                     /db_xref="GeneID:361377"
                     /db_xref="RGD:620186"
     exon            1..93
                     /gene="Phkb"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..3320
                     /gene="Phkb"
                     /EC_number="2.7.11.19"
                     /note="isoform 4 is encoded by transcript variant 4;
                     phosphorylase b kinase regulatory subunit beta;
                     phosphorylase kinase, beta; phosphorylase kinase beta
                     subunit"
                     /codon_start=1
                     /product="phosphorylase b kinase regulatory subunit beta
                     isoform 4"
                     /protein_id="NP_001014174.1"
                     /db_xref="GeneID:361377"
                     /db_xref="RGD:620186"
                     /translation="MAGEEGLMSEVSWKLLERRARAKRSGSVYEPLKSINLPRPDNET
                     LWDKLDHYYRIVKSTMLTYQSPTTGLFPTKTCGGDQKSKVHESLYCAAGAWALALAYR
                     RIDDDKGRTHELEHSAIKCMRGVLYCYMRQADKVQQFKQDPRPTTCLHSVFNVHTGDE
                     VLSYEEYGHLQINAVSLFLLYLVEMISSGLQIIYNTDEVSFIQNLVFCVERVYRVPDF
                     GVWERGSKYNNGSTELHSSSVGLAKAALEAINGFNLFGNQGCSWSVIFVDLDAHNRNR
                     QTLCSLLPRESRSHNTDAALLPCITYPAFALDDEALFSQTLDKVIRKLKGKYGFKRFL
                     RDGYRTPLEDPNRRYYKPAEIKLFDGIECEFPIFFLYLMIDGVFRGNLEQVKEYQDLL
                     TPLLHQTTEGYPVVPKYYYVPADFVEYEKRNPGSQKRFPSNCGRDGKLFLWGQALYII
                     AKLLADELISPKDIDPVHRFVPLQNQRNVSMRFSNQGPLENDLVVHVALVAESQRLQV
                     FLNTYGIQTQTPQQVEPIQIWPQQELVKAYFHLGINEKLGLSGRPDRPIGCLGTSKIY
                     RILGRTVVCYPIIFDLSDFYMSQDVLLLIDDIKNALQFIKQYWKMHGRPLFLVLIRED
                     NIRGSRFNPILDMLAAFKKGIIGGVKVHVDRLQTLISGAVVEQLDFLRISDTEKLPEF
                     KSFEELEFPKHSKVKRQSSTADAPELRQEPDITITEWKNKSTHEILQKLNDCGCLAGQ
                     TILLGILLKREGPNFITMEGTVSDHIERVYRRAGSKKLWSVVRRAASLLNKVVDSLAP
                     SITNVLVQGKQVTLGAFGHEEEVISNPLSPRVIKNIIYYKCNTHDEREAVIQQELVIH
                     IGWIISNNPELFSGMLKIRIGWIIHAMEYELQIRGGDKPAVDLYQLSPSEVKQLLLDI
                     LQPQQSGRCWLNRRQIDGSLNRTPPGFYDRVWQILERTPNGIVVAGKHLPQQPTLSDM
                     TMYEMNFSLLVEDMLGNIDQPKYRQIIVELLMVVSIVLERNPELEFQDKVDLDKLVKE
                     AFHEFQKDESRLKEIEKQVSGEARVPQNAFIVSTVEILSNLPTFQTDGQSTKEDALQA
                     VRLTEELILLFS"
     exon            94..183
                     /gene="Phkb"
                     /inference="alignment:Splign:2.1.0"
     exon            184..322
                     /gene="Phkb"
                     /inference="alignment:Splign:2.1.0"
     exon            323..422
                     /gene="Phkb"
                     /inference="alignment:Splign:2.1.0"
     exon            423..530
                     /gene="Phkb"
                     /inference="alignment:Splign:2.1.0"
     exon            531..611
                     /gene="Phkb"
                     /inference="alignment:Splign:2.1.0"
     exon            612..727
                     /gene="Phkb"
                     /inference="alignment:Splign:2.1.0"
     exon            728..791
                     /gene="Phkb"
                     /inference="alignment:Splign:2.1.0"
     exon            792..887
                     /gene="Phkb"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1085
                     /gene="Phkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1143
                     /gene="Phkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1221
                     /gene="Phkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1380
                     /gene="Phkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1475
                     /gene="Phkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1531
                     /gene="Phkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1625
                     /gene="Phkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1709
                     /gene="Phkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1814
                     /gene="Phkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1897
                     /gene="Phkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..1988
                     /gene="Phkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2050
                     /gene="Phkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2213
                     /gene="Phkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2295
                     /gene="Phkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2353
                     /gene="Phkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2444
                     /gene="Phkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..2647
                     /gene="Phkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..2782
                     /gene="Phkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2783..2912
                     /gene="Phkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..3020
                     /gene="Phkb"
                     /inference="alignment:Splign:2.1.0"
     exon            3021..3604
                     /gene="Phkb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggtgggca ctgtgcaatg gcgggggaag agggactcat gtctgaagta agctggaagc
       61 tcttggaacg acgagcccgg gccaagcgct caggctcagt ttatgaacct cttaaaagca
      121 ttaatcttcc aagacctgat aatgaaactc tatgggataa gttggatcat tattacagaa
      181 ttgtcaagtc aacgatgctg acatatcaaa gcccaactac aggtctcttt cctactaaaa
      241 cttgtggtgg agatcagaag tccaaagtgc atgagagcct gtactgtgct gcgggtgctt
      301 gggccttggc tctggcgtac aggcgcattg atgatgacaa gggaaggacc catgagctgg
      361 agcactcggc cataaagtgt atgagaggag ttctctactg ctacatgcgg caggctgata
      421 aggtccagca gttcaagcag gatccccggc ccacgacgtg tctacactct gttttcaatg
      481 tgcacactgg ggatgaagtg ctctcctatg aagaatatgg ccatcttcag ataaatgcag
      541 tctcactctt tctcctttac ctggtggaaa tgatttcctc aggtctccag ataatctata
      601 acacggatga ggtctctttt attcaaaacc ttgtgttttg tgtagagaga gtttaccgtg
      661 ttcccgactt cggtgtctgg gaaagaggaa gcaaatataa caacggcagc acagaactgc
      721 actcgagctc tgttggtttg gcaaaagcag ccttagaagc gattaatgga tttaacctct
      781 ttggaaacca gggctgttct tggtcagtta tattcgtgga tctcgatgct cacaaccgca
      841 acaggcagac gttgtgttca ctgttaccca gagaatcacg ctctcataac acagatgctg
      901 ccctgctccc gtgcatcacc taccccgcct ttgccctgga cgatgaagct ctgttcagcc
      961 agacactcga taaagtgata agaaaattaa aagggaaata tggatttaag cgtttcttgc
     1021 gagatgggta cagaacgccc ctggaagacc ccaacagacg ctactacaaa ccagcggaga
     1081 ttaagctgtt tgatggcatc gaatgtgaat ttcccatatt cttcctttac ctgatgatcg
     1141 atggtgtttt tagaggcaat cttgaacaag tcaaggaata tcaggacctg ttgacacctt
     1201 tgcttcacca gaccacagaa ggatatcctg ttgtaccaaa gtactattat gtgccagctg
     1261 actttgtaga atatgaaaaa agaaaccctg gtagtcagaa gcggtttcct agtaactgtg
     1321 gccgtgatgg gaaattgttt ctttggggac aagctcttta tatcattgca aaactcctag
     1381 ctgatgagtt aatcagtcct aaagacattg accccgtcca tcgctttgtc ccacttcaga
     1441 atcaacgtaa cgtgagcatg agattctcta atcagggccc actggaaaat gacttggtgg
     1501 ttcatgtggc acttgtagca gaaagccaac gccttcaggt cttcctcaat acttacggga
     1561 ttcagactca aacgccccag caggtggagc ctattcagat ctggcctcag caggagctcg
     1621 tgaaagctta tttccacctg ggtatcaatg aaaagttggg tctgtctgga aggccagata
     1681 ggcccattgg ctgccttggt acttcaaaga tttaccgcat cctaggaagg accgtggttt
     1741 gttaccctat catcttcgac ctcagtgatt tctacatgtc tcaggacgtt ctcctgctca
     1801 tagatgacat aaagaatgca ctacagttca ttaagcagta ttggaaaatg catggacgcc
     1861 cactttttct tgttctcatc cgggaagaca acataagagg tagcagattc aaccccatat
     1921 tagacatgct ggcagccttt aaaaagggga taattggagg agtcaaagtt catgttgacc
     1981 gtttacagac attgatatct ggagctgtag tagaacagct tgactttctg cggattagcg
     2041 acacagaaaa gcttccagag tttaagagct ttgaagaact agaatttccc aagcattcaa
     2101 aagtcaaacg acagagcagt actgcagatg ctcctgaact gcgacaggag ccagacatca
     2161 ccatcacaga gtggaaaaac aaatccaccc acgaaatcct tcagaagctt aatgactgcg
     2221 gttgtctggc tggccaaacc atcctgctgg gtatactgct caaaagagag ggccctaact
     2281 tcatcacgat ggaaggaact gtgtctgatc acattgagag ggtgtacaga agagctggca
     2341 gcaaaaagct ttggtcggtt gtacgccgtg cagcaagtct tttaaataaa gtagtggaca
     2401 gcctggcccc atccattact aatgttttag tgcagggcaa acaggtaacc ctaggtgcct
     2461 ttggacacga agaggaggtc atctctaatc cactatctcc aagagtgatt aagaacatca
     2521 tctattataa gtgtaacacc catgatgaga gggaggctgt cattcagcaa gagctggtca
     2581 tccatattgg ctggatcatc tccaacaacc ccgagctgtt cagtggcatg ctgaaaatca
     2641 gaattgggtg gatcatccat gccatggagt acgaactgca gatccgtggc ggggataagc
     2701 cagctgtgga cttgtaccag ctctcgccca gtgaggttaa gcagctgctg ctcgacatcc
     2761 tgcagcctca gcagagtggg agatgttggc tgaatagacg tcagattgat gggtcactga
     2821 atagaacacc cccaggattc tacgaccgcg tgtggcagat cctggagcgc acacctaatg
     2881 gtatcgttgt agctggcaag catttgccac agcaaccaac cttgtcagat atgaccatgt
     2941 atgagatgaa tttttctctc cttgttgaag atatgttggg aaacattgac cagccaaagt
     3001 atagacagat cattgtagag ttactaatgg ttgtatccat tgtgctggaa agaaatcctg
     3061 agctagaatt tcaagacaaa gtggatctgg acaaactggt caaagaagcg tttcatgagt
     3121 ttcaaaaaga tgagagccgg ctaaaagaaa tcgaaaagca agtaagtgga gaggcccgtg
     3181 tcccacagaa cgctttcatt gtttccactg ttgaaatcct ctctaatctt cccactttcc
     3241 agacagatgg acagagcaca aaagaggatg ctctacaagc agtcaggctt actgaggaat
     3301 taatattgct ttttagctaa ttactggtcg attgagctag gaagttctgg tcaaaaaaaa
     3361 aataaatgaa atctaagatg aaatattttt tttaatgtgg ttgacaatta aaatgtgttt
     3421 gccagggagg atccactgat cccagaaggc tgtaaaataa attcagaaga cgatgggagt
     3481 gtagaacagg catcacaggg gctgtgtact gtctgatgta gtcccttctg ggctctctgc
     3541 ttaatattgt atgcccatct gtaaaagggc tccctacata aataaaattg actagcaaag
     3601 agaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
