LOCUS       NM_031620               1906 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus phosphoglycerate dehydrogenase (Phgdh), mRNA.
ACCESSION   NM_031620 XM_006233010
VERSION     NM_031620.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1906)
  AUTHORS   Huang,H., Liu,K., Ou,H., Qian,X. and Wan,J.
  TITLE     Phgdh serves a protective role in Il-1beta induced chondrocyte
            inflammation and oxidative-stress damage
  JOURNAL   Mol Med Rep 23 (6) (2021)
   PUBMED   33846783
  REMARK    GeneRIF: Phgdh serves a protective role in Il1beta induced
            chondrocyte inflammation and oxidativestress damage.
REFERENCE   2  (bases 1 to 1906)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   3  (bases 1 to 1906)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   4  (bases 1 to 1906)
  AUTHORS   Kawakami,Y., Yoshida,K., Yang,J.H., Suzuki,T., Azuma,N., Sakai,K.,
            Hashikawa,T., Watanabe,M., Yasuda,K., Kuhara,S., Hirabayashi,Y. and
            Furuya,S.
  TITLE     Impaired neurogenesis in embryonic spinal cord of Phgdh knockout
            mice, a serine deficiency disorder model
  JOURNAL   Neurosci Res 63 (3), 184-193 (2009)
   PUBMED   19114063
REFERENCE   5  (bases 1 to 1906)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 1906)
  AUTHORS   Werner,H.B., Kuhlmann,K., Shen,S., Uecker,M., Schardt,A.,
            Dimova,K., Orfaniotou,F., Dhaunchak,A., Brinkmann,B.G., Mobius,W.,
            Guarente,L., Casaccia-Bonnefil,P., Jahn,O. and Nave,K.A.
  TITLE     Proteolipid protein is required for transport of sirtuin 2 into CNS
            myelin
  JOURNAL   J Neurosci 27 (29), 7717-7730 (2007)
   PUBMED   17634366
REFERENCE   7  (bases 1 to 1906)
  AUTHORS   Laes,J.F., Ravoet,M., Quan,X., Van Vooren,P., Szpirer,J. and
            Szpirer,C.
  TITLE     Improved radiation hybrid map of rat chromosome 2: colocalization
            of the genes encoding corticotropin-releasing hormone and
            IL6-receptor with quantitative trait loci regulating the
            inflammatory response
  JOURNAL   Cytogenet Cell Genet 92 (1-2), 130-133 (2001)
   PUBMED   11306811
REFERENCE   8  (bases 1 to 1906)
  AUTHORS   Klomp,L.W., de Koning,T.J., Malingre,H.E., van Beurden,E.A.,
            Brink,M., Opdam,F.L., Duran,M., Jaeken,J., Pineda,M., Van
            Maldergem,L., Poll-The,B.T., van den Berg,I.E. and Berger,R.
  TITLE     Molecular characterization of 3-phosphoglycerate dehydrogenase
            deficiency--a neurometabolic disorder associated with reduced
            L-serine biosynthesis
  JOURNAL   Am J Hum Genet 67 (6), 1389-1399 (2000)
   PUBMED   11055895
REFERENCE   9  (bases 1 to 1906)
  AUTHORS   Achouri,Y., Rider,M.H., Schaftingen,E.V. and Robbi,M.
  TITLE     Cloning, sequencing and expression of rat liver 3-phosphoglycerate
            dehydrogenase
  JOURNAL   Biochem J 323 (Pt 2) (Pt 2), 365-370 (1997)
   PUBMED   9163325
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before Jun 4, 2021 this sequence version replaced
            XM_006233010.2, NM_031620.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086327.1, X97772.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-347               JAXUCZ010000002.1  188624443-188624789 c
            348-499             JAXUCZ010000002.1  188618250-188618401 c
            500-565             JAXUCZ010000002.1  188616794-188616859 c
            566-620             JAXUCZ010000002.1  188613998-188614052 c
            621-719             JAXUCZ010000002.1  188613801-188613899 c
            720-852             JAXUCZ010000002.1  188603164-188603296 c
            853-1001            JAXUCZ010000002.1  188602579-188602727 c
            1002-1154           JAXUCZ010000002.1  188601516-188601668 c
            1155-1287           JAXUCZ010000002.1  188598841-188598973 c
            1288-1418           JAXUCZ010000002.1  188597787-188597917 c
            1419-1656           JAXUCZ010000002.1  188596663-188596900 c
            1657-1906           JAXUCZ010000002.1  188595700-188595949 c
FEATURES             Location/Qualifiers
     source          1..1906
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1906
                     /gene="Phgdh"
                     /note="phosphoglycerate dehydrogenase"
                     /db_xref="GeneID:58835"
                     /db_xref="RGD:61987"
     exon            1..347
                     /gene="Phgdh"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..1811
                     /gene="Phgdh"
                     /EC_number="1.1.1.95"
                     /function="catalyses the first step of L-serine
                     biosynthesis"
                     /note="3-phosphoglycerate dehydrogenase; 3-PGDH"
                     /codon_start=1
                     /product="D-3-phosphoglycerate dehydrogenase"
                     /protein_id="NP_113808.1"
                     /db_xref="GeneID:58835"
                     /db_xref="RGD:61987"
                     /translation="MAFANLRKILISDSLDPCCRKILQDGGLQVVEKQNLSKEELIAE
                     LQDCEGLIVRSATKVTADVINAAEKLQVVGRAGTGVDNVDLEAATRKGVLVMNTPNGN
                     SLSAAELTCGMLMCLARQIPQATASMKDGKWDRKKFMGTELNGKTLGILGLGRIGREV
                     AARMQAFGMKTVGYDPIISPEVAASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLN
                     DSTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTEEPPRDRALVDHE
                     NVISCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLTGVVNAQALTSAFSPHTKPWIG
                     LAEALGTLMHAWAGSPKGTIQVVTQGTSLKNAGTCLSPAVIVGLLREASKQADVNLVN
                     AKLLVKEAGLNVTTSHSPGVPGEQGIGECLLTVALAGAPYQAVGLVQGTTPMLQMLNG
                     AVFRPEVPLRRGQPLLLFRAQPSDPVMLPTMIGLLAEAGVQLLSYQTSKVSDGDTWHV
                     MGLSSLLPSLDAWKQHVSEAFQFCF"
     exon            348..499
                     /gene="Phgdh"
                     /inference="alignment:Splign:2.1.0"
     exon            500..565
                     /gene="Phgdh"
                     /inference="alignment:Splign:2.1.0"
     exon            566..620
                     /gene="Phgdh"
                     /inference="alignment:Splign:2.1.0"
     exon            621..719
                     /gene="Phgdh"
                     /inference="alignment:Splign:2.1.0"
     exon            720..852
                     /gene="Phgdh"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1001
                     /gene="Phgdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1154
                     /gene="Phgdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1287
                     /gene="Phgdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1418
                     /gene="Phgdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1656
                     /gene="Phgdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1906
                     /gene="Phgdh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaggctct gcccggggag gcggagtcag cagagtttaa gcatttctga ccaatcaaaa
       61 ggagactatt ggcgcgagga gggggaggat aaagggggag cgggagatcg agaaccctgc
      121 ctagtcactg gagccagccc tgccttcagt ttcctgtact aagtgcttct gcccaccaga
      181 gcaaccgatt ctaaggcctg gctctagcaa tggccttcgc aaatctgcgc aaaatactca
      241 tcagtgatag cctcgacccc tgctgccgga agatcctgca agatggaggg ctgcaggtgg
      301 tggagaagca gaacttgagc aaggaggagc tgatagccga actccaggac tgtgaaggcc
      361 ttatcgtccg gtcagctact aaggtcactg ctgatgtcat caatgcagca gagaagctcc
      421 aggtggtggg cagggctggt acaggcgtgg acaatgtgga tctggaggct gccacaagga
      481 agggcgtcct cgtcatgaac acccccaatg gaaatagcct cagtgctgcg gaactcacct
      541 gtgggatgct catgtgcctg gccaggcaga tcccccaggc gacggcttcg atgaaagatg
      601 gcaaatggga ccggaagaag ttcatgggga cagagctgaa cgggaagaca ctgggaattc
      661 ttggcctggg cagaattgga agagaggtgg ccgcccgaat gcaggccttt ggaatgaaga
      721 ctgtaggcta tgaccccatc atttctccag aagtcgctgc ctcctttggt gttcagcagc
      781 tgccgctaga ggagatctgg cctctctgtg atttcatcac tgtccatacc ccgctcctgc
      841 cctccactac aggcttgctc aatgacagca cctttgccca gtgcaagaaa ggcgtgcggg
      901 tggtgaactg tgctcgagga ggcattgtgg atgaaggtgc cctgctccgt gccctgcagt
      961 ctggtcagtg tgctggtgct gcactggatg tgtttacaga agagccacca cgggaccggg
     1021 ccttagtgga ccacgagaac gtcatcagct gtccccacct gggcgccagc accaaggagg
     1081 cccagagccg ctgtggggag gaaatcgcag tccagtttgt ggacatggtg aaggggaaat
     1141 ctctaacagg ggttgtaaac gcccaggctc ttaccagtgc cttctctcca cacaccaagc
     1201 cttggattgg tctggcagaa gcattgggca cactgatgca cgcctgggct ggctccccta
     1261 aagggaccat ccaggtggtg acacaaggaa catctctgaa gaatgctggg acctgcctga
     1321 gccctgcggt cattgtcggc cttctgagag aagcatcaaa acaggcagat gtgaacttgg
     1381 tgaacgctaa gctactggtg aaagaggctg gcctcaatgt caccacctcc cacagtcctg
     1441 gtgtcccagg agagcagggc atcggggaat gcctcctgac tgtggccttg gcaggtgccc
     1501 cctaccaagc tgtgggcttg gtccagggca ccacaccaat gttgcagatg ctcaacggag
     1561 ctgtcttcag gccagaggtg cctctacgca ggggccagcc cctgctcctg ttccgggctc
     1621 agccctccga ccctgtcatg ctgcccacta tgatcggcct actggcagag gcgggggtac
     1681 agctgctgtc ctaccagacc tccaaggtgt ctgacggaga cacttggcac gtcatgggcc
     1741 tctcctccct actgcccagc ctggacgcat ggaagcagca tgtttctgag gctttccagt
     1801 tctgcttctg acccaggggc tcagcggtcc cagcccctca ggctcttctg aggaaacccg
     1861 ctcactgtga cctgaactaa tatctagtaa agaatctaac tccaca
//
