LOCUS       NM_001108253            5692 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus PHD finger protein 8 (Phf8), mRNA.
ACCESSION   NM_001108253 XM_001062175 XM_001062233 XM_001062296
VERSION     NM_001108253.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5692)
  AUTHORS   Black,J.C., Van Rechem,C. and Whetstine,J.R.
  TITLE     Histone lysine methylation dynamics: establishment, regulation, and
            biological impact
  JOURNAL   Mol Cell 48 (4), 491-507 (2012)
   PUBMED   23200123
  REMARK    Review article
REFERENCE   2  (bases 1 to 5692)
  AUTHORS   Bjorkman,M., Ostling,P., Harma,V., Virtanen,J., Mpindi,J.P.,
            Rantala,J., Mirtti,T., Vesterinen,T., Lundin,M., Sankila,A.,
            Rannikko,A., Kaivanto,E., Kohonen,P., Kallioniemi,O. and Nees,M.
  TITLE     Systematic knockdown of epigenetic enzymes identifies a novel
            histone demethylase PHF8 overexpressed in prostate cancer with an
            impact on cell proliferation, migration and invasion
  JOURNAL   Oncogene 31 (29), 3444-3456 (2012)
   PUBMED   22120715
REFERENCE   3  (bases 1 to 5692)
  AUTHORS   Bartke,T., Vermeulen,M., Xhemalce,B., Robson,S.C., Mann,M. and
            Kouzarides,T.
  TITLE     Nucleosome-interacting proteins regulated by DNA and histone
            methylation
  JOURNAL   Cell 143 (3), 470-484 (2010)
   PUBMED   21029866
REFERENCE   4  (bases 1 to 5692)
  AUTHORS   Liu,W., Tanasa,B., Tyurina,O.V., Zhou,T.Y., Gassmann,R., Liu,W.T.,
            Ohgi,K.A., Benner,C., Garcia-Bassets,I., Aggarwal,A.K., Desai,A.,
            Dorrestein,P.C., Glass,C.K. and Rosenfeld,M.G.
  TITLE     PHF8 mediates histone H4 lysine 20 demethylation events involved in
            cell cycle progression
  JOURNAL   Nature 466 (7305), 508-512 (2010)
   PUBMED   20622854
REFERENCE   5  (bases 1 to 5692)
  AUTHORS   Qi,H.H., Sarkissian,M., Hu,G.Q., Wang,Z., Bhattacharjee,A.,
            Gordon,D.B., Gonzales,M., Lan,F., Ongusaha,P.P., Huarte,M.,
            Yaghi,N.K., Lim,H., Garcia,B.A., Brizuela,L., Zhao,K., Roberts,T.M.
            and Shi,Y.
  TITLE     Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and
            craniofacial development
  JOURNAL   Nature 466 (7305), 503-507 (2010)
   PUBMED   20622853
REFERENCE   6  (bases 1 to 5692)
  AUTHORS   Kleine-Kohlbrecher,D., Christensen,J., Vandamme,J., Abarrategui,I.,
            Bak,M., Tommerup,N., Shi,X., Gozani,O., Rappsilber,J., Salcini,A.E.
            and Helin,K.
  TITLE     A functional link between the histone demethylase PHF8 and the
            transcription factor ZNF711 in X-linked mental retardation
  JOURNAL   Mol Cell 38 (2), 165-178 (2010)
   PUBMED   20346720
REFERENCE   7  (bases 1 to 5692)
  AUTHORS   Feng,W., Yonezawa,M., Ye,J., Jenuwein,T. and Grummt,I.
  TITLE     PHF8 activates transcription of rRNA genes through H3K4me3 binding
            and H3K9me1/2 demethylation
  JOURNAL   Nat Struct Mol Biol 17 (4), 445-450 (2010)
   PUBMED   20208542
REFERENCE   8  (bases 1 to 5692)
  AUTHORS   Loenarz,C., Ge,W., Coleman,M.L., Rose,N.R., Cooper,C.D.,
            Klose,R.J., Ratcliffe,P.J. and Schofield,C.J.
  TITLE     PHF8, a gene associated with cleft lip/palate and mental
            retardation, encodes for an Nepsilon-dimethyl lysine demethylase
  JOURNAL   Hum Mol Genet 19 (2), 217-222 (2010)
   PUBMED   19843542
REFERENCE   9  (bases 1 to 5692)
  AUTHORS   Horton,J.R., Upadhyay,A.K., Qi,H.H., Zhang,X., Shi,Y. and Cheng,X.
  TITLE     Enzymatic and structural insights for substrate specificity of a
            family of jumonji histone lysine demethylases
  JOURNAL   Nat Struct Mol Biol 17 (1), 38-43 (2010)
   PUBMED   20023638
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474063.2.
            
            [WARNING] On Oct 22, 2024 this sequence was replaced by
            NM_001108253.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001062296.1, XM_001062175.1, XM_001062233.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..5692
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..5692
                     /gene="Phf8"
                     /gene_synonym="RGD1561065"
                     /note="PHD finger protein 8"
                     /db_xref="GeneID:317425"
                     /db_xref="RGD:1561065"
     exon            1..139
                     /gene="Phf8"
                     /gene_synonym="RGD1561065"
                     /inference="alignment:Splign:2.1.0"
     exon            140..334
                     /gene="Phf8"
                     /gene_synonym="RGD1561065"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..3308
                     /gene="Phf8"
                     /gene_synonym="RGD1561065"
                     /EC_number="1.14.11.27"
                     /codon_start=1
                     /product="histone lysine demethylase PHF8"
                     /protein_id="NP_001101723.1"
                     /db_xref="GeneID:317425"
                     /db_xref="RGD:1561065"
                     /translation="MASVPVYCLCRLPYDVTRFMIECDMCQDWFHGSCVGVEEEKAAD
                     IDLYHCPNCEVLHGPSIMKKRRGSSKGHDNHKGKPLKTGSSMFIRELRGRTFDSSDEV
                     ILKPTGSQLTVEFLEENSFSVPILVLKKDGLGMTLPSPSFTVRDVEHYVGSDKEIDVI
                     DVARQADCKMKLGDFVKYYYSGKREKVLNVISLEFSDTRLSNLVETPKIVRKLSWVEN
                     LWPEECVFERPNVQKYCLMSVRDSYTDFHIDFGGTSVWYHVLKGEKIFYLIRPTNANL
                     TLFECWSSSSNQNEMFFGDQVEKCYKCSVKQGQTLFIPTGWIHAVLTPVDCLAFGGNF
                     LHSLNIEMQLKAYEIEKRLSTADLFKFPNFETICWYVGKHILDIFRGLRENRRHPASY
                     LVHGGKALNLAFRAWTRKEALPDHEDEIPETVRTVQLIKDLAREIRLVEDIFQQNVGK
                     TSNIFGLQRIFPAGSIPLTRPAHSTSVSMSKLSLPSKNGSKKKGLKPKDIFKKAERKG
                     KQSSALGPAGQLSYNLMDPYSHQALKTGPSQKAKLNIGGACLNDSDDDSADMDVDGSE
                     NPLALLMANGSTKRMKSVSKSRRAKIAKKVDSARLVAEQVMGDEFDLDSDDELQIDER
                     LGKEKANLLMRSKFPRKLPRAKPCSDPNRIREPGEVEFDIEEDYTTDEDMVEGVESKL
                     GNGSGAGGILDLLKASRQVGGPDYAALTEAPASPSTQEAIQGMLCMANLQSSSSSPAT
                     SSLQAWWTGGQDRSSGSSSSGLGTVSNSPISQRTPGKRPIKRPAYWKNESEEEENASM
                     DEQDSLGACFKDAEYIYPSLESDDDDPALKSRPKKKKNSDDAPWSPKARVTPTLPKQD
                     RPVREGTRVASIETGLAAAAAKLAQQELQKAQKKKYIKKKPLLKEVEQPRPQDSNTTM
                     TMPAPTLATTPQPVTSSSPQPPPEPKQEALSGSLADHEYTARPNAFGMAQANRSTTPM
                     APGVFLTQRRPSVGSQSSQAGQGKRPKKGLATAKQRLGRILKIHRNGKLLL"
     exon            335..420
                     /gene="Phf8"
                     /gene_synonym="RGD1561065"
                     /inference="alignment:Splign:2.1.0"
     exon            421..529
                     /gene="Phf8"
                     /gene_synonym="RGD1561065"
                     /inference="alignment:Splign:2.1.0"
     exon            530..690
                     /gene="Phf8"
                     /gene_synonym="RGD1561065"
                     /inference="alignment:Splign:2.1.0"
     exon            691..832
                     /gene="Phf8"
                     /gene_synonym="RGD1561065"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1019
                     /gene="Phf8"
                     /gene_synonym="RGD1561065"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1182
                     /gene="Phf8"
                     /gene_synonym="RGD1561065"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1270
                     /gene="Phf8"
                     /gene_synonym="RGD1561065"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1377
                     /gene="Phf8"
                     /gene_synonym="RGD1561065"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1469
                     /gene="Phf8"
                     /gene_synonym="RGD1561065"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1559
                     /gene="Phf8"
                     /gene_synonym="RGD1561065"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1862
                     /gene="Phf8"
                     /gene_synonym="RGD1561065"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1966
                     /gene="Phf8"
                     /gene_synonym="RGD1561065"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2145
                     /gene="Phf8"
                     /gene_synonym="RGD1561065"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..2231
                     /gene="Phf8"
                     /gene_synonym="RGD1561065"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2365
                     /gene="Phf8"
                     /gene_synonym="RGD1561065"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2676
                     /gene="Phf8"
                     /gene_synonym="RGD1561065"
                     /inference="alignment:Splign:2.1.0"
     exon            2677..2772
                     /gene="Phf8"
                     /gene_synonym="RGD1561065"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..2882
                     /gene="Phf8"
                     /gene_synonym="RGD1561065"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..3219
                     /gene="Phf8"
                     /gene_synonym="RGD1561065"
                     /inference="alignment:Splign:2.1.0"
     exon            3220..5692
                     /gene="Phf8"
                     /gene_synonym="RGD1561065"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagagctgt gttgccccgg agcgagccta gccgctggcg agtctctggg gctgagctct
       61 gcgccctgag gagttccccc tgcagcctcg ggcatgaaga gatctttgta gcgtttggga
      121 ccgtggacgt ttttatcagc catcgtctag ggaaggcggc ttgcttgttg ctgcctttct
      181 gaccctgtaa agcttcaaaa ctggcacggc gcaaaacgat ccaaccccct gtgaagatgg
      241 cctcggtgcc tgtgtattgc ctctgtcgac tgccttacga tgtgacccgc ttcatgatcg
      301 agtgtgacat gtgccaggac tggtttcacg gcagttgtgt tggtgttgag gaggagaagg
      361 ctgctgatat tgatctgtac cattgcccca actgtgaagt cttacacgga ccctccatta
      421 tgaaaaaacg tcgtggatct tccaaaggac atgataatca caagggtaaa ccattgaaga
      481 ctgggagctc catgtttatc cgagaactac ggggtaggac ttttgacagc tcagacgaag
      541 tgattctgaa acccactgga agtcagctga cagtggaatt cttggaagag aatagcttca
      601 gcgtgcctat ccttgtcttg aagaaggatg gcttggggat gacattaccc tctccatcat
      661 tcactgtgag ggatgtggag cactatgttg gttctgacaa agagattgat gtgattgatg
      721 tggcccgcca ggctgactgc aaaatgaaac ttggtgattt tgtcaaatac tattacagtg
      781 ggaagaggga aaaagtcctc aatgtcatta gtttggaatt ctctgatacc agactttcaa
      841 accttgtgga aacacccaag attgttcgaa agctgtcgtg ggtggagaac ttgtggccgg
      901 aggaatgtgt ctttgagagg cccaatgtgc agaagtactg cctcatgagt gtgcgggata
      961 gctatacaga ttttcacatt gactttggtg ggacctcagt ttggtaccat gtgcttaagg
     1021 gtgagaagat cttctacctg atccgcccaa caaatgctaa tctgactctc tttgagtgct
     1081 ggagcagctc ctctaatcag aatgagatgt tctttggtga ccaggtggaa aaatgctaca
     1141 agtgttctgt gaagcaagga caaacactgt ttattcctac agggtggata catgctgtgc
     1201 taacaccagt ggactgctta gcctttggag ggaacttttt acatagcctt aacattgaaa
     1261 tgcaactcaa ggcctatgaa attgagaagc ggctgagcac agcagacctt ttcaagtttc
     1321 ccaacttcga gaccatctgt tggtatgtgg gaaaacatat tctggacatc ttccgaggct
     1381 tacgagagaa caggagacat cctgcctcct acctggtcca tggtggtaaa gctctgaact
     1441 tggcctttag agcctggaca aggaaagaag ctctgccaga ccatgaggat gagatcccag
     1501 agacagtgcg gactgtacag ctcattaaag atctggctag ggagatccgc ctggtcgaag
     1561 acatcttcca acagaacgtt gggaagacga gcaatatctt tgggctgcag aggatcttcc
     1621 cagctggttc catcccctta accaggccag cccattccac ttcagtatcc atgtccaagc
     1681 tgtcactgcc ctccaaaaat ggttcaaaga agaaaggcct gaagcccaag gatatcttca
     1741 agaaggcaga acgaaagggc aagcagagtt cagccttggg gcctgctggc cagttgagct
     1801 ataatctcat ggacccatac agtcatcagg cactgaagac aggcccttcc cagaaagcaa
     1861 agctcaacat tggtggtgcc tgcttgaatg actcagatga tgactcagca gacatggacg
     1921 ttgatggcag tgagaacccc ctggccctgt tgatggctaa tggcagtaca aagaggatga
     1981 agagtgtatc caagtctcga agagccaaaa ttgcgaagaa ggtagacagt gcaagactgg
     2041 tagcagaaca ggtcatgggg gatgaatttg acttggactc agatgatgag ctgcagattg
     2101 atgagagact gggaaaggaa aaagcgaacc tgttaatgag atcaaaattt ccccggaaat
     2161 tgccccgtgc aaaaccttgc tctgacccca accgaattcg tgaacctgga gaagttgagt
     2221 ttgacattga ggaggactat acaacagatg aggacatggt ggaaggggtt gaaagcaagc
     2281 ttggtaatgg gagtggagct ggtggaattc ttgatctact taaggccagc aggcaggtcg
     2341 ggggacctga ctatgctgcc ctcactgagg ccccagcctc ccccagcaca caagaggcca
     2401 tccagggcat gttatgtatg gccaacctgc agtcctcatc atcctcacca gctacctcca
     2461 gtctgcaggc ttggtggacc ggagggcaag accgaagcag tgggagctcc agcagtgggc
     2521 tgggcactgt gtctaatagt cctatttccc agcgcacccc agggaagcgg cccatcaaga
     2581 ggccagcata ctggaaaaac gagagtgagg aggaagagaa tgccagtatg gatgaacaag
     2641 acagcttggg agcatgcttc aaggatgctg agtatatcta tccatccctg gagtctgatg
     2701 atgatgaccc tgctttgaaa tctcgaccca agaaaaagaa gaattcagat gatgctccat
     2761 ggagtcctaa agcccgtgtg actccaactc tacccaagca ggaccgtcct gttcgtgaag
     2821 gaaccagagt tgcctccatt gagacaggct tggctgcagc agctgcaaag cttgcccagc
     2881 aggagctgca aaaggcccaa aagaagaaat atatcaagaa gaagcctttg ctgaaggagg
     2941 tagaacagcc tcgccctcaa gattccaata ccaccatgac aatgcctgca ccaacactgg
     3001 ctactacacc ccagcctgtc acctcctcct caccccagcc acctcctgag cctaaacaag
     3061 aggctctgtc aggaagtctt gctgaccatg agtacactgc tcgtcccaat gcctttggca
     3121 tggctcaggc aaatcgcagc accacaccta tggcccctgg agtcttcctc acccagcggc
     3181 gcccttcagt tggttcccag agcagtcagg caggacaagg aaagcgtccg aaaaagggcc
     3241 tggccacagc aaagcaaaga ctcggccgca tcctgaaaat ccacagaaat ggcaagttac
     3301 ttctgtgaga caagccccgt catgtcctac tccttcatcc cttcaccccc attgccttct
     3361 tcgttgtcaa ctcggggcac tcctggatcc tatgagcccc ggacaaggtg cattgtcctg
     3421 ctttcttggg actgaccaaa ggcacggact atccccaact ccctttccca cttcccctat
     3481 gagtatccta ccttctcttt ccatacccat aagtagcagg taaatgggag aagtttccaa
     3541 ctgacaagaa cttttcctgt tccacccaca tatttcactt acaccttgtc tttgtacttt
     3601 tccaccactc ctccatatgg aaggaatgat gaggagcagc ataaagggag tctgggccct
     3661 tcagtttcct cagccatgga ttgagaggcc cagtgctcaa cattttcggc acatttagcc
     3721 ctgtctctaa gcctgcccac ctccacccat tcctacccct tcctcacaac cagtggatat
     3781 accctacctt cagtcttgtt ccttatagaa ggttgtggtc tttatctcct tttacctctt
     3841 ttcataacaa aaatgaaaag ggtctttatg acccttacag gccatctcca gagctggcct
     3901 agaaaagctg actgtctttt ggggttgggg ggctttttga ggtggaagaa gaaacagata
     3961 cccaagcctt tgaccatggt tgttggccta gcctaccaga ggaaactact tttgtctgac
     4021 tgcacatgaa gcccctatga tgatcttcag gaatttgcct gtatttttga ggccctgtag
     4081 aacattatcc ccttagctat aactgggttc cagcaggtac aaactcacct cctagaaatc
     4141 tgaagtacca gccacactga taactctggc tctggcctgc tcctaccacc ccaactgtac
     4201 cacaaagcac agcctggacc ttctgaagag ggtgtggtga aacaacctaa ccctgcaggt
     4261 cattatcagg aacttccatg tttcttttcc catctgagct tagtctaaag aagatttcag
     4321 gactaagatc ttcaccgctg ggacttttca ctttcagacc acaggccaac agtcaagcat
     4381 agtgcagata ggctattcaa gtctgaagtt agaaacgatg cccatctgtg aagtagcaga
     4441 tattcggatc cacttttctc tcctttgtga ttgtcactat tttctagaga gtgtccccca
     4501 cctccctctt gtcttgcctt actggcaatt tggacttgat ggagactgcc ccttctgaac
     4561 aacccgtttt ggcactgccc aagtgggagt gtcctctacc ttccactcgt cctcatccca
     4621 gcttgcctag ggcttctggg gaatttaaca gctatgatgc agaccacagg gaatttgtga
     4681 ggcctctgtg ttatctttta tgtttgtggc ttatctttct tttttctata gatatatcta
     4741 taccctccat ccttgttgga atgggggagg gtactttaga atatttgctt tttctacctt
     4801 ggggaccccc aggggccaag cagtcctcct ttagtcacac caaaggcaaa aggcctggct
     4861 acctcccctt tagcacgtga ggtccctact cccctccttt ctactcagct ttgctcatct
     4921 tggagatttc agggcagcag tggggaagta aggggaaagc aggggaagct tctgaccctg
     4981 tatgggcaac ttcctgacta aaggctgact gttgtcacca aaaacaggtc cctagccctt
     5041 acacctatta aaactccctc ttgatctttc aaaggcagct aattgctagc accctctccc
     5101 tacccattcc aggcctcttt tccctctgtt tctttgttag aaggttctgt ggagctgaaa
     5161 cccaccctct aatggggttt gtttagttta gttgggttct cagagtctcc tgttattttg
     5221 tgttgtttcc aatgaaaagc aagtttaccc tcaaagttat gcttttccaa agaagctagt
     5281 gtgttgttgt tgttgttgtt gttgttgttg ctgttgttgt tgttttgttt gttttgtttt
     5341 tatgtttcag gttctaagtg aagtgaggtg gagaggagtt gggaataacc aaggtttaga
     5401 catggtgaga tagttacctc tgatctgcaa accccagcag agagctgggg taggataaga
     5461 gggcagagag gatttctatt cacctttaat atatttttac aaaaaagcaa acaatttaaa
     5521 aacaaaccca ccgcttctgt acatgtctaa atatattttt agaagtgggt aggattgtga
     5581 tttctgatgc agggcctttt tataaatagg ttagagtagc ctcatccaga tttctctgtt
     5641 gtttgttccc cttgtttttt cttatgttgt gttactaatg taatttatat at
//
