LOCUS       NM_001402228            4399 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus PHD finger protein 6 (Phf6), mRNA.
ACCESSION   NM_001402228 XM_008773660
VERSION     NM_001402228.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4399)
  AUTHORS   Kiefer,K.C., Cremer,S., Pardali,E., Assmus,B., Abou-El-Ardat,K.,
            Kirschbaum,K., Dorsheimer,L., Rasper,T., Berkowitsch,A., Serve,H.,
            Dimmeler,S., Zeiher,A.M. and Rieger,M.A.
  TITLE     Full spectrum of clonal haematopoiesis-driver mutations in chronic
            heart failure and their associations with mortality
  JOURNAL   ESC Heart Fail 8 (3), 1873-1884 (2021)
   PUBMED   33779075
REFERENCE   2  (bases 1 to 4399)
  AUTHORS   Yu,Q., Zhou,J., Jian,Y., Xiu,Z., Xiang,L., Yang,D. and Zeng,W.
  TITLE     MicroRNA-214 suppresses cell proliferation and migration and cell
            metabolism by targeting PDK2 and PHF6 in hepatocellular carcinoma
  JOURNAL   Cell Biol Int 44 (1), 117-126 (2020)
   PUBMED   31329335
REFERENCE   3  (bases 1 to 4399)
  AUTHORS   Zhang,G., Shi,J., Yang,X., Zhang,X., Zhang,L., Zhang,J., Yang,S.,
            Wang,J., Hu,K., Ke,X. and Fu,L.
  TITLE     High expression of microRNA-500 is associated with poor prognosis
            in patients with acute myeloid leukemia receiving allogeneic
            hematopoietic stem cell transplantation
  JOURNAL   Oncol Lett 17 (6), 5815-5820 (2019)
   PUBMED   31186809
REFERENCE   4  (bases 1 to 4399)
  AUTHORS   Yu,Q., Yin,L., Jian,Y., Li,P., Zeng,W. and Zhou,J.
  TITLE     Downregulation of PHF6 Inhibits Cell Proliferation and Migration in
            Hepatocellular Carcinoma
  JOURNAL   Cancer Biother Radiopharm 34 (4), 245-251 (2019)
   PUBMED   30888215
REFERENCE   5  (bases 1 to 4399)
  AUTHORS   Slattery,M.L., Herrick,J.S., Mullany,L.E., Samowitz,W.S.,
            Sevens,J.R., Sakoda,L. and Wolff,R.K.
  TITLE     The co-regulatory networks of tumor suppressor genes, oncogenes,
            and miRNAs in colorectal cancer
  JOURNAL   Genes Chromosomes Cancer 56 (11), 769-787 (2017)
   PUBMED   28675510
REFERENCE   6  (bases 1 to 4399)
  AUTHORS   Cui,W., Dai,X., Marcho,C., Han,Z., Zhang,K., Tremblay,K.D. and
            Mager,J.
  TITLE     Towards Functional Annotation of the Preimplantation Transcriptome:
            An RNAi Screen in Mammalian Embryos
  JOURNAL   Sci Rep 6, 37396 (2016)
   PUBMED   27869233
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4399)
  AUTHORS   Liu,Z., Li,F., Ruan,K., Zhang,J., Mei,Y., Wu,J. and Shi,Y.
  TITLE     Structural and functional insights into the human
            Borjeson-Forssman-Lehmann syndrome-associated protein PHF6
  JOURNAL   J Biol Chem 289 (14), 10069-10083 (2014)
   PUBMED   24554700
REFERENCE   8  (bases 1 to 4399)
  AUTHORS   Todd,M.A. and Picketts,D.J.
  TITLE     PHF6 interacts with the nucleosome remodeling and deacetylation
            (NuRD) complex
  JOURNAL   J Proteome Res 11 (8), 4326-4337 (2012)
   PUBMED   22720776
REFERENCE   9  (bases 1 to 4399)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   10 (bases 1 to 4399)
  AUTHORS   Voss,A.K., Gamble,R., Collin,C., Shoubridge,C., Corbett,M., Gecz,J.
            and Thomas,T.
  TITLE     Protein and gene expression analysis of Phf6, the gene mutated in
            the Borjeson-Forssman-Lehmann Syndrome of intellectual disability
            and obesity
  JOURNAL   Gene Expr Patterns 7 (8), 858-871 (2007)
   PUBMED   17698420
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Mar 8, 2022 this sequence version replaced XM_008773660.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.329458.1,
                                           SRR26360176.895707.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               JAXUCZ010000021.1  137576240-137576428
            190-374             JAXUCZ010000021.1  137580508-137580692
            375-476             JAXUCZ010000021.1  137580931-137581032
            477-610             JAXUCZ010000021.1  137596458-137596591
            611-654             JAXUCZ010000021.1  137596836-137596879
            655-821             JAXUCZ010000021.1  137603774-137603940
            822-965             JAXUCZ010000021.1  137604085-137604228
            966-1070            JAXUCZ010000021.1  137606133-137606237
            1071-1204           JAXUCZ010000021.1  137609395-137609528
            1205-1331           JAXUCZ010000021.1  137615788-137615914
            1332-4399           JAXUCZ010000021.1  137616230-137619297
FEATURES             Location/Qualifiers
     source          1..4399
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq36"
     gene            1..4399
                     /gene="Phf6"
                     /note="PHD finger protein 6"
                     /db_xref="GeneID:100359714"
                     /db_xref="RGD:2323526"
     exon            1..189
                     /gene="Phf6"
                     /inference="alignment:Splign:2.1.0"
     exon            190..374
                     /gene="Phf6"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..1331
                     /gene="Phf6"
                     /codon_start=1
                     /product="PHD finger protein 6"
                     /protein_id="NP_001389157.1"
                     /db_xref="GeneID:100359714"
                     /db_xref="RGD:2323526"
                     /translation="MSSSIEQKKGSTRQRKCGFCKSNRDKECGQLLISENQKVAAHHK
                     CMLFSSALVSSHSDNESLGGFSIEDVQKEIKRGTKLMCSLCHCPGATIGCDVKTCHRT
                     YHYHCALHDKAQIREKPSQGIYMVYCRKHKKTAHNSEADLEESFNEHELEPSSPKTKK
                     KSRKGRPRKTNLKGLAEDTRSTSSHGTDETESSSYRDRSPHRSSPNDTRPKCGFCHVG
                     EEENEARGKLHIFNAKKAAAHYKCMLFSSGTVQLTTTSRAEFGDFDIKTVLQEIKRGK
                     RMKCTLCSQPGATIGCEIKACVKTYHYHCGVQDKAKYIENMSRGIYKLYCKNHSGNDE
                     RDEEDEERESKSRGRVAIDQQLTQQQLNGN"
     exon            375..476
                     /gene="Phf6"
                     /inference="alignment:Splign:2.1.0"
     exon            477..610
                     /gene="Phf6"
                     /inference="alignment:Splign:2.1.0"
     exon            611..654
                     /gene="Phf6"
                     /inference="alignment:Splign:2.1.0"
     exon            655..821
                     /gene="Phf6"
                     /inference="alignment:Splign:2.1.0"
     exon            822..965
                     /gene="Phf6"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1070
                     /gene="Phf6"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1204
                     /gene="Phf6"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1331
                     /gene="Phf6"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..4399
                     /gene="Phf6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgtgggtcg tgtgcgtacg gagggaggca acgtaagggc gctcggccag cccgtctctc
       61 ctcgaatgaa aggaaacaac ccctggcaac agagctccgc tcttcggcac tgccggagaa
      121 ccgactcccg ccttccccgt ctcccctcgt gggcgctgtc ctcccttcgc ccagccgtga
      181 gccccactgc atttttttga ggcttaaagt ggcattctct aaacaattta aaaatcatgt
      241 caagctcaat tgaacagaaa aaagggtcta cgagacagcg caaatgtggc ttttgtaagt
      301 caaatagaga caaggaatgc ggacaattac tgatatctga aaaccagaag gtggcagcac
      361 accataagtg catgctgttt tcatctgctt tggtatcctc acattctgat aatgagagtc
      421 ttggtggatt ttctattgaa gatgtccaaa aggaaattaa aagaggcaca aagctgatgt
      481 gttctctttg tcattgtcct ggagcaacca ttggctgtga tgtgaaaacc tgccacagga
      541 cataccacta ccactgtgca ctgcatgata aagctcagat ccgagagaaa ccttcgcaag
      601 ggatttacat ggtttattgt cgaaaacaca agaaaactgc ccataactct gaagctgatt
      661 tagaagaaag ttttaatgaa catgaactgg agccctcatc tccaaaaact aagaagaaaa
      721 gtcgcaaagg aagaccaaga aaaaccaacc ttaaaggtct ggcggaagac accagatcca
      781 catcctccca tggaacagat gaaacggaaa gcagttccta ccgagatagg tctccacaca
      841 ggagcagtcc taatgatacc aggcctaaat gtggattttg ccatgtaggg gaggaagaaa
      901 atgaagcaag agggaaattg catatattta atgccaagaa ggcagccgcg cattacaagt
      961 gcatgttgtt ttcttctggc actgtgcagc tcacaacaac atcaagagca gaatttggag
     1021 attttgatat taaaactgta cttcaggaga ttaagcgagg aaaaaggatg aaatgtacac
     1081 tttgcagtca gcctggtgct actattggat gtgaaataaa agcctgtgtt aaaacctacc
     1141 attaccactg tggagtacaa gacaaggcaa aatacattga aaacatgtcc cgaggaattt
     1201 acaaactata ttgtaaaaac catagtggga acgatgaacg agatgaagaa gacgaggagc
     1261 gagagagtaa aagccgtgga agagtagcga ttgatcagca actaacccag cagcagctta
     1321 acggaaacta ggttcgtggg acagagagag ttaaaaaact gagaataaga caactataac
     1381 tcctgtgctt cttttccact cttttctaaa ataaagggtt tgtaactttt tactgcccgc
     1441 ctcttagatc cttcattgaa ctgtctaaaa ataccttgtt agttttctta gccttcagta
     1501 gatggccgga tttgacatac tgatattatg tagctgtagt ttgcagtttc tgggaagcaa
     1561 tcgaaacact attagccctg tgtatactgt caacagttaa agcagacatt gagtgaagta
     1621 aactgtattt ctggactgaa caaagttcta ctatttagag tgtttaagtt tgtgtagtag
     1681 atccatgcgc aaaggaaacc ggaagcaagt tgggcttcac catgcaaaca cgcctctggt
     1741 agcaacatct ggtaatgtgg ggactttttc ttgttttcat actcaagcag tggaaactac
     1801 aaatgaagag aaccttcttt tggtcttggc tttgacagca catgctctaa ccatttcttt
     1861 caaggagcgt gctgaagcct tcctttggtc ctttttacag ttgttgtcac tgagcagcat
     1921 ggactctggg cgactggtga tgacaaactg agttccagtg cttctgccaa aactcttgac
     1981 agtgcgcctt tctgtgctgt acagagagct tctggcgaca taatggaatc gtaccaagat
     2041 caaaataaca tttggcaaca tcagattaaa cctctttgag atgaaagagg tcaccaacgc
     2101 gctaaggact ttggacatcc tgtctgaaac cagtttctct caagtgccct gttgtgtgga
     2161 acacttcaca tattggccca atgtatataa ggaggtctta tgtgctaaaa gatttttttt
     2221 taaaaaaagg aaccatcttt gtgcaaaaca gtatttattt ttgattctgt gaccactatt
     2281 ttagaaacat taacgctttc agtcatcagt ttgcttacat gttgaataag cttttgtgcc
     2341 ctgtttttct tcgagggctc acaagtgttt tcttaatgac cagaatttta gaaaggcttt
     2401 cccctggtgt ttctcgcttg tgacacacat ccacttacct gctgaagcac acttacatat
     2461 ttctttatgg caaaaccaaa aactttagtt gcagtctgcc taatgttacc atagcacctc
     2521 aatatgaaag gtaaggattc tgagtccaaa tcattagtta ccctaccaca atgaatcaga
     2581 tttgcaaata agaaataccg tactaactga ctgtacattg ttctgttctg tagctggtag
     2641 agcagcattt ttaaatgtaa caggtggaaa atcacactgt gcttattgac tgggttttta
     2701 aactgctagt cccttaagat catttttgtt aaggtgtgta tttacacatt tacttaaatc
     2761 aagggactca atgctcgctt tcttttaacc atcttttatt gttattttag aaggaaacta
     2821 gctttagtag tggattgcct tgtgcgtctt ctccttctgc tcttaacatg ccatgatgtg
     2881 tatgattaat tttcaaggtt catcacgact tgaagtgcaa ggacagatct tagtttgttt
     2941 accaagcgat gtgacttttc ccaaaggatc tgtactttat ttccttataa cagcttgaaa
     3001 accattattt tttaaatctt taaatcactg tgtctaggta atttttacat tgtgtgccat
     3061 agaattaccc atggagaaat agagctcctt catttttgga caactactgt aatgattttt
     3121 ttaaagaaaa atggaaggtg ccaggggtaa ttatggccag tcaataatta tataaaggac
     3181 ttcaaatact atagctgtca gttgatggat ttgatatgta atacatgtat gactttgtat
     3241 gggtttcttc agccctttct ctgccactag caaccagaaa agcactttac cttttggttg
     3301 cttagataag tggctaacta cctggttttt ttttcactgt ggtgtgattg gctaaataac
     3361 cttcatttaa agttgcgatg taaactgaag tcacattaaa cactcacgtt tggttgtaaa
     3421 cttccaatat tttgattctt tgttcctgtt ttcattctat gctgagtaaa agtgccttac
     3481 aatgtaaaaa ttgtacagta cttacgttcc caagtagcat cttcatcatc tggctagcaa
     3541 tcacattgtg gtattaatat ttagataaat agacctcagc agtgtattta ctgtacaact
     3601 cttaagtcct taactgtagt tttaataagc atgacattat ttggcaaata tatggcattt
     3661 acatcatttc caaaaatact tccattgccg tctaacgcgt atttttagcc tgaaattttg
     3721 atgcgtctat ttttcttgtt ttttttcttc atttgttttg ttcctttttg tcattattaa
     3781 tattaaactg tgtaatcttt gcaagcgtat attgaagatt attctggagc atttattgcc
     3841 ttaccagaaa tgttagtgag acatgttctt tagagtagaa gggtagactt gagtttctat
     3901 actttaataa gacctctttg ttcctggggg gagggggagt tttgctttca tctcattgtt
     3961 ttaaaagcca cacctgaaat gaatttcatg tcaaggatca gcagtttcca aacttgaggt
     4021 ggtacttgct tagtacatga ctcaagatcc taagagagta acatgatcga tctacagatc
     4081 tgctatcaaa tcgaatctat gtacttgaac aaatgtgtga atctcaaata tctcaaagca
     4141 aaagtgttgt agaatgttgt tgctttttga aaaagcactg aagttagacc aaggcacagt
     4201 tttgttttaa cagacattta agttaattgt aaagataagg aatgcatcat gggtcagaaa
     4261 tcaaacattc ctcaatgtta tgtatatttt gttcctgtta tattggcttt attttcaaaa
     4321 ttgtagtttg tagtattagt ttcctttaaa tggtattctt gcatatacta ttcattcaat
     4381 aaatgagttc tgaatttca
//
