LOCUS       NP_001389157             364 aa            linear   ROD 31-MAR-2024
DEFINITION  PHD finger protein 6 [Rattus norvegicus].
ACCESSION   NP_001389157 XP_008771882
VERSION     NP_001389157.1
DBSOURCE    REFSEQ: accession NM_001402228.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 364)
  AUTHORS   Kiefer,K.C., Cremer,S., Pardali,E., Assmus,B., Abou-El-Ardat,K.,
            Kirschbaum,K., Dorsheimer,L., Rasper,T., Berkowitsch,A., Serve,H.,
            Dimmeler,S., Zeiher,A.M. and Rieger,M.A.
  TITLE     Full spectrum of clonal haematopoiesis-driver mutations in chronic
            heart failure and their associations with mortality
  JOURNAL   ESC Heart Fail 8 (3), 1873-1884 (2021)
   PUBMED   33779075
REFERENCE   2  (residues 1 to 364)
  AUTHORS   Yu,Q., Zhou,J., Jian,Y., Xiu,Z., Xiang,L., Yang,D. and Zeng,W.
  TITLE     MicroRNA-214 suppresses cell proliferation and migration and cell
            metabolism by targeting PDK2 and PHF6 in hepatocellular carcinoma
  JOURNAL   Cell Biol Int 44 (1), 117-126 (2020)
   PUBMED   31329335
REFERENCE   3  (residues 1 to 364)
  AUTHORS   Zhang,G., Shi,J., Yang,X., Zhang,X., Zhang,L., Zhang,J., Yang,S.,
            Wang,J., Hu,K., Ke,X. and Fu,L.
  TITLE     High expression of microRNA-500 is associated with poor prognosis
            in patients with acute myeloid leukemia receiving allogeneic
            hematopoietic stem cell transplantation
  JOURNAL   Oncol Lett 17 (6), 5815-5820 (2019)
   PUBMED   31186809
REFERENCE   4  (residues 1 to 364)
  AUTHORS   Yu,Q., Yin,L., Jian,Y., Li,P., Zeng,W. and Zhou,J.
  TITLE     Downregulation of PHF6 Inhibits Cell Proliferation and Migration in
            Hepatocellular Carcinoma
  JOURNAL   Cancer Biother Radiopharm 34 (4), 245-251 (2019)
   PUBMED   30888215
REFERENCE   5  (residues 1 to 364)
  AUTHORS   Slattery,M.L., Herrick,J.S., Mullany,L.E., Samowitz,W.S.,
            Sevens,J.R., Sakoda,L. and Wolff,R.K.
  TITLE     The co-regulatory networks of tumor suppressor genes, oncogenes,
            and miRNAs in colorectal cancer
  JOURNAL   Genes Chromosomes Cancer 56 (11), 769-787 (2017)
   PUBMED   28675510
REFERENCE   6  (residues 1 to 364)
  AUTHORS   Cui,W., Dai,X., Marcho,C., Han,Z., Zhang,K., Tremblay,K.D. and
            Mager,J.
  TITLE     Towards Functional Annotation of the Preimplantation Transcriptome:
            An RNAi Screen in Mammalian Embryos
  JOURNAL   Sci Rep 6, 37396 (2016)
   PUBMED   27869233
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 364)
  AUTHORS   Liu,Z., Li,F., Ruan,K., Zhang,J., Mei,Y., Wu,J. and Shi,Y.
  TITLE     Structural and functional insights into the human
            Borjeson-Forssman-Lehmann syndrome-associated protein PHF6
  JOURNAL   J Biol Chem 289 (14), 10069-10083 (2014)
   PUBMED   24554700
REFERENCE   8  (residues 1 to 364)
  AUTHORS   Todd,M.A. and Picketts,D.J.
  TITLE     PHF6 interacts with the nucleosome remodeling and deacetylation
            (NuRD) complex
  JOURNAL   J Proteome Res 11 (8), 4326-4337 (2012)
   PUBMED   22720776
REFERENCE   9  (residues 1 to 364)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   10 (residues 1 to 364)
  AUTHORS   Voss,A.K., Gamble,R., Collin,C., Shoubridge,C., Corbett,M., Gecz,J.
            and Thomas,T.
  TITLE     Protein and gene expression analysis of Phf6, the gene mutated in
            the Borjeson-Forssman-Lehmann Syndrome of intellectual disability
            and obesity
  JOURNAL   Gene Expr Patterns 7 (8), 858-871 (2007)
   PUBMED   17698420
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Mar 8, 2022 this sequence version replaced XP_008771882.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.329458.1,
                                           SRR26360176.895707.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..364
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq36"
     Protein         1..364
                     /product="PHD finger protein 6"
                     /calculated_mol_wt=40966
     Region          17..131
                     /region_name="ePHD1_PHF6"
                     /note="Extended PHD finger 1 found in PHD finger protein 6
                     (PHF6); cd15710"
                     /db_xref="CDD:277180"
     Site            order(81,90..94,100,126)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277180"
     Region          212..329
                     /region_name="ePHD2_PHF6"
                     /note="Extended PHD finger 2 found in PHD finger protein 6
                     (PHF6); cd15711"
                     /db_xref="CDD:277181"
     Site            order(279,288..292,298,324)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277181"
     CDS             1..364
                     /gene="Phf6"
                     /coded_by="NM_001402228.1:237..1331"
                     /db_xref="GeneID:100359714"
                     /db_xref="RGD:2323526"
ORIGIN      
        1 msssieqkkg strqrkcgfc ksnrdkecgq llisenqkva ahhkcmlfss alvsshsdne
       61 slggfsiedv qkeikrgtkl mcslchcpga tigcdvktch rtyhyhcalh dkaqirekps
      121 qgiymvycrk hkktahnsea dleesfnehe lepsspktkk ksrkgrprkt nlkglaedtr
      181 stsshgtdet esssyrdrsp hrsspndtrp kcgfchvgee eneargklhi fnakkaaahy
      241 kcmlfssgtv qltttsraef gdfdiktvlq eikrgkrmkc tlcsqpgati gceikacvkt
      301 yhyhcgvqdk akyienmsrg iyklycknhs gnderdeede eresksrgrv aidqqltqqq
      361 lngn
//
