LOCUS       NM_001013169            3773 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus polyhomeotic homolog 2 (Phc2), mRNA.
ACCESSION   NM_001013169 XM_001059705 XM_232751
VERSION     NM_001013169.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3773)
  AUTHORS   Gil,J. and O'Loghlen,A.
  TITLE     PRC1 complex diversity: where is it taking us?
  JOURNAL   Trends Cell Biol 24 (11), 632-641 (2014)
   PUBMED   25065329
  REMARK    Review article
REFERENCE   2  (bases 1 to 3773)
  AUTHORS   Simon,J.A. and Kingston,R.E.
  TITLE     Occupying chromatin: Polycomb mechanisms for getting to genomic
            targets, stopping transcriptional traffic, and staying put
  JOURNAL   Mol Cell 49 (5), 808-824 (2013)
   PUBMED   23473600
  REMARK    Review article
REFERENCE   3  (bases 1 to 3773)
  AUTHORS   Vandamme,J., Volkel,P., Rosnoblet,C., Le Faou,P. and Angrand,P.O.
  TITLE     Interaction proteomics analysis of polycomb proteins defines
            distinct PRC1 complexes in mammalian cells
  JOURNAL   Mol Cell Proteomics 10 (4), M110.002642 (2011)
   PUBMED   21282530
REFERENCE   4  (bases 1 to 3773)
  AUTHORS   Maertens,G.N., El Messaoudi-Aubert,S., Racek,T., Stock,J.K.,
            Nicholls,J., Rodriguez-Niedenfuhr,M., Gil,J. and Peters,G.
  TITLE     Several distinct polycomb complexes regulate and co-localize on the
            INK4a tumor suppressor locus
  JOURNAL   PLoS One 4 (7), e6380 (2009)
   PUBMED   19636380
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3773)
  AUTHORS   Puschendorf,M., Terranova,R., Boutsma,E., Mao,X., Isono,K.,
            Brykczynska,U., Kolb,C., Otte,A.P., Koseki,H., Orkin,S.H., van
            Lohuizen,M. and Peters,A.H.
  TITLE     PRC1 and Suv39h specify parental asymmetry at constitutive
            heterochromatin in early mouse embryos
  JOURNAL   Nat Genet 40 (4), 411-420 (2008)
   PUBMED   18311137
REFERENCE   6  (bases 1 to 3773)
  AUTHORS   Takada,Y., Isono,K., Shinga,J., Turner,J.M., Kitamura,H., Ohara,O.,
            Watanabe,G., Singh,P.B., Kamijo,T., Jenuwein,T., Burgoyne,P.S. and
            Koseki,H.
  TITLE     Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes
            from the XY body in the pachytene spermatocytes
  JOURNAL   Development 134 (3), 579-590 (2007)
   PUBMED   17215307
REFERENCE   7  (bases 1 to 3773)
  AUTHORS   Cao,R., Tsukada,Y. and Zhang,Y.
  TITLE     Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene
            silencing
  JOURNAL   Mol Cell 20 (6), 845-854 (2005)
   PUBMED   16359901
REFERENCE   8  (bases 1 to 3773)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
REFERENCE   9  (bases 1 to 3773)
  AUTHORS   Levine,S.S., Weiss,A., Erdjument-Bromage,H., Shao,Z., Tempst,P. and
            Kingston,R.E.
  TITLE     The core of the polycomb repressive complex is compositionally and
            functionally conserved in flies and humans
  JOURNAL   Mol Cell Biol 22 (17), 6070-6078 (2002)
   PUBMED   12167701
REFERENCE   10 (bases 1 to 3773)
  AUTHORS   Yamaki,M., Isono,K., Takada,Y., Abe,K., Akasaka,T., Tanzawa,H. and
            Koseki,H.
  TITLE     The mouse Edr2 (Mph2) gene has two forms of mRNA encoding 90- and
            36-kDa polypeptides
  JOURNAL   Gene 288 (1-2), 103-110 (2002)
   PUBMED   12034499
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Sep 13, 2008 this sequence version replaced
            XM_001059705.1, XM_232751.4, NM_001013169.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.29087.1,
                                           SRR26643297.20188.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-228               JAXUCZ010000005.1  146335238-146335465
            229-387             JAXUCZ010000005.1  146338563-146338721
            388-465             JAXUCZ010000005.1  146339599-146339676
            466-630             JAXUCZ010000005.1  146340670-146340834
            631-717             JAXUCZ010000005.1  146342393-146342479
            718-1030            JAXUCZ010000005.1  146343408-146343720
            1031-1419           JAXUCZ010000005.1  146354883-146355271
            1420-1585           JAXUCZ010000005.1  146355410-146355575
            1586-1788           JAXUCZ010000005.1  146374496-146374698
            1789-1918           JAXUCZ010000005.1  146376183-146376312
            1919-2033           JAXUCZ010000005.1  146376789-146376903
            2034-2175           JAXUCZ010000005.1  146378050-146378191
            2176-2452           JAXUCZ010000005.1  146378992-146379268
            2453-3773           JAXUCZ010000005.1  146382344-146383664
FEATURES             Location/Qualifiers
     source          1..3773
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3773
                     /gene="Phc2"
                     /note="polyhomeotic homolog 2"
                     /db_xref="GeneID:313038"
                     /db_xref="RGD:1307912"
     exon            1..228
                     /gene="Phc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..2607
                     /gene="Phc2"
                     /note="polyhomeotic-like 2"
                     /codon_start=1
                     /product="polyhomeotic-like protein 2"
                     /protein_id="NP_001013187.2"
                     /db_xref="GeneID:313038"
                     /db_xref="RGD:1307912"
                     /translation="MENELPVPHTSSRASITTNTSGTNSSSGCSSSSGGGSGRPTAPQ
                     ISVYSGIPDRQTVQVIQQALHRQPSTAAQYLQQMYAAQQQHLMLQTAALQQQHLSSAQ
                     LQSLAAVQQASLVANRQGSTSGSSVSSQAPAQSSSLNLAASPAAAQLINRAQSVNSAT
                     ASGLAQQAVLLGNTSSPALTASQAQMYLRAQMLIFTPTATVATVQPELGTGSPARPPT
                     PAQVQNLTLRTQQTPAAAAAAAASGPAPTQPVLPSLALKPTPSSSQPLPPTPQGRTVV
                     QGSPVGAKPSVTDNVTEPLKTDGNSNMEARPGPDRATVPTVATHQLTAPAYTQLQPHQ
                     LLPQPSSKHPQPQFVAQQQPQPPRPTPQVQSQPQLAAVSPSLALQPSPEGHAMPLGPV
                     TQALPLQCSTAHVHKPGSSQQCHLPTPDSGSQNGHPEGVSHAPQRRFQHTSAVILQLQ
                     PASPVPQQCAPDDWKEVVPAEKSVPVTRPGLSPHQQAIITAIPGGLPGPKSPNIQQCP
                     AHETGQGIVHALTDLSSPGMTSGNGNSASSITGTAPQNGENKPPQAIVKPQILTHVIE
                     GFVIQEGAEPFPVGRSSLLVGNLKKKYAQGFLPEKLPQQDHTTTTDSEMEEPYLQESK
                     EEGTPLKLKCELCGRVDFAYKFKRSKRFCSMACAKRYNVGCTKRVGLFHSDRSKLQKA
                     GTTTHNRRRASKASLPTLTKDTKKQPSGTVPLSVTAALQLAHSQEDSSRCSDNSSYEE
                     PLSPISASSSTSRRRQGQRDLELSDMHMRDLVGMGHHFLPSEPTKWNVEDVYEFIRSL
                     PGCQEIAEEFRAQEIDGQALLLLKEDHLMSAMNIKLGPALKIYARISMLKDS"
     exon            229..387
                     /gene="Phc2"
                     /inference="alignment:Splign:2.1.0"
     exon            388..465
                     /gene="Phc2"
                     /inference="alignment:Splign:2.1.0"
     exon            466..630
                     /gene="Phc2"
                     /inference="alignment:Splign:2.1.0"
     exon            631..717
                     /gene="Phc2"
                     /inference="alignment:Splign:2.1.0"
     exon            718..1030
                     /gene="Phc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1419
                     /gene="Phc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1585
                     /gene="Phc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1788
                     /gene="Phc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1918
                     /gene="Phc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2033
                     /gene="Phc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2175
                     /gene="Phc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2452
                     /gene="Phc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..3773
                     /gene="Phc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catccacctg ctcttctgcc accggagcac cctgactgtg ccaccccgta ggccatggag
       61 aatgagctgc cagtccccca cacatccagc cgggccagca tcaccaccaa caccagtggg
      121 accaatagta gcagtggctg cagcagcagc agtggtggtg gcagtggccg ccccactgca
      181 ccccagattt ctgtctacag tggtattcct gaccggcaga ctgtgcaggt gatccagcag
      241 gccctgcaca ggcagcccag cacggcggca cagtacctgc agcagatgta tgctgcccaa
      301 cagcagcacc tcatgctgca gacagcagcc ttgcagcagc agcacctcag cagcgcacag
      361 ctccagagcc ttgcagcagt gcagcaggca agcctggtgg ccaacagaca agggagtact
      421 tctggtagca gtgtgtcctc acaggctccc gcccagtctt cctcactgaa tctggcagcc
      481 tccccagcag cagcccagct tatcaaccgg gcacagagtg tcaattcagc cacagcctcg
      541 ggccttgccc agcaggccgt gctcttgggc aacacgtcct ctcctgccct gactgccagc
      601 caagcacaga tgtacctcag ggcacagatg ctcatcttca cgcccacggc caccgtcgct
      661 actgtacagc ctgagctcgg cactggctcc cccgctcggc cccctacccc tgcccaggta
      721 cagaacctga cgcttcgaac acagcagaca ccagcagcag cagcagcagc agcagcctcg
      781 ggccctgccc ctacccagcc cgtcctgccc agcttggccc tgaaacccac acccagcagt
      841 agccagcctc tgcctcccac accacagggc aggaccgtgg ttcagggttc ccctgtgggt
      901 gccaagccta gtgtgactga caatgtgacg gagccactca agacagatgg caacagcaac
      961 atggaggccc ggcctgggcc tgaccgcgcc accgttccta ctgtggctac tcaccagctc
     1021 actgcaccag cttacactca actgcagcca caccaactcc tcccacagcc gtcatcaaag
     1081 catccacagc cccagtttgt ggcccagcag caaccacagc caccacggcc tacaccccaa
     1141 gtccagtccc aaccccagct tgccgcagtc tctccaagcc tggccctaca gcccagtcca
     1201 gaaggccatg ccatgcctct aggcccagtg acacaggccc tgcctctcca gtgctctact
     1261 gcgcatgtcc acaagccagg gagcagccag cagtgccacc ttcccacacc agacagcggg
     1321 tctcagaatg gacatcctga gggtgtgtcc cacgcccccc agcgaaggtt ccagcacacc
     1381 tcagctgtga tcttacagtt gcagcccgct tctccagtgc cccagcagtg tgctcccgat
     1441 gactggaagg aagtggtgcc agcagagaag agtgtgcctg tgactcggcc aggcctgtcc
     1501 ccacaccagc aagccatcat cactgccata cctggtggcc tgcctggacc caagagtccc
     1561 aacatccagc agtgcccagc tcacgagact gggcagggca ttgttcatgc actgaccgac
     1621 ctcagcagcc ccggcatgac ctcagggaac ggaaactctg cctccagcat caccggcact
     1681 gccccccaga atggtgagaa taaaccacca caggccattg tgaaacccca aatcctgacg
     1741 catgttatcg aagggtttgt gatccaggag ggggcggagc ctttcccggt gggacgctcg
     1801 tccctgctgg tggggaatct caagaagaag tatgcacagg ggttcttgcc tgagaagctt
     1861 ccacagcagg atcataccac cactaccgac tcagagatgg aggagcccta cctgcaagaa
     1921 tccaaagagg agggtactcc cctcaaactc aagtgcgagc tctgtggacg ggtggacttt
     1981 gcctacaagt tcaagcgttc caagcgcttc tgctccatgg cttgtgcaaa gaggtataat
     2041 gtgggatgca ccaaacgggt gggacttttt cactcagacc ggagcaagct gcagaaggca
     2101 gggaccacaa cccacaaccg ccggcgggcc agcaaggcca gtctgcccac acttaccaag
     2161 gacaccaaga agcagccctc aggcactgta cccctttcag ttactgctgc cttgcagctg
     2221 gcacatagcc aggaagactc cagccggtgc tcagataact caagctatga ggagcccttg
     2281 tcacccatct cagccagctc atccacctcc cgacggcgac aaggccagag ggatctggag
     2341 ctctctgaca tgcacatgag ggacctggtg ggcatgggac accacttcct accaagtgag
     2401 cccacaaaat ggaatgtaga agatgtctat gagtttatcc gctctctgcc aggctgccag
     2461 gagatcgctg aggagttccg tgcccaagag attgacgggc aagccttgct gctgctcaag
     2521 gaggaccatc taatgagcgc catgaacatc aagctgggcc ctgccctgaa gatctacgca
     2581 cgcatcagca tgctcaagga ctcctagagt ctgctgcttg cccactgcgc caccaggcag
     2641 ccagggttct agccccaggc gggccccgcc tcctgatgga gcagagccac acagacattc
     2701 ctgaggagcc caagaaaggg ccagtttgga gggaagggct ctccctaggg gtgcagctgt
     2761 gaggaggtct gagtacctct tcagtggctc tcaggggcca tttctgttgg aaggggtaga
     2821 ggtaggtggc acagaagatg gggctttgcg cttgtaaata ctaatagcac tggcttcctc
     2881 caaagtccca atgttctagc cccccccccc tcttctcctt tctctgtccc ccattttcca
     2941 gggggtttat ggtcagggct ccccaacctg agttgggtta ttcccaaggg cagccgcagg
     3001 cctggacaga ggtcttgaaa gcccttgcct tctctcccct taccccctcc aggcctggtt
     3061 aatcttccgt tgccagcttc tcccacttca acctgttccc acagcaccca ggggttctac
     3121 ccctgtaccc actgcaggtg gagagagaga agctgggccc agtttggcca tgcctgctgg
     3181 cacagacgcc ttaacgctgt gtgtatgact gtgtgactgg gagcctggac tggctgacag
     3241 gccatgagat ccctctggca tctccaggtg ttttgtagca aacagccact tagtgctttg
     3301 tcctggactc cactcagcct gaggctgggg aatataaaag gcagacccca agagttggag
     3361 attagaggtc ccctccagat agcaggaggt ttctaggaag gtctccatag cagacttgca
     3421 gtgcgtcctg ctggttggca aacaacataa gctacaggga cgagaccatg tggcccaaag
     3481 gctgtgccga ctgaaggctg gctggaggca ctgtggacga agcctttggt tttccactcc
     3541 atacctgctc ataagacttg tatagcagtg ccagctacct aaggaggggc aggcaggaag
     3601 ggccagggcc tgcccctgtc ctcaccaact ctgggaagtc cgctcttcct gaggggggta
     3661 ggcaccttct cagcttgcta tgcccttttc cccatacctc caggcagggt tggaaatgaa
     3721 ggactttttt aaccttttct tttgttttta aaaaataaat gtgtaaaatc tgc
//
