LOCUS       NP_001101356            1042 aa            linear   ROD 24-JUN-2024
DEFINITION  polyhomeotic-like protein 1 [Rattus norvegicus].
ACCESSION   NP_001101356 XP_001060049 XP_232336
VERSION     NP_001101356.1
DBSOURCE    REFSEQ: accession NM_001107886.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1042)
  AUTHORS   Gil,J. and O'Loghlen,A.
  TITLE     PRC1 complex diversity: where is it taking us?
  JOURNAL   Trends Cell Biol 24 (11), 632-641 (2014)
   PUBMED   25065329
  REMARK    Review article
REFERENCE   2  (residues 1 to 1042)
  AUTHORS   Awad,S., Al-Dosari,M.S., Al-Yacoub,N., Colak,D., Salih,M.A.,
            Alkuraya,F.S. and Poizat,C.
  TITLE     Mutation in PHC1 implicates chromatin remodeling in primary
            microcephaly pathogenesis
  JOURNAL   Hum Mol Genet 22 (11), 2200-2213 (2013)
   PUBMED   23418308
REFERENCE   3  (residues 1 to 1042)
  AUTHORS   Simon,J.A. and Kingston,R.E.
  TITLE     Occupying chromatin: Polycomb mechanisms for getting to genomic
            targets, stopping transcriptional traffic, and staying put
  JOURNAL   Mol Cell 49 (5), 808-824 (2013)
   PUBMED   23473600
  REMARK    Review article
REFERENCE   4  (residues 1 to 1042)
  AUTHORS   Vandamme,J., Volkel,P., Rosnoblet,C., Le Faou,P. and Angrand,P.O.
  TITLE     Interaction proteomics analysis of polycomb proteins defines
            distinct PRC1 complexes in mammalian cells
  JOURNAL   Mol Cell Proteomics 10 (4), M110.002642 (2011)
   PUBMED   21282530
REFERENCE   5  (residues 1 to 1042)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   6  (residues 1 to 1042)
  AUTHORS   de Napoles,M., Mermoud,J.E., Wakao,R., Tang,Y.A., Endoh,M.,
            Appanah,R., Nesterova,T.B., Silva,J., Otte,A.P., Vidal,M.,
            Koseki,H. and Brockdorff,N.
  TITLE     Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A
            to heritable gene silencing and X inactivation
  JOURNAL   Dev Cell 7 (5), 663-676 (2004)
   PUBMED   15525528
REFERENCE   7  (residues 1 to 1042)
  AUTHORS   Kaneko,T., Miyagishima,H., Hasegawa,T., Mizutani-Koseki,Y.,
            Isono,K. and Koseki,H.
  TITLE     The mouse YAF2 gene generates two distinct transcripts and is
            expressed in pre-and postimplantation embryos
  JOURNAL   Gene 315, 183-192 (2003)
   PUBMED   14557078
REFERENCE   8  (residues 1 to 1042)
  AUTHORS   Suzuki,M., Mizutani-Koseki,Y., Fujimura,Y., Miyagishima,H.,
            Kaneko,T., Takada,Y., Akasaka,T., Tanzawa,H., Takihara,Y.,
            Nakano,M., Masumoto,H., Vidal,M., Isono,K. and Koseki,H.
  TITLE     Involvement of the Polycomb-group gene Ring1B in the specification
            of the anterior-posterior axis in mice
  JOURNAL   Development 129 (18), 4171-4183 (2002)
   PUBMED   12183370
REFERENCE   9  (residues 1 to 1042)
  AUTHORS   Levine,S.S., Weiss,A., Erdjument-Bromage,H., Shao,Z., Tempst,P. and
            Kingston,R.E.
  TITLE     The core of the polycomb repressive complex is compositionally and
            functionally conserved in flies and humans
  JOURNAL   Mol Cell Biol 22 (17), 6070-6078 (2002)
   PUBMED   12167701
REFERENCE   10 (residues 1 to 1042)
  AUTHORS   Nomura,M., Takihara,Y. and Shimada,K.
  TITLE     Isolation and characterization of retinoic acid-inducible cDNA
            clones in F9 cells: one of the early inducible clones encodes a
            novel protein sharing several highly homologous regions with a
            Drosophila polyhomeotic protein
  JOURNAL   Differentiation 57 (1), 39-50 (1994)
   PUBMED   8070621
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473964.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_232336.4, XP_001060049.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760389,
                              SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1042
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     Protein         1..1042
                     /product="polyhomeotic-like protein 1"
                     /note="polyhomeotic-like 1"
                     /calculated_mol_wt=109827
     Region          866..973
                     /region_name="PHC2_SAM_assoc"
                     /note="Unstructured region on Polyhomeotic-like protein 1
                     and 2; pfam16616"
                     /db_xref="CDD:465202"
     Region          973..1041
                     /region_name="SAM_Ph1,2,3"
                     /note="SAM domain of Ph (polyhomeotic) proteins of
                     Polycomb group; cd09577"
                     /db_xref="CDD:188976"
     Site            order(991..992,1026..1027,1030..1031,1034)
                     /site_type="other"
                     /note="oligomer interface EH [polypeptide binding]"
                     /db_xref="CDD:188976"
     Site            order(1002..1006,1008..1009,1012..1013,1017,1022)
                     /site_type="other"
                     /note="oligomer interface ML [polypeptide binding]"
                     /db_xref="CDD:188976"
     CDS             1..1042
                     /gene="Phc1"
                     /coded_by="NM_001107886.1:51..3179"
                     /db_xref="GeneID:312690"
                     /db_xref="RGD:1309203"
ORIGIN      
        1 mfpqpprrvq rpglesehhs wgpwnaimet eseqnssstn gssssgassr pqiaqmslye
       61 rqavqalqal qrqpnaaqyf hqfmlqqqls naqlhslaav qqatiaasrq asspnsstaq
      121 qqtattqasi nlattsaaql isrsqsvssp sattltqsvl lgnttsppln qsqaqmylrp
      181 qlgnllqvnr tlgrnvplas qlilmpngav aavqqevppa qspgvhadad qvqnlavrnq
      241 qasaqgpqip gstqkaippg aspvsglsqa ssqalavaqa sgasgqslnl sqagggsgns
      301 lpgsmgpggg gqapgglgql pssglaggnc prkgtgvvqp lpaaqtvtvs qgsqteaesa
      361 aakkaegdgs sqqsvgmnlt rtatpapsqt lissatytqi qphsliqqqq qihlqqkqvv
      421 iqqqiaihhq qqfqhrqsql lhtathlqla qqqqqqqqqq qqqqqqqqqq qqqqqqqqqa
      481 ttlaapqppq vpptqqvpps qsqqqaqtlv vqpmlqsspl slppeptpkp pipiqskppv
      541 apikppqlga akmsatqqpp phipvqvvgt rqpgtaqaqa lglaqlaaav ptsrgmpgav
      601 qpgqahlass qpssqapgal qecppalatg mtlapvqgta hvvkggptas spvvaqvpaa
      661 fymqsvhlpg kaqtlavkrk aeseeeredl salgsvlptk aspaaespkv ieeknslvek
      721 aepvaslnan ppnsdlvala ptpsappptl alvsrqmgds kppqaivkpq ilthiiegfv
      781 iqegaepfpv gcsqflkete kplpaglptg lnesqsggpl ggdspcvdld kkanllkcey
      841 cgkyapaeqf rgskrfcsmt cakrynvscs hqfrlkrkkm kefqeasyar vrrrgprrss
      901 sdiarakiqg krhrgqedss rgsdnssyde alsptspgpl svraghgerd lgntittpst
      961 pelqginpvf lssnpsqwsv eevyefiasl qgcqeiaeef rsqeidgqal lllkeehlms
     1021 amniklgpal kicakinvlk et
//
