LOCUS       NM_001013035            1373 bp    mRNA    linear   ROD 13-MAY-2024
DEFINITION  Rattus norvegicus prohibitin 2 (Phb2), mRNA.
ACCESSION   NM_001013035 XM_342755
VERSION     NM_001013035.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1373)
  AUTHORS   Liu,S., Zhang,R., Zhang,L., Yang,A., Guo,Y., Jiang,L., Wang,H.,
            Xu,S. and Zhou,H.
  TITLE     Oxidative stress suppresses PHB2-mediated mitophagy in beta-cells
            via the Nrf2/PHB2 pathway
  JOURNAL   J Diabetes Investig 15 (5), 559-571 (2024)
   PUBMED   38260951
  REMARK    GeneRIF: Oxidative stress suppresses PHB2-mediated mitophagy in
            beta-cells via the Nrf2/PHB2 pathway.
REFERENCE   2  (bases 1 to 1373)
  AUTHORS   Zheng,X., Liu,K., Xie,Q., Xin,H., Chen,W., Lin,S., Feng,D. and
            Zhu,T.
  TITLE     PHB2 Alleviates Neurotoxicity of Prion Peptide PrP106-126 via
            PINK1/Parkin-Dependent Mitophagy
  JOURNAL   Int J Mol Sci 24 (21), 15919 (2023)
   PUBMED   37958902
  REMARK    GeneRIF: PHB2 Alleviates Neurotoxicity of Prion Peptide
            PrP[106-126] via PINK1/Parkin-Dependent Mitophagy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1373)
  AUTHORS   Vila,E., Pinacho,R., Prades,R., Tarrago,T., Castro,E.,
            Munarriz-Cuezva,E., Meana,J.J., Eugui-Anta,A., Roldan,M.,
            Vera-Montecinos,A. and Ramos,B.
  TITLE     Inhibition of Prolyl Oligopeptidase Restores Prohibitin 2 Levels in
            Psychosis Models: Relationship to Cognitive Deficits in
            Schizophrenia
  JOURNAL   Int J Mol Sci 24 (7), 6016 (2023)
   PUBMED   37046989
  REMARK    GeneRIF: Inhibition of Prolyl Oligopeptidase Restores Prohibitin 2
            Levels in Psychosis Models: Relationship to Cognitive Deficits in
            Schizophrenia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1373)
  AUTHORS   Jia,Y., Wang,M., Mao,C., Yu,F., Wang,Y., Xiao,R., Jiang,C.,
            Zheng,L., Xu,Q., Zheng,M., Fu,Y., Hu,Q. and Kong,W.
  TITLE     COMP-prohibitin 2 interaction maintains mitochondrial homeostasis
            and controls smooth muscle cell identity
  JOURNAL   Cell Death Dis 9 (6), 676 (2018)
   PUBMED   29867124
  REMARK    GeneRIF: COMP-prohibitin 2 interaction in mitochondria plays an
            important role in maintaining the contractile phenotype of Vascular
            smooth muscle cells by regulating mitochondrial oxidative
            phosphorylation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1373)
  AUTHORS   Zhou,T.B., Ou,C., Rong,L. and Drummen,G.P.
  TITLE     Effect of all-trans retinoic acid treatment on prohibitin and
            renin-angiotensin-aldosterone system expression in hypoxia-induced
            renal tubular epithelial cell injury
  JOURNAL   J Renin Angiotensin Aldosterone Syst 15 (3), 243-249 (2014)
   PUBMED   25031298
REFERENCE   6  (bases 1 to 1373)
  AUTHORS   Kurtev,V., Margueron,R., Kroboth,K., Ogris,E., Cavailles,V. and
            Seiser,C.
  TITLE     Transcriptional regulation by the repressor of estrogen receptor
            activity via recruitment of histone deacetylases
  JOURNAL   J Biol Chem 279 (23), 24834-24843 (2004)
   PUBMED   15140878
REFERENCE   7  (bases 1 to 1373)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 1373)
  AUTHORS   Coates,P.J., Nenutil,R., McGregor,A., Picksley,S.M., Crouch,D.H.,
            Hall,P.A. and Wright,E.G.
  TITLE     Mammalian prohibitin proteins respond to mitochondrial stress and
            decrease during cellular senescence
  JOURNAL   Exp Cell Res 265 (2), 262-273 (2001)
   PUBMED   11302691
REFERENCE   9  (bases 1 to 1373)
  AUTHORS   Adams,L.D., Lemire,J.M. and Schwartz,S.M.
  TITLE     A systematic analysis of 40 random genes in cultured vascular
            smooth muscle subtypes reveals a heterogeneity of gene expression
            and identifies the tight junction gene zonula occludens 2 as a
            marker of epithelioid 'pup' smooth muscle cells and a participant
            in carotid neointimal formation
  JOURNAL   Arterioscler Thromb Vasc Biol 19 (11), 2600-2608 (1999)
   PUBMED   10559001
REFERENCE   10 (bases 1 to 1373)
  AUTHORS   Montano,M.M., Ekena,K., Delage-Mourroux,R., Chang,W., Martini,P.
            and Katzenellenbogen,B.S.
  TITLE     An estrogen receptor-selective coregulator that potentiates the
            effectiveness of antiestrogens and represses the activity of
            estrogens
  JOURNAL   Proc Natl Acad Sci U S A 96 (12), 6947-6952 (1999)
   PUBMED   10359819
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083705.1.
            
            On Apr 20, 2005 this sequence version replaced XM_342755.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083705.1, CF110063.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1373
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1373
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /note="prohibitin 2"
                     /db_xref="GeneID:114766"
                     /db_xref="RGD:620203"
     exon            1..253
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1026
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /note="B-cell receptor associated protein 37; B-cell
                     receptor-associated protein BAP37"
                     /codon_start=1
                     /product="prohibitin-2"
                     /protein_id="NP_001013053.1"
                     /db_xref="GeneID:114766"
                     /db_xref="RGD:620203"
                     /translation="MAQNLKDLAGRLPSGPRGMGTALKLLLGAGAVAYGVRESVFTVE
                     GGHRAIFFNRIGGVQQDTILAEGLHFRIPWFQYPIIYDIRARPRKISSPTGSKDLQMV
                     NISLRVLSRPNAQELPSMYQRLGLDYEERVLPSIVNEVLKSVVAKFNASQLITQRAQV
                     SLLIRRELTERAKDFSLILDDVAITELSFSREYTAAVEAKQVAQQEAQRAQFLVEKAK
                     QEQRQKIVQAEGEAEAAKMLGEALSKNPGYIKLRKIRAAQNISKTIATSQNRIYLTAD
                     NLVLNLQDESFTRGSDSLIKGKK"
     exon            254..338
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /inference="alignment:Splign:2.1.0"
     exon            339..418
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /inference="alignment:Splign:2.1.0"
     exon            419..603
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /inference="alignment:Splign:2.1.0"
     exon            604..733
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /inference="alignment:Splign:2.1.0"
     exon            734..837
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /inference="alignment:Splign:2.1.0"
     exon            838..915
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /inference="alignment:Splign:2.1.0"
     exon            916..992
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /inference="alignment:Splign:2.1.0"
     exon            993..998
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1350
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttctcccgcg agctctaagg cctccaatcc tcgtgtgcaa ggcgaggtgt gtaaactgga
       61 gtggggtaga agctggcggg caccccctcc tgaccactgg tgccgccgcc ttcaggagaa
      121 tcagacatgg cccagaactt aaaggaccta gcgggacgcc tgccctccgg gcctcggggc
      181 atgggcacgg cgctgaagct gctgctgggg gccggggctg tggcctacgg cgtccgtgag
      241 tccgtattca ctgtggaagg tggtcacaga gccatcttct ttaatcgtat tggtggcgta
      301 caacaggaca caatcctagc cgaaggcctt cacttcagga ttccctggtt ccagtacccc
      361 atcatctatg acattcgggc cagacctcga aaaatctcct cccccacagg ctccaaagac
      421 ctgcagatgg tgaacatctc cctgcgtgta ctgtctcggc ccaatgccca ggagctcccc
      481 agcatgtacc agcgcctagg cctagactat gaggagcgag tgctgccgtc cattgttaat
      541 gaggtgctca agagtgtggt ggccaagttc aacgcctcgc agctcattac ccagcgggct
      601 caggtgtctc tgttgatccg aagagagctg acagagcgtg ccaaggactt cagcctcatc
      661 ctggacgatg tagctatcac agagctaagc ttcagccgag agtacacagc tgctgtagaa
      721 gccaaacaag tggcccagca ggaagcccag agggcccagt ttttggtgga gaaagcaaag
      781 caggaacaac gacagaagat tgtgcaggct gagggggagg cggaggctgc taagatgctt
      841 ggagaagcac tgagcaagaa tcctggctat atcaagctcc gaaagatccg ggctgcccag
      901 aacatctcta aaacgatcgc cacatcacag aaccggatct atctcacagc tgacaacctt
      961 gtgctgaatc tgcaggatga aagctttact cggggaagtg acagcctcat taagggtaag
     1021 aagtgagtgt ggacatcaag aaccccacca ccagagaagt tggcacactt ctccagtttg
     1081 gaggggccag ctagggggtc aagcataccc caccctgacc caagcatcat gtgatggatt
     1141 cttctgtatc tgctctcttg gattaaggaa gactgaagac caaccctttc agaggggttt
     1201 tcctccttct tgtattggct gggaaggggg ggggacagga gacagtgtga tttctcagtg
     1261 atttcctgta gtgttgtccc tctccctgaa tggggggaga taaccaccat gccaggaagt
     1321 ctcaataaaa tttttattac ttaaactaaa aaaaaaaaaa aaaaaaaaaa aaa
//
