LOCUS       NM_031851               1765 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus prohibitin 1 (Phb1), mRNA.
ACCESSION   NM_031851 XM_346516
VERSION     NM_031851.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1765)
  AUTHORS   Chakrabarti,M., Raut,G.K., Jain,N. and Bhadra,M.P.
  TITLE     Prohibitin1 maintains mitochondrial quality in
            isoproterenol-induced cardiac hypertrophy in H9C2 cells
  JOURNAL   Biol Cell 115 (2), e2200094 (2023)
   PUBMED   36453777
  REMARK    GeneRIF: Prohibitin1 maintains mitochondrial quality in
            isoproterenol-induced cardiac hypertrophy in H9C2 cells.
REFERENCE   2  (bases 1 to 1765)
  AUTHORS   Mattox,T.A., Psaltis,C., Weihbrecht,K., Robidoux,J.,
            Kilburg-Basnyat,B., Murphy,M.P., Gowdy,K.M. and Anderson,E.J.
  TITLE     Prohibitin-1 Is a Dynamically Regulated Blood Protein With
            Cardioprotective Effects in Sepsis
  JOURNAL   J Am Heart Assoc 10 (14), e019877 (2021)
   PUBMED   34219469
  REMARK    GeneRIF: Prohibitin-1 Is a Dynamically Regulated Blood Protein With
            Cardioprotective Effects in Sepsis.
REFERENCE   3  (bases 1 to 1765)
  AUTHORS   Cao,Y.Y., Ba,H.X., Li,Y., Tang,S.Y., Luo,Z.Q. and Li,X.H.
  TITLE     Regulatory effects of Prohibitin 1 on proliferation and apoptosis
            of pulmonary arterial smooth muscle cells in monocrotaline-induced
            PAH rats
  JOURNAL   Life Sci 250, 117548 (2020)
   PUBMED   32173312
  REMARK    GeneRIF: PHB1 contributes to pulmonary vascular remodeling by
            accelerating proliferation of pulmonary arterial smooth muscle
            cells which involves AKT phosphorylation
REFERENCE   4  (bases 1 to 1765)
  AUTHORS   Sun,L., Li,H., Sun,J., Guo,C., Feng,Y., Li,Y., Zhao,X., Xie,X. and
            Hu,J.
  TITLE     Antibodies against H1N1 influenza virus hemagglutinin cross-react
            with prohibitin
  JOURNAL   Biochem Biophys Res Commun 513 (2), 446-451 (2019)
   PUBMED   30967257
  REMARK    GeneRIF: This study concluded that prohibitin is an autoantigen
            that cross-reacts with H1N1 influenza virus hemagglutinin.
REFERENCE   5  (bases 1 to 1765)
  AUTHORS   Terzenidou,M.E., Segklia,A., Kano,T., Papastefanaki,F.,
            Karakostas,A., Charalambous,M., Ioakeimidis,F., Papadaki,M.,
            Kloukina,I., Chrysanthou-Piterou,M., Samiotaki,M., Panayotou,G.,
            Matsas,R. and Douni,E.
  TITLE     Novel insights into SLC25A46-related pathologies in a genetic mouse
            model
  JOURNAL   PLoS Genet 13 (4), e1006656 (2017)
   PUBMED   28376086
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1765)
  AUTHORS   Altus,M.S., Wood,C.M., Stewart,D.A., Roskams,A.J., Friedman,V.,
            Henderson,T., Owens,G.A., Danner,D.B., Jupe,E.R., Dell'Orco,R.T. et
            al.
  TITLE     Regions of evolutionary conservation between the rat and human
            prohibitin-encoding genes
  JOURNAL   Gene 158 (2), 291-294 (1995)
   PUBMED   7607556
REFERENCE   7  (bases 1 to 1765)
  AUTHORS   Ikonen,E., Fiedler,K., Parton,R.G. and Simons,K.
  TITLE     Prohibitin, an antiproliferative protein, is localized to
            mitochondria
  JOURNAL   FEBS Lett 358 (3), 273-277 (1995)
   PUBMED   7843414
REFERENCE   8  (bases 1 to 1765)
  AUTHORS   Asamoto,M. and Cohen,S.M.
  TITLE     Prohibitin gene is overexpressed but not mutated in rat bladder
            carcinomas and cell lines
  JOURNAL   Cancer Lett 83 (1-2), 201-207 (1994)
   PUBMED   8062216
REFERENCE   9  (bases 1 to 1765)
  AUTHORS   Sato,T., Saito,H., Swensen,J., Olifant,A., Wood,C., Danner,D.,
            Sakamoto,T., Takita,K., Kasumi,F., Miki,Y. et al.
  TITLE     The human prohibitin gene located on chromosome 17q21 is mutated in
            sporadic breast cancer
  JOURNAL   Cancer Res 52 (6), 1643-1646 (1992)
   PUBMED   1540973
REFERENCE   10 (bases 1 to 1765)
  AUTHORS   Nuell,M.J., Stewart,D.A., Walker,L., Friedman,V., Wood,C.M.,
            Owens,G.A., Smith,J.R., Schneider,E.L., Dell' Orco,R., Lumpkin,C.K.
            et al.
  TITLE     Prohibitin, an evolutionarily conserved intracellular protein that
            blocks DNA synthesis in normal fibroblasts and HeLa cells
  JOURNAL   Mol Cell Biol 11 (3), 1372-1381 (1991)
   PUBMED   1996099
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC072518.1.
            
            [WARNING] On May 3, 2024 this sequence was replaced by NM_031851.3.
            
            On Apr 20, 2006 this sequence version replaced NM_031851.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072518.1, FQ229278.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1765
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..1765
                     /gene="Phb1"
                     /gene_synonym="Phb"
                     /note="prohibitin 1"
                     /db_xref="GeneID:25344"
                     /db_xref="RGD:3322"
     exon            1..31
                     /gene="Phb1"
                     /gene_synonym="Phb"
                     /inference="alignment:Splign:2.1.0"
     exon            32..146
                     /gene="Phb1"
                     /gene_synonym="Phb"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..877
                     /gene="Phb1"
                     /gene_synonym="Phb"
                     /note="prohibitin"
                     /codon_start=1
                     /product="prohibitin 1"
                     /protein_id="NP_114039.1"
                     /db_xref="GeneID:25344"
                     /db_xref="RGD:3322"
                     /translation="MAAKVFESIGKFGLALAVAGGVVNSALYNVDAGHRAVIFDRFRG
                     VQDIVVGEGTHFLIPWVQKPIIFDCRSRPRNVPVITGSKDLQNVNITLRILFRPVASQ
                     LPRIYTSIGEDYDERVLPSITTEILKSVVARFDAGELITQRELVSRQVSDDLTERAAT
                     FGLILDDVSLTHLTFGKEFTEAVEAKQVAQQEAERARFVVEKAEQQKKAAIISAEGDS
                     KAAELIANSLATAGDGLIELRKLEAAEDIAYQLSRSRNITYLPAGQSVLLQLPQ"
     exon            147..308
                     /gene="Phb1"
                     /gene_synonym="Phb"
                     /inference="alignment:Splign:2.1.0"
     exon            309..451
                     /gene="Phb1"
                     /gene_synonym="Phb"
                     /inference="alignment:Splign:2.1.0"
     exon            452..568
                     /gene="Phb1"
                     /gene_synonym="Phb"
                     /inference="alignment:Splign:2.1.0"
     exon            569..664
                     /gene="Phb1"
                     /gene_synonym="Phb"
                     /inference="alignment:Splign:2.1.0"
     exon            665..1739
                     /gene="Phb1"
                     /gene_synonym="Phb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaattcatg tggaggtcag agtggaaaca ggtgtgagcg gaagcaacag aaggagtcat
       61 ggctgccaaa gtgtttgagt ccatcggaaa gttcggcctg gccttagcag ttgcaggagg
      121 cgtggtgaac tctgctctat ataacgtgga tgccggacac agagctgtca tcttcgaccg
      181 attccgtggc gtgcaggaca tcgtggtagg ggaagggact cacttcctca tcccctgggt
      241 acagaagcca atcatctttg actgccgctc tcgaccacgt aatgtgccgg tcatcaccgg
      301 cagcaaagac ttgcagaatg tcaacatcac actacgtatc ctcttccggc cggtggccag
      361 ccagcttcct cgtatctaca ccagcattgg cgaggactat gatgagcggg tgctgccatc
      421 tatcaccaca gagatcctca agtcggtggt ggctcgattc gatgctggag aattgattac
      481 ccagcgagag ctggtctcca ggcaggtgag tgatgacctc acagagcgag cagcaacatt
      541 cgggctcatc ctggatgacg tgtccctgac acatctgacc ttcgggaagg agttcacaga
      601 ggcggtggaa gccaaacagg tggctcagca ggaagcagag agagccagat ttgtggtgga
      661 aaaggctgag cagcagaaga aggcggccat catctctgct gagggtgact ccaaagcggc
      721 tgagctgatc gccaactcac tggccaccgc cggggatggc ctgatcgagc tgcgaaagct
      781 ggaagctgct gaggacattg cttatcagct ctcccgctct cggaacatca cctacctgcc
      841 agcagggcag tccgtgctcc tccagctccc ccagtaaggc cagccaggcc agggcctcca
      901 tcgctctgaa tgacgccttc cttctgcccc accccagaaa tcactgtgaa atttaatgat
      961 tggcttaaca tgaaggaaat aaaggtaaaa tcacttcata tctctaatta tcaaatgaag
     1021 cttttattgt tacacttttt gcccactttc ataacaaaat tgccaagtgc ctatgcagac
     1081 tggccttcca ccctgggtgc tggcagtcgg cggaagaaag gcagggcagt gtgtgtggtg
     1141 gacggggagc cagctggcag cctgagtaga ccttgagcct ccattctgcc atatattgaa
     1201 gatttacaga cagtggtgca cacacgtgaa ccaaaaggca agccctcaat ttttccagcc
     1261 atacgaaccc ggacagatgc agctgaggag ggcctgagga agtggtctgt cttaactgta
     1321 aggccattcc ctcttaaccg tgaccagcgg aagcaggtgt gtgcgtgcga ctagggcatg
     1381 gagtgaagaa tctgcccatc acggtgggtg ggcctaattt tgctgccccc accagagacc
     1441 taaactttgg atagacttgg atagaataag aggcctggac tgagatgtga gtcctgtgga
     1501 agacttcctg tccacccccc acattggtcc tctcaaatac ccaatgggat tccagcttga
     1561 aggattgcat cctgccgggg ctgagcacac ctgccaagga cacgtgcgcc tgccttcccg
     1621 ctccctctct tcgagattgc ccttccttcc caagggctgt gggccagagc tccgaaggaa
     1681 gcaatcaagg aaagaaaaca caatgtaagc tgctgtcaat aaatgacacc cagaccctca
     1741 aaaaaaaaaa aaaaaaaaaa aaaaa
//
