LOCUS       NM_214459               1559 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus phosphatase and actin regulator 3 (Phactr3),
            mRNA.
ACCESSION   NM_214459 XM_342597
VERSION     NM_214459.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1559)
  AUTHORS   Miyata,T., Kikuchi,K., Ihara,D., Kaito,M., Ishibashi,Y.,
            Hakamata,T., Yamada,T., Ishikawa,M., Mizukoshi,M., Shoji,S.,
            Fukuchi,M., Tsuda,M., Hida,Y., Ohtsuka,T., Kaneda,M. and Tabuchi,A.
  TITLE     Neuron-enriched phosphatase and actin regulator 3 (Phactr3)/
            nuclear scaffold-associated PP1-inhibiting protein (Scapinin)
            regulates dendritic morphology via its protein phosphatase
            1-binding domain
  JOURNAL   Biochem Biophys Res Commun 528 (2), 322-329 (2020)
   PUBMED   32423795
  REMARK    GeneRIF: Neuron-enriched phosphatase and actin regulator 3
            (Phactr3)/ nuclear scaffold-associated PP1-inhibiting protein
            (Scapinin) regulates dendritic morphology via its protein
            phosphatase 1-binding domain.
REFERENCE   2  (bases 1 to 1559)
  AUTHORS   Farghaian,H., Chen,Y., Fu,A.W., Fu,A.K., Ip,J.P., Ip,N.Y.,
            Turnley,A.M. and Cole,A.R.
  TITLE     Scapinin-induced inhibition of axon elongation is attenuated by
            phosphorylation and translocation to the cytoplasm
  JOURNAL   J Biol Chem 286 (22), 19724-19734 (2011)
   PUBMED   21487013
  REMARK    GeneRIF: Because its expression is highest in relatively plastic
            regions of the adult brain (cortex, hippocampus), scapinin is a new
            regulator of neurite outgrowth and neuroplasticity in the brain.
REFERENCE   3  (bases 1 to 1559)
  AUTHORS   Allen,P.B., Greenfield,A.T., Svenningsson,P., Haspeslagh,D.C. and
            Greengard,P.
  TITLE     Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (18), 7187-7192 (2004)
   PUBMED   15107502
REFERENCE   4  (bases 1 to 1559)
  AUTHORS   Sagara,J., Higuchi,T., Hattori,Y., Moriya,M., Sarvotham,H.,
            Shima,H., Shirato,H., Kikuchi,K. and Taniguchi,S.
  TITLE     Scapinin, a putative protein phosphatase-1 regulatory subunit
            associated with the nuclear nonchromatin structure
  JOURNAL   J Biol Chem 278 (46), 45611-45619 (2003)
   PUBMED   12925532
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            [WARNING] On Oct 26, 2024 this sequence was replaced by
            NM_214459.4.
            
            On Nov 27, 2020 this sequence version replaced NM_214459.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY500157.1, SRR26643293.20788.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               JAXUCZ010000003.1  185720980-185721141
            163-240             JAXUCZ010000003.1  185726125-185726202
            241-423             JAXUCZ010000003.1  185735039-185735221
            424-630             JAXUCZ010000003.1  185744860-185745066
            631-805             JAXUCZ010000003.1  185749533-185749707
            806-1053            JAXUCZ010000003.1  185750386-185750633
            1054-1207           JAXUCZ010000003.1  185771282-185771435
            1208-1263           JAXUCZ010000003.1  185793240-185793295
            1264-1325           JAXUCZ010000003.1  185796687-185796748
            1326-1466           JAXUCZ010000003.1  185797933-185798073
            1467-1543           JAXUCZ010000003.1  185799312-185799388
            1544-1559           JAXUCZ010000003.1  185800844-185800859
FEATURES             Location/Qualifiers
     source          1..1559
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q43"
     gene            1..1559
                     /gene="Phactr3"
                     /gene_synonym="Scapin1; scapinin"
                     /note="phosphatase and actin regulator 3"
                     /db_xref="GeneID:362284"
                     /db_xref="RGD:1303029"
     exon            1..162
                     /gene="Phactr3"
                     /gene_synonym="Scapin1; scapinin"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..1559
                     /gene="Phactr3"
                     /gene_synonym="Scapin1; scapinin"
                     /note="scaffold-associated PP1-inhibiting protein"
                     /codon_start=1
                     /product="phosphatase and actin regulator 3"
                     /protein_id="NP_999624.1"
                     /db_xref="GeneID:362284"
                     /db_xref="RGD:1303029"
                     /translation="MDQTPPARSEPLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKKN
                     EKLKQTTSALEKKMAGRQGREELIKQGLLEMMEQDSESKACSPKEGSQPAQSEPSAGE
                     QETLTSEGVQPGSPSASGTDQASQDELLSSDAHPDDTAKMSSASSGEEADAGNLLPTT
                     DEPSQEALSGSLDSPPRTLERSASQLPSPPLLPTPPPKASSKATKNVTGQAALFQGSS
                     MKNNEPVLRGQLPTPTGSPHLTTVHRPLPPSRVIEELHRALATKHRQDSFQGRECRGS
                     PKKRMDVRLSRTSSMERGKERDEAWSFDGASENKWTAAKDSEENKENLILSSELKDDL
                     LLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIR
                     QQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKLNQRPTVDEL
                     RDRKILIRFSDYVEVARAQDYDRRADKPWTRLSAADKAAIRKELNEYKSNEMEVHASS
                     KHLTRFHRP"
     exon            163..240
                     /gene="Phactr3"
                     /gene_synonym="Scapin1; scapinin"
                     /inference="alignment:Splign:2.1.0"
     exon            241..423
                     /gene="Phactr3"
                     /gene_synonym="Scapin1; scapinin"
                     /inference="alignment:Splign:2.1.0"
     exon            424..630
                     /gene="Phactr3"
                     /gene_synonym="Scapin1; scapinin"
                     /inference="alignment:Splign:2.1.0"
     exon            631..805
                     /gene="Phactr3"
                     /gene_synonym="Scapin1; scapinin"
                     /inference="alignment:Splign:2.1.0"
     exon            806..1053
                     /gene="Phactr3"
                     /gene_synonym="Scapin1; scapinin"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1207
                     /gene="Phactr3"
                     /gene_synonym="Scapin1; scapinin"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1263
                     /gene="Phactr3"
                     /gene_synonym="Scapin1; scapinin"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1325
                     /gene="Phactr3"
                     /gene_synonym="Scapin1; scapinin"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1466
                     /gene="Phactr3"
                     /gene_synonym="Scapin1; scapinin"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1543
                     /gene="Phactr3"
                     /gene_synonym="Scapin1; scapinin"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1559
                     /gene="Phactr3"
                     /gene_synonym="Scapin1; scapinin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgagatgga ccaaactccc ccagcacgct ccgagcctct ggtctcaggg attcgaactc
       61 cccctgtgcg gaggaacagc aagctggcca cgctgggcag gatcttcaaa ccctggaaat
      121 ggaggaaaaa gaaaaacgag aagctgaagc agacaacgtc agcactggag aagaagatgg
      181 ccggtaggca aggccgggag gagctgatca agcaggggct gctggagatg atggagcaag
      241 attctgagag taaggcatgc agtcccaagg aaggctccca acctgcacag agtgagccgt
      301 ccgctggcga gcaggagacg ctgacctcgg agggtgtcca gcccggaagc ccctcggcca
      361 gtggaacaga ccaggcctcc caggatgagc ttctgtcctc cgatgcccat ccggatgaca
      421 cagccaagat gtcgtctgca tccagtgggg aagaagcaga tgctggcaac ctcctgccca
      481 ccaccgatga gccctctcaa gaagccttat ctgggtccct agacagtcct cccagaaccc
      541 tggagagatc tgcgagccag ctccccagcc ctccactgct gcccaccccg ccacccaagg
      601 ccagctctaa agccacgaaa aacgtcacag gtcaagctgc gctcttccaa ggctccagca
      661 tgaagaacaa tgagcctgtt ctcagaggac agcttcccac ccccacaggg tcccctcatc
      721 tcaccactgt ccaccggcca ctgcccccaa gccgcgtgat agaggagctg cacagggcac
      781 tggccacgaa gcaccgtcag gacagttttc aagggcggga atgcagaggg tctccaaaga
      841 agcggatgga tgtgcgtctg tccaggacat cgagcatgga gcggggcaag gagagggatg
      901 aggcgtggag ctttgacggg gcctcagaga acaagtggac tgctgccaaa gactctgagg
      961 agaacaagga gaatctgatt ctgagctccg agctcaagga tgacttgctt ctgtatcagg
     1021 atgaagaggc gctcaacgac tccatcattt ctggaacatt gccaaggaag tgcaagaagg
     1081 agttgctggc agtgaagctg aggaaccggc ccagcaagca ggagctggag gaccggaaca
     1141 tctttcccag gaggaccgat gaggagagac aggagatccg acagcagata gagatgaagc
     1201 tgtccaaaag gctgagccag agacctgccg tggaagaact ggaaagaaga aatatcctga
     1261 agcaaaggaa tgatcagaca gagcaggaag aaaggagaga aatcaagcaa agattaacca
     1321 ggaagcttaa ccagagaccc actgttgatg aactgagaga caggaaaatt ctgatccgtt
     1381 tcagtgacta tgtggaagta gcgagagcac aggactatga caggagagca gacaagccct
     1441 ggacgagact gtcagcagca gataaggcag caattcgtaa agaattaaat gagtataaga
     1501 gtaatgaaat ggaggtgcac gcatccagca agcacttgac aagattccac aggccatag
//
