LOCUS       NM_214457               2078 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus phosphatase and actin regulator 1 (Phactr1),
            mRNA.
ACCESSION   NM_214457 XM_225229
VERSION     NM_214457.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2078)
  AUTHORS   Jing,Y., Zhang,L., Chen,S.W., Guo,Y., Ju,S.M., Yuan,F., Chen,H.,
            Yang,D.X., Tian,H.L., Xu,Z.M. and Ding,J.
  TITLE     Inhibiting phosphatase and actin regulator 1 expression is
            neuroprotective in the context of traumatic brain injury
  JOURNAL   Neural Regen Res 18 (7), 1578-1583 (2023)
   PUBMED   36571365
REFERENCE   2  (bases 1 to 2078)
  AUTHORS   Ma,X., Su,M., He,Q., Zhang,Z., Zhang,F., Liu,Z., Sun,L., Weng,J.
            and Xu,S.
  TITLE     PHACTR1, a coronary artery disease risk gene, mediates endothelial
            dysfunction
  JOURNAL   Front Immunol 13, 958677 (2022)
   PUBMED   36091033
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2078)
  AUTHORS   Li,Z., Hu,X., Wan,J., Yang,J., Jia,Z., Tian,L., Wu,X., Song,C. and
            Yan,C.
  TITLE     The alleles of AGT and HIF1A gene affect the risk of hypertension
            in plateau residents
  JOURNAL   Exp Biol Med (Maywood) 247 (3), 237-245 (2022)
   PUBMED   34758666
REFERENCE   4  (bases 1 to 2078)
  AUTHORS   Lu,Y., Dimitrov,L., Chen,S.H., Bielak,L.F., Bis,J.C., Feitosa,M.F.,
            Lu,L., Kavousi,M., Raffield,L.M., Smith,A.V., Wang,L., Weiss,S.,
            Yao,J., Zhu,J., Gudmundsson,E.F., Gudmundsdottir,V., Bos,D.,
            Ghanbari,M., Ikram,M.A., Hwang,S.J., Taylor,K.D., Budoff,M.J.,
            Gislason,G.K., O'Donnell,C.J., An,P., Franceschini,N.,
            Freedman,B.I., Fu,Y.P., Guo,X., Heiss,G., Kardia,S.L.R.,
            Wilson,J.G., Langefeld,C.D., Schminke,U., Uitterlinden,A.G.,
            Lange,L.A., Peyser,P.A., Gudnason,V.G., Psaty,B.M., Rotter,J.I.,
            Bowden,D.W. and Ng,M.C.Y.
  TITLE     Multiethnic Genome-Wide Association Study of Subclinical
            Atherosclerosis in Individuals With Type 2 Diabetes
  JOURNAL   Circ Genom Precis Med 14 (4), e003258 (2021)
   PUBMED   34241534
REFERENCE   5  (bases 1 to 2078)
  AUTHORS   Kuveljic,J., Djuric,T., Stankovic,G., Dekleva,M., Stankovic,A.,
            Alavantic,D. and Zivkovic,M.
  TITLE     Association of PHACTR1 intronic variants with the first myocardial
            infarction and their effect on PHACTR1 mRNA expression in PBMCs
  JOURNAL   Gene 775, 145428 (2021)
   PUBMED   33460763
REFERENCE   6  (bases 1 to 2078)
  AUTHORS   Wiezlak,M., Diring,J., Abella,J., Mouilleron,S., Way,M.,
            McDonald,N.Q. and Treisman,R.
  TITLE     G-actin regulates the shuttling and PP1 binding of the RPEL protein
            Phactr1 to control actomyosin assembly
  JOURNAL   J Cell Sci 125 (Pt 23), 5860-5872 (2012)
   PUBMED   22976292
REFERENCE   7  (bases 1 to 2078)
  AUTHORS   Hager,J., Kamatani,Y., Cazier,J.B., Youhanna,S.,
            Ghassibe-Sabbagh,M., Platt,D.E., Abchee,A.B., Romanos,J.,
            Khazen,G., Othman,R., Badro,D.A., Haber,M., Salloum,A.K.,
            Douaihy,B., Shasha,N., Kabbani,S., Sbeite,H., Chammas,E., el
            Bayeh,H., Rousseau,F., Zelenika,D., Gut,I., Lathrop,M., Farrall,M.,
            Gauguier,D. and Zalloua,P.A.
  CONSRTM   FGENTCARD Consortium
  TITLE     Genome-wide association study in a Lebanese cohort confirms PHACTR1
            as a major determinant of coronary artery stenosis
  JOURNAL   PLoS One 7 (6), e38663 (2012)
   PUBMED   22745674
REFERENCE   8  (bases 1 to 2078)
  AUTHORS   Qi,L., Parast,L., Cai,T., Powers,C., Gervino,E.V., Hauser,T.H.,
            Hu,F.B. and Doria,A.
  TITLE     Genetic susceptibility to coronary heart disease in type 2
            diabetes: 3 independent studies
  JOURNAL   J Am Coll Cardiol 58 (25), 2675-2682 (2011)
   PUBMED   22152955
REFERENCE   9  (bases 1 to 2078)
  AUTHORS   Kathiresan,S., Voight,B.F., Purcell,S., Musunuru,K., Ardissino,D.,
            Mannucci,P.M., Anand,S., Engert,J.C., Samani,N.J., Schunkert,H.,
            Erdmann,J., Reilly,M.P., Rader,D.J., Morgan,T., Spertus,J.A.,
            Stoll,M., Girelli,D., McKeown,P.P., Patterson,C.C., Siscovick,D.S.,
            O'Donnell,C.J., Elosua,R., Peltonen,L., Salomaa,V., Schwartz,S.M.,
            Melander,O., Altshuler,D., Ardissino,D., Merlini,P.A., Berzuini,C.,
            Bernardinelli,L., Peyvandi,F., Tubaro,M., Celli,P., Ferrario,M.,
            Fetiveau,R., Marziliano,N., Casari,G., Galli,M., Ribichini,F.,
            Rossi,M., Bernardi,F., Zonzin,P., Piazza,A., Mannucci,P.M.,
            Schwartz,S.M., Siscovick,D.S., Yee,J., Friedlander,Y., Elosua,R.,
            Marrugat,J., Lucas,G., Subirana,I., Sala,J., Ramos,R.,
            Kathiresan,S., Meigs,J.B., Williams,G., Nathan,D.M., MacRae,C.A.,
            O'Donnell,C.J., Salomaa,V., Havulinna,A.S., Peltonen,L.,
            Melander,O., Berglund,G., Voight,B.F., Kathiresan,S.,
            Hirschhorn,J.N., Asselta,R., Duga,S., Spreafico,M., Musunuru,K.,
            Daly,M.J., Purcell,S., Voight,B.F., Purcell,S., Nemesh,J.,
            Korn,J.M., McCarroll,S.A., Schwartz,S.M., Yee,J., Kathiresan,S.,
            Lucas,G., Subirana,I., Elosua,R., Surti,A., Guiducci,C.,
            Gianniny,L., Mirel,D., Parkin,M., Burtt,N., Gabriel,S.B.,
            Samani,N.J., Thompson,J.R., Braund,P.S., Wright,B.J.,
            Balmforth,A.J., Ball,S.G., Hall,A., Schunkert,H., Erdmann,J.,
            Linsel-Nitschke,P., Lieb,W., Ziegler,A., Konig,I., Hengstenberg,C.,
            Fischer,M., Stark,K., Grosshennig,A., Preuss,M., Wichmann,H.E.,
            Schreiber,S., Schunkert,H., Samani,N.J., Erdmann,J., Ouwehand,W.,
            Hengstenberg,C., Deloukas,P., Scholz,M., Cambien,F., Reilly,M.P.,
            Li,M., Chen,Z., Wilensky,R., Matthai,W., Qasim,A., Hakonarson,H.H.,
            Devaney,J., Burnett,M.S., Pichard,A.D., Kent,K.M., Satler,L.,
            Lindsay,J.M., Waksman,R., Knouff,C.W., Waterworth,D.M.,
            Walker,M.C., Mooser,V., Epstein,S.E., Rader,D.J., Scheffold,T.,
            Berger,K., Stoll,M., Huge,A., Girelli,D., Martinelli,N.,
            Olivieri,O., Corrocher,R., Morgan,T., Spertus,J.A., McKeown,P.,
            Patterson,C.C., Schunkert,H., Erdmann,E., Linsel-Nitschke,P.,
            Lieb,W., Ziegler,A., Konig,I.R., Hengstenberg,C., Fischer,M.,
            Stark,K., Grosshennig,A., Preuss,M., Wichmann,H.E., Schreiber,S.,
            Holm,H., Thorleifsson,G., Thorsteinsdottir,U., Stefansson,K.,
            Engert,J.C., Do,R., Xie,C., Anand,S., Kathiresan,S., Ardissino,D.,
            Mannucci,P.M., Siscovick,D., O'Donnell,C.J., Samani,N.J.,
            Melander,O., Elosua,R., Peltonen,L., Salomaa,V., Schwartz,S.M. and
            Altshuler,D.
  CONSRTM   Myocardial Infarction Genetics Consortium; Wellcome Trust Case
            Control Consortium
  TITLE     Genome-wide association of early-onset myocardial infarction with
            single nucleotide polymorphisms and copy number variants
  JOURNAL   Nat Genet 41 (3), 334-341 (2009)
   PUBMED   19198609
  REMARK    Erratum:[Nat Genet. 2009 Jun;41(6):762. Knouff, Christopher W
            [added]; Waterworth, Dawn M [added]; Walker, Max C [added]; Mooser,
            Vincent [added]]
REFERENCE   10 (bases 1 to 2078)
  AUTHORS   Allen,P.B., Greenfield,A.T., Svenningsson,P., Haspeslagh,D.C. and
            Greengard,P.
  TITLE     Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (18), 7187-7192 (2004)
   PUBMED   15107502
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098634.1.
            
            On Aug 23, 2007 this sequence version replaced NM_214457.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098634.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132263 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2078
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14-p12"
     gene            1..2078
                     /gene="Phactr1"
                     /note="phosphatase and actin regulator 1"
                     /db_xref="GeneID:306844"
                     /db_xref="RGD:1303187"
     exon            1..144
                     /gene="Phactr1"
                     /inference="alignment:Splign:2.1.0"
     exon            145..295
                     /gene="Phactr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..1935
                     /gene="Phactr1"
                     /codon_start=1
                     /product="phosphatase and actin regulator 1"
                     /protein_id="NP_999622.2"
                     /db_xref="GeneID:306844"
                     /db_xref="RGD:1303187"
                     /translation="MDYPKMDYFLDVESAHRLLDVESAQRFFYSQGAQARRATLLLPP
                     TLMAASSEDDIDRRPIRRVRSKSDTPYLAEARISFNLGAAEEVERLAAMRSDSLVPGT
                     HTPPIRRRSKFANLGRIFKPWKWRKKKSEKFKHTSAALERKISMRQSREELIKRGVLK
                     EIYDKDGELSISNEDDSLTNGQSLSSSQLSLPALSEMEPVPMPRDPCSYEVLQASDIM
                     DGPDPGAPVKLPCLPVKLSPPLPPKKVLICMPVGGPELSLASYTAQKSSQQAVAQHHH
                     TVLPSQMQHQLQYGSHGQHLPSSTGTLPMHPSGCRMIDELNKTLAMTMQRLESSEQRV
                     PCSTSYHSSGLHSSDGVTKAGPLGLPEIRQVPTVVIECDDNKENVPHEPDYEDSSCLY
                     AREEEEEEEDEDDDASLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNILPRQTDEE
                     RLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQEEKREIKRRLTRKLSQRP
                     TVEELRERKILIRFSDYVEVADAQDYDRRADKPWTRLTAADKAAIRKELNEFKSTEME
                     VHELSRHLTRFHRP"
     exon            296..442
                     /gene="Phactr1"
                     /inference="alignment:Splign:2.1.0"
     exon            443..607
                     /gene="Phactr1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..688
                     /gene="Phactr1"
                     /inference="alignment:Splign:2.1.0"
     exon            689..856
                     /gene="Phactr1"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1178
                     /gene="Phactr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1426
                     /gene="Phactr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1583
                     /gene="Phactr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1639
                     /gene="Phactr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1701
                     /gene="Phactr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1842
                     /gene="Phactr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1919
                     /gene="Phactr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2063
                     /gene="Phactr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cattattcat caccgatcta atcagataat caaaaccgtt tacttttgct gggaatattt
       61 aataagatca aagcagctgg ttgaaattgt tcacttggac tatcgacaag cccttggttt
      121 tactttttat ttttttcttt cacaagatct aagtgattgc cttctctcaa aatcctgttc
      181 tgaacattga agatggatta tcccaaaatg gattattttc tggacgttga gtcggctcac
      241 agactcctgg atgtggagtc agcacagaga ttcttctata gccaaggagc tcaagctcgc
      301 cgggcgaccc tgctcctgcc tcccacatta atggcggctt cttcggagga tgacatagac
      361 cggcggccca tcagaagagt ccgctccaag agcgacacgc catatctcgc agaggccagg
      421 atctccttta acctgggggc agctgaggaa gtggaaaggc tggcggccat gcgctctgac
      481 tcgttggtcc caggtacgca caccccgccc atccggagga ggagtaagtt tgccaacctg
      541 ggaaggattt tcaagccttg gaaatggagg aagaagaaaa gcgaaaagtt caagcacacg
      601 tcagcagctc tggaaaggaa gatatcgatg aggcagagca gagaggagct gatcaagcga
      661 ggggtcttga aggagatcta cgataaagat ggagagctct ccatatcaaa tgaagatgac
      721 tccctcacaa acggccagtc cctgagctcc agccagctct ctttgcctgc tctgtcggaa
      781 atggagcctg tcccaatgcc cagggacccc tgctcatatg aggtgctcca agcttcagac
      841 attatggatg gaccagatcc tggcgccccc gtgaaattgc cttgtctgcc agtgaaactg
      901 tcgcctccgc tacctccaaa gaaagtcctg atctgcatgc ctgtaggggg cccagagctc
      961 tccctggcat cctacacagc ccagaagagc agccagcagg ctgtggccca gcaccaccac
     1021 accgtcctgc catcccagat gcagcaccag ctgcagtatg gcagccacgg ccagcatctc
     1081 ccgtcctcca ccggcacctt acccatgcac ccctcgggct gcaggatgat cgatgagctg
     1141 aacaagacac ttgctatgac catgcagagg ctggaaagct ccgagcaacg cgtcccctgc
     1201 tccacttctt accacagctc tggtttgcac tcaagtgacg gcgtcacaaa agcaggaccc
     1261 ttgggccttc cggaaataag acaagtgcca actgttgtga ttgaatgtga cgacaataag
     1321 gaaaatgtgc ctcatgaacc cgactatgaa gactcgtcct gcctgtatgc acgggaagag
     1381 gaggaagagg aggaggacga agatgacgac gcctccttgt acaccagctc actggccatg
     1441 aaggtctgca ggaaggactc cttagccatc aaactgagca acaggccctc caagcgagag
     1501 ctagaggaaa agaacatcct tcccaggcag acggatgagg aacggctgga actcagacaa
     1561 cagatcggca ccaagctcac caggcggcta agccaaagac ccactgcaga ggaactggag
     1621 cagaggaaca ttctgaaacc tcggaatgaa caagaggagc aggaggagaa gcgggaaata
     1681 aagaggaggc tgactcgcaa gctcagccaa agacccacgg tggaagaact ccgggagagg
     1741 aagatcctta ttcgtttcag tgactatgtg gaggtggcag acgcccaaga ctatgaccga
     1801 agggcggaca agccatggac ccgcctcacc gctgcagaca aagctgccat tcggaaggaa
     1861 ctcaatgagt ttaaaagtac cgaaatggaa gtccacgagt taagtagaca cttaaccagg
     1921 tttcatcgac cttaacagtg ggattactct tgagtgctct gctgtcttca aaacataaat
     1981 ttctaagaac cataagtgct gacgtctgtc cacttccccg tcaccatgta aatccgaact
     2041 gccttttttt aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
