LOCUS       NM_001008374            1974 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus progesterone receptor membrane component 2
            (Pgrmc2), mRNA.
ACCESSION   NM_001008374 XM_342239
VERSION     NM_001008374.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1974)
  AUTHORS   Galmozzi,A., Kok,B.P., Kim,A.S., Montenegro-Burke,J.R., Lee,J.Y.,
            Spreafico,R., Mosure,S., Albert,V., Cintron-Colon,R., Godio,C.,
            Webb,W.R., Conti,B., Solt,L.A., Kojetin,D., Parker,C.G.,
            Peluso,J.J., Pru,J.K., Siuzdak,G., Cravatt,B.F. and Saez,E.
  TITLE     PGRMC2 is an intracellular haem chaperone critical for adipocyte
            function
  JOURNAL   Nature 576 (7785), 138-142 (2019)
   PUBMED   31748741
REFERENCE   2  (bases 1 to 1974)
  AUTHORS   Parker,C.G., Galmozzi,A., Wang,Y., Correia,B.E., Sasaki,K.,
            Joslyn,C.M., Kim,A.S., Cavallaro,C.L., Lawrence,R.M., Johnson,S.R.,
            Narvaiza,I., Saez,E. and Cravatt,B.F.
  TITLE     Ligand and Target Discovery by Fragment-Based Screening in Human
            Cells
  JOURNAL   Cell 168 (3), 527-541 (2017)
   PUBMED   28111073
REFERENCE   3  (bases 1 to 1974)
  AUTHORS   Juhlen,R., Landgraf,D., Huebner,A. and Koehler,K.
  TITLE     Identification of a novel putative interaction partner of the
            nucleoporin ALADIN
  JOURNAL   Biol Open 5 (11), 1697-1705 (2016)
   PUBMED   27754849
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1974)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1974)
  AUTHORS   Peluso,J.J., Griffin,D., Liu,X. and Horne,M.
  TITLE     Progesterone receptor membrane component-1 (PGRMC1) and PGRMC-2
            interact to suppress entry into the cell cycle in spontaneously
            immortalized rat granulosa cells
  JOURNAL   Biol Reprod 91 (5), 104 (2014)
   PUBMED   25253729
  REMARK    GeneRIF: PGRMC1 and PGRMC2 are involved in regulating entry into
            the G1 stage of the cell cycle.
REFERENCE   6  (bases 1 to 1974)
  AUTHORS   Intlekofer,K.A. and Petersen,S.L.
  TITLE     Distribution of mRNAs encoding classical progestin receptor,
            progesterone membrane components 1 and 2, serpine mRNA binding
            protein 1, and progestin and ADIPOQ receptor family members 7 and 8
            in rat forebrain
  JOURNAL   Neuroscience 172, 55-65 (2011)
   PUBMED   20977928
  REMARK    GeneRIF: Pgrmc1 and Pgrmc2 may play roles in neuroendocrine
            functions of the female rat.
REFERENCE   7  (bases 1 to 1974)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (bases 1 to 1974)
  AUTHORS   Hoffert,J.D., Pisitkun,T., Wang,G., Shen,R.F. and Knepper,M.A.
  TITLE     Quantitative phosphoproteomics of vasopressin-sensitive renal
            cells: regulation of aquaporin-2 phosphorylation at two sites
  JOURNAL   Proc Natl Acad Sci U S A 103 (18), 7159-7164 (2006)
   PUBMED   16641100
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083571.1.
            
            On Dec 16, 2004 this sequence version replaced XM_342239.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083571.1, EV765311.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1974
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q26"
     gene            1..1974
                     /gene="Pgrmc2"
                     /note="progesterone receptor membrane component 2"
                     /db_xref="GeneID:361940"
                     /db_xref="RGD:1308804"
     exon            1..407
                     /gene="Pgrmc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..661
                     /gene="Pgrmc2"
                     /note="progesterone membrane binding protein"
                     /codon_start=1
                     /product="membrane-associated progesterone receptor
                     component 2"
                     /protein_id="NP_001008375.1"
                     /db_xref="GeneID:361940"
                     /db_xref="RGD:1308804"
                     /translation="MAAGDGDVKLSTLGSGGERGGDGSPGGAGATAARSSWVAALLAT
                     GGEMLLNVALVALVLLGAYRLWVRWGRRGLCSGPGAGEESPAATLPRMKKRDFSLEQL
                     RQYDGARTPRILLAVNGKVFDVTKGSKFYGPAGPYGIFAGRDASRGLATFCLDKDALR
                     DEYDDLSDLNAVQMESVREWEMQFKEKYDYVGRLLKPGEEPSEYTDEEDTKDHSKQD"
     exon            408..563
                     /gene="Pgrmc2"
                     /inference="alignment:Splign:2.1.0"
     exon            564..1830
                     /gene="Pgrmc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagtgatg gcggcgggtg atggggacgt aaagctaagc accctgggga gcggcgggga
       61 gcgtggcggc gacgggagcc cgggtggcgc gggagcgacg gcagcgagga gcagttgggt
      121 ggcagcgctg ctggcgacgg gcggggagat gctgctgaac gtggcgctgg tggcgctggt
      181 gctgctgggg gcctaccggc tgtgggtgcg ctgggggcgg cgtggtctat gctcgggacc
      241 cggggcgggc gaggagagcc cggccgccac gctgccgcgc atgaagaagc gggacttcag
      301 cctggagcag ctgcgccagt acgacggggc gcgcacgccg cgcatcctgc tcgcggtcaa
      361 tgggaaagtc ttcgacgtga ccaaaggcag caagttctac ggccccgcgg gcccatatgg
      421 catctttgct ggcagggacg cctccagggg actggcgacc ttctgcctgg ataaggatgc
      481 acttagagat gagtacgatg acctctcaga tttgaacgca gtgcagatgg agagcgttcg
      541 agagtgggaa atgcagttta aagaaaaata tgattatgta ggcagactcc taaagccagg
      601 ggaagagcca tcagagtaca cagacgagga ggacaccaag gatcacagta aacaggactg
      661 aactttgtga acaaccaaag ccaggggcct tcagaactgc aactcgtacc cctttgagag
      721 aatgtccagt ctggctgtga tgctcctgct gtgagaacca tttcaccaga gtgtacaaga
      781 tactatgccc aactgtgaag atctgaatat gaggcattgc ctgtgctgcc tgccggtgaa
      841 cctgttgcag ttgtttgtga tgtctggtgg gcttcatcac cctgaaaagg agacaggacc
      901 ttctcaacag caagaaagtc tccgggttat tttaccctcc tctcctctcg attttcctcc
      961 cttccttcct cctcttcctt ttcttcttcc tccctccctc tctctccgcc ttcctttctt
     1021 tcccccaccc ctcccatgtc tttcttttaa aacaaaacaa aaaagtatca aagacaacca
     1081 gataggtatt tgctactcag tgtgcagatc tctggaagga gcaagggatc ctgtttcaca
     1141 ggctgtgctt tatttgtgtt aagggaagag ccctgggcag gggaaagggg gtcacatatt
     1201 catttaagaa gttcaggcta ctgaaacatt taaacgtgaa ttcccaaact tttctttcgg
     1261 ggctttgtca gggaagaggg aaaaatgtcc ttctaagatt tgaaagaagg atttccagta
     1321 gattaaagtc aacagttccc agctaagata atttgaaacc agttttattt ctttcccttc
     1381 cttccgctag gtcaaaacaa tattaattgt gccttatttc acttccataa acttgaatta
     1441 ctttttggga aagcccctgt gaattgagaa gtcagtacaa gcagcactga gactgaggct
     1501 gatgtcactg tgtgtggagt ggaggaggag ttctcagtgt taactgccat gagttagtgc
     1561 acaaacatcg ctagcatcgt gatggccaag tgcatccctg tgcttttttc ttttctaaga
     1621 aagattgaaa accaacagtt cttccccaac agctgcctaa attttagggg tctgaccctc
     1681 acatgtcact ggtgtgagtg agtggggccg agcggtatga atgtctgtgt gagtgagtct
     1741 ggatgtctgt gagagcacct tgggagggac tcttcctgca atgctgtaaa tacgagtacc
     1801 gttttaataa agcatgtaca ataaaccaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1861 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1921 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
