LOCUS       NM_021766               1863 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus progesterone receptor membrane component 1
            (Pgrmc1), mRNA.
ACCESSION   NM_021766 XM_212843
VERSION     NM_021766.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1863)
  AUTHORS   Cao,T., Chen,Q., Zhang,B., Wu,X., Zeng,C., Zhang,S. and Cai,H.
  TITLE     Clozapine Induced Disturbances in Hepatic Glucose Metabolism: The
            Potential Role of PGRMC1 Signaling
  JOURNAL   Front Endocrinol (Lausanne) 12, 727371 (2021)
   PUBMED   34970218
  REMARK    GeneRIF: Clozapine Induced Disturbances in Hepatic Glucose
            Metabolism: The Potential Role of PGRMC1 Signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1863)
  AUTHORS   Chen,Y.J., Knupp,J., Arunagiri,A., Haataja,L., Arvan,P. and Tsai,B.
  TITLE     PGRMC1 acts as a size-selective cargo receptor to drive ER-phagic
            clearance of mutant prohormones
  JOURNAL   Nat Commun 12 (1), 5991 (2021)
   PUBMED   34645803
  REMARK    GeneRIF: PGRMC1 acts as a size-selective cargo receptor to drive
            ER-phagic clearance of mutant prohormones.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1863)
  AUTHORS   Galmozzi,A., Kok,B.P., Kim,A.S., Montenegro-Burke,J.R., Lee,J.Y.,
            Spreafico,R., Mosure,S., Albert,V., Cintron-Colon,R., Godio,C.,
            Webb,W.R., Conti,B., Solt,L.A., Kojetin,D., Parker,C.G.,
            Peluso,J.J., Pru,J.K., Siuzdak,G., Cravatt,B.F. and Saez,E.
  TITLE     PGRMC2 is an intracellular haem chaperone critical for adipocyte
            function
  JOURNAL   Nature 576 (7785), 138-142 (2019)
   PUBMED   31748741
REFERENCE   4  (bases 1 to 1863)
  AUTHORS   Piel,R.B. 3rd, Shiferaw,M.T., Vashisht,A.A., Marcero,J.R.,
            Praissman,J.L., Phillips,J.D., Wohlschlegel,J.A. and Medlock,A.E.
  TITLE     A Novel Role for Progesterone Receptor Membrane Component 1
            (PGRMC1): A Partner and Regulator of Ferrochelatase
  JOURNAL   Biochemistry 55 (37), 5204-5217 (2016)
   PUBMED   27599036
REFERENCE   5  (bases 1 to 1863)
  AUTHORS   Kabe,Y., Nakane,T., Koike,I., Yamamoto,T., Sugiura,Y., Harada,E.,
            Sugase,K., Shimamura,T., Ohmura,M., Muraoka,K., Yamamoto,A.,
            Uchida,T., Iwata,S., Yamaguchi,Y., Krayukhina,E., Noda,M.,
            Handa,H., Ishimori,K., Uchiyama,S., Kobayashi,T. and Suematsu,M.
  TITLE     Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates
            cancer proliferation and chemoresistance
  JOURNAL   Nat Commun 7, 11030 (2016)
   PUBMED   26988023
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1863)
  AUTHORS   Leel,V., Elrick,L.J., Solares,J., Ingram,N., Charlton,K.A.,
            Porter,A.J. and Wright,M.C.
  TITLE     Identification of a truncated ratp28-related protein expressed in
            kidney
  JOURNAL   Biochem Biophys Res Commun 316 (3), 872-877 (2004)
   PUBMED   15033482
REFERENCE   7  (bases 1 to 1863)
  AUTHORS   Sakamoto,H., Ukena,K., Takemori,H., Okamoto,M., Kawata,M. and
            Tsutsui,K.
  TITLE     Expression and localization of 25-Dx, a membrane-associated
            putative progesterone-binding protein, in the developing Purkinje
            cell
  JOURNAL   Neuroscience 126 (2), 325-334 (2004)
   PUBMED   15207350
REFERENCE   8  (bases 1 to 1863)
  AUTHORS   Nolte,I., Jeckel,D., Wieland,F.T. and Sohn,K.
  TITLE     Localization and topology of ratp28, a member of a novel family of
            putative steroid-binding proteins
  JOURNAL   Biochim Biophys Acta 1543 (1), 123-130 (2000)
   PUBMED   11087948
REFERENCE   9  (bases 1 to 1863)
  AUTHORS   Runko,E., Wideman,C. and Kaprielian,Z.
  TITLE     Cloning and expression of VEMA: a novel ventral midline antigen in
            the rat CNS
  JOURNAL   Mol Cell Neurosci 14 (6), 428-443 (1999)
   PUBMED   10656251
REFERENCE   10 (bases 1 to 1863)
  AUTHORS   Selmin,O., Lucier,G.W., Clark,G.C., Tritscher,A.M., Vanden
            Heuvel,J.P., Gastel,J.A., Walker,N.J., Sutter,T.R. and Bell,D.A.
  TITLE     Isolation and characterization of a novel gene induced by
            2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver
  JOURNAL   Carcinogenesis 17 (12), 2609-2615 (1996)
   PUBMED   9006096
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Dec 2, 2020 this sequence version replaced NM_021766.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062073.1, AF163321.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-428               JAXUCZ010000021.1  120698610-120699037
            429-584             JAXUCZ010000021.1  120702579-120702734
            585-1863            JAXUCZ010000021.1  120705527-120706805
FEATURES             Location/Qualifiers
     source          1..1863
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq34"
     gene            1..1863
                     /gene="Pgrmc1"
                     /gene_synonym="25-Dx; 25Dx; MPR; VEMA"
                     /note="progesterone receptor membrane component 1"
                     /db_xref="GeneID:291948"
                     /db_xref="RGD:70890"
     exon            1..428
                     /gene="Pgrmc1"
                     /gene_synonym="25-Dx; 25Dx; MPR; VEMA"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..688
                     /gene="Pgrmc1"
                     /gene_synonym="25-Dx; 25Dx; MPR; VEMA"
                     /note="membrane-bound progesterone receptor; ventral
                     midline antigen; acidic 25 kDa protein"
                     /codon_start=1
                     /product="membrane-associated progesterone receptor
                     component 1"
                     /protein_id="NP_068534.2"
                     /db_xref="GeneID:291948"
                     /db_xref="RGD:70890"
                     /translation="MAAEDVVATGADPSELEGGGLLQEIFTSPLNLLLLGLCIFLLYK
                     IVRGDQPGASGDNDDDEPPPLPRLKPRDFTPAELRRYDGVQDPRILMAINGKVFDVTK
                     GRKFYGPEGPYGVFAGRDASRGLATFCLDKEALKDEYDDLSDLTPAQQETLNDWDSQF
                     TFKYHHVGKLLKEGEEPTVYSDDEEPKDEAARKSD"
     exon            429..584
                     /gene="Pgrmc1"
                     /gene_synonym="25-Dx; 25Dx; MPR; VEMA"
                     /inference="alignment:Splign:2.1.0"
     exon            585..1863
                     /gene="Pgrmc1"
                     /gene_synonym="25-Dx; 25Dx; MPR; VEMA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagccactga acgctgcgcg ccactgttcg cttagagggc ggaggaagcc gactgttccg
       61 gatctctgca tagcagggcc caacctttgc tccagagatc atggctgccg aggatgtggt
      121 ggcgactggc gccgacccca gcgagctgga gggcggcggg ctgcttcaag agattttcac
      181 gtcgcctctc aacctgctgc tccttggcct ctgcatcttc ctgctctaca agatcgttcg
      241 cggggaccag cccggtgcca gtggggacaa cgacgacgac gagccgcccc cgctgccccg
      301 cctcaagccg cgtgacttca cccctgccga actaaggcga tacgatggag tccaggaccc
      361 gcgcattctt atggccatca acggcaaggt gttcgacgtg accaaaggcc gcaagttcta
      421 tgggccggag gggccatacg gggtctttgc tggaagagat gcatccaggg gccttgccac
      481 attttgcctg gacaaagaag cactgaagga tgagtatgat gacctttctg acctcactcc
      541 tgcccagcag gagaccctga atgactggga ctctcagttc accttcaagt accatcacgt
      601 gggaaaactg ctgaaggaag gggaggagcc gactgtgtac tcggatgatg aagaaccaaa
      661 agatgaggct gctcggaaga gtgactgaag cagtcagtgg agcatatcta tttttgtatt
      721 ttgcaaaatc atttgtaaca ttccagtctg tctttacaac atggtgattt caatatttag
      781 agaagttttg aacttgtaag ttttttaagt aacatcacta gtgacaccga taaaatcaac
      841 tcgtcttaga atgcatgatg tgtttgtacg tcacaaatcc agaaagtgaa cttcagtgct
      901 ctaatgcaaa tggtaaagct gtttctcttc tatctgtagt taaaactgaa ttacaatttt
      961 attttcctga gagggaaaac ttgggttatc cacaaactgg ccaaaatggc aagtgcacac
     1021 acacacagtg gccaaaatgg tcaatgtact aagaatgaag agagaaggtc ttagccatgc
     1081 tatagtctga aaacaagccc attttaccca acagacttaa ctgcatgatt tttgttttat
     1141 ctacctctaa agcaaaactg cagtgttcca aagtctgtgg tattgattca aaacagaagt
     1201 ccagtaacaa aatgaaaact caataatggg tttagttggg gcaaacacat tgcctgtgtt
     1261 catggactga tttatcatcc ctgtccccac gtggacactc ccacacacag taactctcac
     1321 acacctggta attggcagtt ggaactacaa cagaatctga aaattcaagg tagaactttg
     1381 caaaagaaaa atctgttgct tgtagcaggg caatggttat gtggttattg gccaaatgta
     1441 aaatttgaga gcaatataca ggacaggaac aggtgtgcgc ttttcaaaag cttccactga
     1501 catctctgaa gaatgagaaa acactacatg gcactagctg ggtgattttg aaaggaaaat
     1561 acattcctaa ggtaacagtt aaatccttct gttgttacaa aactcgtagt cgcttcaaaa
     1621 atagtagtca ggtgtctagg tcttggataa tactcttggt taatactaaa cctagcttaa
     1681 gtagactctg cagttgtata catttgtaaa agtattatct gaacaactag tgaggtttca
     1741 gactcttgta attgtagtta aatagtcatt gtattttctt gtgagctgtg tttaatggtt
     1801 ttacctcaaa tcagaaaaaa aatgaagtgc ttgggtcagt taataaaacg gttttgccca
     1861 ata
//
