LOCUS       NM_022847               3607 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus progesterone receptor (Pgr), mRNA.
ACCESSION   NM_022847 XM_346818
VERSION     NM_022847.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3607)
  AUTHORS   Forbes-Lorman,R.M.
  TITLE     Sex-specific effects of neonatal progestin receptor antagonism on
            juvenile social play behavior in rats
  JOURNAL   Behav Brain Funct 17 (1), 10 (2021)
   PUBMED   34740365
  REMARK    GeneRIF: Sex-specific effects of neonatal progestin receptor
            antagonism on juvenile social play behavior in rats.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3607)
  AUTHORS   Fahrenkopf,A. and Wagner,C.K.
  TITLE     Bisphenol A (BPA) induces progesterone receptor expression in an
            estrogen receptor alpha-dependent manner in perinatal brain
  JOURNAL   Neurotoxicol Teratol 78, 106864 (2020)
   PUBMED   31926947
  REMARK    GeneRIF: Bisphenol A (BPA) induces progesterone receptor expression
            in an estrogen receptor alpha-dependent manner in perinatal brain.
REFERENCE   3  (bases 1 to 3607)
  AUTHORS   Newell,A.J., Lalitsasivimol,D., Willing,J., Gonzales,K.,
            Waters,E.M., Milner,T.A., McEwen,B.S. and Wagner,C.K.
  TITLE     Progesterone receptor expression in cajal-retzius cells of the
            developing rat dentate gyrus: Potential role in
            hippocampus-dependent memory
  JOURNAL   J Comp Neurol 526 (14), 2285-2300 (2018)
   PUBMED   30069875
  REMARK    GeneRIF: virtually all PR cells co-expressed the calcium binding
            protein, calretinin, and the glycoprotein, reelin, both reliable
            markers for Cajal-Retzius neurons, a transient population of
            developmentally critical pioneer neurons that guide synaptogenesis
REFERENCE   4  (bases 1 to 3607)
  AUTHORS   Sa,S.I., Fonseca,B.M., Teixeira,N. and Madeira,M.D.
  TITLE     Estrogen receptors alpha and beta have different roles in the
            induction and trafficking of progesterone receptors in hypothalamic
            ventromedial neurons
  JOURNAL   FEBS J 282 (6), 1126-1136 (2015)
   PUBMED   25612677
  REMARK    GeneRIF: individual and simultaneous activation of ERalpha and
            ERbeta have different effects on the levels and subcellular
            location of PRs in VMNvl neurons
REFERENCE   5  (bases 1 to 3607)
  AUTHORS   Goswami,D., Callaway,C., Pascal,B.D., Kumar,R., Edwards,D.P. and
            Griffin,P.R.
  TITLE     Influence of domain interactions on conformational mobility of the
            progesterone receptor detected by hydrogen/deuterium exchange mass
            spectrometry
  JOURNAL   Structure 22 (7), 961-973 (2014)
   PUBMED   24909783
REFERENCE   6  (bases 1 to 3607)
  AUTHORS   Park-Sarge,O.K. and Mayo,K.E.
  TITLE     Regulation of the progesterone receptor gene by gonadotropins and
            cyclic adenosine 3',5'-monophosphate in rat granulosa cells
  JOURNAL   Endocrinology 134 (2), 709-718 (1994)
   PUBMED   8299566
REFERENCE   7  (bases 1 to 3607)
  AUTHORS   Kato,J., Hirata,S., Nozawa,A. and Mouri,N.
  TITLE     The ontogeny of gene expression of progestin receptors in the
            female rat brain
  JOURNAL   J Steroid Biochem Mol Biol 47 (1-6), 173-182 (1993)
   PUBMED   8274433
REFERENCE   8  (bases 1 to 3607)
  AUTHORS   Kraus,W.L., Montano,M.M. and Katzenellenbogen,B.S.
  TITLE     Cloning of the rat progesterone receptor gene 5'-region and
            identification of two functionally distinct promoters
  JOURNAL   Mol Endocrinol 7 (12), 1603-1616 (1993)
   PUBMED   8145766
REFERENCE   9  (bases 1 to 3607)
  AUTHORS   Natraj,U. and Richards,J.S.
  TITLE     Hormonal regulation, localization, and functional activity of the
            progesterone receptor in granulosa cells of rat preovulatory
            follicles
  JOURNAL   Endocrinology 133 (2), 761-769 (1993)
   PUBMED   8344215
REFERENCE   10 (bases 1 to 3607)
  AUTHORS   Park,O.K. and Mayo,K.E.
  TITLE     Transient expression of progesterone receptor messenger RNA in
            ovarian granulosa cells after the preovulatory luteinizing hormone
            surge
  JOURNAL   Mol Endocrinol 5 (7), 967-978 (1991)
   PUBMED   1840636
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Feb 25, 2021 this sequence version replaced NM_022847.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM037361.1, HM037362.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2159              JAXUCZ010000008.1  14354398-14356556
            2160-2311           JAXUCZ010000008.1  14358100-14358251
            2312-2428           JAXUCZ010000008.1  14375727-14375843
            2429-2734           JAXUCZ010000008.1  14394190-14394495
            2735-2879           JAXUCZ010000008.1  14403910-14404054
            2880-3010           JAXUCZ010000008.1  14405990-14406120
            3011-3168           JAXUCZ010000008.1  14409594-14409751
            3169-3607           JAXUCZ010000008.1  14412833-14413271
FEATURES             Location/Qualifiers
     source          1..3607
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q11"
     gene            1..3607
                     /gene="Pgr"
                     /note="progesterone receptor"
                     /db_xref="GeneID:25154"
                     /db_xref="RGD:3317"
     exon            1..2159
                     /gene="Pgr"
                     /inference="alignment:Splign:2.1.0"
     CDS             544..3324
                     /gene="Pgr"
                     /note="PR; nuclear receptor subfamily 3 group C member 3"
                     /codon_start=1
                     /product="progesterone receptor"
                     /protein_id="NP_074038.2"
                     /db_xref="GeneID:25154"
                     /db_xref="RGD:3317"
                     /translation="MTELQAKDPRTLHTSGAAPSPTHVGSPLLARLDPDPFQGSQHSD
                     ASSVVSPIPISLDRLLFSRSCQAQELPDEKTQNQQSLSDVEGAFSGVEAARAEGSRNP
                     RAPEKDSRLLDSVLDTLLAPSGPEQSQTSPPACEAITSWCLFGPELPEDPRSVPATKG
                     LLSPLMSRPESKAGDSSGTGAGQKVLPKGLSPPRQLLLPTSGSAHWPGAGVKPSQQPA
                     TVEVEEDGGLETEGSAGPLLKSKPRALEGMCSGGGVTANAPAAAPGGVTLVPKEDSRF
                     SAPRVSLEQDAPVAPGRSPLATTVVDFIHVPILPLNHALLAARTRQLLEGDSYDGGAA
                     AQVPFAPPRGSPSAPSPPVPCGDFPDCTYPPEGDPKEDGFPVYGEFQPPGLKIKEEEE
                     GTEAASRSPRPYLLAGASAATFPDFPLPPAPPRAPPSRPGEAAVAGGPGSAAVSPVSS
                     SGSALECILYKAEGAPPTQGSFAPLPCKPPAASSCLLPRDSLPAAPTSSAAPAIYPPL
                     GLNGLPQLGYQAAVLKDSLPQVYPPYLNYLRPDSEASQSPQYGFDSLPQKICLICGDE
                     ASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAG
                     MVLGGRKFKKFNKVRVMRALDGVALPQSVGLPNESQTLGQRITFSPNQEIQLVPPLIN
                     LLMSIEPDVVYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQ
                     ITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKELSFYSLCLTMWQIP
                     QEFVKLQVTHEEFLCMKVLLLLNTIPLEGLRSQSQFEEMRSSYIRELIKAIGLRQKGV
                     VPSSQRFYQLTKLLDSLHDLVKQLHLYCLNTFIQSRALAVEFPEMMSEVIAAQLPKIL
                     AGMVKPLLFHKK"
     exon            2160..2311
                     /gene="Pgr"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2428
                     /gene="Pgr"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2734
                     /gene="Pgr"
                     /inference="alignment:Splign:2.1.0"
     exon            2735..2879
                     /gene="Pgr"
                     /inference="alignment:Splign:2.1.0"
     exon            2880..3010
                     /gene="Pgr"
                     /inference="alignment:Splign:2.1.0"
     exon            3011..3168
                     /gene="Pgr"
                     /inference="alignment:Splign:2.1.0"
     exon            3169..3607
                     /gene="Pgr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaccaacct gcaaccagaa ctcgctgaga ctgtagaaaa cccagggact gtactgactg
       61 tcacagcctg aaaacgacta agaacgggct acttcttagt cccagggttt tggtgaggac
      121 tgtgatgtaa acctcctaag atgcctagct ttcaactaac gtaagaagtc ctgagagcgg
      181 gagccctttt ttgcagcacc ggctgcttca gcaccgggtc tcccatccaa ggagaaacag
      241 ggcaaaagtc tcttgaaaac ttgcccaatt ctgagaccag cttgatccag ctacttcttc
      301 ctgctctcac cccacgccgc cgggacagcg cgactaccac ccttcctctg catctgggtg
      361 gagggtaaga acaggagctg accaagactg cccctcccga ccaggaggtg gagatcccac
      421 gggtccggcg actcaacacc cacttccccc tccctgtgcc cctatatcac cggcaccccc
      481 tcctccttcc cttttccctc ctcccaggag acaggggagg agaaaagggg atctcgggtc
      541 gtcatgactg agctgcaggc aaaggatccg cggactctcc acacatctgg cgccgcgccc
      601 tcccccaccc acgtcgggtc tcccttgctt gcacgcttgg acccggatcc cttccaggga
      661 agtcagcact cggacgcatc gtctgtagtc tcgcctatac cgatctccct ggaccggctg
      721 ctcttctctc ggtcctgcca ggctcaggag ctcccagacg aaaagacaca aaatcagcag
      781 tcgctgtccg acgtggaggg agctttctct ggagtcgaag ccgctcgcgc cgaaggaagc
      841 agaaatccca gagctccgga gaaggacagc agactcttag acagtgtctt agacaccctg
      901 ttggcgccct cggggcccga gcaaagccaa accagccctc cagcctgcga ggccatcact
      961 tcttggtgtc tctttgggcc agagcttcca gaagaccccc gcagtgtccc cgctaccaag
     1021 gggttgttgt ccccgctcat gagccggcca gagagcaagg ctggcgacag ctccgggaca
     1081 ggagcagggc agaaggtgct gcccaaaggg ctgtcaccac cccggcagct gttgctcccg
     1141 acctcgggga gtgctcactg gcccggggca ggggtgaagc catctcagca gcctgctacg
     1201 gtggaggtgg aggaggacgg tggtctcgag accgagggct ctgcgggtcc gcttctgaag
     1261 agcaaacctc gagcactgga aggcatgtgc agcggaggag gagtcacagc caacgcgccc
     1321 gcggcggccc caggaggcgt caccttggtc cccaaggaag attcccggtt ttctgctccc
     1381 agggtctcct tggagcaaga cgctccagtt gcccccgggc gctccccact ggccaccaca
     1441 gtggtggatt tcattcacgt gcccattctg cctctgaacc acgctctcct agccgcccgc
     1501 acccggcagc tgctggaggg ggacagctac gacggcgggg ctgcagcgca ggtccctttt
     1561 gctccacctc ggggctcgcc ctccgcgccc tccccgccgg tgccctgcgg tgacttccca
     1621 gactgcacct accctccaga aggcgaccct aaagaggacg ggttcccagt ttacggcgaa
     1681 ttccagcctc ccggcttgaa gatcaaggag gaggaggagg gcacggaggc tgcttcccgc
     1741 tcgccgcgcc cctacctgtt ggccggagcc agcgccgcca ccttcccaga cttcccgctg
     1801 ccgccggcgc cgccgcgagc gccaccctcc aggcccggag aggcggcggt agccggcggc
     1861 ccgggcagcg ccgcggtgtc gccagtgtcc tcgtcgggct ccgcactgga gtgcatcctg
     1921 tacaaagcgg agggcgcgcc gcccacgcag ggttcgttcg ccccattgcc ctgtaaaccc
     1981 ccggccgcca gctcctgcct gcttccccgg gacagcctgc ccgccgctcc gacctcctcc
     2041 gcagcaccgg ccatctaccc gccgctcggc ctcaatgggc tccctcagct gggttaccag
     2101 gccgcggtgc tcaaggacag cctgccccaa gtctacccgc cctacctcaa ctacctgagg
     2161 ccagattcag aagccagcca gagcccacaa tatggctttg attccttacc tcagaagatc
     2221 tgtttaatct gcggggatga agcatctggc tgtcactatg gtgtgcttac ctgtgggagc
     2281 tgcaaggtct tctttaagag ggcgatggaa gggcagcata actatttatg tgccggaaga
     2341 aatgattgca ttgttgataa aatccgcaga aaaaactgtc cagcatgtcg tctgagaaag
     2401 tgctgtcagg ctggcatggt ccttggaggt cgtaagttta agaagttcaa taaagtccga
     2461 gttatgagag ccctcgatgg tgttgctctc ccccagtcag tgggccttcc taatgagagc
     2521 cagaccctgg gccagagaat cacattttca ccaaatcaag agattcaact ggttccgcca
     2581 ctcatcaacc tgctcatgag cattgaacct gatgtggttt atgcagggca tgacaacaca
     2641 aagcccgaca cttccagctc tttgctgacc agtctcaacc aactaggcga gaggcagctg
     2701 ctttcagtag tcaaatggtc taagtctctg ccaggtttcc ggaacttaca catcgatgac
     2761 cagataaccc tgattcagta ctcctggatg agcctgatgg tgtttggcct ggggtggagg
     2821 tcgtacaagc atgtcagtgg acagatgcta tattttgcac ctgatctaat cctgaatgag
     2881 cagaggatga aggagttgtc attctactcg ctgtgcctta ccatgtggca aatcccacag
     2941 gagtttgtca agctccaggt gacccacgag gagttcctct gtatgaaagt cttacttctt
     3001 cttaacacaa ttcctttgga aggcctgagg agtcaaagcc agtttgaaga gatgaggtca
     3061 agctatattc gggaattgat caaggcaatt ggcttaagac agaaaggggt ggtccccagt
     3121 tcacaacgct tctatcaact tacaaaactt cttgacagct tgcatgatct tgtgaaacag
     3181 ctccacctgt actgcttgaa tacgttcatc caatcccggg cactggctgt ggaatttccg
     3241 gaaatgatgt ctgaagttat tgctgcccag ttgcccaaga tcctggcggg catggtgaag
     3301 cctctcctct ttcacaaaaa gtgatgactt ttctttgttt cctctgcaaa aattgaattt
     3361 tgtggtgtgt cattttgtct cagtcaggac agtcagctct gtgtctttat aatgtccttc
     3421 tgaaagcctt acgtgtatac atatcacact gtaaacttag gagaaaacca atgaaatttg
     3481 gattttcctt tgtgatgtct aagcagaatt tttaaagtgt tttgtgcacc catattttga
     3541 gagtttacat ggttaaaaag gactaaagtt gattgtataa gtaaactata tctcacccgt
     3601 gttattt
//
