LOCUS       NP_074038                926 aa            linear   ROD 27-MAR-2024
DEFINITION  progesterone receptor [Rattus norvegicus].
ACCESSION   NP_074038 XP_346819
VERSION     NP_074038.2
DBSOURCE    REFSEQ: accession NM_022847.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 926)
  AUTHORS   Forbes-Lorman,R.M.
  TITLE     Sex-specific effects of neonatal progestin receptor antagonism on
            juvenile social play behavior in rats
  JOURNAL   Behav Brain Funct 17 (1), 10 (2021)
   PUBMED   34740365
  REMARK    GeneRIF: Sex-specific effects of neonatal progestin receptor
            antagonism on juvenile social play behavior in rats.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 926)
  AUTHORS   Fahrenkopf,A. and Wagner,C.K.
  TITLE     Bisphenol A (BPA) induces progesterone receptor expression in an
            estrogen receptor alpha-dependent manner in perinatal brain
  JOURNAL   Neurotoxicol Teratol 78, 106864 (2020)
   PUBMED   31926947
  REMARK    GeneRIF: Bisphenol A (BPA) induces progesterone receptor expression
            in an estrogen receptor alpha-dependent manner in perinatal brain.
REFERENCE   3  (residues 1 to 926)
  AUTHORS   Newell,A.J., Lalitsasivimol,D., Willing,J., Gonzales,K.,
            Waters,E.M., Milner,T.A., McEwen,B.S. and Wagner,C.K.
  TITLE     Progesterone receptor expression in cajal-retzius cells of the
            developing rat dentate gyrus: Potential role in
            hippocampus-dependent memory
  JOURNAL   J Comp Neurol 526 (14), 2285-2300 (2018)
   PUBMED   30069875
  REMARK    GeneRIF: virtually all PR cells co-expressed the calcium binding
            protein, calretinin, and the glycoprotein, reelin, both reliable
            markers for Cajal-Retzius neurons, a transient population of
            developmentally critical pioneer neurons that guide synaptogenesis
REFERENCE   4  (residues 1 to 926)
  AUTHORS   Sa,S.I., Fonseca,B.M., Teixeira,N. and Madeira,M.D.
  TITLE     Estrogen receptors alpha and beta have different roles in the
            induction and trafficking of progesterone receptors in hypothalamic
            ventromedial neurons
  JOURNAL   FEBS J 282 (6), 1126-1136 (2015)
   PUBMED   25612677
  REMARK    GeneRIF: individual and simultaneous activation of ERalpha and
            ERbeta have different effects on the levels and subcellular
            location of PRs in VMNvl neurons
REFERENCE   5  (residues 1 to 926)
  AUTHORS   Goswami,D., Callaway,C., Pascal,B.D., Kumar,R., Edwards,D.P. and
            Griffin,P.R.
  TITLE     Influence of domain interactions on conformational mobility of the
            progesterone receptor detected by hydrogen/deuterium exchange mass
            spectrometry
  JOURNAL   Structure 22 (7), 961-973 (2014)
   PUBMED   24909783
REFERENCE   6  (residues 1 to 926)
  AUTHORS   Park-Sarge,O.K. and Mayo,K.E.
  TITLE     Regulation of the progesterone receptor gene by gonadotropins and
            cyclic adenosine 3',5'-monophosphate in rat granulosa cells
  JOURNAL   Endocrinology 134 (2), 709-718 (1994)
   PUBMED   8299566
REFERENCE   7  (residues 1 to 926)
  AUTHORS   Kato,J., Hirata,S., Nozawa,A. and Mouri,N.
  TITLE     The ontogeny of gene expression of progestin receptors in the
            female rat brain
  JOURNAL   J Steroid Biochem Mol Biol 47 (1-6), 173-182 (1993)
   PUBMED   8274433
REFERENCE   8  (residues 1 to 926)
  AUTHORS   Kraus,W.L., Montano,M.M. and Katzenellenbogen,B.S.
  TITLE     Cloning of the rat progesterone receptor gene 5'-region and
            identification of two functionally distinct promoters
  JOURNAL   Mol Endocrinol 7 (12), 1603-1616 (1993)
   PUBMED   8145766
REFERENCE   9  (residues 1 to 926)
  AUTHORS   Natraj,U. and Richards,J.S.
  TITLE     Hormonal regulation, localization, and functional activity of the
            progesterone receptor in granulosa cells of rat preovulatory
            follicles
  JOURNAL   Endocrinology 133 (2), 761-769 (1993)
   PUBMED   8344215
REFERENCE   10 (residues 1 to 926)
  AUTHORS   Park,O.K. and Mayo,K.E.
  TITLE     Transient expression of progesterone receptor messenger RNA in
            ovarian granulosa cells after the preovulatory luteinizing hormone
            surge
  JOURNAL   Mol Endocrinol 5 (7), 967-978 (1991)
   PUBMED   1840636
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Feb 25, 2021 this sequence version replaced NP_074038.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM037361.1, HM037362.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..926
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q11"
     Protein         1..926
                     /product="progesterone receptor"
                     /note="PR; nuclear receptor subfamily 3 group C member 3"
                     /calculated_mol_wt=99187
     Region          1..557
                     /region_name="Prog_receptor"
                     /note="Progesterone receptor; pfam02161"
                     /db_xref="CDD:460470"
     Region          1..49
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63449.1)"
     Site            20
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P06401; propagated from
                     UniProtKB/Swiss-Prot (Q63449.1)"
     Region          56..60
                     /region_name="LXXL motif 1.
                     /evidence=ECO:0000250|UniProtKB:P06401"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63449.1)"
     Site            82
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P06401; propagated from
                     UniProtKB/Swiss-Prot (Q63449.1)"
     Region          116..120
                     /region_name="LXXL motif 2.
                     /evidence=ECO:0000250|UniProtKB:P06401"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63449.1)"
     Site            131
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P06401; propagated from
                     UniProtKB/Swiss-Prot (Q63449.1)"
     Region          153..240
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63449.1)"
     Site            163
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P06401; propagated from
                     UniProtKB/Swiss-Prot (Q63449.1)"
     Region          166..305
                     /region_name="Mediates transcriptional transrepression (in
                     isoform A). /evidence=ECO:0000250|UniProtKB:P06401"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63449.1)"
     Region          185..189
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63449.1)"
     Site            191
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P06401; propagated from
                     UniProtKB/Swiss-Prot (Q63449.1)"
     Site            214
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P06401; propagated from
                     UniProtKB/Swiss-Prot (Q63449.1)"
     Site            294
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MAPK1.
                     /evidence=ECO:0000250|UniProtKB:P06401; propagated from
                     UniProtKB/Swiss-Prot (Q63449.1)"
     Region          334..372
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63449.1)"
     Site            345
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MAPK.
                     /evidence=ECO:0000250|UniProtKB:P06401; propagated from
                     UniProtKB/Swiss-Prot (Q63449.1)"
     Site            400
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CDK2.
                     /evidence=ECO:0000250|UniProtKB:P06401; propagated from
                     UniProtKB/Swiss-Prot (Q63449.1)"
     Region          413..436
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63449.1)"
     Region          453..539
                     /region_name="AF1, mediates transcriptional activation.
                     /evidence=ECO:0000250|UniProtKB:P06401"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63449.1)"
     Region          556..633
                     /region_name="NR_DBD_GR_PR"
                     /note="DNA-binding domain of glucocorticoid receptor (GR)
                     is composed of two C4-type zinc fingers; cd07172"
                     /db_xref="CDD:143546"
     Site            order(560,563,577,580,596,602,612,615)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:143546"
     Site            order(570..572,578..579,581..582,585..586,594,609..610,
                     616)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143546"
     Site            order(595..597,599,602..603,607..608,611)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:143546"
     Site            669
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P06401; propagated from
                     UniProtKB/Swiss-Prot (Q63449.1)"
     Region          679..926
                     /region_name="NR_LBD_PR"
                     /note="Ligand binding domain of the progesterone receptor,
                     a member of the nuclear hormone receptor; cd07074"
                     /db_xref="CDD:132759"
     Region          680..926
                     /region_name="AF2, mediates transcriptional activation.
                     /evidence=ECO:0000250|UniProtKB:P06401"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63449.1)"
     Site            order(708,711..712,714..715,718,749,752..753,759,771,787,
                     790..791,794,880,883..884,887,896,898,902)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:132759"
     Site            order(723,727,737..738,741,901,904,908)
                     /site_type="active"
                     /note="putative coactivator recognition site [active]"
                     /db_xref="CDD:132759"
     Site            order(878,882,886,889..890,907,911,914..915)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:132759"
     CDS             1..926
                     /gene="Pgr"
                     /coded_by="NM_022847.2:544..3324"
                     /db_xref="GeneID:25154"
                     /db_xref="RGD:3317"
ORIGIN      
        1 mtelqakdpr tlhtsgaaps pthvgsplla rldpdpfqgs qhsdassvvs pipisldrll
       61 fsrscqaqel pdektqnqqs lsdvegafsg veaaraegsr nprapekdsr lldsvldtll
      121 apsgpeqsqt sppaceaits wclfgpelpe dprsvpatkg llsplmsrpe skagdssgtg
      181 agqkvlpkgl spprqlllpt sgsahwpgag vkpsqqpatv eveedgglet egsagpllks
      241 kpralegmcs gggvtanapa aapggvtlvp kedsrfsapr vsleqdapva pgrsplattv
      301 vdfihvpilp lnhallaart rqllegdsyd ggaaaqvpfa pprgspsaps ppvpcgdfpd
      361 ctyppegdpk edgfpvygef qppglkikee eegteaasrs prpyllagas aatfpdfplp
      421 papprappsr pgeaavaggp gsaavspvss sgsalecily kaegapptqg sfaplpckpp
      481 aasscllprd slpaaptssa apaiypplgl nglpqlgyqa avlkdslpqv yppylnylrp
      541 dseasqspqy gfdslpqkic licgdeasgc hygvltcgsc kvffkrameg qhnylcagrn
      601 dcivdkirrk ncpacrlrkc cqagmvlggr kfkkfnkvrv mraldgvalp qsvglpnesq
      661 tlgqritfsp nqeiqlvppl inllmsiepd vvyaghdntk pdtsssllts lnqlgerqll
      721 svvkwskslp gfrnlhiddq itliqyswms lmvfglgwrs ykhvsgqmly fapdlilneq
      781 rmkelsfysl cltmwqipqe fvklqvthee flcmkvllll ntipleglrs qsqfeemrss
      841 yirelikaig lrqkgvvpss qrfyqltkll dslhdlvkql hlyclntfiq sralavefpe
      901 mmseviaaql pkilagmvkp llfhkk
//
