LOCUS       NM_001169152            2535 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus phosphoglycolate phosphatase (Pgp), mRNA.
ACCESSION   NM_001169152 XM_001055264 XM_213235
VERSION     NM_001169152.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2535)
  AUTHORS   Mugabo,Y., Zhao,S., Seifried,A., Gezzar,S., Al-Mass,A., Zhang,D.,
            Lamontagne,J., Attane,C., Poursharifi,P., Iglesias,J., Joly,E.,
            Peyot,M.L., Gohla,A., Madiraju,S.R. and Prentki,M.
  TITLE     Identification of a mammalian glycerol-3-phosphate phosphatase:
            Role in metabolism and signaling in pancreatic beta-cells and
            hepatocytes
  JOURNAL   Proc Natl Acad Sci U S A 113 (4), E430-E439 (2016)
   PUBMED   26755581
  REMARK    GeneRIF: In vivo overexpression of PGP (functioning as
            glycerol-3-phosphate phosphatase) in rat liver lowers body weight
            gain and hepatic glucose production from glycerol and elevates
            plasma HDL levels. It is expressed in different tissues and
            nutritional states.
REFERENCE   2  (bases 1 to 2535)
  AUTHORS   Seifried,A., Knobloch,G., Duraphe,P.S., Segerer,G., Manhard,J.,
            Schindelin,H., Schultz,J. and Gohla,A.
  TITLE     Evolutionary and structural analyses of mammalian haloacid
            dehalogenase-type phosphatases AUM and chronophin provide insight
            into the basis of their different substrate specificities
  JOURNAL   J Biol Chem 289 (6), 3416-3431 (2014)
   PUBMED   24338473
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Dec 18, 2009 this sequence version replaced
            XM_001055264.1, XM_213235.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.59193.1,
                                           SRR26643293.61824.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-679               JAXUCZ010000010.1  13999782-14000460
            680-2535            JAXUCZ010000010.1  14000553-14002408
FEATURES             Location/Qualifiers
     source          1..2535
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..2535
                     /gene="Pgp"
                     /gene_synonym="AUM; G3PP; RGD1307773"
                     /note="phosphoglycolate phosphatase"
                     /db_xref="GeneID:287115"
                     /db_xref="RGD:1307773"
     exon            1..679
                     /gene="Pgp"
                     /gene_synonym="AUM; G3PP; RGD1307773"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1005
                     /gene="Pgp"
                     /gene_synonym="AUM; G3PP; RGD1307773"
                     /EC_number="3.1.3.48"
                     /EC_number="3.1.3.21"
                     /note="aspartate-based ubiquitous Mg(2+)-dependent
                     phosphatase"
                     /codon_start=1
                     /product="glycerol-3-phosphate phosphatase"
                     /protein_id="NP_001162623.1"
                     /db_xref="GeneID:287115"
                     /db_xref="RGD:1307773"
                     /translation="MAEAEAGGDEVRCVRLSAERAKLLLAEVDTLLFDCDGVLWRGET
                     AVPGAPETLRALRARGKRLGFITNNSSKTRTAYAEKLRRLGFGGPMGPEAGLEVFGTA
                     YCSALYLRQRLAGVPDPKAYVLGSPALAAELEAVGVTSVGVGPDVLHGDGPSDWLAVP
                     LEPDVRAVVVGFDPHFSYMKLTKAVRYLQQPDCLLVGTNMDNRLPLENGRFIAGTGCL
                     VRAVEMAAQRQADIIGKPSRFIFDCVSQEYGINPERTVMVGDRLDTDILLGSTCSLKT
                     ILTLTGVSSLEDVKSNQESDCMFKKKMVPDFYVDSIADLLPALQG"
     exon            680..2535
                     /gene="Pgp"
                     /gene_synonym="AUM; G3PP; RGD1307773"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggcggcgg cgggtggcgg cagcggtcag cggtcggcca tggcggaggc ggaggccggc
       61 ggcgacgaag tccgctgcgt gcggctgagc gccgagcggg ccaagttgct gctggccgaa
      121 gtggacacgc tgctgttcga ctgcgatggc gtgctgtggc gcggcgagac ggccgtgccg
      181 ggcgcgccgg agactctgcg ggcgctgcgg gcccgcggca agcgactggg cttcatcacc
      241 aacaacagca gcaagactcg tacggcctac gcggagaagc tcaggcgctt gggtttcggt
      301 ggcccgatgg ggcccgaagc gggcctcgag gtcttcggca cggcctactg cagcgcgctc
      361 tatctgcgcc aacgcctggc cggcgtgccg gaccccaagg cctacgtgct gggcagcccg
      421 gccttagccg cggagctgga ggccgtgggt gtcactagcg tgggcgtggg cccggacgtg
      481 cttcacggcg atggcccaag cgactggcta gccgtgccgc tcgaacccga cgtgcgcgcg
      541 gtagtggtgg gcttcgaccc acacttcagc tacatgaagc ttaccaaggc cgtgcggtac
      601 ctgcagcagc ccgactgtct gctcgtgggc accaacatgg acaaccggct cccgctagag
      661 aacggccgtt tcattgcggg taccggctgt ctggtgcgag ccgtggagat ggccgcccag
      721 cgccaggcgg acatcatcgg gaagcctagc cgcttcatct tcgactgcgt gtcccaggag
      781 tatggtatca acccggagcg caccgtcatg gtgggagacc gcctggacac agacatcctc
      841 ctgggctcca cctgtagcct gaagactatc ctgaccctca ccggagtctc cagtcttgag
      901 gatgtgaaga gcaatcagga aagtgactgc atgttcaaga agaaaatggt ccctgacttc
      961 tatgttgaca gcatagccga cctcttgcct gcccttcaag gttaaagatc tcgtgtcttt
     1021 aatctctgga ataaaaaaaa aaaaaaaaag aaaagaaaaa gaaaatcagc tacctaaatt
     1081 aataggtggg gcttaggaat agctgagtta ggtggctgca ggttaactga agtaaaggcg
     1141 gtagttaatc ttgtaagtaa gtgttggggg gaggtgttgt ttacagagaa ttatatttta
     1201 agatgcactt ttaagcttgg aaggcattat gaggtgggca tagcacatgc ccaacgttca
     1261 ggtaacctca ggctctgttg ctccgactga agtgggtcaa gggttgtgtc ttgcttttta
     1321 ctgaagtgta gtcagggatc aggccctaag gtgggcagag taaagaaaag gggctctgaa
     1381 gtaaccaaac actggggttt cccctaatgt gatcatgcag cagaggtgcc tgttactgta
     1441 ccccagttcc tcaccttcgg ggtgggagcg ctctattgtt ggggtttgga tgctgctctt
     1501 gacaacctcc actcactctg cttctttgaa aaccactttg acatcacagt tgtctgttct
     1561 gtttcagatg cccagcactg cagaccccca tgcacagtaa cagcagccca gctaaacttt
     1621 ggctgtcttg tgtgaattta acccaggtgt catagtgtgg cctgctgagc agccaattgg
     1681 gtccggaggg cctgccctgg gctccgtgct gctttatggg agctcagaac agtgcttact
     1741 tcttcaaact agtgaatggc attgtcaagt gtggaattgg atcttaagtg tctgaattaa
     1801 tagcgctgct ctgtctcaag ggtaaacccc actgaagaaa tctcatgccc cagtcagcag
     1861 cacagccagt gtgcaagtca aggattgcct tgtttcccag agtaccctct gggtaggaag
     1921 gaatgaggag cccagaagat agttaagtct ctaagaaagc atacaattcc ccttgtccag
     1981 gtcactttcg gttgtgcatg ggttaagtat cggtgctcct tgataccacc accaatctcg
     2041 atcttggact tccttgttgg tagccagcca taaggcctac caaccacttg gcttctcaac
     2101 atctctggcc ttttcctctg ctcttcaagt ccctgacctt tagcaatctg ctgagcagac
     2161 tgggaaacat tcatggggca tacccgggaa gttgctcctt ttggccgact cctttctggc
     2221 accttgccct gtaccaagtg gctactctca tggtcacagt acttcacctg ttcaccaagt
     2281 tctcagagca ataaaagtct gaagctgctc acaggccggg tgggagtgga atggtgccat
     2341 agatcaacat gatggcagta gtgcctgtaa cattggtggt gctgatccca agtctgaata
     2401 atgaccaggc ttggcagatg tgcagccagg gatgccctct ctgggcagat gctagagaac
     2461 ctatgtgtgt tacatttcca gcttgtcttg ctgtgtgacc tcaaatgcac attaaactca
     2521 aacccacaat gatta
//
