LOCUS       NM_001401193            2036 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus phosphoglucomutase 3 (Pgm3), mRNA.
ACCESSION   NM_001401193 XM_006243482
VERSION     NM_001401193.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2036)
  AUTHORS   Zhang,Y., Yu,X., Ichikawa,M., Lyons,J.J., Datta,S., Lamborn,I.T.,
            Jing,H., Kim,E.S., Biancalana,M., Wolfe,L.A., DiMaggio,T.,
            Matthews,H.F., Kranick,S.M., Stone,K.D., Holland,S.M., Reich,D.S.,
            Hughes,J.D., Mehmet,H., McElwee,J., Freeman,A.F., Freeze,H.H.,
            Su,H.C. and Milner,J.D.
  TITLE     Autosomal recessive phosphoglucomutase 3 (PGM3) mutations link
            glycosylation defects to atopy, immune deficiency, autoimmunity,
            and neurocognitive impairment
  JOURNAL   J Allergy Clin Immunol 133 (5), 1400-1409 (2014)
   PUBMED   24589341
REFERENCE   2  (bases 1 to 2036)
  AUTHORS   Greig,K.T., Antonchuk,J., Metcalf,D., Morgan,P.O., Krebs,D.L.,
            Zhang,J.G., Hacking,D.F., Bode,L., Robb,L., Kranz,C., de Graaf,C.,
            Bahlo,M., Nicola,N.A., Nutt,S.L., Freeze,H.H., Alexander,W.S.,
            Hilton,D.J. and Kile,B.T.
  TITLE     Agm1/Pgm3-mediated sugar nucleotide synthesis is essential for
            hematopoiesis and development
  JOURNAL   Mol Cell Biol 27 (16), 5849-5859 (2007)
   PUBMED   17548465
REFERENCE   3  (bases 1 to 2036)
  AUTHORS   Bouche,C., Serdy,S., Kahn,C.R. and Goldfine,A.B.
  TITLE     The cellular fate of glucose and its relevance in type 2 diabetes
  JOURNAL   Endocr Rev 25 (5), 807-830 (2004)
   PUBMED   15466941
  REMARK    Review article
REFERENCE   4  (bases 1 to 2036)
  AUTHORS   Mio,T., Yamada-Okabe,T., Arisawa,M. and Yamada-Okabe,H.
  TITLE     Functional cloning and mutational analysis of the human cDNA for
            phosphoacetylglucosamine mutase: identification of the amino acid
            residues essential for the catalysis
  JOURNAL   Biochim Biophys Acta 1492 (2-3), 369-376 (2000)
   PUBMED   11004509
REFERENCE   5  (bases 1 to 2036)
  AUTHORS   Whitehouse,D.B., Tomkins,J., Lovegrove,J.U., Hopkinson,D.A. and
            McMillan,W.O.
  TITLE     A phylogenetic approach to the identification of phosphoglucomutase
            genes
  JOURNAL   Mol Biol Evol 15 (4), 456-462 (1998)
   PUBMED   9549096
REFERENCE   6  (bases 1 to 2036)
  AUTHORS   Peters,J. and Andrews,S.J.
  TITLE     The Pk-3 gene determines both the heart, M1, and the kidney, M2,
            pyruvate kinase isozymes in the mouse; and a simple electrophoretic
            method for separating phosphoglucomutase-3
  JOURNAL   Biochem Genet 22 (11-12), 1047-1063 (1984)
   PUBMED   6241468
REFERENCE   7  (bases 1 to 2036)
  AUTHORS   Stallings,R.L. and Siciliano,M.J.
  TITLE     Confirmational, provisional, and/or regional assignment of 15
            enzyme loci onto Chinese hamster autosomes 1, 2, and 7
  JOURNAL   Somatic Cell Genet 7 (6), 683-698 (1981)
   PUBMED   7323947
REFERENCE   8  (bases 1 to 2036)
  AUTHORS   Nadeau,J.H., Kompf,J., Siebert,G. and Taylor,B.A.
  TITLE     Linkage of Pgm-3 in the house mouse and homologies of three
            phosphoglucomutase loci in mouse and man
  JOURNAL   Biochem Genet 19 (5-6), 465-474 (1981)
   PUBMED   6457599
REFERENCE   9  (bases 1 to 2036)
  AUTHORS   Marshall,M.J., Neal,F.E. and Goldberg,D.M.
  TITLE     Isoenzymes of hexokinase, 6-phosphogluconate dehydrogenase,
            phosphoglucomutase and lactate dehydrogenase in uterine cancer
  JOURNAL   Br J Cancer 40 (3), 380-390 (1979)
   PUBMED   508567
REFERENCE   10 (bases 1 to 2036)
  AUTHORS   Linder,D.
  TITLE     Gene loss in human teratomas
  JOURNAL   Proc Natl Acad Sci U S A 63 (3), 699-704 (1969)
   PUBMED   5259759
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Feb 3, 2022 this sequence version replaced XM_006243482.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166838.1, SRR22582424.1434886.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               JAXUCZ010000008.1  96415919-96416021   c
            104-309             JAXUCZ010000008.1  96414390-96414595   c
            310-494             JAXUCZ010000008.1  96413571-96413755   c
            495-562             JAXUCZ010000008.1  96411916-96411983   c
            563-696             JAXUCZ010000008.1  96409059-96409192   c
            697-892             JAXUCZ010000008.1  96408192-96408387   c
            893-1050            JAXUCZ010000008.1  96406148-96406305   c
            1051-1134           JAXUCZ010000008.1  96405408-96405491   c
            1135-1233           JAXUCZ010000008.1  96403107-96403205   c
            1234-1347           JAXUCZ010000008.1  96401716-96401829   c
            1348-1470           JAXUCZ010000008.1  96400843-96400965   c
            1471-1644           JAXUCZ010000008.1  96399390-96399563   c
            1645-2036           JAXUCZ010000008.1  96398331-96398722   c
FEATURES             Location/Qualifiers
     source          1..2036
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..2036
                     /gene="Pgm3"
                     /note="phosphoglucomutase 3"
                     /db_xref="GeneID:363109"
                     /db_xref="RGD:1305221"
     exon            1..103
                     /gene="Pgm3"
                     /inference="alignment:Splign:2.1.0"
     exon            104..309
                     /gene="Pgm3"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1734
                     /gene="Pgm3"
                     /EC_number="5.4.2.3"
                     /codon_start=1
                     /product="phosphoacetylglucosamine mutase"
                     /protein_id="NP_001388122.1"
                     /db_xref="GeneID:363109"
                     /db_xref="RGD:1305221"
                     /translation="MDLEAVSKRSAFHAKPQGLILQYGTAGFRTNAQHLDHIMFRMGL
                     LAVLRSKQTRSTIGVMVTASHNPEEDNGVKLVDPLGEMLAPSWEEHATRLASAEEQDL
                     PKVLAAIVEREAVDPQQTAFIVVGRDTRPSSEKLSQSVIDGVTVLGGQFHDYGLLTTP
                     QLHYMVYCRNSEGRYGQATIEGYCQKLSRAFVELMKQASCSGDGSRWVKVDCANGIGA
                     LKLKEMEHYFRQGLSVLLFNDGTEGRLNHLCGADFVKSQQKPPQGMAMKPGDRCCSFD
                     GDADRIVYYYCDAAGRFHLIDGDKIATLISSFLKELLLEIGENLNIGVVQTAYANGSS
                     TRYLEEVMKVPVYCTKTGVKHLHHKAQEFDIGVYFEANGHGTALFSEAVEARIKRLAQ
                     ELEDEKGRAARMLASFIDLFNQAAGDAISDMLVIEAILALKGLSVQQWDAIYADLPNR
                     QLKVKVADRRVISTTDAERQAVTPPGLQEAINDLVKKYKLARAFVRPSGTEDVVRVYA
                     EATSQESADTLAYEVSLAVFQLAGGIGERPQPPF"
     exon            310..494
                     /gene="Pgm3"
                     /inference="alignment:Splign:2.1.0"
     exon            495..562
                     /gene="Pgm3"
                     /inference="alignment:Splign:2.1.0"
     exon            563..696
                     /gene="Pgm3"
                     /inference="alignment:Splign:2.1.0"
     exon            697..892
                     /gene="Pgm3"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1050
                     /gene="Pgm3"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1134
                     /gene="Pgm3"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1233
                     /gene="Pgm3"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1347
                     /gene="Pgm3"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1470
                     /gene="Pgm3"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1644
                     /gene="Pgm3"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..2036
                     /gene="Pgm3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagccaggct cggccacgtc tgcgagatct gagtgagctg gttaggtgca cactgcgcgg
       61 ccgcatctcg cctttggaga gaacgttctt gctccagatc tagacatgga tctggaggct
      121 gtttctaagc gctcggcatt ccatgccaag cctcaggggc tcattcttca gtatgggact
      181 gctggattcc ggacaaatgc ccaacatctt gatcatatca tgtttcgaat ggggttgcta
      241 gctgttctga ggtcaaagca gacaagatct accattggag tcatggttac ggcctcacac
      301 aaccctgagg aagacaatgg cgtgaaattg gtcgatcctc tgggggaaat gttggcccct
      361 tcctgggagg agcatgccac ccgtctggcc agtgccgagg agcaggacct gcccaaggtg
      421 cttgctgcca tcgtggagag agaagccgtg gatccgcagc agactgcctt catagttgtt
      481 ggcagagaca ccagacccag cagcgagaaa ctttcccagt ctgtaataga cggcgtgact
      541 gttttaggag gtcaattcca tgattatggc ctcttgacca cacctcagct acactacatg
      601 gtgtattgcc ggaattccga aggccgctat ggacaggcca ccatagaagg ctactgccag
      661 aaactctcca gggctttcgt agaactcatg aaacaggctt cctgcagtgg agacggaagc
      721 agatgggtta aggttgactg tgccaacggc ataggggcct tgaagctaaa ggaaatggag
      781 cactacttcc gccagggact gtcggttctg ctgtttaatg atgggactga agggcggctc
      841 aaccacctgt gcggtgctga cttcgtgaaa agtcagcaga agccccccca gggaatggca
      901 atgaagccgg gtgacagatg ctgctccttt gacggggatg cagacaggat cgtgtattac
      961 tactgcgatg cagctggccg ctttcatctc atagacggag acaagatagc gacgctcatc
     1021 agcagcttcc ttaaagagct actgttggag attggagaaa atctgaatat cggcgtcgta
     1081 cagacagcat atgcaaatgg aagttccaca aggtaccttg aagaagttat gaaggtacct
     1141 gtgtattgca ctaaaaccgg tgtcaaacat ttgcatcaca aggctcaaga gtttgacatt
     1201 ggagtttatt ttgaagcgaa tgggcatggc acagctctgt tcagtgaagc ggttgaagcg
     1261 aggataaaga gactcgccca agagctggaa gatgaaaagg gaagagctgc caggatgctt
     1321 gcgagcttca tcgacttatt caaccaggca gctggagatg ctatttctga catgctggtg
     1381 attgaggcca tcctggctct gaaggggctg tctgtacagc agtgggatgc tatttatgcc
     1441 gatcttccta acagacaact caaagttaag gttgcggaca gaagagttat tagcaccaca
     1501 gatgctgaga gacaagcagt cactccacca ggactccagg aggcaatcaa tgacctggtg
     1561 aagaagtaca agcttgcccg agcttttgta cggccctctg gtactgagga tgttgtccga
     1621 gtctatgcag aagccacctc acaagaaagt gcagatacgc ttgcctatga ggtgagcttg
     1681 gcggtgtttc agctggccgg aggcattgga gaaagaccac aaccaccttt ctgaagatga
     1741 attttatatt ctgtggaaat ggacttctga aatgttttta taacacttta taatactaaa
     1801 gcactaaggc atttgcaatc gtgacatgac aaatgcatgc taatggatta tttctagatg
     1861 gtttttaaat gctaccagga aaaaaatgtt tagaagctct aaatcttaga catgggaatg
     1921 aagcttaccc tgattttaat ctgtattatg ttttaatagc tcaagtgtca ttaattttac
     1981 agggtatgca gtgaattcat gtagggtatt gggaattaaa ctttattacc aactaa
//
