LOCUS       NM_017033               2307 bp    mRNA    linear   ROD 03-FEB-2024
DEFINITION  Rattus norvegicus phosphoglucomutase 1 (Pgm1), mRNA.
ACCESSION   NM_017033
VERSION     NM_017033.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2307)
  AUTHORS   Stiers,K.M., Kain,B.N., Graham,A.C. and Beamer,L.J.
  TITLE     Induced Structural Disorder as a Molecular Mechanism for Enzyme
            Dysfunction in Phosphoglucomutase 1 Deficiency
  JOURNAL   J Mol Biol 428 (8), 1493-1505 (2016)
   PUBMED   26972339
REFERENCE   2  (bases 1 to 2307)
  AUTHORS   Lee,Y., Stiers,K.M., Kain,B.N. and Beamer,L.J.
  TITLE     Compromised catalysis and potential folding defects in in vitro
            studies of missense mutants associated with hereditary
            phosphoglucomutase 1 deficiency
  JOURNAL   J Biol Chem 289 (46), 32010-32019 (2014)
   PUBMED   25288802
REFERENCE   3  (bases 1 to 2307)
  AUTHORS   Arimura,T., Inagaki,N., Hayashi,T., Shichi,D., Sato,A.,
            Hinohara,K., Vatta,M., Towbin,J.A., Chikamori,T., Yamashina,A. and
            Kimura,A.
  TITLE     Impaired binding of ZASP/Cypher with phosphoglucomutase 1 is
            associated with dilated cardiomyopathy
  JOURNAL   Cardiovasc Res 83 (1), 80-88 (2009)
   PUBMED   19377068
REFERENCE   4  (bases 1 to 2307)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 2307)
  AUTHORS   Olivares-Banuelos,T., Navarro,L., Gonzalez,A. and Drucker-Colin,R.
  TITLE     Differentiation of chromaffin cells elicited by ELF MF modifies
            gene expression pattern
  JOURNAL   Cell Biol Int 28 (4), 273-279 (2004)
   PUBMED   15109983
REFERENCE   6  (bases 1 to 2307)
  AUTHORS   Whitehouse,D.B., Putt,W., Lovegrove,J.U., Morrison,K.,
            Hollyoake,M., Fox,M.F., Hopkinson,D.A. and Edwards,Y.H.
  TITLE     Phosphoglucomutase 1: complete human and rabbit mRNA sequences and
            direct mapping of this highly polymorphic marker on human
            chromosome 1
  JOURNAL   Proc Natl Acad Sci U S A 89 (1), 411-415 (1992)
   PUBMED   1530890
REFERENCE   7  (bases 1 to 2307)
  AUTHORS   Drago,G.A., Hopkinson,D.A., Westwood,S.A. and Whitehouse,D.B.
  TITLE     Antigenic analysis of the major human phosphoglucomutase isozymes:
            PGM1, PGM2, PGM3 and PGM4
  JOURNAL   Ann Hum Genet 55 (4), 263-271 (1991)
   PUBMED   1840235
REFERENCE   8  (bases 1 to 2307)
  AUTHORS   Normand,G., Kuchler,S., Meyer,A., Vincendon,G. and Zanetta,J.P.
  TITLE     Isolation and immunohistochemical localization of a chondroitin
            sulfate proteoglycan from adult rat brain
  JOURNAL   J Neurochem 51 (3), 665-676 (1988)
   PUBMED   3411319
REFERENCE   9  (bases 1 to 2307)
  AUTHORS   Marshall,M.J., Neal,F.E. and Goldberg,D.M.
  TITLE     Isoenzymes of hexokinase, 6-phosphogluconate dehydrogenase,
            phosphoglucomutase and lactate dehydrogenase in uterine cancer
  JOURNAL   Br J Cancer 40 (3), 380-390 (1979)
   PUBMED   508567
REFERENCE   10 (bases 1 to 2307)
  AUTHORS   Miner,G.D. and Wolfe,H.G.
  TITLE     Phosphoglucomutase isozymes of red cells in Mus musculus:
            additional polymorphism at PGM-l compared by two electrophoretic
            systems
  JOURNAL   Biochem Genet 7 (3), 247-252 (1972)
   PUBMED   4646763
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC099807.1.
            
            [WARNING] On Apr 15, 2024 this sequence was replaced by
            NM_017033.3.
            
            On Oct 13, 2005 this sequence version replaced NM_017033.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099807.1, BC128703.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2307
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..2307
                     /gene="Pgm1"
                     /note="phosphoglucomutase 1"
                     /db_xref="GeneID:24645"
                     /db_xref="RGD:3316"
     exon            1..306
                     /gene="Pgm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1749
                     /gene="Pgm1"
                     /EC_number="5.4.2.2"
                     /note="PGM 1; glucose phosphomutase 1"
                     /codon_start=1
                     /product="phosphoglucomutase-1"
                     /protein_id="NP_058729.2"
                     /db_xref="GeneID:24645"
                     /db_xref="RGD:3316"
                     /translation="MVKIVTVKTQAYPDQKPGTSGLRKRVKVFQGNANYAENFIQSIV
                     STVEPALRQEATLVVGGDGRFYMTEAIQLIVRIAAANGIGRLVIGQNGILSTPAVSCI
                     IRKIKAIGGIILTASHNPGGPNGDFGIKFNISNGGPAPEAITDKIFQISKTIEEYAIC
                     PDLKVDLSVLGKQQFDLENKFKPFTVEIVDSVEAYATMLRNIFDFNALKELLSGPNRL
                     KIRIDAMHGVVGPYVKKILCEELGAPANSAVNCVPLEDFGGHHPDPNLTYAADLVETM
                     KSGEHDFGAAFDGDGDRNMILGKHGFFVNPSDSVAVIAANIFSIPYFQQTGVRGFARS
                     MPTSGALDRVANATKIALYETPTGWKFFGNLMDASKLSLCGEESFGTGSDHIREKDGL
                     WAVLAWLSILATRKQSVEDILKDHWQKFGRNFFTRYDYEEVEAEGANKMMKDLEALML
                     DRSFVGKQFSANDKVYTVEKADNFEYSDPVDGSISKNQGLRLIFADGSRIIFRLSGTG
                     SAGATIRLYIDSYEKDAAKINQDPQVMLAPLISIALKVSQLQERTGRTAPTVIT"
     exon            307..469
                     /gene="Pgm1"
                     /inference="alignment:Splign:2.1.0"
     exon            470..616
                     /gene="Pgm1"
                     /inference="alignment:Splign:2.1.0"
     exon            617..742
                     /gene="Pgm1"
                     /inference="alignment:Splign:2.1.0"
     exon            743..933
                     /gene="Pgm1"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1088
                     /gene="Pgm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1204
                     /gene="Pgm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1340
                     /gene="Pgm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1524
                     /gene="Pgm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1659
                     /gene="Pgm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..2280
                     /gene="Pgm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctgagccct ctgcagcagc cagagccgca gcttctgtcg ccccgcagcc cgtcgccacc
       61 atggtgaaga tcgtgacagt gaagacgcag gcatatccgg atcagaagcc gggcaccagc
      121 gggttgcgga agcgagtgaa ggtgttccag ggcaacgcta actatgcgga gaatttcatc
      181 caaagcatcg tctccaccgt ggagccggcg ttgaggcagg aggccacgct ggttgtgggc
      241 ggggacggtc gcttctacat gaccgaggcc atccagctca tcgtacgcat cgccgcagcc
      301 aacgggattg gccgcctggt tattggacag aatggaatcc tctccactcc tgctgtatcc
      361 tgcattatcc gaaaaatcaa agccattggt gggatcattc tgacagctag ccacaatcca
      421 ggagggccca atggagattt tggaattaaa ttcaatattt ctaatggggg tcctgctcca
      481 gaagcaatca cggataaaat tttccaaatc agcaagacaa tcgaagaata tgccatttgc
      541 cctgacttga aggtagacct cagtgttctg gggaagcagc agtttgactt ggaaaacaag
      601 ttcaagccct tcacagtgga gatcgtggac tcagtcgagg cctatgccac aatgctgaga
      661 aacatctttg atttcaacgc actgaaggag ctactctctg gcccaaacag actgaagatc
      721 cgcatcgacg ccatgcacgg agttgtggga ccgtacgtca agaagatcct ctgtgaagaa
      781 cttggtgccc ccgcaaactc agctgtgaac tgtgttcccc tggaggattt tggaggccac
      841 caccctgacc ccaacctcac ctacgctgct gacctggtgg aaaccatgaa gtcaggagag
      901 catgatttcg gggctgcctt tgatggtgat ggggatagga acatgattct gggcaagcac
      961 gggttctttg tgaacccttc tgactctgtg gctgtcatcg ccgccaacat cttcagcatt
     1021 ccgtatttcc agcagactgg ggtccgtggc tttgcccgca gcatgcccac aagtggtgct
     1081 ctggaccggg tagcaaacgc cacaaagatc gctttgtatg agaccccaac tggctggaag
     1141 ttttttggga atttgatgga tgcaagcaag ctttccctct gtggagagga gagctttggg
     1201 actggttcag accacatccg agagaaagat ggactgtggg ccgtcctggc ctggctctcc
     1261 attctggcca cccgcaaaca gagcgtggag gacattctca aagaccactg gcagaagttt
     1321 ggtcggaact tcttcaccag gtatgactac gaggaggtgg aagccgaggg tgcaaacaaa
     1381 atgatgaagg acctggaggc cctgatgctg gaccgctcct ttgtggggaa gcagttctca
     1441 gcaaacgata aagtctacac ggtggagaaa gcggataatt tcgaatatag tgacccagta
     1501 gatggaagca tttcaaaaaa tcagggcttg cggcttattt ttgcagatgg ttctcgtatc
     1561 atcttcagac tgagcggcac cgggagtgct ggggctacca tccggctcta tattgatagc
     1621 tacgagaagg acgctgccaa gatcaaccag gacccccagg tcatgctggc gcccctgatc
     1681 tccattgctc tgaaagtgtc ccagctccag gagaggacag gccgcactgc gcccactgtc
     1741 atcacctaga gagatggctg gatgtggcac atccctcccc caggaactat ccacgctgcc
     1801 tgattgaaga gcacagacag aaacagtgta ttcgcctggg ccttttagga ctccatcttg
     1861 atttttttta cttcccactt gataaacagc catttgggag gcactgccac tgtttggggg
     1921 ggggtgcgaa gaagcagacc tgagggctcg cacccatgtc tgtcccttct cttgccctat
     1981 tggatacccg ctgtgtgagc ctttgtctcc cagcatcagg tacagtacac tacactgtaa
     2041 agatttggag gccatctcct gtccctgggt gtgcgcctgt agagtgatac tgaagttcct
     2101 gcttcactgt gaaagtctcc ccattaatgt ttacatgcaa tccagcagaa gacagtttct
     2161 ggtgccttct ctctaatcaa tttttctccg agtgagatgc gcttgtcttc agatctgtgt
     2221 tatttctcat ctctcatctg cacagatagt tgaggtatta aagcagaatg tgcccctgtt
     2281 aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
