LOCUS       NM_001412554            2573 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus peptidoglycan recognition protein 4 (Pglyrp4),
            mRNA.
ACCESSION   NM_001412554 XM_039102298
VERSION     NM_001412554.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2573)
  AUTHORS   Saha,S., Jing,X., Park,S.Y., Wang,S., Li,X., Gupta,D. and
            Dziarski,R.
  TITLE     Peptidoglycan recognition proteins protect mice from experimental
            colitis by promoting normal gut flora and preventing induction of
            interferon-gamma
  JOURNAL   Cell Host Microbe 8 (2), 147-162 (2010)
   PUBMED   20709292
REFERENCE   2  (bases 1 to 2573)
  AUTHORS   Cho,S., Wang,Q., Swaminathan,C.P., Hesek,D., Lee,M., Boons,G.J.,
            Mobashery,S. and Mariuzza,R.A.
  TITLE     Structural insights into the bactericidal mechanism of human
            peptidoglycan recognition proteins
  JOURNAL   Proc Natl Acad Sci U S A 104 (21), 8761-8766 (2007)
   PUBMED   17502600
REFERENCE   3  (bases 1 to 2573)
  AUTHORS   Lu,X., Wang,M., Qi,J., Wang,H., Li,X., Gupta,D. and Dziarski,R.
  TITLE     Peptidoglycan recognition proteins are a new class of human
            bactericidal proteins
  JOURNAL   J Biol Chem 281 (9), 5895-5907 (2006)
   PUBMED   16354652
REFERENCE   4  (bases 1 to 2573)
  AUTHORS   Dziarski,R. and Gupta,D.
  TITLE     The peptidoglycan recognition proteins (PGRPs)
  JOURNAL   Genome Biol 7 (8), 232 (2006)
   PUBMED   16930467
  REMARK    Review article
REFERENCE   5  (bases 1 to 2573)
  AUTHORS   Liu,C., Xu,Z., Gupta,D. and Dziarski,R.
  TITLE     Peptidoglycan recognition proteins: a novel family of four human
            innate immunity pattern recognition molecules
  JOURNAL   J Biol Chem 276 (37), 34686-34694 (2001)
   PUBMED   11461926
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Oct 5, 2022 this sequence version replaced XM_039102298.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06680412,
                              SAMN06680413 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: lack of evidence for use of
                                                upstream AUG
            RefSeq Select criteria           :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-387               JAXUCZ010000002.1  178500238-178500624
            388-481             JAXUCZ010000002.1  178517414-178517507
            482-589             JAXUCZ010000002.1  178518375-178518482
            590-788             JAXUCZ010000002.1  178519094-178519292
            789-907             JAXUCZ010000002.1  178520620-178520738
            908-1060            JAXUCZ010000002.1  178522773-178522925
            1061-1262           JAXUCZ010000002.1  178534365-178534566
            1263-1381           JAXUCZ010000002.1  178537473-178537591
            1382-2573           JAXUCZ010000002.1  178538677-178539868
FEATURES             Location/Qualifiers
     source          1..2573
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2573
                     /gene="Pglyrp4"
                     /note="peptidoglycan recognition protein 4"
                     /db_xref="GeneID:310611"
                     /db_xref="RGD:1308520"
     exon            1..387
                     /gene="Pglyrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            388..481
                     /gene="Pglyrp4"
                     /inference="alignment:Splign:2.1.0"
     CDS             433..1560
                     /gene="Pglyrp4"
                     /codon_start=1
                     /product="peptidoglycan recognition protein 4 precursor"
                     /protein_id="NP_001399483.1"
                     /db_xref="GeneID:310611"
                     /db_xref="RGD:1308520"
                     /translation="MLSWLLVFHTLVLPALGVSSLEKPQTNQVSKGLQQLLGNISQFF
                     EKDILGRDDAFIMVSRKGWGAEATGCSSKLGRPVDVLVIHHVPGLECHNQTVCSQKLR
                     ELQAYHIRNHWCDVAYNFLVGDDGKVYEGVGWNVQGSHDQGYNNISLGVAFFGTQEGH
                     SPSPVALLAMEALISHAVKKGHLSSKYIQPLLVKSEDCLVPPQKGKQKKAACPHIVPR
                     SAWGARESHCFKMTLPAKYAIILHTAGRTCSQPDECRLLIQDLQSFFMDRLNACDIGY
                     NFLVGQDGGVYEGVGWNNQGSKTDGYNDIALSIAFMGIFTGSSPNAAALQAAQDLIQC
                     AVVKGYLTPNYLLMGHSDVSNTLSPGQALYNIIKTWPHFKH"
     exon            482..589
                     /gene="Pglyrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            590..788
                     /gene="Pglyrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            789..907
                     /gene="Pglyrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1060
                     /gene="Pglyrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1262
                     /gene="Pglyrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1381
                     /gene="Pglyrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..2573
                     /gene="Pglyrp4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaatgtgat cagaagtggt tgtgtcccct gacttctcag gattgtctgt gcttctagac
       61 tccttttgtt agttctacgt ctaatatgga cagagcaggt tagggtagaa gagctatttg
      121 ggcaggttaa accaagaggt tggaaatggc ttgggtgaaa tgaagttagg tggacagatg
      181 actggcgtac aagcttggag tgctagggta gatctggatg ggtagaaggg tttggtgtgg
      241 cataggaagg gcttgggcat tgtgaaaata ggtaaggaag gtcctggcag aagtctagag
      301 atcagttgtg acatagatag tagaggacag actagaccag agcactggat gtggagtctg
      361 ggttacatcg agctgcttgg ggagaagggt tgattatcat acttcatgtg ggtgtcttgg
      421 gaccacctga ggatgctgtc ctggcttctt gtcttccata ccttggttct tccagcattg
      481 ggtgtttcct ccttggaaaa accacaaact aatcaagtgt caaaagggct gcagcaactg
      541 cttggcaaca tctcccagtt ctttgagaaa gacatactgg gccgtgatga tgccttcatc
      601 atggtttctc gtaagggatg gggggcagaa gcaactggct gcagctccaa gcttggcagg
      661 ccagtggatg tccttgttat acaccatgtc cctggattag aatgccacaa ccagactgtc
      721 tgtagccaga agcttcggga attgcaagct tatcacatcc gcaaccactg gtgtgatgtg
      781 gcttacaatt tcctggttgg ggatgatggc aaagtatatg aaggtgttgg ttggaatgtc
      841 caaggctctc acgaccaggg ctacaacaac atctccttag gtgttgcttt ctttggcacc
      901 caggaaggcc atagtcccag ccctgttgct ctgttggcca tggaggccct gatttcccat
      961 gctgtgaaga aaggccactt atcatccaag tatatccagc cacttcttgt gaaaagtgaa
     1021 gactgcttgg tccctccaca gaaggggaaa cagaagaaag cagcttgtcc ccacatagtt
     1081 ccacggtctg cctggggggc aagagagtcc cactgcttca agatgactct gcctgcaaag
     1141 tatgccatca tccttcacac tgctggaaga acatgcagtc agcctgatga gtgccgcctg
     1201 ctgatccaag atctccagtc cttcttcatg gacaggctaa acgcatgtga cattgggtat
     1261 aacttccttg tgggccagga tggtggtgtt tatgaaggcg tgggctggaa taaccaaggc
     1321 tctaaaactg atgggtacaa tgacattgct ttgagtatcg ccttcatggg tatcttcaca
     1381 ggttcctcac ccaatgcagc tgcactgcag gcagcccagg acttgatcca gtgtgctgtg
     1441 gtcaaggggt acctgactcc caactacctg ctaatgggcc acagtgatgt gtccaatact
     1501 ctgtcccctg ggcaggcatt gtacaacatt atcaagacgt ggccccattt caagcactga
     1561 gggaagtgtt tagccctatt tgaggatgtt cctgctgctg tgtgtctgtc tttacctctc
     1621 accttggatt agtatctctg tcctctcatt taaaaaactt taccttgttc atttccccag
     1681 tttggatgac cttgtcttct cttggtgact tctaccagtg tcccccaagt tttacattta
     1741 tagtcccttg agtctgagtc aagcctcttc tctcctgggt acttgtctgc tcagccaggt
     1801 gaggtaatgg gttggttctt gtcatacctc cttccttagt tgtctgcccc tctgcctggt
     1861 atctatggtt tgtttgatag tttccagtgc tcatccatgg cccagggaga gtgccctccc
     1921 ctcctctgct tatacatcca cttgtgcata tgtgaatgct cccttggaaa catgtaagtt
     1981 ttcttctgga ttgtgagttt ttccaggaca gcagcagaat tttctttacc actaggtagc
     2041 ctgtgtcaac tctcaacctg tgtttaaatg ttagtagata ttatagatgt ttgttgaaga
     2101 aatggaggaa caagttaaag accccagacc tttcccaaaa gtttgctatc acccctctgt
     2161 ggaaaccttg ctgtccagtg tcccatcctg ctgttattct cagcattgct acttcttggt
     2221 cagaggtcca cagatgactt tgatgacttg tccataacag atgccatgtc tctgaagtcc
     2281 tgtgccattg tatccataga gcaacctgag tgccaggacc atatgctcct ccaataggaa
     2341 ggcagacgcc aacacttgct gcctagtact atggcctgtc tttgcctgat ggcttctgct
     2401 ggctctgaaa ccctccctac tttcatcatt tgttgtaagc acatggagcc ttatttttgt
     2461 ccatggtgct ctgaaaaatg gaagggtaag aggaaagaca aataaaagga atatatgtag
     2521 agattgtctt gttaaagttt tgataaaata aagttttacc ttgttttata tga
//
