LOCUS       NM_001399713            2098 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus peptidoglycan recognition protein 2 (Pglyrp2),
            mRNA.
ACCESSION   NM_001399713 XM_039080047
VERSION     NM_001399713.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2098)
  AUTHORS   Park,S.Y., Gupta,D., Hurwich,R., Kim,C.H. and Dziarski,R.
  TITLE     Peptidoglycan recognition protein Pglyrp2 protects mice from
            psoriasis-like skin inflammation by promoting regulatory T cells
            and limiting Th17 responses
  JOURNAL   J Immunol 187 (11), 5813-5823 (2011)
   PUBMED   22048773
REFERENCE   2  (bases 1 to 2098)
  AUTHORS   Saha,S., Jing,X., Park,S.Y., Wang,S., Li,X., Gupta,D. and
            Dziarski,R.
  TITLE     Peptidoglycan recognition proteins protect mice from experimental
            colitis by promoting normal gut flora and preventing induction of
            interferon-gamma
  JOURNAL   Cell Host Microbe 8 (2), 147-162 (2010)
   PUBMED   20709292
REFERENCE   3  (bases 1 to 2098)
  AUTHORS   Saha,S., Qi,J., Wang,S., Wang,M., Li,X., Kim,Y.G., Nunez,G.,
            Gupta,D. and Dziarski,R.
  TITLE     PGLYRP-2 and Nod2 are both required for peptidoglycan-induced
            arthritis and local inflammation
  JOURNAL   Cell Host Microbe 5 (2), 137-150 (2009)
   PUBMED   19218085
REFERENCE   4  (bases 1 to 2098)
  AUTHORS   Dziarski,R. and Gupta,D.
  TITLE     The peptidoglycan recognition proteins (PGRPs)
  JOURNAL   Genome Biol 7 (8), 232 (2006)
   PUBMED   16930467
  REMARK    Review article
REFERENCE   5  (bases 1 to 2098)
  AUTHORS   Wang,Z.M., Li,X., Cocklin,R.R., Wang,M., Wang,M., Fukase,K.,
            Inamura,S., Kusumoto,S., Gupta,D. and Dziarski,R.
  TITLE     Human peptidoglycan recognition protein-L is an
            N-acetylmuramoyl-L-alanine amidase
  JOURNAL   J Biol Chem 278 (49), 49044-49052 (2003)
   PUBMED   14506276
REFERENCE   6  (bases 1 to 2098)
  AUTHORS   Liu,C., Xu,Z., Gupta,D. and Dziarski,R.
  TITLE     Peptidoglycan recognition proteins: a novel family of four human
            innate immunity pattern recognition molecules
  JOURNAL   J Biol Chem 276 (37), 34686-34694 (2001)
   PUBMED   11461926
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Jan 13, 2022 this sequence version replaced XM_039080047.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ219280.1, SRR26643286.21790.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               JAXUCZ010000007.1  12078173-12078369   c
            198-1181            JAXUCZ010000007.1  12074092-12075075   c
            1182-1392           JAXUCZ010000007.1  12072799-12073009   c
            1393-1690           JAXUCZ010000007.1  12071722-12072019   c
            1691-2098           JAXUCZ010000007.1  12069414-12069821   c
FEATURES             Location/Qualifiers
     source          1..2098
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2098
                     /gene="Pglyrp2"
                     /note="peptidoglycan recognition protein 2"
                     /db_xref="GeneID:299567"
                     /db_xref="RGD:1359183"
     exon            1..197
                     /gene="Pglyrp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1702
                     /gene="Pglyrp2"
                     /EC_number="3.5.1.28"
                     /note="N-acetylmuramoyl-L-alanine amidase"
                     /codon_start=1
                     /product="N-acetylmuramoyl-L-alanine amidase precursor"
                     /protein_id="NP_001386642.1"
                     /db_xref="GeneID:299567"
                     /db_xref="RGD:1359183"
                     /translation="MKAWGVLWIVLGLSLWPKPGTASSLPMVMDSIIQALEELEQKVL
                     VTEAGVTASAWILSAKNYSSHNSLHQHLLLKAPSQNTTEPDTHSLSPELQALISEVAQ
                     HDVRDGQEYGVVLAPDGSTVAVKPLLVGLEAGLQGRSVANLSSDCLDTCDTGAIWPGL
                     KDAFTNVSSPDAGATLPNDKAKTPTTVDRLLAVTLAGDLGLTFLHRSQTWSPPGLGIE
                     GCWDQLSAPRVFTLLDHKASRLTMAFLNGALDGALLGAHLSRIPKPHPPLSRLLREYY
                     GAGVDGDPAFRSNFRRQNGVALTSAPTLAQQVWEALVLLQKLEPGHPRLQNMSQKQLA
                     QVATFATKEFTEAFLGCPAIHPRCRWGAAPYRGHPTPLRLPLGLLYVHHTYVPAPPCT
                     TFQSCAADMRSMQRFHQNVRGWADIGYSFVVGSDGYVYQGRGWHWVGAHTLGYNSRGF
                     GVAFVGNYTGSLPSEAALNTVRDVLPSCAIRAGLLRPDYKLFGHRQLGKTDCPGNALF
                     NLLRTWPHFTVVEN"
     exon            198..1181
                     /gene="Pglyrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1392
                     /gene="Pglyrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1690
                     /gene="Pglyrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..2098
                     /gene="Pglyrp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgctccctt aactctgctg gggtgacttc tgccctgggg cgttttggta gagcagatta
       61 attctcatgc ccctatcctc ctagggcctc agaggttctc tgcttggttg taccctggaa
      121 ctggagcccc aaaatgaagg cctggggtgt cctctggatt gtgcttggat tgtcgctgtg
      181 gccaaagcca gggacagcct cctccttacc catggtcatg gactccatca tccaggctct
      241 tgaggaactt gagcaaaagg tactggtgac tgaggccggc gtcactgcct ctgcatggat
      301 tctgtcagcc aagaactaca gctcccacaa ttcccttcac cagcacttgc tgctgaaggc
      361 accaagccaa aacactacag agccagatac tcactcgctc agtccggagc tacaagccct
      421 gatttctgag gtggcccaac atgatgtacg ggatgggcag gagtacggag tggtgctggc
      481 acctgatggc tccactgtag ccgtgaagcc cctgctggtt gggctggagg ccggcctaca
      541 ggggcgcagt gttgctaact tgtcttcaga ttgcttggat acttgcgata ctggagccat
      601 ctggccagga ctcaaagatg ccttcacaaa tgtctcttct ccagatgctg gagccacttt
      661 accaaatgac aaagccaaga cacccaccac tgtggacaga ctcctggcag tcaccttggc
      721 tggagactta ggtctgacct tcctccacag gtcccagact tggagtcctc caggcctggg
      781 aattgagggt tgctgggacc agctttctgc ccccagggtc ttcacactct tggaccacaa
      841 ggcatccagg ctcaccatgg ctttcctcaa tggtgccttg gatggagctc tccttggggc
      901 ccacttgagc cggatcccta agccccaccc acccctcagt cgcctgctga gagagtacta
      961 tggagctggg gtggatggag atccagcgtt ccgcagcaac ttccgaaggc agaacggggt
     1021 tgctttgact tcagccccta ccctagccca gcaagtatgg gaggcccttg tcctgctaca
     1081 gaaactggag ccgggacatc cgcggttgca gaacatgagt caaaaacagc tggctcaggt
     1141 agccaccttt gctaccaagg agttcactga ggctttcttg ggatgcccag ccattcatcc
     1201 ccgttgccgc tggggagcgg cgccctaccg aggccaccca acgccactcc gactgccact
     1261 tggactctta tatgtgcatc acacatacgt gccagcgcca ccctgcacca ccttccagag
     1321 ctgcgccgcc gatatgcgct caatgcagcg tttccatcag aacgtgcgcg gctgggctga
     1381 catcggctac agtttcgtgg taggctccga cggctatgtg taccagggcc gtggctggca
     1441 ctgggtaggt gcgcacacgc tcggctacaa ctcccgcggc ttcggtgtgg ccttcgtggg
     1501 caactacact gggtcactgc ccagcgaagc tgcgctgaac accgtgcgtg acgtgctacc
     1561 gagctgcgcg attcgcgcag gtctcttgcg gccagactac aagctattcg gtcaccgcca
     1621 gctagggaaa actgactgcc cggggaacgc gctcttcaac ttgctgcgca cctggcctca
     1681 cttcactgtg gttgaaaact gagaactcct ttgagggacc cttgaagacc caggaggcac
     1741 tgtctatccc cgctgatcct ttgagcaacc accggcctcc attaaaggga ccactgaaag
     1801 gagatctctg tgaggaccat cttcctcaga gaccagaatg aaagcaaagt gtatgtggct
     1861 cagtgggaga gcacatagtt gacaagcaag aggctttttg ttttgttttg ttttttgatt
     1921 ttcatgacag ggtttctctg tgttgccttg gctgtcctgg aactcacaga gatctgcctg
     1981 cctctgcctc ttcagtgctg ggattaaagc cattgaacca ctgtccatcc gaggttcttg
     2041 atccctactc tagcaccaca gaataaataa aactggctat gggagctcat acttgtaa
//
