LOCUS       NM_053373                630 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Rattus norvegicus peptidoglycan recognition protein 1 (Pglyrp1),
            mRNA.
ACCESSION   NM_053373
VERSION     NM_053373.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 630)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   2  (bases 1 to 630)
  AUTHORS   Saha,S., Jing,X., Park,S.Y., Wang,S., Li,X., Gupta,D. and
            Dziarski,R.
  TITLE     Peptidoglycan recognition proteins protect mice from experimental
            colitis by promoting normal gut flora and preventing induction of
            interferon-gamma
  JOURNAL   Cell Host Microbe 8 (2), 147-162 (2010)
   PUBMED   20709292
REFERENCE   3  (bases 1 to 630)
  AUTHORS   Saha,S., Qi,J., Wang,S., Wang,M., Li,X., Kim,Y.G., Nunez,G.,
            Gupta,D. and Dziarski,R.
  TITLE     PGLYRP-2 and Nod2 are both required for peptidoglycan-induced
            arthritis and local inflammation
  JOURNAL   Cell Host Microbe 5 (2), 137-150 (2009)
   PUBMED   19218085
REFERENCE   4  (bases 1 to 630)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 630)
  AUTHORS   Cho,S., Wang,Q., Swaminathan,C.P., Hesek,D., Lee,M., Boons,G.J.,
            Mobashery,S. and Mariuzza,R.A.
  TITLE     Structural insights into the bactericidal mechanism of human
            peptidoglycan recognition proteins
  JOURNAL   Proc Natl Acad Sci U S A 104 (21), 8761-8766 (2007)
   PUBMED   17502600
REFERENCE   6  (bases 1 to 630)
  AUTHORS   Lu,X., Wang,M., Qi,J., Wang,H., Li,X., Gupta,D. and Dziarski,R.
  TITLE     Peptidoglycan recognition proteins are a new class of human
            bactericidal proteins
  JOURNAL   J Biol Chem 281 (9), 5895-5907 (2006)
   PUBMED   16354652
REFERENCE   7  (bases 1 to 630)
  AUTHORS   Dziarski,R. and Gupta,D.
  TITLE     The peptidoglycan recognition proteins (PGRPs)
  JOURNAL   Genome Biol 7 (8), 232 (2006)
   PUBMED   16930467
  REMARK    Review article
REFERENCE   8  (bases 1 to 630)
  AUTHORS   Liu,C., Xu,Z., Gupta,D. and Dziarski,R.
  TITLE     Peptidoglycan recognition proteins: a novel family of four human
            innate immunity pattern recognition molecules
  JOURNAL   J Biol Chem 276 (37), 34686-34694 (2001)
   PUBMED   11461926
REFERENCE   9  (bases 1 to 630)
  AUTHORS   Rehman,A., Taishi,P., Fang,J., Majde,J.A. and Krueger,J.M.
  TITLE     The cloning of a rat peptidoglycan recognition protein (PGRP) and
            its induction in brain by sleep deprivation
  JOURNAL   Cytokine 13 (1), 8-17 (2001)
   PUBMED   11145837
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF154114.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF154114.1, SRR8487230.123774.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..630
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..630
                     /gene="Pglyrp1"
                     /gene_synonym="Pglyrp; Pgrp"
                     /note="peptidoglycan recognition protein 1"
                     /db_xref="GeneID:84387"
                     /db_xref="RGD:621429"
     exon            1..270
                     /gene="Pglyrp1"
                     /gene_synonym="Pglyrp; Pgrp"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..571
                     /gene="Pglyrp1"
                     /gene_synonym="Pglyrp; Pgrp"
                     /note="PGRP-S"
                     /codon_start=1
                     /product="peptidoglycan recognition protein 1 precursor"
                     /protein_id="NP_445825.1"
                     /db_xref="GeneID:84387"
                     /db_xref="RGD:621429"
                     /translation="MLFAWAPFPALLGLADSCCFVVPRSEWKALPSECSKGLKKPVRY
                     VVISHTAGSFCSSPDSCEQQARNVQLYQMKQLGWCDVAYNFLIGEDGHVYEGRGWTIK
                     GDHTGPIWNPMSIGITFMGDYSHRVPAKRALRAALNLLKCGVSEGFLRSNYEVKGHRD
                     VQSTLSPGDQLYEIIQSWDHYRE"
     exon            271..392
                     /gene="Pglyrp1"
                     /gene_synonym="Pglyrp; Pgrp"
                     /inference="alignment:Splign:2.1.0"
     exon            393..630
                     /gene="Pglyrp1"
                     /gene_synonym="Pglyrp; Pgrp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtgtgcagc acgtccagca tgttgtttgc ctgggctccc ttccctgccc tcctgggcct
       61 ggcagactcc tgctgtttcg tcgtgccccg cagtgagtgg aaggccctgc catccgagtg
      121 ctccaagggc ctgaagaaac cagtccgcta cgtggtgatc tcacacacag ccggcagctt
      181 ctgcagcagc ccagactcct gtgaacagca ggcccgcaat gtgcagcttt accaaatgaa
      241 acagctgggc tggtgcgatg tagcctacaa cttcctcatt ggagaggatg gtcatgtcta
      301 cgaaggccga ggctggacca tcaagggtga ccacacaggg cccatctgga accccatgtc
      361 tatcggcatc accttcatgg gtgactactc acaccgggta cctgcaaagc gggctctccg
      421 tgctgcccta aatcttctga aatgtggggt gtctgagggc ttcctgagat ctaactatga
      481 ggtcaaagga catcgagatg tgcaaagcac tctgtctcca ggtgaccagc tctacgagat
      541 catccaaagc tgggaccact accgagagtg agatcttgag accttgtgga gttcccaccc
      601 tgaaatccct cctaccacct gctgcttccc
//
