LOCUS       NP_445825                183 aa            linear   ROD 11-DEC-2024
DEFINITION  peptidoglycan recognition protein 1 precursor [Rattus norvegicus].
ACCESSION   NP_445825
VERSION     NP_445825.1
DBSOURCE    REFSEQ: accession NM_053373.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 183)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   2  (residues 1 to 183)
  AUTHORS   Saha,S., Jing,X., Park,S.Y., Wang,S., Li,X., Gupta,D. and
            Dziarski,R.
  TITLE     Peptidoglycan recognition proteins protect mice from experimental
            colitis by promoting normal gut flora and preventing induction of
            interferon-gamma
  JOURNAL   Cell Host Microbe 8 (2), 147-162 (2010)
   PUBMED   20709292
REFERENCE   3  (residues 1 to 183)
  AUTHORS   Saha,S., Qi,J., Wang,S., Wang,M., Li,X., Kim,Y.G., Nunez,G.,
            Gupta,D. and Dziarski,R.
  TITLE     PGLYRP-2 and Nod2 are both required for peptidoglycan-induced
            arthritis and local inflammation
  JOURNAL   Cell Host Microbe 5 (2), 137-150 (2009)
   PUBMED   19218085
REFERENCE   4  (residues 1 to 183)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (residues 1 to 183)
  AUTHORS   Cho,S., Wang,Q., Swaminathan,C.P., Hesek,D., Lee,M., Boons,G.J.,
            Mobashery,S. and Mariuzza,R.A.
  TITLE     Structural insights into the bactericidal mechanism of human
            peptidoglycan recognition proteins
  JOURNAL   Proc Natl Acad Sci U S A 104 (21), 8761-8766 (2007)
   PUBMED   17502600
REFERENCE   6  (residues 1 to 183)
  AUTHORS   Lu,X., Wang,M., Qi,J., Wang,H., Li,X., Gupta,D. and Dziarski,R.
  TITLE     Peptidoglycan recognition proteins are a new class of human
            bactericidal proteins
  JOURNAL   J Biol Chem 281 (9), 5895-5907 (2006)
   PUBMED   16354652
REFERENCE   7  (residues 1 to 183)
  AUTHORS   Dziarski,R. and Gupta,D.
  TITLE     The peptidoglycan recognition proteins (PGRPs)
  JOURNAL   Genome Biol 7 (8), 232 (2006)
   PUBMED   16930467
  REMARK    Review article
REFERENCE   8  (residues 1 to 183)
  AUTHORS   Liu,C., Xu,Z., Gupta,D. and Dziarski,R.
  TITLE     Peptidoglycan recognition proteins: a novel family of four human
            innate immunity pattern recognition molecules
  JOURNAL   J Biol Chem 276 (37), 34686-34694 (2001)
   PUBMED   11461926
REFERENCE   9  (residues 1 to 183)
  AUTHORS   Rehman,A., Taishi,P., Fang,J., Majde,J.A. and Krueger,J.M.
  TITLE     The cloning of a rat peptidoglycan recognition protein (PGRP) and
            its induction in brain by sleep deprivation
  JOURNAL   Cytokine 13 (1), 8-17 (2001)
   PUBMED   11145837
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF154114.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF154114.1, SRR8487230.123774.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..183
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     Protein         1..183
                     /product="peptidoglycan recognition protein 1 precursor"
                     /note="PGRP-S"
                     /calculated_mol_wt=18788
     sig_peptide     1..17
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JLN4.1)"
                     /calculated_mol_wt=1820
     mat_peptide     18..183
                     /product="Peptidoglycan recognition protein 1.
                     /id=PRO_0000023903"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN4.1)"
                     /calculated_mol_wt=18788
     Region          21..161
                     /region_name="PGRP"
                     /note="Animal peptidoglycan recognition proteins
                     homologous to Bacteriophage T3 lysozyme; smart00701"
                     /db_xref="CDD:128941"
     Site            order(48,83,158,164,166)
                     /site_type="active"
                     /note="amidase catalytic site [active]"
                     /db_xref="CDD:133475"
     Site            order(48,158,166)
                     /site_type="other"
                     /note="Zn binding residues [ion binding]"
                     /db_xref="CDD:133475"
     Site            order(49..50,79,83,97,104..105,111,158,164..166)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:133475"
     CDS             1..183
                     /gene="Pglyrp1"
                     /gene_synonym="Pglyrp; Pgrp"
                     /coded_by="NM_053373.1:20..571"
                     /db_xref="GeneID:84387"
                     /db_xref="RGD:621429"
ORIGIN      
        1 mlfawapfpa llgladsccf vvprsewkal psecskglkk pvryvvisht agsfcsspds
       61 ceqqarnvql yqmkqlgwcd vaynfliged ghvyegrgwt ikgdhtgpiw npmsigitfm
      121 gdyshrvpak ralraalnll kcgvsegflr snyevkghrd vqstlspgdq lyeiiqswdh
      181 yre
//
