LOCUS       NM_053291               1685 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Rattus norvegicus phosphoglycerate kinase 1 (Pgk1), mRNA.
ACCESSION   NM_053291
VERSION     NM_053291.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1685)
  AUTHORS   Luo,Y., Yang,J., Zhang,L., Tai,Z., Huang,H., Xu,Z. and Zhang,H.
  TITLE     Phosphoglycerate kinase (PGK) 1 succinylation modulates epileptic
            seizures and the blood-brain barrier
  JOURNAL   Exp Anim 72 (4), 475-489 (2023)
   PUBMED   37258131
  REMARK    GeneRIF: Phosphoglycerate kinase (PGK) 1 succinylation modulates
            epileptic seizures and the blood-brain barrier.
REFERENCE   2  (bases 1 to 1685)
  AUTHORS   Chen,H., Li,Y., Gao,J., Cheng,Q., Liu,L. and Cai,R.
  TITLE     Activation of Pgk1 Results in Reduced Protein Aggregation in
            Diverse Neurodegenerative Conditions
  JOURNAL   Mol Neurobiol 60 (9), 5090-5101 (2023)
   PUBMED   37249790
  REMARK    GeneRIF: Activation of Pgk1 Results in Reduced Protein Aggregation
            in Diverse Neurodegenerative Conditions.
REFERENCE   3  (bases 1 to 1685)
  AUTHORS   Liu,H., Shen,L., Sun,Z., Wu,W. and Xu,M.
  TITLE     Downregulated Phosphoglycerate Kinase 1 Attenuates Cerebral
            Ischemia-Reperfusion Injury by Reversing Neuroinflammation and
            Oxidative Stress through the Nuclear Factor Erythroid 2 Related
            Factor 2/ARE Pathway
  JOURNAL   Neuroscience 524, 94-107 (2023)
   PUBMED   37295596
  REMARK    GeneRIF: Downregulated Phosphoglycerate Kinase 1 Attenuates
            Cerebral Ischemia-Reperfusion Injury by Reversing Neuroinflammation
            and Oxidative Stress through the Nuclear Factor Erythroid 2 Related
            Factor 2/ARE Pathway.
REFERENCE   4  (bases 1 to 1685)
  AUTHORS   Cao,W., Feng,Z., Zhu,D., Li,S., Du,M., Ye,S., Qi,D., Li,P., Chen,Y.
            and Fang,Y.
  TITLE     The Role of PGK1 in Promoting Ischemia/Reperfusion Injury-Induced
            Microglial M1 Polarization and Inflammation by Regulating
            Glycolysis
  JOURNAL   Neuromolecular Med 25 (2), 301-311 (2023)
   PUBMED   36749430
  REMARK    GeneRIF: The Role of PGK1 in Promoting Ischemia/Reperfusion
            Injury-Induced Microglial M1 Polarization and Inflammation by
            Regulating Glycolysis.
REFERENCE   5  (bases 1 to 1685)
  AUTHORS   Fork,C., Hitzel,J., Nichols,B.J., Tikkanen,R. and Brandes,R.P.
  TITLE     Flotillin-1 facilitates toll-like receptor 3 signaling in human
            endothelial cells
  JOURNAL   Basic Res Cardiol 109 (6), 439 (2014)
   PUBMED   25204797
REFERENCE   6  (bases 1 to 1685)
  AUTHORS   Brand,I.A. and Heinickel,A.
  TITLE     Key enzymes of carbohydrate metabolism as targets of the 11.5-kDa
            Zn(2+)-binding protein (parathymosin)
  JOURNAL   J Biol Chem 266 (31), 20984-20989 (1991)
   PUBMED   1834654
REFERENCE   7  (bases 1 to 1685)
  AUTHORS   Ciccarese,S., Tommasi,S. and Vonghia,G.
  TITLE     Cloning and cDNA sequence of the rat X-chromosome linked
            phosphoglycerate kinase
  JOURNAL   Biochem Biophys Res Commun 165 (3), 1337-1344 (1989)
   PUBMED   2610697
REFERENCE   8  (bases 1 to 1685)
  AUTHORS   Lavoinne,A.
  TITLE     Influence of beta,gamma-methyleneadenosine 5'-triphosphate and
            2-phosphoglycerate on rat liver phosphoglycerate kinase
  JOURNAL   Biochimie 68 (4), 569-574 (1986)
   PUBMED   3091090
REFERENCE   9  (bases 1 to 1685)
  AUTHORS   Chapman,V.M. and Shows,T.B.
  TITLE     Somatic cell genetic evidence for X-chromosome linkage of three
            enzymes in the mouse
  JOURNAL   Nature 259 (5545), 665-667 (1976)
   PUBMED   943046
REFERENCE   10 (bases 1 to 1685)
  AUTHORS   Yoshida,A. and Watanabe,S.
  TITLE     Human phosphoglycerate kinase. I. Crystallization and
            characterization of normal enzyme
  JOURNAL   J Biol Chem 247 (2), 440-445 (1972)
   PUBMED   5009693
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC087651.1.
            
            On Jun 3, 2007 this sequence version replaced NM_053291.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087651.1, BC063161.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1685
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..1685
                     /gene="Pgk1"
                     /gene_synonym="Pgk"
                     /note="phosphoglycerate kinase 1"
                     /db_xref="GeneID:24644"
                     /db_xref="RGD:619878"
     exon            1..69
                     /gene="Pgk1"
                     /gene_synonym="Pgk"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..1258
                     /gene="Pgk1"
                     /gene_synonym="Pgk"
                     /EC_number="2.7.2.3"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="phosphoglycerate kinase 1"
                     /protein_id="NP_445743.2"
                     /db_xref="GeneID:24644"
                     /db_xref="RGD:619878"
                     /translation="MSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAV
                     PSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAAELKSLLGKDVLFLKDCVGS
                     EVENACANPAAGTVILLENLRFHVEEEGKGKDASGNKVKAEPAKIDAFRASLSKLGDV
                     YVNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVA
                     DKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMEIGTSLYDEEGAKIVKDLMAKAEKN
                     GVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGTESSKKYAEAVARAKQI
                     VWNGPVGVFEWEAFARGTKSLMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHV
                     STGGGASLELLEGKVLPGVDALSNV"
     exon            70..120
                     /gene="Pgk1"
                     /gene_synonym="Pgk"
                     /inference="alignment:Splign:2.1.0"
     exon            121..276
                     /gene="Pgk1"
                     /gene_synonym="Pgk"
                     /inference="alignment:Splign:2.1.0"
     exon            277..421
                     /gene="Pgk1"
                     /gene_synonym="Pgk"
                     /inference="alignment:Splign:2.1.0"
     exon            422..525
                     /gene="Pgk1"
                     /gene_synonym="Pgk"
                     /inference="alignment:Splign:2.1.0"
     exon            526..645
                     /gene="Pgk1"
                     /gene_synonym="Pgk"
                     /inference="alignment:Splign:2.1.0"
     exon            646..760
                     /gene="Pgk1"
                     /gene_synonym="Pgk"
                     /inference="alignment:Splign:2.1.0"
     exon            761..940
                     /gene="Pgk1"
                     /gene_synonym="Pgk"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1118
                     /gene="Pgk1"
                     /gene_synonym="Pgk"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1217
                     /gene="Pgk1"
                     /gene_synonym="Pgk"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1659
                     /gene="Pgk1"
                     /gene_synonym="Pgk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaaatgtcg ctttctaaca agctgacttt ggacaagctg gacgtgaagg ggaagcgggt
       61 cgtgatgagg gtggacttca atgttcctat gaagaacaac cagataacga ataaccaaag
      121 gatcaaggct gctgtcccaa gcatcaaatt ctgcttggac aatggagcca agtcggttgt
      181 gcttatgagc cacctgggcc gtcctgatgg tgtgcccatg cccgacaagt actccttaga
      241 gccagttgct gcagaactca aatctctgct gggcaaggat gttctgttct tgaaggattg
      301 tgtgggctca gaagtagaga atgcctgtgc caacccagcg gctgggactg tcatcctcct
      361 ggagaacctc cgctttcatg tagaggaaga agggaaggga aaagatgctt ctgggaacaa
      421 ggttaaagct gagccagcta aaattgatgc tttccgagcc tccctgtcca aacttggaga
      481 tgtctatgtc aatgatgctt ttgggactgc acacagagcc cacagttcca tggtgggtgt
      541 gaatctgcca cagaaggctg gtggattttt gatgaagaag gagctgaact actttgccaa
      601 ggctttggag agtccagagc gacccttcct ggctatcttg ggaggagcta aagttgcaga
      661 caagatccag ctgatcaata atatgctaga caaagtcaat gagatgatca tcggtggggg
      721 aatggctttt accttcctta aggtgctcaa caacatggag attggcacat ctctgtatga
      781 tgaagaggga gccaagattg tcaaagatct catggccaaa gctgagaaaa atggtgtgaa
      841 gattaccttg cctgttgact ttgtcactgc tgacaaattt gatgagaatg caaagactgg
      901 ccaagctact gtggcctctg gtatacctgc tggctggatg ggcttggact gtggtactga
      961 gagcagtaag aaatatgctg aggctgtggc tcgagctaag cagattgttt ggaacggtcc
     1021 tgttggggta tttgaatggg aagcctttgc caggggaacc aagtccctca tggatgaggt
     1081 ggtgaaagcc acgtctaggg gctgcatcac tatcatagga ggcggagaca ccgccacttg
     1141 ctgtgccaaa tggaacacag aggataaagt cagccatgtg agcactgggg gcggcgccag
     1201 tctagagctc ctggaaggta aagtccttcc tggggtggat gctctcagca atgtttagta
     1261 ttttcctgcc tttggttcct gtgcacagcc cctaagtcga cctagtgttt tccgcatctc
     1321 catttggtgt tagtgcagct agtggccaag acgcagcacc aggaacccta agcagctgca
     1381 cagcatctca gctcgtcttt actgcatcgg gattcatcta ctacgttcaa gatcccattt
     1441 aaattcctta gtgactaaaa ccattgtgca ttgtagaggg catctattta tactctgcct
     1501 gtgaaaggaa gtgagctgta aaagcttagc tctcttcgct gtatgtagcc tctggttagc
     1561 tttgtcactg ttcatgacag catggaaata acggtgagat tccagctgta ggtttggagt
     1621 tgatctattg aacaataaag atgcccactg aaactgaaga aaaaaaaaaa aaaaaaaaaa
     1681 aaaaa
//
