LOCUS       NM_053595               1586 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus placental growth factor (Pgf), mRNA.
ACCESSION   NM_053595
VERSION     NM_053595.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1586)
  AUTHORS   Tatar,M., Uslu,S. and Oner,J.
  TITLE     Expression of placental growth factor and a disintegrin and
            metalloprotease with a thrombospondin type motifs 1-4-8 during the
            three trimesters of rat pregnancy at the maternal-fetal interface
  JOURNAL   Anat Histol Embryol 52 (5), 805-814 (2023)
   PUBMED   37424113
  REMARK    GeneRIF: Expression of placental growth factor and a disintegrin
            and metalloprotease with a thrombospondin type motifs 1-4-8 during
            the three trimesters of rat pregnancy at the maternal-fetal
            interface.
REFERENCE   2  (bases 1 to 1586)
  AUTHORS   Zhang,Z.Q., Hong,H., Li,J., Li,X.X. and Huang,X.M.
  TITLE     MicroRNA-214 promotes alveolarization in neonatal rat models of
            bronchopulmonary dysplasia via the PlGF-dependent STAT3 pathway
  JOURNAL   Mol Med 27 (1), 109 (2021)
   PUBMED   34530740
  REMARK    GeneRIF: MicroRNA-214 promotes alveolarization in neonatal rat
            models of bronchopulmonary dysplasia via the PlGF-dependent STAT3
            pathway.
            Erratum:[Mol Med. 2021 Oct 21;27(1):134. doi:
            10.1186/s10020-021-00396-y.. PMID: 34674634]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1586)
  AUTHORS   Phuthong,S., Reyes-Hernandez,C.G., Rodriguez-Rodriguez,P.,
            Ramiro-Cortijo,D., Gil-Ortega,M., Gonzalez-Blazquez,R.,
            Gonzalez,M.C., Lopez de Pablo,A.L. and Arribas,S.M.
  TITLE     Sex Differences in Placental Protein Expression and Efficiency in a
            Rat Model of Fetal Programming Induced by Maternal Undernutrition
  JOURNAL   Int J Mol Sci 22 (1), 237 (2020)
   PUBMED   33379399
  REMARK    GeneRIF: Sex Differences in Placental Protein Expression and
            Efficiency in a Rat Model of Fetal Programming Induced by Maternal
            Undernutrition.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1586)
  AUTHORS   Lee,Y.J., Ke,C.Y., Tien,N. and Lin,P.K.
  TITLE     Hyperhomocysteinemia Causes Chorioretinal Angiogenesis with
            Placental Growth Factor Upregulation
  JOURNAL   Sci Rep 8 (1), 15755 (2018)
   PUBMED   30361676
  REMARK    GeneRIF: hyperhomocysteinemia might cause choroidal
            angiogenesiswith Placental Growth Factor Upregulation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1586)
  AUTHORS   Chao,W.H., Lai,M.Y., Pan,H.T., Shiu,H.W., Chen,M.M. and Chao,H.M.
  TITLE     Dendrobium nobile Lindley and its bibenzyl component moscatilin are
            able to protect retinal cells from ischemia/hypoxia by
            dowregulating placental growth factor and upregulating Norrie
            disease protein
  JOURNAL   BMC Complement Altern Med 18 (1), 193 (2018)
   PUBMED   29933759
  REMARK    GeneRIF: Studied the influence of dendrobium nobile Lindley (DNL)
            extract and its bibenzyl component moscatilin on the expression of
            placental growth factor (PLGF) and Norrie disease protein (NDP) in
            hypoxia model in retinal cells. Found DNL and moscatilin are able
            to protect against retinal ischemic/hypoxic changes respectively by
            downregulating PLGF and upregulating NDP.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1586)
  AUTHORS   Zhang,H., Palmer,R., Gao,X., Kreidberg,J., Gerald,W., Hsiao,L.,
            Jensen,R.V., Gullans,S.R. and Haber,D.A.
  TITLE     Transcriptional activation of placental growth factor by the
            forkhead/winged helix transcription factor FoxD1
  JOURNAL   Curr Biol 13 (18), 1625-1629 (2003)
   PUBMED   13678594
REFERENCE   7  (bases 1 to 1586)
  AUTHORS   Cho,G.J., Roh,G.S., Kim,H.J., Kim,Y.S., Cho,S.H., Choi,W.J.,
            Paik,W.Y., Kang,S.S. and Choi,W.S.
  TITLE     Differential expression of placenta growth factors and their
            receptors in the normal and pregnancy-induced hypertensive human
            placentas
  JOURNAL   J Korean Med Sci 18 (3), 402-408 (2003)
   PUBMED   12808329
REFERENCE   8  (bases 1 to 1586)
  AUTHORS   Beck,H., Acker,T., Puschel,A.W., Fujisawa,H., Carmeliet,P. and
            Plate,K.H.
  TITLE     Cell type-specific expression of neuropilins in an MCA-occlusion
            model in mice suggests a potential role in post-ischemic brain
            remodeling
  JOURNAL   J Neuropathol Exp Neurol 61 (4), 339-350 (2002)
   PUBMED   11939589
REFERENCE   9  (bases 1 to 1586)
  AUTHORS   Viglietto,G., Romano,A., Manzo,G., Chiappetta,G., Paoletti,I.,
            Califano,D., Galati,M.G., Mauriello,V., Bruni,P., Lago,C.T.,
            Fusco,A. and Persico,M.G.
  TITLE     Upregulation of the angiogenic factors PlGF, VEGF and their
            receptors (Flt-1, Flk-1/KDR) by TSH in cultured thyrocytes and in
            the thyroid gland of thiouracil-fed rats suggest a TSH-dependent
            paracrine mechanism for goiter hypervascularization
  JOURNAL   Oncogene 15 (22), 2687-2698 (1997)
   PUBMED   9400995
REFERENCE   10 (bases 1 to 1586)
  AUTHORS   DiSalvo,J., Bayne,M.L., Conn,G., Kwok,P.W., Trivedi,P.G.,
            Soderman,D.D., Palisi,T.M., Sullivan,K.A. and Thomas,K.A.
  TITLE     Purification and characterization of a naturally occurring vascular
            endothelial growth factor.placenta growth factor heterodimer
  JOURNAL   J Biol Chem 270 (13), 7717-7723 (1995)
   PUBMED   7706320
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087006.1.
            
            On Dec 26, 2004 this sequence version replaced NM_053595.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087006.1, DY471547.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1586
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q31"
     gene            1..1586
                     /gene="Pgf"
                     /gene_synonym="Plgf"
                     /note="placental growth factor"
                     /db_xref="GeneID:94203"
                     /db_xref="RGD:619850"
     exon            1..370
                     /gene="Pgf"
                     /gene_synonym="Plgf"
                     /inference="alignment:Splign:2.1.0"
     CDS             305..781
                     /gene="Pgf"
                     /gene_synonym="Plgf"
                     /note="placenta growth factor"
                     /codon_start=1
                     /product="placenta growth factor precursor"
                     /protein_id="NP_446047.1"
                     /db_xref="GeneID:94203"
                     /db_xref="RGD:619850"
                     /translation="MLAMKLFTCFLQVLAGLAVHSQGALSAGNNSTEMEVVPFNEVWG
                     RSYCRPMEKLVYIADEHPNEVSHIFSPSCVLLSRCSGCCGDEGLHCVALKTANITMQI
                     LKIPPNRDPHSYVEMTFSQDVLCECRPILETTKAERRKTKGKRKQSKTPQTEEPHL"
     exon            371..410
                     /gene="Pgf"
                     /gene_synonym="Plgf"
                     /inference="alignment:Splign:2.1.0"
     exon            411..607
                     /gene="Pgf"
                     /gene_synonym="Plgf"
                     /inference="alignment:Splign:2.1.0"
     exon            608..687
                     /gene="Pgf"
                     /gene_synonym="Plgf"
                     /inference="alignment:Splign:2.1.0"
     exon            688..717
                     /gene="Pgf"
                     /gene_synonym="Plgf"
                     /inference="alignment:Splign:2.1.0"
     exon            718..777
                     /gene="Pgf"
                     /gene_synonym="Plgf"
                     /inference="alignment:Splign:2.1.0"
     exon            778..1563
                     /gene="Pgf"
                     /gene_synonym="Plgf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctgagaag gaaactgcgt cttcagactt ctgctcaccc acgagaggag ctagggtcat
       61 tggacacctg agaccctttc acatctctcc aactcaccgg gacgctcctc actagtttcc
      121 tcagccacag ccctacctgt gagctccgga ctttcccggc ttccagtgga tgctcaggca
      181 gactgcagag actcaggaca gcagtgaacg ggacacccat ctcctcccct atcagcgtct
      241 cctcctagga ggacgggcat ggtgattttg ccttgaagga ccttggctct ggacgtctga
      301 gaagatgctg gccatgaagc tgttcacttg cttcttgcag gtcctagctg ggttggctgt
      361 gcactcccag ggggccctgt ctgctgggaa caactcaaca gaaatggaag tggtgccttt
      421 caatgaagtg tggggccgca gctactgccg gccaatggag aagctggtgt acattgcaga
      481 tgaacaccct aatgaagtgt ctcatatatt cagtccgtca tgtgtccttc tgagtcgctg
      541 tagtggctgc tgtggtgacg agggtctgca ctgtgtggcg ctaaagacag ccaacatcac
      601 tatgcagatc ttaaagattc cccccaatcg ggatccacat tcctacgtgg agatgacatt
      661 ctctcaggat gtgctctgcg aatgcaggcc tattctggag acgacaaagg cagaaaggag
      721 gaaaaccaag gggaagagga agcaaagcaa aaccccacag actgaggaac cccacctgtg
      781 atgctgtttc ccggaggtaa ccagccactc agaggagaga cccacaccca gctcatatat
      841 ttattaccgt caccctctca gaaccctccc tgctggtacc taccctctat ttattagcca
      901 actcgtccct gctgaatgac ttgctccctc caagataagg ggcatggaag gacaagaccc
      961 tcaggaattc agtgccttaa aacagaacgt gagagaaagg aagaagccag ccacggttcc
     1021 gtgggagctt ccttcggctt gggaagaagc aagacacgga catggccgta ctagggataa
     1081 gccacacccc agaggccctg ggtctccagg gaactggaga agaaaagagg agacccagag
     1141 cctgccttgg tcctctgttc cacccagaca gcagctccgg ccctggctgc attgaagaca
     1201 tgtggagggg acccagtcta ctgtatcctg gagatcagga cgggatattt ggctctggag
     1261 gacagagctc gcctgtgggc tttgcctgtc agcctagaag ttcacgcttc accctttgca
     1321 aagcaccacc aagctgtccc ctctctggga cacaggcaga gtggcccggg gctgaacaga
     1381 gggcaggctg catgaggagt actagcccat ggactttgac cactgcaagt ctgggccatg
     1441 tgcacagcta tgaaaagcga accaattcct ggagggccct tgcagcccac cagttgtctc
     1501 ttccgggact gtctaactgc caagccagat tctcttgaat aaagcattct agtctggaac
     1561 caaaaaaaaa aaaaaaaaaa aaaaaa
//
