LOCUS       NM_001305435            2127 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus phosphogluconate dehydrogenase (Pgd), mRNA.
ACCESSION   NM_001305435 XM_002729565 XM_003754118
VERSION     NM_001305435.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2127)
  AUTHORS   Demirdag,R., Comakli,V., Ozkaya,A., Sahin,Z., Dag,U., Yerlikaya,E.
            and Kuzu,M.
  TITLE     Examination of changes in enzyme activities of erythrocyte glucose
            6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in
            rats given Naringenin and Lead acetate
  JOURNAL   J Biochem Mol Toxicol 29 (1), 43-47 (2015)
   PUBMED   25228019
  REMARK    GeneRIF: Examination of changes in enzyme activities of erythrocyte
            glucose 6-phosphate dehydrogenase and 6-phosphogluconate
            dehydrogenase in rats given Naringenin and Lead acetate.
REFERENCE   2  (bases 1 to 2127)
  AUTHORS   Adem,S. and Ciftci,M.
  TITLE     Purification of rat kidney glucose 6-phosphate dehydrogenase,
            6-phosphogluconate dehydrogenase, and glutathione reductase enzymes
            using 2',5'-ADP Sepharose 4B affinity in a single chromatography
            step
  JOURNAL   Protein Expr Purif 81 (1), 1-4 (2012)
   PUBMED   21930213
  REMARK    GeneRIF: The enzymes of glucose 6-phosphate dehydrogenase,
            6-phosphogluconate dehydrogenase,and glutathione reductase were
            purified from rat kidney in one chromatographic step consisting of
            the use of the 2',5'-ADP Sepharose 4B by using different elution
            buffers.
REFERENCE   3  (bases 1 to 2127)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   4  (bases 1 to 2127)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   5  (bases 1 to 2127)
  AUTHORS   Maurya,D.K., Sundaram,C.S. and Bhargava,P.
  TITLE     Proteome profile of the mature rat olfactory bulb
  JOURNAL   Proteomics 9 (9), 2593-2599 (2009)
   PUBMED   19343716
REFERENCE   6  (bases 1 to 2127)
  AUTHORS   Bublitz,C. and Steavenson,S.
  TITLE     The pentose phosphate pathway in the endoplasmic reticulum
  JOURNAL   J Biol Chem 263 (26), 12849-12853 (1988)
   PUBMED   2843500
REFERENCE   7  (bases 1 to 2127)
  AUTHORS   Beutler,E., Kuhl,W. and Gelbart,T.
  TITLE     6-Phosphogluconolactonase deficiency, a hereditary erythrocyte
            enzyme deficiency: possible interaction with glucose-6-phosphate
            dehydrogenase deficiency
  JOURNAL   Proc Natl Acad Sci U S A 82 (11), 3876-3878 (1985)
   PUBMED   3858849
REFERENCE   8  (bases 1 to 2127)
  AUTHORS   Hino,Y. and Minakami,S.
  TITLE     Hexose-6-phosphate and 6-phosphogluconate dehydrogenases of rat
            liver microsomes. Involvement in NADPH and carbon dioxide
            generation in the luminal space of microsomal vesicles
  JOURNAL   J Biochem 92 (2), 547-557 (1982)
   PUBMED   6813321
REFERENCE   9  (bases 1 to 2127)
  AUTHORS   Kozak,C.A. and Ruddle,F.H.
  TITLE     Assignment of the genes for thymidine kinase and galactokinase to
            Mus musculus chromosome 11 and the preferential segregation of this
            chromosome in Chinese hamster/mouse somatic cell hybrids
  JOURNAL   Somatic Cell Genet 3 (2), 121-133 (1977)
   PUBMED   204065
REFERENCE   10 (bases 1 to 2127)
  AUTHORS   Kozak,C., Nichols,E. and Ruddle,F.H.
  TITLE     Gene linkage analysis in the mouse by somatic cell hybridization:
            assignment of adenine phosphoribosyltransferase to chromosome 8 and
            alpha-galactosidase to the X chromosome
  JOURNAL   Somatic Cell Genet 1 (4), 371-382 (1975)
   PUBMED   1235912
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM036675.1, FN802313.1, FM065848.1 and JAXUCZ010000005.1.
            
            On or before Mar 12, 2015 this sequence version replaced
            XM_002729565.4, XM_003754118.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582424.716522.1,
                                           SRR26360194.376413.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760400,
                                           SAMN06680445 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-446               FM036675.1         1-446
            447-1045            FN802313.1         138-736
            1046-1538           FM065848.1         148-640
            1539-2127           JAXUCZ010000005.1  164865830-164866418 c
FEATURES             Location/Qualifiers
     source          1..2127
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2127
                     /gene="Pgd"
                     /gene_synonym="Cc2-27"
                     /note="phosphogluconate dehydrogenase"
                     /db_xref="GeneID:100360180"
                     /db_xref="RGD:1583832"
     exon            1..98
                     /gene="Pgd"
                     /gene_synonym="Cc2-27"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1542
                     /gene="Pgd"
                     /gene_synonym="Cc2-27"
                     /EC_number="1.1.1.44"
                     /note="6-phosphogluconate dehydrogenase,
                     decarboxylating-like"
                     /codon_start=1
                     /product="6-phosphogluconate dehydrogenase,
                     decarboxylating"
                     /protein_id="NP_001292364.1"
                     /db_xref="GeneID:100360180"
                     /db_xref="RGD:1583832"
                     /translation="MAQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLA
                     KEAKGTKVIGAKSLKDMVSKLKKPRRVILLVKAGQAVDDFIEKLVPLLDTGDIIIDGG
                     NSEYRDTTRRCQDLKAKGILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKTIFQAI
                     AAKVGTGEPCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMRHEEMAQ
                     AFEDWNKTELDSFLIEITANILKFQDTDGKELLPKIRDSAGQKGTGKWTAISALEYGM
                     PVTLIGEAVFARCLSSLKEERVQASRKLKGPKMVQLEGSKQAFLEDVRKALYASKIIS
                     YAQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFERNPELQNLLLD
                     DFFKSAVDDCQDSWRRVISTGVQAGIPMPCFTTALSFYDGYRHEMLPANLIQAQRDYF
                     GAHTYELLSKPGEFIHTNWTGHGGSVSSSSYNA"
     exon            99..174
                     /gene="Pgd"
                     /gene_synonym="Cc2-27"
                     /inference="alignment:Splign:2.1.0"
     exon            175..354
                     /gene="Pgd"
                     /gene_synonym="Cc2-27"
                     /inference="alignment:Splign:2.1.0"
     exon            355..420
                     /gene="Pgd"
                     /gene_synonym="Cc2-27"
                     /inference="alignment:Splign:2.1.0"
     exon            421..539
                     /gene="Pgd"
                     /gene_synonym="Cc2-27"
                     /inference="alignment:Splign:2.1.0"
     exon            540..609
                     /gene="Pgd"
                     /gene_synonym="Cc2-27"
                     /inference="alignment:Splign:2.1.0"
     exon            610..744
                     /gene="Pgd"
                     /gene_synonym="Cc2-27"
                     /inference="alignment:Splign:2.1.0"
     exon            745..934
                     /gene="Pgd"
                     /gene_synonym="Cc2-27"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1065
                     /gene="Pgd"
                     /gene_synonym="Cc2-27"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1199
                     /gene="Pgd"
                     /gene_synonym="Cc2-27"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1299
                     /gene="Pgd"
                     /gene_synonym="Cc2-27"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1422
                     /gene="Pgd"
                     /gene_synonym="Cc2-27"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..2127
                     /gene="Pgd"
                     /gene_synonym="Cc2-27"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccgggagc cggagttcac agcactttct ccggagcgct cagtcttttc gtgtttcttc
       61 ctcctcggat ctgctctgtc taccgccgcc atggcccaag ctgacattgc actgattgga
      121 ctggctgtca tgggccagaa cttaattttg aacatgaatg atcatgggtt tgtggtctgt
      181 gctttcaata ggaccgtctc caaagttgat gacttcttgg ccaaggaggc gaaaggaacc
      241 aaagtgattg gtgctaagtc cttaaaggac atggtctcca agctgaagaa gccccgccgg
      301 gtcatactgc tcgtgaaggc tgggcaagca gtggatgatt tcatcgagaa actagtaccc
      361 ttgctggaca ccggtgacat catcattgat ggaggaaatt ctgaataccg ggatacgaca
      421 agaagatgcc aggacctcaa ggccaagggc atcttgttcg tggggagtgg agtcagtggt
      481 ggtgaggaag gggctcggta tgggccatcc ctcatgccag gagggaacaa agaggcctgg
      541 ccccacatca agacgatctt ccaggccatc gctgcaaaag taggaaccgg agaaccctgc
      601 tgtgactggg tgggggacga gggggcgggg cactttgtga agatggtgca caacgggata
      661 gagtatggtg acatgcagct gatctgcgag gcttaccact tgatgaagga tgttctgggc
      721 atgcggcatg aggagatggc tcaggcgttt gaagactgga acaagacaga gctggactca
      781 ttcctgattg agatcactgc taacattctc aagttccagg acactgatgg caaagagctc
      841 ttaccaaaga tccgggacag tgcagggcag aagggcactg ggaagtggac ggccatctcc
      901 gcgctggagt acggcatgcc tgtcaccctc atcggagaag ctgtctttgc tcggtgcttg
      961 tcttctctga aggaggagcg agttcaggcc agcagaaagc tgaagggccc caagatggtc
     1021 cagctagaag gcagtaagca ggcattcctg gaggatgtcc gtaaggccct ttatgcttcc
     1081 aagatcatct cctatgctca aggctttatg ctgctcagac aggcagccac tgagtttggc
     1141 tggaccctca attatggtgg cattgccctg atgtggagag ggggctgcat tatccgaagt
     1201 gtattcctgg gaaaaattaa agatgccttt gagcgaaacc cagaacttca gaacctactg
     1261 ctagatgact tctttaagtc agcagtcgac gactgccagg actcctggcg ccgggtgatc
     1321 agcaccgggg tgcaagcggg catccccatg ccctgcttca caaccgccct ctccttctac
     1381 gatgggtaca gacatgagat gctgcccgcc aacctcatcc aggctcaacg ggactacttt
     1441 ggggcccaca cctatgaact cttatccaaa ccaggagaat tcatccacac caactggaca
     1501 ggccacggtg gcagtgtgtc gtcctcttca tacaatgcct agtgggcctg tggctttgcc
     1561 ctccctccca gcggcaggac agcctctgcg gcactcagca cccctctttg ccctagttcc
     1621 tgctcagtgc tcttagccaa gtgttggctg tgatcgccga agaagtcacc acgtgctcca
     1681 cctcgatctt ttgcgctgcc caggaactga ccttgtgctc cactgcgtga tggcccgctc
     1741 cctgactgag ctgtgccatg tgggtcagag agcctgctgc tccccgcaca cagaggggtg
     1801 ggtggggttg tacagccgga ccgtggatca tgagtgtggg ttctgatgtc ctacacccag
     1861 taggagtgtg tggggacact cttcactcct ctggtgcgcc tggtagaaag gtctgcacta
     1921 ttggggattg atttgatttg atttcctaag actccaactg aaacaggaca cgttaactta
     1981 gggtaatgag taagtctggg gaggtgagga gccaaggagt gggtgggcag aggctctctt
     2041 gggtcttttc ttactggcac acttggatgt tcacgtgaca tccgcccgat cacacacctg
     2101 taataaactt tttaggctgg cttggcc
//
