LOCUS       NM_133284               1371 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus progastricsin (Pgc), mRNA.
ACCESSION   NM_133284
VERSION     NM_133284.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1371)
  AUTHORS   Sorensen,O.E., Gram,L., Johnsen,A.H., Andersson,E., Bangsboll,S.,
            Tjabringa,G.S., Hiemstra,P.S., Malm,J., Egesten,A. and
            Borregaard,N.
  TITLE     Processing of seminal plasma hCAP-18 to ALL-38 by gastricsin: a
            novel mechanism of generating antimicrobial peptides in vagina
  JOURNAL   J Biol Chem 278 (31), 28540-28546 (2003)
   PUBMED   12759353
  REMARK    Erratum:[J Biol Chem. 2006 May 5;281(18):12999]
REFERENCE   2  (bases 1 to 1371)
  AUTHORS   Ishihara,T., Ichihara,Y., Hayano,T., Katsura,I., Sogawa,K.,
            Fujii-Kuriyama,Y. and Takahashi,K.
  TITLE     Primary structure and transcriptional regulation of rat pepsinogen
            C gene
  JOURNAL   J Biol Chem 264 (17), 10193-10199 (1989)
   PUBMED   2722863
REFERENCE   3  (bases 1 to 1371)
  AUTHORS   Ichihara,Y., Sogawa,K., Morohashi,K., Fujii-Kuriyama,Y. and
            Takahashi,K.
  TITLE     Nucleotide sequence of a nearly full-length cDNA coding for
            pepsinogen of rat gastric mucosa
  JOURNAL   Eur J Biochem 161 (1), 7-12 (1986)
   PUBMED   3780741
REFERENCE   4  (bases 1 to 1371)
  AUTHORS   Arai,K.M., Muto,N., Tani,S. and Akahane,K.
  TITLE     The N-terminal sequence of rat pepsinogen
  JOURNAL   Biochim Biophys Acta 788 (2), 256-261 (1984)
   PUBMED   6743670
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On May 14, 2011 this sequence version replaced NM_133284.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X04644.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               JAXUCZ010000009.1  20763102-20763220   c
            120-279             JAXUCZ010000009.1  20761186-20761345   c
            280-397             JAXUCZ010000009.1  20760722-20760839   c
            398-516             JAXUCZ010000009.1  20759724-20759842   c
            517-716             JAXUCZ010000009.1  20759114-20759313   c
            717-836             JAXUCZ010000009.1  20756963-20757082   c
            837-987             JAXUCZ010000009.1  20756337-20756487   c
            988-1086            JAXUCZ010000009.1  20755583-20755681   c
            1087-1371           JAXUCZ010000009.1  20755002-20755286   c
FEATURES             Location/Qualifiers
     source          1..1371
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..1371
                     /gene="Pgc"
                     /gene_synonym="Pg-1; PG1; Upg1"
                     /note="progastricsin"
                     /db_xref="GeneID:24864"
                     /db_xref="RGD:3943"
     exon            1..119
                     /gene="Pgc"
                     /gene_synonym="Pg-1; PG1; Upg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1239
                     /gene="Pgc"
                     /gene_synonym="Pg-1; PG1; Upg1"
                     /EC_number="3.4.23.3"
                     /note="gastricsin; progastricsin (pepsinogen C); Urinary
                     pepsinogen 1"
                     /codon_start=1
                     /product="gastricsin precursor"
                     /protein_id="NP_579818.1"
                     /db_xref="GeneID:24864"
                     /db_xref="RGD:3943"
                     /translation="MKWMVVALLCLPLLEASLLRVPLRKMKSIRETMKEQGVLKDFLK
                     THKYDPGQKYHFGNFGDYSVLYEPMAYMDASYFGEISIGTPPQNFLVLFDTGSSNLWV
                     SSVYCQSEACTTHARFNPSKSSTYYTEGQTFSLQYGTGSLTGFFGYDTLTVQSIQVPN
                     QEFGLSENEPGTNFVYAQFDGIMGLAYPGLSSGGATTALQGMLGEGALSQPLFGVYLG
                     SQQGSNGGQIVFGGVDKNLYTGEITWVPVTQELYWQITIDDFLIGDQASGWCSSQGCQ
                     GIVDTGTSLLVMPAQYLSELLQTIGAQEGEYGEYFVSCDSVSSLPTLSFVLNGVQFPL
                     SPSSYIIQEDNFCMVGLESISLTSESGQPLWILGDVFLRSYYAIFDMGNNKVGLATSV
                     "
     exon            120..279
                     /gene="Pgc"
                     /gene_synonym="Pg-1; PG1; Upg1"
                     /inference="alignment:Splign:2.1.0"
     exon            280..397
                     /gene="Pgc"
                     /gene_synonym="Pg-1; PG1; Upg1"
                     /inference="alignment:Splign:2.1.0"
     exon            398..516
                     /gene="Pgc"
                     /gene_synonym="Pg-1; PG1; Upg1"
                     /inference="alignment:Splign:2.1.0"
     exon            517..716
                     /gene="Pgc"
                     /gene_synonym="Pg-1; PG1; Upg1"
                     /inference="alignment:Splign:2.1.0"
     exon            717..836
                     /gene="Pgc"
                     /gene_synonym="Pg-1; PG1; Upg1"
                     /inference="alignment:Splign:2.1.0"
     exon            837..987
                     /gene="Pgc"
                     /gene_synonym="Pg-1; PG1; Upg1"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1086
                     /gene="Pgc"
                     /gene_synonym="Pg-1; PG1; Upg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1371
                     /gene="Pgc"
                     /gene_synonym="Pg-1; PG1; Upg1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caccgcaacg gttgagctcg aagggatttc ttcctgtgag accagctgca aaccggcatc
       61 atgaagtgga tggtagtagc cttgctctgc ctcccgctct tggaggcatc cctgctcagg
      121 gtccccctga ggaaaatgaa gagtatccgt gagaccatga aggaacaggg cgtccttaaa
      181 gactttctga agacccacaa atatgaccct ggccagaagt accacttcgg caacttcggt
      241 gactacagtg tactctatga gcccatggcc tacatggatg cttcctactt cggtgagatc
      301 agcattggga ctccacccca gaacttcctg gtccttttcg acaccggctc ctccaacctg
      361 tgggtgtctt ctgtctactg ccagagcgag gcctgcacca cacacgcccg cttcaacccc
      421 agcaagtcct ccacttacta caccgaaggg cagaccttct ccctgcagta cggcactggc
      481 agccttactg gcttctttgg ctatgacact ctgaccgtcc aaagcattca ggttcccaac
      541 caggagtttg gcctgagtga gaatgagcct ggtaccaatt ttgtctatgc ccaatttgat
      601 ggcatcatgg gcctggccta ccccggcctg tcttcagggg gtgccaccac cgccttgcag
      661 ggcatgttgg gggagggcgc tctctcccag cccctcttcg gagtctacct tggcagccag
      721 caggggtcta acggtgggca gattgtgttt ggaggcgtgg acaagaacct ctacactggg
      781 gagatcacct gggttcctgt cactcaggag ctctactggc agattaccat tgacgacttc
      841 ctcattggcg accaggcctc tggatggtgc tcctcccagg gctgccaagg cattgtagac
      901 acaggtacct ctctgctcgt catgcctgcc cagtacctca gtgaacttct gcagaccata
      961 ggagcccagg aaggagagta cggagagtat tttgtgagct gcgacagtgt cagtagcctg
     1021 cctaccctca gtttcgtcct caatggtgtc cagttccccc tgtcaccctc ttcctacatc
     1081 atccaggagg acaacttctg catggtgggt cttgagagca tctctctgac ctctgagagt
     1141 ggccagcccc tctggatcct tggggatgtc ttcctcaggt cttactatgc catcttcgac
     1201 atgggcaaca acaaggtggg ccttgccact tctgtctaga cttgccctct agacacgcct
     1261 gtgcccttct tcccctcagc ctgcctgccc cctctgttcc tcctctctgc atccagcttg
     1321 tcttttccgg accctagact tgccctaata ataaatagtc ttccatattg a
//
