LOCUS       NM_001025272            2016 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Rattus norvegicus PGAM family member 5, mitochondrial
            serine/threonine protein phosphatase (Pgam5), mRNA; nuclear gene
            for mitochondrial product.
ACCESSION   NM_001025272 XM_222256
VERSION     NM_001025272.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2016)
  AUTHORS   Chen,Y., Huang,J., Zhou,H., Lin,J. and Tao,J.
  TITLE     Pgam5 aggravates hyperglycemia-induced myocardial dysfunction
            through disrupting Phb2-dependent mitochondrial dynamics
  JOURNAL   Int J Med Sci 21 (7), 1194-1203 (2024)
   PUBMED   38818468
  REMARK    GeneRIF: Pgam5 aggravates hyperglycemia-induced myocardial
            dysfunction through disrupting Phb2-dependent mitochondrial
            dynamics.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2016)
  AUTHORS   Zhang,J., Li,X., Zhang,Z., Zhang,J., Ma,L., Wang,S., Guo,X., Li,H.,
            Pan,B. and Niu,Q.
  TITLE     Role of the RIP3-PGAM5-Drp1 pathway in aluminum-induced PC12 cells
            necroptosis
  JOURNAL   Ecotoxicol Environ Saf 270, 115860 (2024)
   PUBMED   38142589
  REMARK    GeneRIF: Role of the RIP3-PGAM5-Drp1 pathway in aluminum-induced
            PC12 cells necroptosis.
REFERENCE   3  (bases 1 to 2016)
  AUTHORS   Fu,G., Wang,B., He,B., Feng,M. and Yu,Y.
  TITLE     LPS induces cardiomyocyte necroptosis through the Ripk3/Pgam5
            signaling pathway
  JOURNAL   J Recept Signal Transduct Res 41 (1), 32-37 (2021)
   PUBMED   32580628
  REMARK    GeneRIF: LPS induces cardiomyocyte necroptosis through the
            Ripk3/Pgam5 signaling pathway.
REFERENCE   4  (bases 1 to 2016)
  AUTHORS   Liu,G., Qian,M., Chen,M., Chen,T. and Qin,S.
  TITLE     miR-21-5p Suppresses Mitophagy to Alleviate Hyperoxia-Induced Acute
            Lung Injury by Directly Targeting PGAM5
  JOURNAL   Biomed Res Int 2020, 4807254 (2020)
   PUBMED   33681349
  REMARK    GeneRIF: miR-21-5p Suppresses Mitophagy to Alleviate
            Hyperoxia-Induced Acute Lung Injury by Directly Targeting PGAM5.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2016)
  AUTHORS   Yang,C., Liu,X., Yang,F., Zhang,W., Chen,Z., Yan,D., You,Q. and
            Wu,X.
  TITLE     Mitochondrial phosphatase PGAM5 regulates Keap1-mediated Bcl-xL
            degradation and controls cardiomyocyte apoptosis driven by
            myocardial ischemia/reperfusion injury
  JOURNAL   In Vitro Cell Dev Biol Anim 53 (3), 248-257 (2017)
   PUBMED   27815660
  REMARK    GeneRIF: PGAM5 controls cardiomyocyte apoptosis induced by MIRI
            through regulating Keap1-mediated Bcl-xL degradation, which may
            supply a novel molecular target for acute myocardial infarction
            (AMI) therapy.
REFERENCE   6  (bases 1 to 2016)
  AUTHORS   Sekine,S., Yao,A., Hattori,K., Sugawara,S., Naguro,I., Koike,M.,
            Uchiyama,Y., Takeda,K. and Ichijo,H.
  TITLE     The Ablation of Mitochondrial Protein Phosphatase Pgam5 Confers
            Resistance Against Metabolic Stress
  JOURNAL   EBioMedicine 5, 82-92 (2016)
   PUBMED   27077115
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2016)
  AUTHORS   Wei,H., Liu,L. and Chen,Q.
  TITLE     Selective removal of mitochondria via mitophagy: distinct pathways
            for different mitochondrial stresses
  JOURNAL   Biochim Biophys Acta 1853 (10 Pt B), 2784-2790 (2015)
   PUBMED   25840011
  REMARK    Review article
REFERENCE   8  (bases 1 to 2016)
  AUTHORS   Hayes,J.D. and Dinkova-Kostova,A.T.
  TITLE     The Nrf2 regulatory network provides an interface between redox and
            intermediary metabolism
  JOURNAL   Trends Biochem Sci 39 (4), 199-218 (2014)
   PUBMED   24647116
  REMARK    Review article
REFERENCE   9  (bases 1 to 2016)
  AUTHORS   Wang,Z., Jiang,H., Chen,S., Du,F. and Wang,X.
  TITLE     The mitochondrial phosphatase PGAM5 functions at the convergence
            point of multiple necrotic death pathways
  JOURNAL   Cell 148 (1-2), 228-243 (2012)
   PUBMED   22265414
REFERENCE   10 (bases 1 to 2016)
  AUTHORS   Takeda,K., Komuro,Y., Hayakawa,T., Oguchi,H., Ishida,Y.,
            Murakami,S., Noguchi,T., Kinoshita,H., Sekine,Y., Iemura,S.,
            Natsume,T. and Ichijo,H.
  TITLE     Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic
            activity as a protein serine/threonine phosphatase to activate ASK1
  JOURNAL   Proc Natl Acad Sci U S A 106 (30), 12301-12305 (2009)
   PUBMED   19590015
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC092607.1.
            
            On Jul 13, 2005 this sequence version replaced XM_222256.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092607.1, SRR8487231.58917.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2016
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..2016
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /note="PGAM family member 5, mitochondrial
                     serine/threonine protein phosphatase"
                     /db_xref="GeneID:288731"
                     /db_xref="RGD:1312028"
     exon            1..221
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..900
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /EC_number="3.1.3.16"
                     /note="phosphoglycerate mutase family member 5"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase PGAM5,
                     mitochondrial"
                     /protein_id="NP_001020443.1"
                     /db_xref="GeneID:288731"
                     /db_xref="RGD:1312028"
                     /translation="MAFRQALQLAACGLAGGSAAVLFSAVAVGKPRAGGDADTRTTEP
                     LAWTGARPGHGVWDSNWDRREPLSLINLKKRNVEFGEDELASRLDHYKAKATRHIFLI
                     RHSQYNVDGSMEKDRTLTPLGREQAELTGIRLASLGLKFNKIVHSSMTRAVETTDIIS
                     KHLPGVCRVSTDLLREGAPIEPDPPVSHWKPEAVQYYEDGARIEAAFRNYIHRADAKQ
                     EEDSYEIFICHANVIRYIVCRALQFPPEGWLRLSLNNGSITHLVIRPNGRVALRTLGD
                     TGFMPPDKITRS"
     exon            222..400
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /inference="alignment:Splign:2.1.0"
     exon            401..526
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /inference="alignment:Splign:2.1.0"
     exon            527..615
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /inference="alignment:Splign:2.1.0"
     exon            616..749
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /inference="alignment:Splign:2.1.0"
     exon            750..1992
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcatcccgc cgtccggtcg tgcggcttgc ggcatggctt tccggcaggc tcttcagctg
       61 gcggcctgtg gtctggcggg tggctcggcc gctgttctct tctcggcggt agcggtaggg
      121 aagccgagag ctggcgggga tgcagacacg cgcacgacag agccgctggc ctggaccgga
      181 gcgcgccccg ggcacggcgt ctgggactcc aactgggaca ggcgagagcc actgtcactc
      241 attaacctga agaaaaggaa cgtggaattt ggagaagatg aactggcttc caggctggac
      301 cactataagg caaaggctac aagacacata ttcctcatcc ggcattccca gtacaatgtg
      361 gatggctcga tggagaagga ccgcaccctg accccattag gtcgggaaca ggctgaactc
      421 acggggatcc gacttgcaag cctgggactg aagtttaata aaatcgtcca ttcctctatg
      481 acccgtgcag tagagaccac agacatcatc agtaagcacc tgccaggtgt ctgcagagtc
      541 agcacagact tgctacggga aggtgccccc attgaaccgg atccacctgt gtctcactgg
      601 aagccagagg ctgtgcagta ttatgaagat ggagcccgga ttgaggctgc cttcaggaac
      661 tacatccacc gagctgatgc caagcaggag gaggacagct acgagatctt catatgtcac
      721 gccaatgtca tccgttatat tgtttgtagg gcactgcagt ttcccccaga aggttggctc
      781 cgcctgtccc tcaacaatgg tagtatcacc cacctggtga ttcgacccaa tggtcgtgtt
      841 gcactcagga cccttgggga cacagggttc atgcccccag acaagattac tcggtcctga
      901 ggctgtctgt aagactgcac cctgtcctct gctggtggcc tgcctacagc cttcccttgt
      961 cttccacagc tgtgctgtgg cttcacgttc gtctccagaa gaggatatct caagtgtcac
     1021 atttgggtgc ttacttctgg ctcaggctga agaaggcaac gtatgagtta gatggccttt
     1081 ttgaaagctc tctactttac tattaccacc agcatagccc taggaggtgc gacaggagcc
     1141 ttcctaggca gaaggcgggc ctgtcacggg tactgtatca cgggattgta gtagatcaac
     1201 cgaacactct atgacctctg gaagacctgt caggtagtgg ggtggtgttt acaggtggtt
     1261 atttcactgc aatctaggga ctttggttgc ttatttatca aagattttcc tcatgtgggt
     1321 tcttgctttg aaaaccaact tctcagctca attaggagat tctgtgtcta ctgcatttga
     1381 atgatggaca aaggggctgg cttcctataa ggtagataaa agccaagaaa gtggcactgc
     1441 taaaggactg tggcctgtat aaggcaagta ggtgatagtt ctgtaagagg ttccttggaa
     1501 gcaaagatag ccccactgac cagaagaggt ggcatatact tgtaattcta gcatctggga
     1561 ggcagaagca ggatcgtgag tctctagcca gcctgagtta tgttaaaaga cccagaaaaa
     1621 tatccctgag tgacggttcc attttagttt gctactgtta accttgaact tgtaggttat
     1681 ttagaaatga tgtgtttatt ccagatattc tgataagaaa aaaatggttt ttgtatgtgt
     1741 ggtttttgtt tttgtgacag aatcttaact gttgcccagg ctggcttcaa acttgagacc
     1801 cttctgagtc ttgtaattgt tgggattgca ggtatatact accacacctg tccgttcgtc
     1861 cccctatcct ccaaaaaacc cagtacagtt tctatgaaat ggttgtgagc atcttctgta
     1921 atcaatgcaa tgaattggaa tatttgatgt atctctctgc cctctttgga aataataaaa
     1981 ttttactttg ttaaaaaaaa aaaaaaaaaa aaaaaa
//
