LOCUS       NP_001020443             288 aa            linear   ROD 03-SEP-2024
DEFINITION  serine/threonine-protein phosphatase PGAM5, mitochondrial [Rattus
            norvegicus].
ACCESSION   NP_001020443 XP_222256
VERSION     NP_001020443.1
DBSOURCE    REFSEQ: accession NM_001025272.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 288)
  AUTHORS   Chen,Y., Huang,J., Zhou,H., Lin,J. and Tao,J.
  TITLE     Pgam5 aggravates hyperglycemia-induced myocardial dysfunction
            through disrupting Phb2-dependent mitochondrial dynamics
  JOURNAL   Int J Med Sci 21 (7), 1194-1203 (2024)
   PUBMED   38818468
  REMARK    GeneRIF: Pgam5 aggravates hyperglycemia-induced myocardial
            dysfunction through disrupting Phb2-dependent mitochondrial
            dynamics.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 288)
  AUTHORS   Zhang,J., Li,X., Zhang,Z., Zhang,J., Ma,L., Wang,S., Guo,X., Li,H.,
            Pan,B. and Niu,Q.
  TITLE     Role of the RIP3-PGAM5-Drp1 pathway in aluminum-induced PC12 cells
            necroptosis
  JOURNAL   Ecotoxicol Environ Saf 270, 115860 (2024)
   PUBMED   38142589
  REMARK    GeneRIF: Role of the RIP3-PGAM5-Drp1 pathway in aluminum-induced
            PC12 cells necroptosis.
REFERENCE   3  (residues 1 to 288)
  AUTHORS   Fu,G., Wang,B., He,B., Feng,M. and Yu,Y.
  TITLE     LPS induces cardiomyocyte necroptosis through the Ripk3/Pgam5
            signaling pathway
  JOURNAL   J Recept Signal Transduct Res 41 (1), 32-37 (2021)
   PUBMED   32580628
  REMARK    GeneRIF: LPS induces cardiomyocyte necroptosis through the
            Ripk3/Pgam5 signaling pathway.
REFERENCE   4  (residues 1 to 288)
  AUTHORS   Liu,G., Qian,M., Chen,M., Chen,T. and Qin,S.
  TITLE     miR-21-5p Suppresses Mitophagy to Alleviate Hyperoxia-Induced Acute
            Lung Injury by Directly Targeting PGAM5
  JOURNAL   Biomed Res Int 2020, 4807254 (2020)
   PUBMED   33681349
  REMARK    GeneRIF: miR-21-5p Suppresses Mitophagy to Alleviate
            Hyperoxia-Induced Acute Lung Injury by Directly Targeting PGAM5.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 288)
  AUTHORS   Yang,C., Liu,X., Yang,F., Zhang,W., Chen,Z., Yan,D., You,Q. and
            Wu,X.
  TITLE     Mitochondrial phosphatase PGAM5 regulates Keap1-mediated Bcl-xL
            degradation and controls cardiomyocyte apoptosis driven by
            myocardial ischemia/reperfusion injury
  JOURNAL   In Vitro Cell Dev Biol Anim 53 (3), 248-257 (2017)
   PUBMED   27815660
  REMARK    GeneRIF: PGAM5 controls cardiomyocyte apoptosis induced by MIRI
            through regulating Keap1-mediated Bcl-xL degradation, which may
            supply a novel molecular target for acute myocardial infarction
            (AMI) therapy.
REFERENCE   6  (residues 1 to 288)
  AUTHORS   Sekine,S., Yao,A., Hattori,K., Sugawara,S., Naguro,I., Koike,M.,
            Uchiyama,Y., Takeda,K. and Ichijo,H.
  TITLE     The Ablation of Mitochondrial Protein Phosphatase Pgam5 Confers
            Resistance Against Metabolic Stress
  JOURNAL   EBioMedicine 5, 82-92 (2016)
   PUBMED   27077115
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 288)
  AUTHORS   Wei,H., Liu,L. and Chen,Q.
  TITLE     Selective removal of mitochondria via mitophagy: distinct pathways
            for different mitochondrial stresses
  JOURNAL   Biochim Biophys Acta 1853 (10 Pt B), 2784-2790 (2015)
   PUBMED   25840011
  REMARK    Review article
REFERENCE   8  (residues 1 to 288)
  AUTHORS   Hayes,J.D. and Dinkova-Kostova,A.T.
  TITLE     The Nrf2 regulatory network provides an interface between redox and
            intermediary metabolism
  JOURNAL   Trends Biochem Sci 39 (4), 199-218 (2014)
   PUBMED   24647116
  REMARK    Review article
REFERENCE   9  (residues 1 to 288)
  AUTHORS   Wang,Z., Jiang,H., Chen,S., Du,F. and Wang,X.
  TITLE     The mitochondrial phosphatase PGAM5 functions at the convergence
            point of multiple necrotic death pathways
  JOURNAL   Cell 148 (1-2), 228-243 (2012)
   PUBMED   22265414
REFERENCE   10 (residues 1 to 288)
  AUTHORS   Takeda,K., Komuro,Y., Hayakawa,T., Oguchi,H., Ishida,Y.,
            Murakami,S., Noguchi,T., Kinoshita,H., Sekine,Y., Iemura,S.,
            Natsume,T. and Ichijo,H.
  TITLE     Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic
            activity as a protein serine/threonine phosphatase to activate ASK1
  JOURNAL   Proc Natl Acad Sci U S A 106 (30), 12301-12305 (2009)
   PUBMED   19590015
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC092607.1.
            
            On Jul 13, 2005 this sequence version replaced XP_222256.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092607.1, SRR8487231.58917.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..288
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     Protein         1..288
                     /product="serine/threonine-protein phosphatase PGAM5,
                     mitochondrial"
                     /EC_number="3.1.3.16"
                     /note="phosphoglycerate mutase family member 5"
                     /calculated_mol_wt=31929
     Site            7..29
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q562B5.1)"
     Region          13..286
                     /region_name="HP"
                     /note="Histidine phosphatase domain found in a
                     functionally diverse set of proteins, mostly phosphatases;
                     contains a His residue which is phosphorylated during the
                     reaction; cl11399"
                     /db_xref="CDD:472174"
     Site            24..25
                     /site_type="cleavage"
                     /note="Cleavage, by PARL.
                     /evidence=ECO:0000250|UniProtKB:Q96HS1; propagated from
                     UniProtKB/Swiss-Prot (Q562B5.1)"
     Region          76..81
                     /region_name="Interaction with KEAP1.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q562B5.1)"
     Site            86
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96HS1; propagated from
                     UniProtKB/Swiss-Prot (Q562B5.1)"
     Site            order(103..104,151,229..230)
                     /site_type="active"
                     /note="catalytic core [active]"
                     /db_xref="CDD:132718"
     Site            115
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q96HS1; propagated from
                     UniProtKB/Swiss-Prot (Q562B5.1)"
     Site            143
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q96HS1; propagated from
                     UniProtKB/Swiss-Prot (Q562B5.1)"
     Site            190
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q96HS1; propagated from
                     UniProtKB/Swiss-Prot (Q562B5.1)"
     CDS             1..288
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /coded_by="NM_001025272.1:34..900"
                     /db_xref="GeneID:288731"
                     /db_xref="RGD:1312028"
ORIGIN      
        1 mafrqalqla acglaggsaa vlfsavavgk praggdadtr tteplawtga rpghgvwdsn
       61 wdrreplsli nlkkrnvefg edelasrldh ykakatrhif lirhsqynvd gsmekdrtlt
      121 plgreqaelt girlaslglk fnkivhssmt ravettdiis khlpgvcrvs tdllregapi
      181 epdppvshwk peavqyyedg arieaafrny ihradakqee dsyeificha nviryivcra
      241 lqfppegwlr lslnngsith lvirpngrva lrtlgdtgfm ppdkitrs
//
