LOCUS       NM_030873               2085 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus profilin 2 (Pfn2), mRNA.
ACCESSION   NM_030873 XM_006232390
VERSION     NM_030873.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2085)
  AUTHORS   Wang,T., Dai,L., Shen,S., Yang,Y., Yang,M., Yang,X., Qiu,Y. and
            Wang,W.
  TITLE     Comprehensive Molecular Analyses of a Macrophage-Related Gene
            Signature With Regard to Prognosis, Immune Features, and Biomarkers
            for Immunotherapy in Hepatocellular Carcinoma Based on WGCNA and
            the LASSO Algorithm
  JOURNAL   Front Immunol 13, 843408 (2022)
   PUBMED   35693827
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2085)
  AUTHORS   Michaelsen-Preusse,K., Zessin,S., Grigoryan,G., Scharkowski,F.,
            Feuge,J., Remus,A. and Korte,M.
  TITLE     Neuronal profilins in health and disease: Relevance for spine
            plasticity and Fragile X syndrome
  JOURNAL   Proc Natl Acad Sci U S A 113 (12), 3365-3370 (2016)
   PUBMED   26951674
REFERENCE   3  (bases 1 to 2085)
  AUTHORS   Mouneimne,G., Hansen,S.D., Selfors,L.M., Petrak,L., Hickey,M.M.,
            Gallegos,L.L., Simpson,K.J., Lim,J., Gertler,F.B., Hartwig,J.H.,
            Mullins,R.D. and Brugge,J.S.
  TITLE     Differential remodeling of actin cytoskeleton architecture by
            profilin isoforms leads to distinct effects on cell migration and
            invasion
  JOURNAL   Cancer Cell 22 (5), 615-630 (2012)
   PUBMED   23153535
REFERENCE   4  (bases 1 to 2085)
  AUTHORS   Haikarainen,T., Chen,W.Q., Lubec,G. and Kursula,P.
  TITLE     Structure, modifications and ligand-binding properties of rat
            profilin 2a
  JOURNAL   Acta Crystallogr D Biol Crystallogr 65 (Pt 4), 303-311 (2009)
   PUBMED   19307711
  REMARK    GeneRIF: The binding site for proline-rich peptides is
            pre-organized. The C-terminus 2a is well ordered in the absence of
            ligand peptide. Pfn2 binds to the neuronal protein palladin.
REFERENCE   5  (bases 1 to 2085)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 2085)
  AUTHORS   Show,M.D., Anway,M.D. and Zirkin,B.R.
  TITLE     An ex vivo analysis of Sertoli cell actin dynamics following
            gonadotropic hormone withdrawal
  JOURNAL   J Androl 25 (6), 1013-1021 (2004)
   PUBMED   15477377
  REMARK    GeneRIF: Following hypophysectomy, the actin cytoskeleton of the
            Sertoli cell shifts to a predominantly depolymerized state, perhaps
            in part because of decreases in profilin II and espin gene
            products.
REFERENCE   7  (bases 1 to 2085)
  AUTHORS   Da Silva,J.S., Medina,M., Zuliani,C., Di Nardo,A., Witke,W. and
            Dotti,C.G.
  TITLE     RhoA/ROCK regulation of neuritogenesis via profilin IIa-mediated
            control of actin stability
  JOURNAL   J Cell Biol 162 (7), 1267-1279 (2003)
   PUBMED   14517206
  REMARK    GeneRIF: RhoA/ROCK/PIIa-mediated regulation of actin stability,
            shown to be essential for neuritogenesis, may constitute a central
            mechanism throughout neuronal differentiation.
REFERENCE   8  (bases 1 to 2085)
  AUTHORS   Giesemann,T., Schwarz,G., Nawrotzki,R., Berhorster,K.,
            Rothkegel,M., Schluter,K., Schrader,N., Schindelin,H., Mendel,R.R.,
            Kirsch,J. and Jockusch,B.M.
  TITLE     Complex formation between the postsynaptic scaffolding protein
            gephyrin, profilin, and Mena: a possible link to the microfilament
            system
  JOURNAL   J Neurosci 23 (23), 8330-8339 (2003)
   PUBMED   12967995
REFERENCE   9  (bases 1 to 2085)
  AUTHORS   Lambrechts,A., Braun,A., Jonckheere,V., Aszodi,A., Lanier,L.M.,
            Robbens,J., Van Colen,I., Vandekerckhove,J., Fassler,R. and Ampe,C.
  TITLE     Profilin II is alternatively spliced, resulting in profilin
            isoforms that are differentially expressed and have distinct
            biochemical properties
  JOURNAL   Mol Cell Biol 20 (21), 8209-8219 (2000)
   PUBMED   11027290
REFERENCE   10 (bases 1 to 2085)
  AUTHORS   Gieselmann,R., Kwiatkowski,D.J., Janmey,P.A. and Witke,W.
  TITLE     Distinct biochemical characteristics of the two human profilin
            isoforms
  JOURNAL   Eur J Biochem 229 (3), 621-628 (1995)
   PUBMED   7758455
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1 and FM077173.1.
            
            On or before Nov 25, 2020 this sequence version replaced
            XM_006232390.3, NM_030873.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087013.1, AY004289.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840107, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               JAXUCZ010000002.1  144222821-144222936 c
            117-801             FM077173.1         1-685
            802-2085            JAXUCZ010000002.1  144217100-144218383 c
FEATURES             Location/Qualifiers
     source          1..2085
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q26"
     gene            1..2085
                     /gene="Pfn2"
                     /note="profilin 2"
                     /db_xref="GeneID:81531"
                     /db_xref="RGD:621826"
     exon            1..262
                     /gene="Pfn2"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..553
                     /gene="Pfn2"
                     /note="profilin II; profilin-2-like"
                     /codon_start=1
                     /product="profilin-2"
                     /protein_id="NP_110500.2"
                     /db_xref="GeneID:81531"
                     /db_xref="RGD:621826"
                     /translation="MAGWQSYVDNLMCDGCCQEAAIVGYCDAKYVWAATAGGVFQSIT
                     PAEIDVIIGKDREGFFTNGLTLGGKKCSVIRDSLYVDSDCTMDIRTKSQGGEPTYNVA
                     VGRAGRVLVFVMGKEGVHGGGLNKKAYSMAKYLRDSGF"
     exon            263..455
                     /gene="Pfn2"
                     /inference="alignment:Splign:2.1.0"
     exon            456..2085
                     /gene="Pfn2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaggggcgg tcggtgcctg cgcagagccg cctcctcccc gcccccgccc cgcctccacc
       61 gccgccgccg ccgccgctgc tgctgcgcct ctgctcctgc cgtccccgct gcagtgcgaa
      121 gggctcgaag atggccggtt ggcagagcta cgtggataac ctgatgtgcg atggctgctg
      181 ccaggaggcc gccattgtcg gctactgcga cgccaaatac gtctgggcag ccacggccgg
      241 gggcgtcttc cagagcatca cgccagcaga aatagatgtg attataggaa aagaccggga
      301 aggtttcttt accaatggtt tgactcttgg aggaaagaag tgctctgtga tcagagatag
      361 cctatacgtt gactcggact gcacaatgga catccggaca aagagtcaag gtggggagcc
      421 aacatacaac gttgctgttg gcagagctgg gagagtcttg gtctttgtaa tgggaaaaga
      481 aggggtccat ggaggcggat tgaataagaa ggcatactca atggcaaaat acttgagaga
      541 ctctgggttc tagctgctag gcagactgtt aagtattagg ggaaaattgc tcttaaattt
      601 tcctagctgt aagcttaagt cttaattctg gaaattttat tagcaatgca gggtgatggg
      661 atatgaacct gtgtctcctt tgtatccctc tgttggtggg gaaaggtgtc tgtctttctt
      721 ccccttcccc ttaaataatt ctgttcattt ttgttttgtt tccttgtgta ctccagcatt
      781 ggttatagtt atgggaaagg aaggtgtcca cacaggcaca attaacaaga aaacatatga
      841 actcgcttta tacctgaaga ggtctgatgt ataagcagcc tctcccatct acctacctat
      901 caactgtctt catcaccacc ctaattatgg tcataatgct accagattgt agatggtagc
      961 tagtttttcc ttccttattt tctactgtca tgattcccaa gggtcatttg tatgttagcc
     1021 actgtgtgcc caacccttat ctggcatcgt gatcgcagca caataatgat ttgcatgata
     1081 tcttgagatt gggggaaggg ggcatgccaa gtcgggcatc acttcgtctt agcaattagt
     1141 ggaatactga ttactaaaat aagttaatat taagcaaggt gccggtgtac aatctctaat
     1201 ttgatcagtg ttttctcagc actttgagca tttacttagc tcatttagtc ttccttttgt
     1261 agcgcatggt tgggaggaaa aagtgcatgc atctgtactt cacacctttc tcatcccctc
     1321 ccttcgaaca tgaggcgttt ggtttgcttc cattctcttt gtgtagtgcc tggtttattt
     1381 aacctaatca atacctcctc gctgagctgt gagagtcgca gtgatttact ttgatacagt
     1441 gattgcactt gggacacact gtttgtagtg tcaatagcac gtgatgagtg cagctgtgga
     1501 gagaaaggca cttcctccca tgaccttact acagtaacca taccgatcaa attcccaggg
     1561 acattcgatc attgcagtag ctcagacttc ttgtcttttc tttgcacacc agctgtactc
     1621 ttgagtaaaa ttgtaaaagg ctgccattat ggatattagg taacccaaca taaccatctg
     1681 gagtgtgtcc agtttatttt tcataggacc aatttttatt tgcagcttag gtttttatat
     1741 gaagttgcat tattgtggac ttggctgtct tgtgatgtat ttttttcata tgtatcctgt
     1801 gccatactat tgttaaaatg aactgttgct attgtgagat ggaatttctt tcgaatggca
     1861 ctactttagg gacattctag tatttgcttc tattgtttgg gcattgtgga taatgtacag
     1921 atttaaaaac aaatcttgtt gctgatttgt ccatttcttt ccctgcactt tgttacatct
     1981 gggatacagt ctaactcatc tgatttaata tgcatttaaa aaaatgccat aactattaaa
     2041 caccttgttt acagacagat gaaataaatt tattccaacc aaata
//
