LOCUS       NM_022511                862 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus profilin 1 (Pfn1), mRNA.
ACCESSION   NM_022511
VERSION     NM_022511.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 862)
  AUTHORS   Xie,Q., Ma,L., Xiao,Z., Yang,M. and Chen,M.
  TITLE     Role of profilin-1 in vasculopathy induced by advanced glycation
            end products (AGEs)
  JOURNAL   J Diabetes Complications 37 (5), 108415 (2023)
   PUBMED   36989867
  REMARK    GeneRIF: Role of profilin-1 in vasculopathy induced by advanced
            glycation end products (AGEs).
REFERENCE   2  (bases 1 to 862)
  AUTHORS   Chen,J.M., Guo,R.R., Gao,Y., Wang,C.X. and Yuan,P.N.
  TITLE     Mechanism of action of Profilin-1 and Fibulin-3 in vascular
            remodeling in hypertensive rats
  JOURNAL   Eur Rev Med Pharmacol Sci 23 (18), 8101-8108 (2019)
   PUBMED   31599437
  REMARK    GeneRIF: Mechanism of action of Profilin-1 and Fibulin-3 in
            vascular remodeling in hypertensive rats.
REFERENCE   3  (bases 1 to 862)
  AUTHORS   Nishizaki,T.
  TITLE     Profilin facilitates PKCepsilon activation by accelerating ATP
            supply
  JOURNAL   Biochem Biophys Res Commun 506 (4), 918-922 (2018)
   PUBMED   30392913
  REMARK    GeneRIF: profilin binds to activated PKCepsilon and facilitates
            PKCepsilon activation by accelerating ATP supply to PKCepsilon.
            Erratum:[Biochem Biophys Res Commun. 2019 May 21;513(1):291. doi:
            10.1016/j.bbrc.2019.03.023.. PMID: 30952433]
REFERENCE   4  (bases 1 to 862)
  AUTHORS   Yang,D., Wang,Y., Jiang,M., Deng,X., Pei,Z., Li,F., Xia,K., Zhu,L.,
            Yang,T. and Chen,M.
  TITLE     Downregulation of Profilin-1 Expression Attenuates Cardiomyocytes
            Hypertrophy and Apoptosis Induced by Advanced Glycation End
            Products in H9c2 Cells
  JOURNAL   Biomed Res Int 2017, 9716087 (2017)
   PUBMED   29238726
  REMARK    GeneRIF: Collectively, these data suggest that PFN-1 may play an
            important role in AGEs-induced hypertrophy and apoptosis in H9c2
            cells.
REFERENCE   5  (bases 1 to 862)
  AUTHORS   Tariq,N., Basharat,Z., Butt,S. and Baig,D.N.
  TITLE     Distribution analysis of profilin isoforms at transcript resolution
            with mRNA-seq and secondary structure in various organs of Rattus
            norvegicus
  JOURNAL   Gene 589 (1), 49-55 (2016)
   PUBMED   27185630
  REMARK    GeneRIF: Distribution analysis of profilin isoforms at transcript
            resolution with mRNA-sequence and secondary structure in various
            organs of Rattus norvegicus has been reported.
REFERENCE   6  (bases 1 to 862)
  AUTHORS   Lanier,L.M., Gates,M.A., Witke,W., Menzies,A.S., Wehman,A.M.,
            Macklis,J.D., Kwiatkowski,D., Soriano,P. and Gertler,F.B.
  TITLE     Mena is required for neurulation and commissure formation
  JOURNAL   Neuron 22 (2), 313-325 (1999)
   PUBMED   10069337
REFERENCE   7  (bases 1 to 862)
  AUTHORS   Tamura,M., Tanaka,H., Hirano,T., Ueta,Y., Higashi,K. and Hirano,H.
  TITLE     Enhanced glomerular profilin gene and protein expression in
            experimental mesangial proliferative glomerulonephritis
  JOURNAL   Biochem Biophys Res Commun 222 (3), 683-687 (1996)
   PUBMED   8651905
REFERENCE   8  (bases 1 to 862)
  AUTHORS   Gieselmann,R., Kwiatkowski,D.J., Janmey,P.A. and Witke,W.
  TITLE     Distinct biochemical characteristics of the two human profilin
            isoforms
  JOURNAL   Eur J Biochem 229 (3), 621-628 (1995)
   PUBMED   7758455
REFERENCE   9  (bases 1 to 862)
  AUTHORS   Nakamura,H., Hirata,K., Yamashiro,K., Hiranuma,K., Shibata,K.,
            Higashi,K., Morita,T. and Hirano,H.
  TITLE     Increase of hepatic mRNAS of profilin, actin and extracellular
            matrix proteins after carbon tetrachloride treatment and partial
            hepatectomy in rats
  JOURNAL   Biochem Biophys Res Commun 198 (2), 568-573 (1994)
   PUBMED   8297366
REFERENCE   10 (bases 1 to 862)
  AUTHORS   Faivre-Sarrailh,C., Lena,J.Y., Had,L., Vignes,M. and Lindberg,U.
  TITLE     Location of profilin at presynaptic sites in the cerebellar cortex;
            implication for the regulation of the actin-polymerization state
            during axonal elongation and synaptogenesis
  JOURNAL   J Neurocytol 22 (12), 1060-1072 (1993)
   PUBMED   8106880
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC062405.1.
            
            On Feb 9, 2004 this sequence version replaced NM_022511.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062405.1, FQ233326.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132303, SAMEA5756307
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..862
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..862
                     /gene="Pfn1"
                     /note="profilin 1"
                     /db_xref="GeneID:64303"
                     /db_xref="RGD:621825"
     exon            1..249
                     /gene="Pfn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..540
                     /gene="Pfn1"
                     /note="profilin I"
                     /codon_start=1
                     /product="profilin-1"
                     /protein_id="NP_071956.2"
                     /db_xref="GeneID:64303"
                     /db_xref="RGD:621825"
                     /translation="MAGWNAYIDSLMADGTCQDAAIVGYKDSPSVWAAVPGKTFVSIT
                     PAEVGVLVGKDRSSFFVNGLTLGGQKCSVIRDSLLQDGEFTMDLRTKSTGGAPTFNVT
                     VTMTAKTLVLLMGKEGVHGGLINKKCYEMASHLRRSQY"
     exon            250..442
                     /gene="Pfn1"
                     /inference="alignment:Splign:2.1.0"
     exon            443..818
                     /gene="Pfn1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagccgcgtt ccggacggca gcgcgtgccc cgagctctct gccttccccc gcccgtcagc
       61 ccgagcccag cccgcgatcc cagcagcagc ccgcagagca gccccagcag cagcgccatg
      121 gccgggtgga acgcctacat cgacagcctt atggcggacg ggacctgtca ggacgcggcc
      181 atcgtaggct acaaggactc gccctccgtc tgggccgctg tccccgggaa gaccttcgtt
      241 agcattacgc cagctgaggt tggtgtcctg gtaggcaaag accggtcaag ttttttcgtg
      301 aatgggctga cacttggggg ccagaaatgt tctgtgatcc gggactcact gctgcaagac
      361 ggggaattta caatggatct tcgtaccaag agcaccgggg gagcccccac cttcaatgtc
      421 actgtcacca tgactgccaa gacgctagtc ctgctgatgg gcaaagaagg tgtccacggt
      481 ggtttgatca acaagaaatg ttatgaaatg gcctctcacc tgcggcgttc ccagtactga
      541 cctcatctgt cccttccccc accgctccct ttggcttttg cacccccttc tttccataca
      601 cacacacacc attatttttt gggccattac cccatttccc ttattgctgc caaaaccaca
      661 tgggctgggg gctggggctg gatggacaga tacctccccc tacccatacc ccctcctgtg
      721 tgtgtttgga aaaaaattgt ttttgggttt catttttgtt ttactttttt tttgttttgt
      781 tctttttttt ttttctgaat aaaaaaagat tctactaaaa aaaaaaaaaa aaaaaaaaaa
      841 aaaaaaaaaa aaaaaaaaaa aa
//
