LOCUS       NM_206847               2749 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus phosphofructokinase, platelet (Pfkp), mRNA.
ACCESSION   NM_206847
VERSION     NM_206847.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2749)
  AUTHORS   Webb,B.A., Forouhar,F., Szu,F.E., Seetharaman,J., Tong,L. and
            Barber,D.L.
  TITLE     Structures of human phosphofructokinase-1 and atomic basis of
            cancer-associated mutations
  JOURNAL   Nature 523 (7558), 111-114 (2015)
   PUBMED   25985179
REFERENCE   2  (bases 1 to 2749)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2749)
  AUTHORS   Zanivan,S., Maione,F., Hein,M.Y., Hernandez-Fernaud,J.R.,
            Ostasiewicz,P., Giraudo,E. and Mann,M.
  TITLE     SILAC-based proteomics of human primary endothelial cell
            morphogenesis unveils tumor angiogenic markers
  JOURNAL   Mol Cell Proteomics 12 (12), 3599-3611 (2013)
   PUBMED   23979707
REFERENCE   4  (bases 1 to 2749)
  AUTHORS   Ahmed,S.M., Theriault,B.L., Uppalapati,M., Chiu,C.W., Gallie,B.L.,
            Sidhu,S.S. and Angers,S.
  TITLE     KIF14 negatively regulates Rap1a-Radil signaling during breast
            cancer progression
  JOURNAL   J Cell Biol 199 (6), 951-967 (2012)
   PUBMED   23209302
REFERENCE   5  (bases 1 to 2749)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   6  (bases 1 to 2749)
  AUTHORS   Gekakis,N., Gehnrich,S.C. and Sul,H.S.
  TITLE     Phosphofructokinase isozyme expression during myoblast
            differentiation
  JOURNAL   J Biol Chem 264 (7), 3658-3661 (1989)
   PUBMED   2521854
REFERENCE   7  (bases 1 to 2749)
  AUTHORS   Vora,S., DiMauro,S., Spear,D., Harker,D. and Danon,M.J.
  TITLE     Characterization of the enzymatic defect in late-onset muscle
            phosphofructokinase deficiency. New subtype of glycogen storage
            disease type VII
  JOURNAL   J Clin Invest 80 (5), 1479-1485 (1987)
   PUBMED   2960695
REFERENCE   8  (bases 1 to 2749)
  AUTHORS   Vora,S., Oskam,R. and Staal,G.E.
  TITLE     Isoenzymes of phosphofructokinase in the rat. Demonstration of the
            three non-identical subunits by biochemical, immunochemical and
            kinetic studies
  JOURNAL   Biochem J 229 (2), 333-341 (1985)
   PUBMED   2931076
REFERENCE   9  (bases 1 to 2749)
  AUTHORS   Vora,S.
  TITLE     Isozymes of human phosphofructokinase in blood cells and cultured
            cell lines: molecular and genetic evidence for a trigenic system
  JOURNAL   Blood 57 (4), 724-732 (1981)
   PUBMED   6451249
REFERENCE   10 (bases 1 to 2749)
  AUTHORS   Vora,S., Seaman,C., Durham,S. and Piomelli,S.
  TITLE     Isozymes of human phosphofructokinase: identification and subunit
            structural characterization of a new system
  JOURNAL   Proc Natl Acad Sci U S A 77 (1), 62-66 (1980)
   PUBMED   6444721
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On May 26, 2021 this sequence version replaced NM_206847.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FN432820.1, BC088847.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-186               JAXUCZ010000017.1  68639813-68639998
            187-260             JAXUCZ010000017.1  68654624-68654697
            261-338             JAXUCZ010000017.1  68664162-68664239
            339-528             JAXUCZ010000017.1  68667301-68667490
            529-694             JAXUCZ010000017.1  68669182-68669347
            695-739             JAXUCZ010000017.1  68670721-68670765
            740-848             JAXUCZ010000017.1  68671013-68671121
            849-944             JAXUCZ010000017.1  68675235-68675330
            945-1037            JAXUCZ010000017.1  68676987-68677079
            1038-1163           JAXUCZ010000017.1  68677642-68677767
            1164-1228           JAXUCZ010000017.1  68679624-68679688
            1229-1298           JAXUCZ010000017.1  68679952-68680021
            1299-1445           JAXUCZ010000017.1  68680263-68680409
            1446-1516           JAXUCZ010000017.1  68682557-68682627
            1517-1604           JAXUCZ010000017.1  68686858-68686945
            1605-1757           JAXUCZ010000017.1  68687651-68687803
            1758-1922           JAXUCZ010000017.1  68697177-68697341
            1923-1984           JAXUCZ010000017.1  68698747-68698808
            1985-2096           JAXUCZ010000017.1  68699199-68699310
            2097-2196           JAXUCZ010000017.1  68701025-68701124
            2197-2299           JAXUCZ010000017.1  68703051-68703153
            2300-2749           JAXUCZ010000017.1  68703606-68704055
FEATURES             Location/Qualifiers
     source          1..2749
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.1"
     gene            1..2749
                     /gene="Pfkp"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; pfkc"
                     /note="phosphofructokinase, platelet"
                     /db_xref="GeneID:60416"
                     /db_xref="RGD:61893"
     exon            1..186
                     /gene="Pfkp"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; pfkc"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..2441
                     /gene="Pfkp"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; pfkc"
                     /EC_number="2.7.1.11"
                     /note="6-phosphofructokinase type C;
                     6-phosphofructo-1-kinase, C-type; phosphofructokinase 1;
                     phosphofructo-1-kinase isozyme C; phosphohexokinase;
                     phosphofructokinase C-type subunit"
                     /codon_start=1
                     /product="ATP-dependent 6-phosphofructokinase, platelet
                     type"
                     /protein_id="NP_996729.1"
                     /db_xref="GeneID:60416"
                     /db_xref="RGD:61893"
                     /translation="MSDQDSSTSSTSFPKYLEHLSGDGKAIGVLTSGGDAQGMNAAVR
                     AVVRMGIYTGAKVYFIYEGYQGMVDGGSNIVEAKWECVSSILQVGGTIIGSARCQAFR
                     SREGRLKAACNLVRLGITNLCVIGGDGSLTGANLFRKEWSGLLEELAKNGEIDSDTVK
                     KHAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMG
                     RHCGYLALVSALACGADWVFLPESPPEEGWEEEMCLKLSENRARKKRLNIIIVSEGAI
                     DTQNKPITSEKIKELVVTNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEAVLALL
                     EATPETPACVVSLRGNQAVRLPLMECVQMTQDVQKAMDERRFDEAVKLRGRSFEGNLN
                     TYKRLAIKEPDDKIPKSNCNVAIINVGAPAAGMNAAVRSAVRVGIAEGHKMFAIYDGF
                     DGLANGQIKEIGWGDVGGWTGQGGSILGTKRTLPGKYLEKIAEQMHSKNINALLIIGG
                     FEAYLGLLELAAARNKHEAFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRI
                     KQSASGTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEQFDIRDLQSNVMHLTE
                     KMKTSIQRGLVLRNENCSVNYTTDFIYQLYSEEGKGVFDCRKNVLGHMQQGGAPSPFD
                     RNFGTKISAKAMEWISAKLKGSHGTGKKFVSDDSICVLGIQKRDLLFKPVAELRKATD
                     FEHRIPKQQWWLKLRPIMKILAKYEASYDMSDVGKLEPVHNHGELSAI"
     exon            187..260
                     /gene="Pfkp"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; pfkc"
                     /inference="alignment:Splign:2.1.0"
     exon            261..338
                     /gene="Pfkp"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; pfkc"
                     /inference="alignment:Splign:2.1.0"
     exon            339..528
                     /gene="Pfkp"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; pfkc"
                     /inference="alignment:Splign:2.1.0"
     exon            529..694
                     /gene="Pfkp"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; pfkc"
                     /inference="alignment:Splign:2.1.0"
     exon            695..739
                     /gene="Pfkp"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; pfkc"
                     /inference="alignment:Splign:2.1.0"
     exon            740..848
                     /gene="Pfkp"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; pfkc"
                     /inference="alignment:Splign:2.1.0"
     exon            849..944
                     /gene="Pfkp"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; pfkc"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1037
                     /gene="Pfkp"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; pfkc"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1163
                     /gene="Pfkp"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; pfkc"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1228
                     /gene="Pfkp"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; pfkc"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1298
                     /gene="Pfkp"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; pfkc"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1445
                     /gene="Pfkp"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; pfkc"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1516
                     /gene="Pfkp"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; pfkc"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1604
                     /gene="Pfkp"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; pfkc"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1757
                     /gene="Pfkp"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; pfkc"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1922
                     /gene="Pfkp"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; pfkc"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..1984
                     /gene="Pfkp"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; pfkc"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2096
                     /gene="Pfkp"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; pfkc"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2196
                     /gene="Pfkp"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; pfkc"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2299
                     /gene="Pfkp"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; pfkc"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2749
                     /gene="Pfkp"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; pfkc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctggcgcg cgtgggacaa ggcttcagtg cttgctgagt acggtagcgt tcggcatctc
       61 acgacctcct taagatgagt gaccaggact cttcgacgtc cagcacctcc tttccgaagt
      121 acctggagca cctctctggg gatggcaaag ccatcggtgt cctgaccagc ggcggggatg
      181 cccaaggcat gaatgctgct gtccgtgctg tggtgcgcat gggaatatac acgggggcca
      241 aagtgtactt tatatacgag ggttaccaag gcatggtgga tggaggctcc aatattgtgg
      301 aagccaagtg ggagtgtgtc tccagcattc tacaagtggg tgggaccatc atcggcagtg
      361 cgcgttgcca agccttccgc agccgtgaag ggcgtctgaa agccgcctgt aacctggtac
      421 gcttgggcat aaccaacctg tgcgtgatcg gtggggacgg aagtctcacg ggagccaacc
      481 tcttccggaa ggagtggagc ggtcttctgg aagagctggc taagaatggt gagatcgatt
      541 cggacacagt gaagaagcac gcctacctca acgtggtggg catggtgggc tccattgaca
      601 atgacttctg tggcacagac atgaccatcg gtacagattc agctctgcac cgaattattg
      661 aagttgttga tgccatcatg accactgccc agagccacca gagaaccttc gtcctggagg
      721 tgatggggag acactgtggt tacttggcct tggtgagcgc cttggcttgc ggtgccgact
      781 gggtgttcct tccagagtct ccgccagagg aaggttggga ggaagaaatg tgcctcaaac
      841 tctccgagaa ccgtgcccga aagaaaaggc tgaatatcat cattgtgtct gaaggagcaa
      901 tcgacaccca aaataagcca atcacctctg agaaaatcaa ggagcttgtg gtgacaaatt
      961 tgggctttga cacccgggtc accattcttg gacatgtcca gagaggaggg accccttctg
     1021 catttgacag gattttggcc agccgtatgg gagtggaggc tgtccttgcc ttgctggaag
     1081 ctacccctga gaccccagcc tgtgtcgtgt cactgagagg aaatcaagct gtacgcctgc
     1141 ctctgatgga gtgcgtgcaa atgacccagg atgtacagaa agcaatggat gaaaggagat
     1201 ttgatgaagc cgtaaaactc cgaggaagga gttttgaggg caacctgaac acctacaagc
     1261 gtcttgccat taaggagcct gatgacaaga tccccaagag caattgcaat gtagccatca
     1321 tcaatgtagg ggcacctgcc gcaggaatga atgcagccgt gcgctccgct gttcgggttg
     1381 ggattgcaga gggccacaag atgttcgcaa tctatgacgg ctttgatggc ctcgccaatg
     1441 gccaaatcaa agaaatcggc tggggagatg tcggaggttg gacgggacaa ggagggtcca
     1501 ttcttgggac gaaacgcacc ctacccggaa agtacttgga gaagatcgca gaacagatgc
     1561 actcgaaaaa tatcaatgcc cttctgatca ttggcggatt cgaggcctac ctgggactcc
     1621 tagagctggc agctgcccgg aacaaacatg aggcgttctg tgtccctatg gttatggttc
     1681 ctgctactgt ctccaacaat gtgccaggtt ctgatttcag catcggggca gacacggctc
     1741 tgaacactat cacagacacg tgcgaccgca taaaacagtc agccagtggg accaagcgcc
     1801 gggtgttcat cattgagacc atgggcggat actgtggcta cctggccaac atggggggac
     1861 ttgcagcggg agccgatgct gcctacatct ttgaagaaca atttgatatc cgagatttgc
     1921 agtccaacgt catgcacttg acggagaaaa tgaagaccag catccagagg ggccttgtcc
     1981 tcagaaatga aaactgcagt gtaaattaca ccacggactt catctaccag ctctactcag
     2041 aggaagggaa aggagtgttt gactgcagga agaacgtgct aggccacatg cagcaggggg
     2101 gagcaccttc tccattcgac agaaactttg gaaccaaaat atctgccaaa gctatggagt
     2161 ggatctcggc caaactgaag ggctcccacg gcacagggaa aaaatttgtt agtgatgatt
     2221 ccatttgtgt cctgggaatt cagaagagag acctcctgtt taaaccagtg gcagagctaa
     2281 ggaaggctac tgactttgag caccgtatcc ccaagcaaca gtggtggctg aaactgcggc
     2341 cgatcatgaa gatcttggca aagtatgagg caagctatga catgtcagac gtaggcaagc
     2401 tggagccggt gcataaccac ggagaactat cagccatctg attgaatatg ccgtctcctg
     2461 acctgcacac ttacctaggg aagcctgtaa tgttctccag ggaccacccc tttttgtaac
     2521 atagttattt atcagcactc tatgcaagaa ttgttggccg agtattgtca gcagtaataa
     2581 tcagagagca tcacttgcta taaccattga cgcaacagac cctaagacat gaaacccagc
     2641 ctcgcgcgat tgatcacgtg tcagttttct actgtaccgg gtactactgt cttgtgcttt
     2701 accatgtgtg tatcttgtgg gattaaacat ttggttacaa ctcccatgg
//
