LOCUS       NM_031715               2884 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus phosphofructokinase, muscle (Pfkm), mRNA.
ACCESSION   NM_031715 XM_346812
VERSION     NM_031715.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2884)
  AUTHORS   Ismail,R. and Ul Hussain,M.
  TITLE     The up regulation of phosphofructokinase1 (PFK1) protein during
            chemically induced hypoxia is mediated by the hypoxia-responsive
            internal ribosome entry site (IRES) element, present in its
            5'untranslated region
  JOURNAL   Biochimie 139, 38-45 (2017)
   PUBMED   28545955
  REMARK    GeneRIF: High phosphofructokinase expression is associated with
            glioma.
REFERENCE   2  (bases 1 to 2884)
  AUTHORS   Enzo,E., Santinon,G., Pocaterra,A., Aragona,M., Bresolin,S.,
            Forcato,M., Grifoni,D., Pession,A., Zanconato,F., Guzzo,G.,
            Bicciato,S. and Dupont,S.
  TITLE     Aerobic glycolysis tunes YAP/TAZ transcriptional activity
  JOURNAL   EMBO J 34 (10), 1349-1370 (2015)
   PUBMED   25796446
REFERENCE   3  (bases 1 to 2884)
  AUTHORS   Nakamura,N., Mori,C. and Eddy,E.M.
  TITLE     Molecular complex of three testis-specific isozymes associated with
            the mouse sperm fibrous sheath: hexokinase 1, phosphofructokinase
            M, and glutathione S-transferase mu class 5
  JOURNAL   Biol Reprod 82 (3), 504-515 (2010)
   PUBMED   19889946
REFERENCE   4  (bases 1 to 2884)
  AUTHORS   Garcia,M., Pujol,A., Ruzo,A., Riu,E., Ruberte,J., Arbos,A.,
            Serafin,A., Albella,B., Feliu,J.E. and Bosch,F.
  TITLE     Phosphofructo-1-kinase deficiency leads to a severe cardiac and
            hematological disorder in addition to skeletal muscle glycogenosis
  JOURNAL   PLoS Genet 5 (8), e1000615 (2009)
   PUBMED   19696889
REFERENCE   5  (bases 1 to 2884)
  AUTHORS   Coelho,W.S., Costa,K.C. and Sola-Penna,M.
  TITLE     Serotonin stimulates mouse skeletal muscle 6-phosphofructo-1-kinase
            through tyrosine-phosphorylation of the enzyme altering its
            intracellular localization
  JOURNAL   Mol Genet Metab 92 (4), 364-370 (2007)
   PUBMED   17720578
REFERENCE   6  (bases 1 to 2884)
  AUTHORS   Amit,R., Bashan,N., Abarbanel,J.M., Shapira,Y., Sofer,S. and
            Moses,S.
  TITLE     Fatal familial infantile glycogen storage disease: multisystem
            phosphofructokinase deficiency
  JOURNAL   Muscle Nerve 15 (4), 455-458 (1992)
   PUBMED   1533013
REFERENCE   7  (bases 1 to 2884)
  AUTHORS   Yamasaki,T., Nakajima,H., Kono,N., Hotta,K., Yamada,K., Imai,E.,
            Kuwajima,M., Noguchi,T., Tanaka,T. and Tarui,S.
  TITLE     Structure of the entire human muscle phosphofructokinase-encoding
            gene: a two-promoter system
  JOURNAL   Gene 104 (2), 277-282 (1991)
   PUBMED   1833270
REFERENCE   8  (bases 1 to 2884)
  AUTHORS   Gekakis,N., Gehnrich,S.C. and Sul,H.S.
  TITLE     Phosphofructokinase isozyme expression during myoblast
            differentiation
  JOURNAL   J Biol Chem 264 (7), 3658-3661 (1989)
   PUBMED   2521854
REFERENCE   9  (bases 1 to 2884)
  AUTHORS   Nakajima,H., Noguchi,T., Yamasaki,T., Kono,N., Tanaka,T. and
            Tarui,S.
  TITLE     Cloning of human muscle phosphofructokinase cDNA
  JOURNAL   FEBS Lett 223 (1), 113-116 (1987)
   PUBMED   2822475
REFERENCE   10 (bases 1 to 2884)
  AUTHORS   Tornheim,K. and Lowenstein,J.M.
  TITLE     Control of phosphofructokinase from rat skeletal muscle. Effects of
            fructose diphosphate, AMP, ATP, and citrate
  JOURNAL   J Biol Chem 251 (23), 7322-7328 (1976)
   PUBMED   12161
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 24, 2020 this sequence version replaced NM_031715.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ211719.1, SRR26643292.31708.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               JAXUCZ010000007.1  131114099-131114251
            154-246             JAXUCZ010000007.1  131118149-131118241
            247-320             JAXUCZ010000007.1  131123136-131123209
            321-398             JAXUCZ010000007.1  131124141-131124218
            399-588             JAXUCZ010000007.1  131125586-131125775
            589-754             JAXUCZ010000007.1  131125995-131126160
            755-799             JAXUCZ010000007.1  131126986-131127030
            800-908             JAXUCZ010000007.1  131127423-131127531
            909-1004            JAXUCZ010000007.1  131127646-131127741
            1005-1097           JAXUCZ010000007.1  131127948-131128040
            1098-1223           JAXUCZ010000007.1  131128594-131128719
            1224-1288           JAXUCZ010000007.1  131129700-131129764
            1289-1352           JAXUCZ010000007.1  131130233-131130296
            1353-1502           JAXUCZ010000007.1  131130965-131131114
            1503-1573           JAXUCZ010000007.1  131131524-131131594
            1574-1661           JAXUCZ010000007.1  131132092-131132179
            1662-1814           JAXUCZ010000007.1  131132275-131132427
            1815-1979           JAXUCZ010000007.1  131132816-131132980
            1980-2041           JAXUCZ010000007.1  131134379-131134440
            2042-2153           JAXUCZ010000007.1  131134850-131134961
            2154-2253           JAXUCZ010000007.1  131136515-131136614
            2254-2359           JAXUCZ010000007.1  131137427-131137532
            2360-2884           JAXUCZ010000007.1  131137726-131138250
FEATURES             Location/Qualifiers
     source          1..2884
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..2884
                     /gene="Pfkm"
                     /gene_synonym="ATP-PFK; PFK-A; Pfk-M"
                     /note="phosphofructokinase, muscle"
                     /db_xref="GeneID:65152"
                     /db_xref="RGD:68419"
     exon            1..153
                     /gene="Pfkm"
                     /gene_synonym="ATP-PFK; PFK-A; Pfk-M"
                     /inference="alignment:Splign:2.1.0"
     exon            154..246
                     /gene="Pfkm"
                     /gene_synonym="ATP-PFK; PFK-A; Pfk-M"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..2504
                     /gene="Pfkm"
                     /gene_synonym="ATP-PFK; PFK-A; Pfk-M"
                     /EC_number="2.7.1.11"
                     /note="6-phosphofructokinase, muscle type;
                     phosphofructokinase 1; phosphofructokinase-M;
                     phosphofructo-1-kinase isozyme A; phosphofructokinase-A;
                     6-phosphofructokinase type A; phosphohexokinase"
                     /codon_start=1
                     /product="ATP-dependent 6-phosphofructokinase, muscle
                     type"
                     /protein_id="NP_113903.2"
                     /db_xref="GeneID:65152"
                     /db_xref="RGD:68419"
                     /translation="MTHEEHHEAKTLGIGKAIAVLTSGGDAQGMNAAVRAVVRVGIFT
                     GARVFFVHEGYQGLVDGGEHIREATWESVSMMLQLGGTVIGSARCKDFREREGRLRAA
                     HNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLNDLQKDGKITAEEATKSSYLNIVG
                     LVGSIDNDFCGTDMTIGTDSALHRIVEIVDAITTTAQSHQRTFVLEVMGRHCGYLALV
                     TSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPITS
                     EDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTPAC
                     VVSLSGNQAVRLPLMECVQVTKDVTKAMDEKRFDEAIKLRGRSFMNNWEVYKLLAHVR
                     PPVSKGGLHTVAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEE
                     AGWSYVGGWTGQGGSKLGTKRTLPKKNLEQISANITKYNIQGLVIIGGFEAYTGGLEL
                     MEGRKQFDELCIPFVVIPATVSNNVPGSDFSIGADTALNTICTTCDRIKQSAAGTKRR
                     VFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQVNVEHLVQKMKTTVKRGL
                     VLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKNVLGHMQQGGSPTPFDRNFATKMGAK
                     AMNWMSGKIKESYRNGRIFANTPDSGCVLGMRKRALVFQPVTELKDQTDFEHRIPKEQ
                     WWLKLRPILKILAKYEIDLDTSDHAHLEHISRKRSGEAAV"
     exon            247..320
                     /gene="Pfkm"
                     /gene_synonym="ATP-PFK; PFK-A; Pfk-M"
                     /inference="alignment:Splign:2.1.0"
     exon            321..398
                     /gene="Pfkm"
                     /gene_synonym="ATP-PFK; PFK-A; Pfk-M"
                     /inference="alignment:Splign:2.1.0"
     exon            399..588
                     /gene="Pfkm"
                     /gene_synonym="ATP-PFK; PFK-A; Pfk-M"
                     /inference="alignment:Splign:2.1.0"
     exon            589..754
                     /gene="Pfkm"
                     /gene_synonym="ATP-PFK; PFK-A; Pfk-M"
                     /inference="alignment:Splign:2.1.0"
     exon            755..799
                     /gene="Pfkm"
                     /gene_synonym="ATP-PFK; PFK-A; Pfk-M"
                     /inference="alignment:Splign:2.1.0"
     exon            800..908
                     /gene="Pfkm"
                     /gene_synonym="ATP-PFK; PFK-A; Pfk-M"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1004
                     /gene="Pfkm"
                     /gene_synonym="ATP-PFK; PFK-A; Pfk-M"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1097
                     /gene="Pfkm"
                     /gene_synonym="ATP-PFK; PFK-A; Pfk-M"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1223
                     /gene="Pfkm"
                     /gene_synonym="ATP-PFK; PFK-A; Pfk-M"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1288
                     /gene="Pfkm"
                     /gene_synonym="ATP-PFK; PFK-A; Pfk-M"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1352
                     /gene="Pfkm"
                     /gene_synonym="ATP-PFK; PFK-A; Pfk-M"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1502
                     /gene="Pfkm"
                     /gene_synonym="ATP-PFK; PFK-A; Pfk-M"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1573
                     /gene="Pfkm"
                     /gene_synonym="ATP-PFK; PFK-A; Pfk-M"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1661
                     /gene="Pfkm"
                     /gene_synonym="ATP-PFK; PFK-A; Pfk-M"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1814
                     /gene="Pfkm"
                     /gene_synonym="ATP-PFK; PFK-A; Pfk-M"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1979
                     /gene="Pfkm"
                     /gene_synonym="ATP-PFK; PFK-A; Pfk-M"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2041
                     /gene="Pfkm"
                     /gene_synonym="ATP-PFK; PFK-A; Pfk-M"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2153
                     /gene="Pfkm"
                     /gene_synonym="ATP-PFK; PFK-A; Pfk-M"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2253
                     /gene="Pfkm"
                     /gene_synonym="ATP-PFK; PFK-A; Pfk-M"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..2359
                     /gene="Pfkm"
                     /gene_synonym="ATP-PFK; PFK-A; Pfk-M"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2884
                     /gene="Pfkm"
                     /gene_synonym="ATP-PFK; PFK-A; Pfk-M"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttgccatct tcggcctgta gaggtttgga agcctcccct cctcccgcgg ctgcctccac
       61 ctggctcctc cccgtgttcg ccaaactccc ctcccccttt ccccaaggac aatctgcagg
      121 aaagcagcgg cggaggagag ctaaaactac aagagtggat catgacccat gaagagcatc
      181 atgaagccaa aaccctgggg atcggcaagg ccatcgccgt gttgacctct ggtggagatg
      241 cccaaggtat gaatgctgcg gtcagggctg tggtacgagt tggcatcttc acgggcgccc
      301 gcgtcttctt tgtccatgag ggttaccaag gcctggtgga tggtggagag cacatcaggg
      361 aggccacctg ggagagcgtg tccatgatgc tccagctggg aggcacggtg attggaagtg
      421 cccgatgcaa ggacttccgg gagcgagaag gacgactccg agctgcccac aacctggtga
      481 agcgggggat caccaatctg tgtgtcatcg gaggcgatgg cagcctcact ggggctgaca
      541 cttttcgttc agagtggagt gacttattga atgacctcca gaaagatggg aagatcacag
      601 ccgaggaggc tacaaagtcc agctacctga acatcgtggg cctggttggc tcaatcgaca
      661 atgacttctg tggcactgat atgaccattg gtactgactc tgccctgcac cgcattgtag
      721 agatcgtgga cgccatcacc accaccgctc agagccacca gaggacattt gtgttagaag
      781 tgatgggccg ccactgtgga tacctggccc ttgtcacctc tctgtcgtgt ggggccgact
      841 gggttttcat tcccgagtgt ccgccagatg acgactggga agaacacctt tgtcgccgtc
      901 tcagtgagac aagaacccgt ggttctcgtc tcaacatcat cattgttgct gagggtgcaa
      961 tcgacaaaaa cgggaagcca atcacctcag aagacatcaa gaacctggtg gtaaagcgtc
     1021 ttggatatga taccagggtc actgttctgg gacatgtaca gaggggtggg acaccatcag
     1081 cctttgaccg gatcctgggc agcaggatgg gtgtggaagc agtgatggca cttttggagg
     1141 ggaccccaga caccccagcc tgtgtggtga gcctctctgg taatcaggct gtgcgcctgc
     1201 ccctcatgga gtgtgtccag gtgaccaaag acgtgaccaa ggctatggat gagaagagat
     1261 ttgatgaagc cattaagctg agaggccgga gcttcatgaa caactgggag gtatacaagc
     1321 ttctagctca tgtcagaccc ccagtctcta agggcgggtt gcacacggtg gctgtgatga
     1381 acgtgggggc cccagctgct ggaatgaatg ctgcagttcg ctctactgtg aggattggcc
     1441 ttatccaagg caaccgagtg ctggtcgtgc atgatggctt tgagggtctg gccaaaggtc
     1501 agattgagga agctggctgg agctatgttg gaggctggac tggtcaaggt ggttccaaac
     1561 ttggtactaa aaggactcta cccaagaaga acctggaaca gatcagtgcc aacataacca
     1621 agtataacat ccagggcctg gttatcattg ggggctttga ggcttacaca gggggcttgg
     1681 agctgatgga gggcaggaag cagtttgatg agctctgcat cccatttgtg gtcattcccg
     1741 ccacggtttc caataatgtc ccagggtcag acttcagcat cggggctgac acagcactga
     1801 acaccatctg cacgacctgt gaccgaatca agcagtctgc agcaggcacc aagcggcgag
     1861 tgtttatcat cgagacgatg ggtggttact gtggctatct ggccaccatg gcaggactgg
     1921 cggctggggc tgatgctgcc tacatttttg aggagccctt caccatccga gatctccagg
     1981 ttaatgttga acatctggtg cagaagatga aaacaactgt gaagagaggc ctggtgctga
     2041 ggaatgagaa gtgcaacgag aactacacta ctgatttcat tttcaacctg tactctgagg
     2101 aggggaaggg catcttcgac agcaggaaga acgtgcttgg ccacatgcag cagggtggaa
     2161 gcccaactcc ctttgacagg aattttgcca ccaagatggg tgctaaggct atgaattgga
     2221 tgtctgggaa aatcaaagag agttaccgta atggacggat ctttgccaac actcccgact
     2281 caggttgtgt tctggggatg cgtaagaggg ccctggtctt tcagccagtg actgagctga
     2341 aggaccagac agattttgag caccgaatcc ccaaagaaca gtggtggctg aagctgaggc
     2401 caatcctcaa aatcctggcc aagtacgaga ttgatctgga cacctctgac cacgcccacc
     2461 tggagcacat ttccaggaag cggtctggag aagctgctgt ctagaccact ttggagtgag
     2521 ggggaaaatc atctgatcat ggtcagctca caccctggta gacctcagcc catggcttct
     2581 cagtgttgta gcccagcccc tacccttcta ggtttccctg tactctgtac ctgcaaccag
     2641 gatcagctgt ggccaggagt tgggggaggg gtggtgagtg cctctcctag gtagctgtcc
     2701 ttccttgcac cctggcttca tctgtcacac aggctggatg tctctagtgc tactgctaga
     2761 tttcagcttc tcaagagtaa aagtgagctt tatttatttc tttgtgataa caaagagtcc
     2821 taggtccttt ccttgtacca cagtgaagtg taactacact aataaaagcc agctggccac
     2881 tgtg
//
