LOCUS       NM_013190               2770 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus phosphofructokinase, liver type (Pfkl), mRNA.
ACCESSION   NM_013190 XM_001079376
VERSION     NM_013190.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2770)
  AUTHORS   Yi,W., Clark,P.M., Mason,D.E., Keenan,M.C., Hill,C., Goddard,W.A.
            3rd, Peters,E.C., Driggers,E.M. and Hsieh-Wilson,L.C.
  TITLE     Phosphofructokinase 1 glycosylation regulates cell growth and
            metabolism
  JOURNAL   Science 337 (6097), 975-980 (2012)
   PUBMED   22923583
REFERENCE   2  (bases 1 to 2770)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   3  (bases 1 to 2770)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 2770)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   5  (bases 1 to 2770)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 2770)
  AUTHORS   Hotta,K., Nakajima,H., Yamasaki,T., Hamaguchi,T., Kuwajima,M.,
            Noguchi,T., Tanaka,T., Kono,N. and Tarui,S.
  TITLE     Rat-liver-type phosphofructokinase mRNA. Structure, tissue
            distribution and regulation
  JOURNAL   Eur J Biochem 202 (2), 293-298 (1991)
   PUBMED   1836995
REFERENCE   7  (bases 1 to 2770)
  AUTHORS   Brand,I.A. and Heinickel,A.
  TITLE     Key enzymes of carbohydrate metabolism as targets of the 11.5-kDa
            Zn(2+)-binding protein (parathymosin)
  JOURNAL   J Biol Chem 266 (31), 20984-20989 (1991)
   PUBMED   1834654
REFERENCE   8  (bases 1 to 2770)
  AUTHORS   Gekakis,N., Gehnrich,S.C. and Sul,H.S.
  TITLE     Phosphofructokinase isozyme expression during myoblast
            differentiation
  JOURNAL   J Biol Chem 264 (7), 3658-3661 (1989)
   PUBMED   2521854
REFERENCE   9  (bases 1 to 2770)
  AUTHORS   Vora,S., Oskam,R. and Staal,G.E.
  TITLE     Isoenzymes of phosphofructokinase in the rat. Demonstration of the
            three non-identical subunits by biochemical, immunochemical and
            kinetic studies
  JOURNAL   Biochem J 229 (2), 333-341 (1985)
   PUBMED   2931076
REFERENCE   10 (bases 1 to 2770)
  AUTHORS   Castano,J.G., Nieto,A. and Feliu,J.E.
  TITLE     Inactivation of phosphofructokinase by glucagon in rat hepatocytes
  JOURNAL   J Biol Chem 254 (13), 5576-5579 (1979)
   PUBMED   156182
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X58865.1.
            
            On or before Jun 25, 2006 this sequence version replaced
            XM_001079376.1, NM_013190.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X58865.1, BC061791.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2770
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..2770
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-L"
                     /note="phosphofructokinase, liver type"
                     /db_xref="GeneID:25741"
                     /db_xref="RGD:3311"
     exon            1..151
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..2409
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-L"
                     /EC_number="2.7.1.11"
                     /note="phosphofructokinase, liver, B-type;
                     6-phosphofructokinase type B; phosphohexokinase;
                     6-phosphofructokinase, liver type; PFK-B;
                     phosphofructokinase 1; phosphofructo-1-kinase isozyme B"
                     /codon_start=1
                     /product="ATP-dependent 6-phosphofructokinase, liver type"
                     /protein_id="NP_037322.1"
                     /db_xref="GeneID:25741"
                     /db_xref="RGD:3311"
                     /translation="MATVDLEKLRMSGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYV
                     GAKVFLIYEGYEGLVEGGENIKPANWLSVSNIIQLGGTIIGSARCKAFTTREGRLAAA
                     YNLLQHGITNLCVIGGDGSLTGANIFRNEWGSLLEELVKEGKISESTAQNYAHLSIAG
                     LVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALV
                     SALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDRHGKPISS
                     SYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRVLSSKMGMEAVMALLEATPDTPAC
                     VVSLSGNQSVRLPLMECVQVTKDVQKAMDEKRFDEAIQLRGRSFENNWKIYKLLAHQK
                     VSKEKSNFSLAILNVGAPAAGMNAAVRSAVRTGISEGHTVYVVHDGFEGLAKGQVQEV
                     GWHDVAGWLGRGGSMLGTKRTLPKPHLEAIVENLRTYNIHALLVIGGFEAYEGVLQLV
                     EARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRV
                     FIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKANVEHMTEKMKTDIQRGLV
                     LRNEKCHEHYTTEFLYNLYSSEGRGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKA
                     MLWMSEKLRDVYRKGRVFANAPDSACVIGLRKKVVAFSSVTELKKETDFEHRMPREQW
                     WLNLRLMLKMLAHYRISMADYVSGELEHVTRRTLSIDKGF"
     exon            152..225
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            226..303
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            304..493
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            494..659
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            660..704
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            705..813
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            814..909
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1002
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1128
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1193
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1257
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1404
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1475
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1563
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1716
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1881
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..1943
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2055
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2155
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2261
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2741
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2740
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-L"
ORIGIN      
        1 ggcgacagcc gcgcggaacg cagagcggcg ggagaggagc tcgggctcct ggtctctgct
       61 gccgtcatgg ctaccgtgga cctggagaag ttgcggatgt cgggggctgg caaggccatc
      121 ggagtgctga caagcggcgg tgacgcgcaa ggtatgaatg ctgctgtcag ggctgtgact
      181 cgtatgggca tatatgtggg ggccaaagtc ttcctcatct acgagggcta cgagggcctc
      241 gtggaaggag gcgagaacat caagccagcc aactggctca gtgtctccaa catcatccag
      301 ctgggcggca ccatcattgg cagtgcccgc tgtaaggcct tcactacgag ggaagggcgc
      361 ctggcagcgg cctacaatct gctccaacac ggcatcacca acctgtgtgt catcggtggg
      421 gatggcagcc tcacgggggc caacatcttc cgcaacgagt ggggcagctt gctggaggaa
      481 ctggtgaagg aaggcaagat ctcagagtcc acagctcaga actacgcaca cttgagcatc
      541 gccggtctgg tgggctccat cgacaacgac ttctgcggca ccgacatgac catcggcacg
      601 gactcggccc tgcaccggat catggaggtc atcgacgcca tcaccaccac tgcccagagc
      661 caccagagga cctttgtgtt ggaggtgatg ggacggcact gcgggtacct ggcgctggtg
      721 tctgcgctgg cctccggggc tgattggctg ttcatccctg aagcgccccc ggaggatggc
      781 tgggagaact tcatgtgtga gaggctgggg gagactcgga gccgggggtc tcgactgaac
      841 atcatcatca tcgcggaggg tgccatcgac cggcatggaa agcctatctc atccagctac
      901 gtgaaagacc tggtggttca gaggctgggc ttcgatacac gagtgaccgt gctgggccac
      961 gtacagcgag gagggacacc ctcggccttt gaccgagtcc tgagtagcaa gatgggtatg
     1021 gaggccgtga tggcgctgct ggaggccacg ccggacacgc cggcctgcgt ggtcagcctc
     1081 tccgggaatc agtctgtgcg gctgcctctc atggagtgtg tgcaagtgac gaaggatgtg
     1141 cagaaggcca tggatgagaa gaggtttgac gaggccatcc agctccgtgg caggagcttc
     1201 gagaacaact ggaaaattta caagctcctc gcccaccaga aggtgtctaa ggagaagtcc
     1261 aacttctccc tggccatcct gaatgtggga gctccagcgg ccggcatgaa cgcagccgtg
     1321 cgctccgcgg tacgcactgg catctccgag ggacacacag tgtacgttgt gcatgatggc
     1381 tttgagggcc tggccaaggg tcaggtgcaa gaagtgggct ggcatgatgt ggcaggttgg
     1441 ctaggacgtg gtggctcaat gctggggacc aagaggaccc tgcccaagcc ccacctggag
     1501 gccattgtag aaaatctccg tacctacaac attcatgccc tgttggtgat cggtggcttt
     1561 gaggcctacg agggtgtgct gcagctggtg gaggctaggg ggcgctacga ggaactctgt
     1621 atcgtcatgt gcgtcatccc agccaccatc agcaacaatg tccctggcac tgacttcagc
     1681 ctgggctcgg acacggccgt caacgctgca atggagagtt gtgaccgcat caaacaatcg
     1741 gcctcgggga caaagcggcg tgtgttcatt gtagagacca tggggggcta ctgtggctac
     1801 ctggccactg tgacaggcat tgctgtgggc gccgatgccg cctacgtctt tgaggaccct
     1861 ttcaacatcc acgacttgaa ggccaatgtg gagcatatga cagagaagat gaagacagac
     1921 atccagaggg gcctggtgct ccggaacgag aagtgtcacg aacactacac cacggaattc
     1981 ctatacaacc tatactcctc ggaaggcaga ggtgtgttcg actgcaggac caacgtgctg
     2041 ggccacctgc agcagggtgg cgctccaacc cccttcgacc ggaactatgg gaccaaactg
     2101 ggggtgaagg ccatgttgtg gatgtcggag aagctgcgtg atgtctaccg caaagggcgg
     2161 gtgtttgcca atgctccgga ctcagcctgt gtgatcggcc tgaggaagaa ggtggtggcc
     2221 ttcagttcgg tcacagaact caagaaagag acagattttg agcaccgtat gccgcgggag
     2281 cagtggtggc tgaatctgcg gctgatgctg aagatgttgg cacactaccg catcagcatg
     2341 gccgactacg tgtctgggga gctggagcac gtcacacgcc gcaccttgag catagacaag
     2401 ggtttctgag cttaccgatc accctcgttc ctgctctccc ggactctctc tccctcccag
     2461 tgctagccac agatcccagc actaagggga actcacatgg aactcggagc ctgtggttgg
     2521 ttgaaggatt tgggggtcta ctgtgctgct ctgggactcc tcccttagcc acccccaccc
     2581 ccccaccccc tcagaacaga gcacctgtgg ggcccttaca ttccagttct ggctgggcag
     2641 acccacatca ccactccctc actggtcagc tggctgcctc accacacggc cgaaaagagc
     2701 ctcatggttt ttttttttag aaataaagtc acctgtttag aaaaaaaaaa aaaaaaaaaa
     2761 aaaaaaaaaa
//
