LOCUS       NM_001007729             524 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus platelet factor 4 (Pf4), mRNA.
ACCESSION   NM_001007729 XM_341192
VERSION     NM_001007729.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 524)
  AUTHORS   Hu,N., An,R., Yu,K., Chang,Y. and Gao,W.
  TITLE     PF4 induces inflammatory response through NF-kB signal pathway in
            rats with intracerebral haemorrhage
  JOURNAL   Folia Neuropathol 61 (4), 379-386 (2023)
   PUBMED   38174673
  REMARK    GeneRIF: PF4 induces inflammatory response through NF-kB signal
            pathway in rats with intracerebral haemorrhage.
REFERENCE   2  (bases 1 to 524)
  AUTHORS   Jiang,Z., Chen,C., Yang,S., He,H., Zhu,X. and Liang,M.
  TITLE     Contribution to the peripheral vasculopathy and endothelial cell
            dysfunction by CXCL4 in Systemic Sclerosis
  JOURNAL   J Dermatol Sci 104 (1), 63-73 (2021)
   PUBMED   34556381
REFERENCE   3  (bases 1 to 524)
  AUTHORS   Su,Y., Chen,Y., Zhang,W., Liu,L., Cao,X. and Wu,J.
  TITLE     Platelet factor 4 and beta-thromboglobulin mRNAs in circulating
            microparticles of trauma patients as diagnostic markers for deep
            vein thrombosis
  JOURNAL   J Thromb Thrombolysis 50 (3), 525-532 (2020)
   PUBMED   32347511
REFERENCE   4  (bases 1 to 524)
  AUTHORS   Khazaei,F., Ghanbari,E. and Khazaei,M.
  TITLE     Protective Effect of Royal Jelly against Cyclophosphamide-Induced
            Thrombocytopenia and Spleen and Bone Marrow Damages in Rats
  JOURNAL   Cell J 22 (3), 302-309 (2020)
   PUBMED   31863655
REFERENCE   5  (bases 1 to 524)
  AUTHORS   Horioka,K., Tanaka,H., Isozaki,S., Okuda,K., Asari,M., Shiono,H.,
            Ogawa,K. and Shimizu,K.
  TITLE     Hypothermia-induced activation of the splenic platelet pool as a
            risk factor for thrombotic disease in a mouse model
  JOURNAL   J Thromb Haemost 17 (10), 1762-1771 (2019)
   PUBMED   31237986
REFERENCE   6  (bases 1 to 524)
  AUTHORS   Ravid,K., Doi,T., Beeler,D.L., Kuter,D.J. and Rosenberg,R.D.
  TITLE     Transcriptional regulation of the rat platelet factor 4 gene:
            interaction between an enhancer/silencer domain and the GATA site
  JOURNAL   Mol Cell Biol 11 (12), 6116-6127 (1991)
   PUBMED   1944279
REFERENCE   7  (bases 1 to 524)
  AUTHORS   Hegyi,E., Heilbrun,L.K. and Nakeff,A.
  TITLE     Immunogold probing of platelet factor 4 in different ploidy classes
            of rat megakaryocytes sorted by flow cytometry
  JOURNAL   Exp Hematol 18 (7), 789-793 (1990)
   PUBMED   2379543
REFERENCE   8  (bases 1 to 524)
  AUTHORS   Han,Z.C., Bellucci,S., Tenza,D. and Caen,J.P.
  TITLE     Negative regulation of human megakaryocytopoiesis by human platelet
            factor 4 and beta thromboglobulin: comparative analysis in bone
            marrow cultures from normal individuals and patients with essential
            thrombocythaemia and immune thrombocytopenic purpura
  JOURNAL   Br J Haematol 74 (4), 395-401 (1990)
   PUBMED   2140694
REFERENCE   9  (bases 1 to 524)
  AUTHORS   Maione,T.E., Gray,G.S., Petro,J., Hunt,A.J., Donner,A.L.,
            Bauer,S.I., Carson,H.F. and Sharpe,R.J.
  TITLE     Inhibition of angiogenesis by recombinant human platelet factor-4
            and related peptides
  JOURNAL   Science 247 (4938), 77-79 (1990)
   PUBMED   1688470
REFERENCE   10 (bases 1 to 524)
  AUTHORS   Doi,T., Greenberg,S.M. and Rosenberg,R.D.
  TITLE     Structure of the rat platelet factor 4 gene: a marker for
            megakaryocyte differentiation
  JOURNAL   Mol Cell Biol 7 (2), 898-904 (1987)
   PUBMED   3821732
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Oct 3, 2022 this sequence version replaced NM_001007729.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AA956032.1, CK842713.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676810, SAMN16676811
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               JAXUCZ010000014.1  17583224-17583392   c
            170-302             JAXUCZ010000014.1  17582836-17582968   c
            303-524             JAXUCZ010000014.1  17582477-17582698   c
FEATURES             Location/Qualifiers
     source          1..524
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..524
                     /gene="Pf4"
                     /gene_synonym="Cxcl4; PF-4; Pf4a; RATPF4A"
                     /note="platelet factor 4"
                     /db_xref="GeneID:360918"
                     /db_xref="RGD:3305"
     exon            1..169
                     /gene="Pf4"
                     /gene_synonym="Cxcl4; PF-4; Pf4a; RATPF4A"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..390
                     /gene="Pf4"
                     /gene_synonym="Cxcl4; PF-4; Pf4a; RATPF4A"
                     /note="C-X-C motif chemokine 4; chemokine (C-X-C motif)
                     ligand 4"
                     /codon_start=1
                     /product="platelet factor 4 precursor"
                     /protein_id="NP_001007730.1"
                     /db_xref="GeneID:360918"
                     /db_xref="RGD:3305"
                     /translation="MSAAAVFRGLRPSPELLLLGLLLLPAVVAVTRASPEESDGDLSC
                     VCVKTSSSRIHLKRITSLEVIKAGPHCAVPQLIATLKNGSKICLDRQVPLYKKIIKKL
                     LES"
     exon            170..302
                     /gene="Pf4"
                     /gene_synonym="Cxcl4; PF-4; Pf4a; RATPF4A"
                     /inference="alignment:Splign:2.1.0"
     exon            303..524
                     /gene="Pf4"
                     /gene_synonym="Cxcl4; PF-4; Pf4a; RATPF4A"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgtctggca cttagagccc cagaccccag tttccccgag gtagcccttg gatctagcag
       61 caccctcttg acatgagtgc cgctgcggtg tttcgaggcc tccggcccag ccctgagctg
      121 cttcttctgg gtctgctgtt gctgccagct gtggttgctg tcaccagggc tagtcctgaa
      181 gaaagcgacg gagatcttag ctgtgtgtgt gtgaagacca gttcttccag gatccatctc
      241 aaacgcatca ccagcctgga ggtgatcaaa gcaggacccc actgtgcggt tccccagctc
      301 atagccacgc tgaagaatgg gagcaaaatt tgcctggacc ggcaagtacc tctgtataag
      361 aaaataatca agaaactcct ggagagttag gtacgagctg cctaaatgtg caacctgtta
      421 catgggattc ctggagtctt gtctactttt aatgtaactg cagtcttctg atgttttatt
      481 atcctcgaga tttaaataaa tgcattgaac caagttgtca taaa
//
