LOCUS       NM_057125               3169 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus peroxisomal biogenesis factor 6 (Pex6), mRNA.
ACCESSION   NM_057125 XM_346844
VERSION     NM_057125.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3169)
  AUTHORS   Zaki,M.S., Heller,R., Thoenes,M., Nurnberg,G., Stern-Schneider,G.,
            Nurnberg,P., Karnati,S., Swan,D., Fateen,E., Nagel-Wolfrum,K.,
            Mostafa,M.I., Thiele,H., Wolfrum,U., Baumgart-Vogt,E. and Bolz,H.J.
  TITLE     PEX6 is Expressed in Photoreceptor Cilia and Mutated in
            Deafblindness with Enamel Dysplasia and Microcephaly
  JOURNAL   Hum Mutat 37 (2), 170-174 (2016)
   PUBMED   26593283
REFERENCE   2  (bases 1 to 3169)
  AUTHORS   Tamura,S., Yasutake,S., Matsumoto,N. and Fujiki,Y.
  TITLE     Dynamic and functional assembly of the AAA peroxins, Pex1p and
            Pex6p, and their membrane receptor Pex26p
  JOURNAL   J Biol Chem 281 (38), 27693-27704 (2006)
   PUBMED   16854980
REFERENCE   3  (bases 1 to 3169)
  AUTHORS   Kikuchi,M., Hatano,N., Yokota,S., Shimozawa,N., Imanaka,T. and
            Taniguchi,H.
  TITLE     Proteomic analysis of rat liver peroxisome: presence of
            peroxisome-specific isozyme of Lon protease
  JOURNAL   J Biol Chem 279 (1), 421-428 (2004)
   PUBMED   14561759
REFERENCE   4  (bases 1 to 3169)
  AUTHORS   Tamura,S., Matsumoto,N., Imamura,A., Shimozawa,N., Suzuki,Y.,
            Kondo,N. and Fujiki,Y.
  TITLE     Phenotype-genotype relationships in peroxisome biogenesis disorders
            of PEX1-defective complementation group 1 are defined by
            Pex1p-Pex6p interaction
  JOURNAL   Biochem J 357 (Pt 2), 417-426 (2001)
   PUBMED   11439091
REFERENCE   5  (bases 1 to 3169)
  AUTHORS   Fukuda,S., Shimozawa,N., Suzuki,Y., Zhang,Z., Tomatsu,S.,
            Tsukamoto,T., Hashiguchi,N., Osumi,T., Masuno,M., Imaizumi,K.,
            Kuroki,Y., Fujiki,Y., Orii,T. and Kondo,N.
  TITLE     Human peroxisome assembly factor-2 (PAF-2): a gene responsible for
            group C peroxisome biogenesis disorder in humans
  JOURNAL   Am J Hum Genet 59 (6), 1210-1220 (1996)
   PUBMED   8940266
REFERENCE   6  (bases 1 to 3169)
  AUTHORS   Yahraus,T., Braverman,N., Dodt,G., Kalish,J.E., Morrell,J.C.,
            Moser,H.W., Valle,D. and Gould,S.J.
  TITLE     The peroxisome biogenesis disorder group 4 gene, PXAAA1, encodes a
            cytoplasmic ATPase required for stability of the PTS1 receptor
  JOURNAL   EMBO J 15 (12), 2914-2923 (1996)
   PUBMED   8670792
REFERENCE   7  (bases 1 to 3169)
  AUTHORS   Tsukamoto,T., Miura,S., Nakai,T., Yokota,S., Shimozawa,N.,
            Suzuki,Y., Orii,T., Fujiki,Y., Sakai,F., Bogaki,A., Yasumo,H. and
            Osumi,T.
  TITLE     Peroxisome assembly factor-2, a putative ATPase cloned by
            functional complementation on a peroxisome-deficient mammalian cell
            mutant
  JOURNAL   Nat Genet 11 (4), 395-401 (1995)
   PUBMED   7493019
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D63673.1.
            
            On Dec 17, 2003 this sequence version replaced XM_346844.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D63673.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3169
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="F344/Jcl"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..3169
                     /gene="Pex6"
                     /gene_synonym="Paf-2; Paf2"
                     /note="peroxisomal biogenesis factor 6"
                     /db_xref="GeneID:117265"
                     /db_xref="RGD:621637"
     exon            1..902
                     /gene="Pex6"
                     /gene_synonym="Paf-2; Paf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..2957
                     /gene="Pex6"
                     /gene_synonym="Paf-2; Paf2"
                     /note="peroxisome assembly factor 2; peroxin-6;
                     peroxisomal-type ATPase 1; peroxisome assembly factor
                     2-like"
                     /codon_start=1
                     /product="peroxisomal ATPase PEX6"
                     /protein_id="NP_476466.1"
                     /db_xref="GeneID:117265"
                     /db_xref="RGD:621637"
                     /translation="MALAVLHVLEPFPTETPPLAVLLPPGGPWPVTGVGLVLALRPAS
                     ESPAGPALLVAAVEGSGAQCEQRGPGPPPLLVSRTLLRVLALSPGARVRARPVRRPPA
                     LGWALLGTSPGPGLGPRVGPLLVRRGETLPVPGSRVLETRPALQGLLGPGTRLAVTEL
                     QGRTKLDPESRDHNHPPPPPVVSSFAVSHSIRQLRGVLGGTGDALGVSRSCLRSLGLF
                     QGEWVWVARVGELPNTSQPHLAQVQVLEPRWDLSARLGPNSGQPGEPLADGLVFVPAT
                     LAFNLGCDPLEVGELRIQRYLEDSTAAEDKGSCSLLPGPPFARELHIEVLPSPHCGVN
                     GKYDHVLYQHFHTPRVVQEGDVLCVSTAGQVEILEGSLERLPRWREVFFKVKKTVGEA
                     PDGPASAFLADTTHTSLYLAGTTLSRVPPLPSGRSPPWDSLSPPGLEALVNELCAVLK
                     PHLQPGGTLLTGTSCVLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSLCADSSRTVE
                     TKLQTTFSRARRCRPVVLLLTALDLLGRDRDGLGEDARVVATLRHLLLDEDPLSRCPP
                     LMVVATTSRVQDLPTDVRTAFPHELEVPVLSESQRLSVLQALTAHLPLGQEVNLSQLA
                     RRCAGFVVGDLYALLTHASRAACTRIKAAGLAMSEEDEGELCAAGFPLLAEDFGQALD
                     QLQTAHSQAVGAPKIPSVSWHDVGGLQDVKKEILETIQLPLEHPELLSLGLRRSGLLL
                     HGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCII
                     FFDELDSLAPSRGRSGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPAL
                     LRPGRFDKLVFVGASEDRASQLRVLSAITRKFKLEASVSLMNVLDCCPPQLTGADLYS
                     LCSDAMMTALKRRVRDLEEGLEPRSSALLLTMEDLLQAAARLQPSVSEQELLRYKRIQ
                     RKFAAC"
     exon            903..1066
                     /gene="Pex6"
                     /gene_synonym="Paf-2; Paf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1150
                     /gene="Pex6"
                     /gene_synonym="Paf-2; Paf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1253
                     /gene="Pex6"
                     /gene_synonym="Paf-2; Paf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1387
                     /gene="Pex6"
                     /gene_synonym="Paf-2; Paf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1499
                     /gene="Pex6"
                     /gene_synonym="Paf-2; Paf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1708
                     /gene="Pex6"
                     /gene_synonym="Paf-2; Paf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1904
                     /gene="Pex6"
                     /gene_synonym="Paf-2; Paf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..1981
                     /gene="Pex6"
                     /gene_synonym="Paf-2; Paf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..2108
                     /gene="Pex6"
                     /gene_synonym="Paf-2; Paf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2314
                     /gene="Pex6"
                     /gene_synonym="Paf-2; Paf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..2376
                     /gene="Pex6"
                     /gene_synonym="Paf-2; Paf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2485
                     /gene="Pex6"
                     /gene_synonym="Paf-2; Paf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2602
                     /gene="Pex6"
                     /gene_synonym="Paf-2; Paf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2603..2680
                     /gene="Pex6"
                     /gene_synonym="Paf-2; Paf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2681..2820
                     /gene="Pex6"
                     /gene_synonym="Paf-2; Paf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2821..3169
                     /gene="Pex6"
                     /gene_synonym="Paf-2; Paf2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggctccagt ctccctcgcc atggcgcttg ctgtattgca tgtcctagaa cccttcccga
       61 ctgagacacc accgttggcg gtgctgttgc cgcccggggg cccgtggcca gtgaccgggg
      121 taggcctggt gctggcgcta cggccggcga gcgaaagtcc tgcgggaccc gcgctgctcg
      181 tggcggccgt ggaagggtcc ggcgcccaat gcgagcagcg agggcccggg cctccgccgc
      241 tgctggtgag ccgcacgctg ctgcgggtcc tagcgctgag ccccggagcg agagtgcgag
      301 cgcggcctgt gcggcggcct ccagccttgg gctgggcgct gcttggcacg tctccgggtc
      361 ctgggcttgg gcctcgagtc gggccgctgc tggtgcgtcg cggggagaca ctaccggtgc
      421 ccggttctcg agtgttggag acgcgaccgg ccttgcaagg gttgctgggc ccggggacac
      481 ggctagctgt aactgagctc caggggcgga ccaaactgga cccggagagt agggaccaca
      541 accatccccc acccccgccc gtagtttcct cctttgcagt ttcccactca atccggcagc
      601 tccgaggagt tctgggaggg actggagatg cactaggtgt gagccggagc tgtctccgga
      661 gtctcgggct cttccagggc gaatgggtat gggtggcccg agtcggagag ttaccaaaca
      721 cctcccagcc gcacttggct caagtacagg ttctagagcc tcgctgggac ctgtccgcga
      781 gactgggacc caactctggg cagccgggag agccactcgc ggacggactg gtgtttgtgc
      841 ctgccactct agcttttaat ctcggctgtg accccctgga agtgggagag ctcagaattc
      901 agaggtatct ggaagactct actgctgctg aggacaaagg aagctgctca ctactgcctg
      961 ggcctccgtt tgctcgagag ttacacatcg aagttctgcc ctcgcctcac tgtggtgtca
     1021 atgggaaata tgaccatgtt ctctaccagc acttccacac gcccagggtg gtccaggaag
     1081 gggatgttct gtgtgtgtca acggctgggc aagttgagat cctggaagga agcctggaga
     1141 gactgcccag gtggcgggag gtgtttttca aagtgaagaa aacggttgga gaagccccag
     1201 atgggccagc cagtgccttc ctggccgata ccacacacac ctctttatac ctggctggta
     1261 ccaccctgag tcgtgtcccc ccgctgcctt caggaaggtc cccaccctgg gacagcttgt
     1321 ctcctccagg cctggaggcc ttggtaaatg agctgtgtgc tgtcctgaag cctcatctgc
     1381 agcccggagg aacactgctc acaggaacca gctgtgtgct cctgcagggt cccccaggca
     1441 gcgggaagac caccgcggtc acagctgcat gcagtcgcct cgggctccat ctgctgaagg
     1501 tgccttgctc cagcctctgt gcagatagca gtaggactgt ggagacaaag ctgcagacca
     1561 ccttctcccg ggcccgccgc tgcaggcctg tggtcctcct gctgacagcc ctggaccttc
     1621 tgggccggga ccgagatggg ctgggtgagg atgcccgcgt tgtggccaca ctgcgtcacc
     1681 tcctcctcga tgaggaccct ctgagcaggt gccctcctct catggtggtg gccactacaa
     1741 gccgtgtcca ggacctgccc accgatgtgc ggacggcatt tcctcatgag ctggaggtgc
     1801 cagtgttgtc tgagagtcag cggctcagtg tcctgcaggc cctcactgcc catcttccct
     1861 tgggccagga ggttaacctg tcacagctgg cacggcgctg tgcgggcttt gtggtagggg
     1921 acctctatgc ccttctgacc catgccagcc gggcagcctg caccaggatc aaagctgcag
     1981 gcttggcgat gagtgaggag gatgaggggg agctgtgtgc cgctggcttt cccctgttgg
     2041 ccgaggactt cgggcaggcg ttagatcaac tacaaacggc tcactcccaa gcagtaggag
     2101 cgcccaagat cccttcagtg tcctggcacg atgtgggtgg gctgcaggat gtgaagaagg
     2161 agatcctgga gaccatccaa ctgcctctgg aacaccctga gctgctaagc ctgggcctaa
     2221 gacgatcagg ccttctgctc catgggcccc caggcactgg caagaccctg ctggccaagg
     2281 cggtagccac tgagtgcagc ctcacctttc tcagtgtaaa ggggccagaa ctcatcaaca
     2341 tgtatgtggg ccaaagtgag gagaatgttc gggaagtgtt tgccagggcc agggctgctg
     2401 ccccgtgcat catcttcttt gatgaactgg actccttagc tccgagccgt ggacggagtg
     2461 gagactctgg aggtgtgatg gacagagttg tgtctcagct cttagctgag ctggacgggc
     2521 ttcacagcac tcaggatgtg tttgtgatcg gagccaccaa cagaccagac ctcctggatc
     2581 ctgcccttct gcggcctggc agatttgaca agctggtgtt tgtaggagca agtgaggacc
     2641 gggcctccca gctgcgcgtt ctgagcgcca tcacacgaaa gttcaagctg gaggcctctg
     2701 tgagcctgat gaatgtgctg gattgctgcc cgcctcagct gaccggcgca gacctctatt
     2761 ctctctgctc tgacgccatg atgaccgccc tcaaacgcag ggtccgagac ctagaggaag
     2821 ggctggagcc tcggagctca gcactgttgc tcaccatgga ggacctgttg caggccgcag
     2881 cccggctgca gccctcagtc agcgagcagg agctgctgcg atacaagcgt atccaacgca
     2941 agtttgctgc ctgctaggag cttcctgccg cctgcaaaag cccacctggc tggaggtagc
     3001 tgccacctgc cacctgaagg ctgcctccct ccaggagata ccctgagatc cctagtggga
     3061 ggcccttgtg cccaggagaa gaggcagggc tggcagcttg ggggcgtggc agcctggaat
     3121 gggcattgag gccccagttc tcagacagaa aataaagtct atactgccc
//
