LOCUS       NM_001170584            3197 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Rattus norvegicus peroxisomal biogenesis factor 5 (Pex5), mRNA.
ACCESSION   NM_001170584 XM_001062081 XM_006237386 XM_232343
VERSION     NM_001170584.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3197)
  AUTHORS   Francisco,T., Pedrosa,A.G., Rodrigues,T.A., Abalkhail,T., Li,H.,
            Ferreira,M.J., van der Heden van Noort,G.J., Fransen,M.,
            Hettema,E.H. and Azevedo,J.E.
  TITLE     Noncanonical and reversible cysteine ubiquitination prevents the
            overubiquitination of PEX5 at the peroxisomal membrane
  JOURNAL   PLoS Biol 22 (3), e3002567 (2024)
   PUBMED   38470934
  REMARK    GeneRIF: Noncanonical and reversible cysteine ubiquitination
            prevents the overubiquitination of PEX5 at the peroxisomal
            membrane.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3197)
  AUTHORS   Wang,M., Li,J., Ding,Y., Cai,S., Li,Z. and Liu,P.
  TITLE     PEX5 prevents cardiomyocyte hypertrophy via suppressing the
            redox-sensitive signaling pathways MAPKs and STAT3
  JOURNAL   Eur J Pharmacol 906, 174283 (2021)
   PUBMED   34174269
  REMARK    GeneRIF: PEX5 prevents cardiomyocyte hypertrophy via suppressing
            the redox-sensitive signaling pathways MAPKs and STAT3.
REFERENCE   3  (bases 1 to 3197)
  AUTHORS   Shinde,A.B., Baboota,R.K., Denis,S., Loizides-Mangold,U.,
            Peeters,A., Espeel,M., Malheiro,A.R., Riezman,H., Vinckier,S.,
            Vaz,F.M., Brites,P., Ferdinandusse,S., Van Veldhoven,P.P. and
            Baes,M.
  TITLE     Mitochondrial disruption in peroxisome deficient cells is
            hepatocyte selective but is not mediated by common hepatic
            peroxisomal metabolites
  JOURNAL   Mitochondrion 39, 51-59 (2018)
   PUBMED   28866057
REFERENCE   4  (bases 1 to 3197)
  AUTHORS   Grou,C.P., Francisco,T., Rodrigues,T.A., Freitas,M.O., Pinto,M.P.,
            Carvalho,A.F., Domingues,P., Wood,S.A., Rodriguez-Borges,J.E.,
            Sa-Miranda,C., Fransen,M. and Azevedo,J.E.
  TITLE     Identification of ubiquitin-specific protease 9X (USP9X) as a
            deubiquitinase acting on ubiquitin-peroxin 5 (PEX5) thioester
            conjugate
  JOURNAL   J Biol Chem 287 (16), 12815-12827 (2012)
   PUBMED   22371489
  REMARK    GeneRIF: Our results suggest that ubiquitin-specific protease 9X
            (USP9X) is by far the most active deubiquitinase acting on Ub-PEX5,
            both in female rat liver and HeLa cells.
REFERENCE   5  (bases 1 to 3197)
  AUTHORS   Freitas,M.O., Francisco,T., Rodrigues,T.A., Alencastre,I.S.,
            Pinto,M.P., Grou,C.P., Carvalho,A.F., Fransen,M., Sa-Miranda,C. and
            Azevedo,J.E.
  TITLE     PEX5 protein binds monomeric catalase blocking its tetramerization
            and releases it upon binding the N-terminal domain of PEX14
  JOURNAL   J Biol Chem 286 (47), 40509-40519 (2011)
   PUBMED   21976670
REFERENCE   6  (bases 1 to 3197)
  AUTHORS   Chang,C.C., Warren,D.S., Sacksteder,K.A. and Gould,S.J.
  TITLE     PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor
            docking in peroxisomal matrix protein import
  JOURNAL   J Cell Biol 147 (4), 761-774 (1999)
   PUBMED   10562279
REFERENCE   7  (bases 1 to 3197)
  AUTHORS   Yamashita,H., Avraham,S., Jiang,S., London,R., Van Veldhoven,P.P.,
            Subramani,S., Rogers,R.A. and Avraham,H.
  TITLE     Characterization of human and murine PMP20 peroxisomal proteins
            that exhibit antioxidant activity in vitro
  JOURNAL   J Biol Chem 274 (42), 29897-29904 (1999)
   PUBMED   10514471
REFERENCE   8  (bases 1 to 3197)
  AUTHORS   Braverman,N., Dodt,G., Gould,S.J. and Valle,D.
  TITLE     An isoform of pex5p, the human PTS1 receptor, is required for the
            import of PTS2 proteins into peroxisomes
  JOURNAL   Hum Mol Genet 7 (8), 1195-1205 (1998)
   PUBMED   9668159
REFERENCE   9  (bases 1 to 3197)
  AUTHORS   Baes,M., Gressens,P., Baumgart,E., Carmeliet,P., Casteels,M.,
            Fransen,M., Evrard,P., Fahimi,D., Declercq,P.E., Collen,D., van
            Veldhoven,P.P. and Mannaerts,G.P.
  TITLE     A mouse model for Zellweger syndrome
  JOURNAL   Nat Genet 17 (1), 49-57 (1997)
   PUBMED   9288097
REFERENCE   10 (bases 1 to 3197)
  AUTHORS   Dodt,G., Braverman,N., Wong,C., Moser,A., Moser,H.W., Watkins,P.,
            Valle,D. and Gould,S.J.
  TITLE     Mutations in the PTS1 receptor gene, PXR1, define complementation
            group 2 of the peroxisome biogenesis disorders
  JOURNAL   Nat Genet 9 (2), 115-125 (1995)
   PUBMED   7719337
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM036217.1, CK477113.1, CB809540.1, CK469240.1, EV779934.1 and
            BC111709.1.
            
            On or before Dec 15, 2013 this sequence version replaced
            XM_006237386.1, XM_232343.5, XM_001062081.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               FM036217.1         1-131
            132-800             CK477113.1         1-669
            801-882             CB809540.1         248-329
            883-1337            CK469240.1         4-458
            1338-1425           EV779934.1         33-120
            1426-3197           BC111709.1         1-1772
FEATURES             Location/Qualifiers
     source          1..3197
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..3197
                     /gene="Pex5"
                     /gene_synonym="PTS1-BP; PTS1R"
                     /note="peroxisomal biogenesis factor 5"
                     /db_xref="GeneID:312703"
                     /db_xref="RGD:1307612"
     exon            1..190
                     /gene="Pex5"
                     /gene_synonym="PTS1-BP; PTS1R"
                     /inference="alignment:Splign:2.1.0"
     exon            191..353
                     /gene="Pex5"
                     /gene_synonym="PTS1-BP; PTS1R"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..2021
                     /gene="Pex5"
                     /gene_synonym="PTS1-BP; PTS1R"
                     /note="peroxin-5; PTS1 receptor; peroxisome receptor 1;
                     peroxisomal C-terminal targeting signal import receptor;
                     peroxisome biogenesis factor 5; peroxisomal targeting
                     signal 1 receptor-like"
                     /codon_start=1
                     /product="peroxisomal targeting signal 1 receptor"
                     /protein_id="NP_001164055.1"
                     /db_xref="GeneID:312703"
                     /db_xref="RGD:1307612"
                     /translation="MAMRELVESECGGANPLMKLATHFTQDKALRQEGLRPGPWPPGA
                     SAAETVSKPLGVGTEDELVAEFLQDQNATLVSRAPQTFKMDDLLAEMQEIEQSNFRQA
                     PQRAPGVADLALSENWAQEFLAAGDAVDVAQDYNETDWSQEFIAEVTDPLSVSPARWA
                     EEYLEQSEEKLWLGDPEGTSTTDRWYDEYHPEEDLQHTASDFVSKVDDPKLANSEGTS
                     EAWVDQFTRPGNKLAALQVEFERAKSAIESDVDFWDKLQAELEEMAKRDAEAHPWLSD
                     YDDLTSASYDKGYQFEEENPLRDHPQPFEEGLRRLEEGDLPNAVLLFEAAVQQDPKHM
                     EAWQYLGTTQAENEQELLAISALRRCLELKPDNRTALMALAVSFTNESLQRQACETLR
                     DWLRYSPAYAHLVAPGEEGASGAGLGPSKRVLGSLLSDSLFLEVKELFLAAVRLDPTS
                     IDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVA
                     AYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQRKSRGPRGEGGAMSE
                     NIWSTLRLALSMLGQSDAYGAADARDLPALLTMFGLPQ"
     exon            354..389
                     /gene="Pex5"
                     /gene_synonym="PTS1-BP; PTS1R"
                     /inference="alignment:Splign:2.1.0"
     exon            390..522
                     /gene="Pex5"
                     /gene_synonym="PTS1-BP; PTS1R"
                     /inference="alignment:Splign:2.1.0"
     exon            523..654
                     /gene="Pex5"
                     /gene_synonym="PTS1-BP; PTS1R"
                     /inference="alignment:Splign:2.1.0"
     exon            655..760
                     /gene="Pex5"
                     /gene_synonym="PTS1-BP; PTS1R"
                     /inference="alignment:Splign:2.1.0"
     exon            761..851
                     /gene="Pex5"
                     /gene_synonym="PTS1-BP; PTS1R"
                     /inference="alignment:Splign:2.1.0"
     exon            852..947
                     /gene="Pex5"
                     /gene_synonym="PTS1-BP; PTS1R"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1067
                     /gene="Pex5"
                     /gene_synonym="PTS1-BP; PTS1R"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1211
                     /gene="Pex5"
                     /gene_synonym="PTS1-BP; PTS1R"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1282
                     /gene="Pex5"
                     /gene_synonym="PTS1-BP; PTS1R"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1495
                     /gene="Pex5"
                     /gene_synonym="PTS1-BP; PTS1R"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1661
                     /gene="Pex5"
                     /gene_synonym="PTS1-BP; PTS1R"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1819
                     /gene="Pex5"
                     /gene_synonym="PTS1-BP; PTS1R"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..3171
                     /gene="Pex5"
                     /gene_synonym="PTS1-BP; PTS1R"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgtttccg ttgagctggg ccgcagcgcc gcggtccagg cccctttaag gccgagtccc
       61 tcccccttgc tcccgccccc tcccctcccc cagcccaccc caggtactcc ggccggccgg
      121 acggtgcgac cagcggcggt gatctttgga gcctaggggg cgcgggtccg ggcaagtccc
      181 cgccgctgcg ggagctggtg gtcaccatgg caatgcggga gctggtggag agcgaatgtg
      241 ggggtgccaa cccgctgatg aagctggcca cccacttcac ccaggacaag gcccttcggc
      301 aggagggact gaggcctggc ccctggcctc caggagcctc agcggcggaa acggtttcca
      361 agcctttggg agtaggcact gaagatgagt tggtggcaga attcctgcag gaccagaatg
      421 caactcttgt atcccgagcc cctcagacct tcaagatgga tgacctcttg gcggagatgc
      481 aggagattga acagtcaaac tttcgccagg ctcctcagag agcccctggt gtggcagact
      541 tggctttgtc tgagaattgg gcccaggagt ttcttgccgc tggagatgct gtggatgtag
      601 ctcaggatta taacgagacc gactggtccc aagaattcat cgccgaagtc acggaccctc
      661 tgtctgtgtc cccagcccga tgggctgagg agtatctgga acagtctgag gagaagctgt
      721 ggttgggaga tccagaagga acctctacca ctgaccgatg gtacgatgaa taccatcctg
      781 aggaggatct gcagcacaca gccagtgact ttgtgtccaa ggtggacgac cccaaattgg
      841 ctaactctga gggcacatcg gaggcctggg ttgatcagtt cacaagacca ggaaacaaac
      901 tggctgctct tcaggtggaa tttgaacgag ccaagtcagc tatagagtca gacgtcgatt
      961 tctgggacaa gttgcaggca gagttggagg agatggcaaa acgggatgct gaggcgcacc
     1021 cctggctttc tgactatgac gacctcacgt ctgcttccta tgacaagggc taccagtttg
     1081 aggaggagaa tcccttgcgt gaccaccctc agccttttga agaagggctg cgtcgacttg
     1141 aggagggaga cctgcccaat gctgtgctgc tcttcgaggc tgcggtgcag caggatccta
     1201 agcacatgga ggcctggcag tacctgggca ccactcaggc tgagaacgag caagagctct
     1261 tggccatcag tgccctgcgc aggtgtctgg agctaaagcc agataaccgg acagcactga
     1321 tggcgctggc tgtaagcttc accaatgagt ccctgcagcg gcaagcctgt gagacgctgc
     1381 gggactggct gcgctactca ccggcctacg ctcacctggt ggctcctggt gaagaagggg
     1441 ctagtggggc aggactgggt cccagcaagc gcgtcttggg atctctgttg tctgactccc
     1501 tgtttcttga agtaaaagaa ctcttcctgg cagctgtgcg tctggaccct acatccattg
     1561 accctgacgt gcagtgtggc ctgggagtcc tcttcaacct gagtggggag tacgacaagg
     1621 ctgtggactg tttcacggct gccctcagtg tccgccccaa tgactatttg ctgtggaaca
     1681 agcttggggc caccctggcc aacgggaacc agagtgaaga agcagtggct gcttaccgca
     1741 gagcccttga actacagcct gggtacatcc gctcccgcta caacctaggc atcagctgca
     1801 tcaaccttgg ggctcaccgt gaggccgtgg aacactttct ggaggccctg aacatgcaga
     1861 ggaagagccg gggccctcgg ggtgaggggg gcgccatgtc tgagaacatc tggagtactc
     1921 tgcggttggc attgtccatg ctaggccaga gtgatgccta tggggcagcc gatgctcggg
     1981 acctgcctgc ccttctaact atgtttggcc tgccccagtg acagtgggat gggctgccct
     2041 gtgagtgtct gcttggaggg gtccgagctc agggtgtgat tccctctcct caaatgggcc
     2101 taccaagggg gtgggctgat gaccataagc ggtacgacct ctcaggagct gcctcagcgt
     2161 aggggtgcat agctgtgtct taggtcctac ttaattgtag ggacgagctg tctctgtcct
     2221 tggtaattca agggctgtat atccagctac agatcctttt ctgttcatca tgccctttct
     2281 tggtgctgct ttttgggtag gacccactga cataggggaa ttgtcatcag ccgccatttc
     2341 tgatagggtc tgccacattt gtacgtctct ccttgcccta ctctttctgg gaattggcaa
     2401 tagtccagct tccctgggca gttgtgtgta agaggttccc ctgagcatgt gtgatgccga
     2461 ctgggacaga tgttagagtt ggtctgctca ctgaaatggt gatccggctt acggtcgaac
     2521 ttgggacaat tgctcacagt tccgtcactc ctgggagtga ccttggatcc tctgtgggtg
     2581 gacactgaag cagtgatgct aatgtggtta ctgtagtgtc ctcagggcca gggcttgtca
     2641 cgcaggcgcc atggcctgtg agggagggat gttcagttgt ggaatgagcc cagagtcagg
     2701 tgggacagtc gtggtgtggt cagtcctgca atcctctctt cttcttggga gccttggaag
     2761 taggaactga acaaactctt gtagcaaact ggttcagaag ttgcattctt gccaaattcc
     2821 ccagggttca gtgttaccat aagccttctt gaaacattta taggggatat cattgaaaat
     2881 cccctccccc tgtattcatt acctccacaa ggtgaagatg aagtgatact gagggagtgg
     2941 ctggagacgt ctccactgtt ttctgtgtgg ggagacgcgc agactcccac aaatgactgc
     3001 taagcctctt accttgtctt cagtagctaa tgatcagaat ttttttttaa actgccatgg
     3061 tcccaaagtt ccatcctgaa atttattttt ctttgtatgc atatgtgtaa atgatttaaa
     3121 aataaaactg taaaatattt gtatgaagaa taaactggac tgatgtgggt aaaaaaaaaa
     3181 aaaaaaaaaa aaaaaaa
//
