LOCUS       NM_017234               1504 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus peroxisomal biogenesis factor 2 (Pex2),
            transcript variant 1, mRNA.
ACCESSION   NM_017234 XM_006232160
VERSION     NM_017234.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1504)
  AUTHORS   Sargent,G., van Zutphen,T., Shatseva,T., Zhang,L., Di Giovanni,V.,
            Bandsma,R. and Kim,P.K.
  TITLE     PEX2 is the E3 ubiquitin ligase required for pexophagy during
            starvation
  JOURNAL   J Cell Biol 214 (6), 677-690 (2016)
   PUBMED   27597759
REFERENCE   2  (bases 1 to 1504)
  AUTHORS   Okumoto,K., Misono,S., Miyata,N., Matsumoto,Y., Mukai,S. and
            Fujiki,Y.
  TITLE     Cysteine ubiquitination of PTS1 receptor Pex5p regulates Pex5p
            recycling
  JOURNAL   Traffic 12 (8), 1067-1083 (2011)
   PUBMED   21554508
REFERENCE   3  (bases 1 to 1504)
  AUTHORS   Bharti,P., Schliebs,W., Schievelbusch,T., Neuhaus,A., David,C.,
            Kock,K., Herrmann,C., Meyer,H.E., Wiese,S., Warscheid,B., Theiss,C.
            and Erdmann,R.
  TITLE     PEX14 is required for microtubule-based peroxisome motility in
            human cells
  JOURNAL   J Cell Sci 124 (Pt 10), 1759-1768 (2011)
   PUBMED   21525035
REFERENCE   4  (bases 1 to 1504)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 1504)
  AUTHORS   Grou,C.P., Carvalho,A.F., Pinto,M.P., Huybrechts,S.J.,
            Sa-Miranda,C., Fransen,M. and Azevedo,J.E.
  TITLE     Properties of the ubiquitin-pex5p thiol ester conjugate
  JOURNAL   J Biol Chem 284 (16), 10504-10513 (2009)
   PUBMED   19208625
REFERENCE   6  (bases 1 to 1504)
  AUTHORS   Faust,P.L. and Hatten,M.E.
  TITLE     Targeted deletion of the PEX2 peroxisome assembly gene in mice
            provides a model for Zellweger syndrome, a human neuronal migration
            disorder
  JOURNAL   J Cell Biol 139 (5), 1293-1305 (1997)
   PUBMED   9382874
REFERENCE   7  (bases 1 to 1504)
  AUTHORS   Baes,M., Gressens,P., Baumgart,E., Carmeliet,P., Casteels,M.,
            Fransen,M., Evrard,P., Fahimi,D., Declercq,P.E., Collen,D., van
            Veldhoven,P.P. and Mannaerts,G.P.
  TITLE     A mouse model for Zellweger syndrome
  JOURNAL   Nat Genet 17 (1), 49-57 (1997)
   PUBMED   9288097
REFERENCE   8  (bases 1 to 1504)
  AUTHORS   Tsukamoto,T., Shimozawa,N. and Fujiki,Y.
  TITLE     Peroxisome assembly factor 1: nonsense mutation in a
            peroxisome-deficient Chinese hamster ovary cell mutant and deletion
            analysis
  JOURNAL   Mol Cell Biol 14 (8), 5458-5465 (1994)
   PUBMED   8035823
REFERENCE   9  (bases 1 to 1504)
  AUTHORS   Shimozawa,N., Tsukamoto,T., Suzuki,Y., Orii,T., Shirayoshi,Y.,
            Mori,T. and Fujiki,Y.
  TITLE     A human gene responsible for Zellweger syndrome that affects
            peroxisome assembly
  JOURNAL   Science 255 (5048), 1132-1134 (1992)
   PUBMED   1546315
REFERENCE   10 (bases 1 to 1504)
  AUTHORS   Tsukamoto,T., Miura,S. and Fujiki,Y.
  TITLE     Restoration by a 35K membrane protein of peroxisome assembly in a
            peroxisome-deficient mammalian cell mutant
  JOURNAL   Nature 350 (6313), 77-81 (1991)
   PUBMED   1750930
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM104606.1, FM078955.1 and JAXUCZ010000002.1.
            
            On or before Nov 25, 2020 this sequence version replaced
            XM_006232160.3, NM_017234.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063169.1, FQ219520.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                FM104606.1         1-29
            30-553              FM078955.1         11-534
            554-1504            JAXUCZ010000002.1  97972817-97973767
FEATURES             Location/Qualifiers
     source          1..1504
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q23"
     gene            1..1504
                     /gene="Pex2"
                     /gene_synonym="Pxmp3"
                     /note="peroxisomal biogenesis factor 2"
                     /db_xref="GeneID:29534"
                     /db_xref="RGD:61814"
     exon            1..134
                     /gene="Pex2"
                     /gene_synonym="Pxmp3"
                     /inference="alignment:Splign:2.1.0"
     exon            135..244
                     /gene="Pex2"
                     /gene_synonym="Pxmp3"
                     /inference="alignment:Splign:2.1.0"
     exon            245..1504
                     /gene="Pex2"
                     /gene_synonym="Pxmp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..1179
                     /gene="Pex2"
                     /gene_synonym="Pxmp3"
                     /EC_number="2.3.2.27"
                     /EC_number="2.3.2.36"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peroxisomal membrane protein 3, 35 kDa; peroxisome
                     assembly factor 1; PAF-1; peroxin-2; peroxisome biogenesis
                     factor 2"
                     /codon_start=1
                     /product="peroxisome biogenesis factor 2 isoform 1"
                     /protein_id="NP_058930.2"
                     /db_xref="GeneID:29534"
                     /db_xref="RGD:61814"
                     /translation="MAAREESTQSANRVLRISQLDALELNKALEQLVWSQFTQCFHGF
                     KPGLLARFEPEVKAFLWLFLWRFTIYSKNATVGQSVLNIQYKNDSSPNPVYQPPSKNQ
                     KLLYAVCTIGGRWLEERCYDLFRNRHLASFGKAKQCMNFVVGLLKLGELMNFLIFLQK
                     GKFATLTERLLGIHSVFCKPQSMREVGFEYMNRELLWHGFAEFLVFLLPLINIQKLKA
                     KLSSWCIPLTSTAGSDSTLGSSGKECALCGEWPTMPHTIGCEHVFCYYCVKSSFLFDM
                     YFTCPKCGTEVHSVQPLKSGIEMSEVNAL"
ORIGIN      
        1 ggtcttccgt cgttccggaa gcccgcgaat tccggaagcg agggctaccc agattcggct
       61 aggaaaagcc cagcttgcca gagaatgttt gagaaaagtt tgcgcggcgc tggtgtgttc
      121 cgcagaccct gcagctcttg acaagtatga ggcaaaagcc tcttgaagca gatgtgcagc
      181 agaattctcc accacctttt gataggccgc tgagtgctga ggggaccaca ggatccaagg
      241 aaagacagca tcagagaaga tatggctgcc agagaagaga gtacacaaag tgccaacaga
      301 gtgctgagga taagtcagct ggatgcactg gaactgaata aggccctgga gcagctcgtg
      361 tggtcccagt ttactcagtg ttttcatgga tttaagccag gactgttagc tcgctttgag
      421 ccagaagtga aagcatttct gtggcttttc ctgtggaggt tcaccatcta ttccaaaaat
      481 gccactgtgg ggcagtcggt tttaaatatt cagtacaaaa atgattcttc tcccaaccca
      541 gtataccaac caccaagtaa aaatcagaaa ctgttgtatg ctgtgtgcac tattgggggg
      601 aggtggttag aagaacgatg ttacgatttg tttcgaaacc gacatttagc atctttcggg
      661 aaagccaaac agtgcatgaa ttttgtggtt ggacttttaa aattaggtga gttgatgaac
      721 ttcttgattt ttctacaaaa aggaaagttt gcaactttga cagaacgcct ccttggcatt
      781 cattctgtat tttgcaagcc ccagagcatg cgtgaagttg gcttcgagta catgaatagg
      841 gaacttctct ggcatggctt tgccgaattt ctggttttcc tcttaccgct catcaatatc
      901 cagaagttga aagccaagtt gtcttcctgg tgcatccccc ttaccagcac tgctggtagt
      961 gacagtacac taggcagcag tggaaaagag tgtgctctat gtggagagtg gcccacaatg
     1021 cctcatacta ttggatgtga gcatgtattt tgttactact gtgttaagag tagcttccta
     1081 tttgacatgt actttacgtg ccctaagtgt ggcacagaag tgcacagtgt gcagccactg
     1141 aaatcaggaa ttgaaatgtc agaagtgaat gctctttaga aaccaagttg tttcctctga
     1201 ggaaagtgta ttgtatccaa ttccttggaa ttcgtcatct tcagtgtcat ctgtaggtgg
     1261 cttttagcag gagtgtgctg tgcggccact ctcttccttt ccaagcacaa ctcagttcta
     1321 atcactggaa accaagtgat tctagagaat cttataaatc ctcatgttat tttttgatcc
     1381 ctaatacaat ttttaatgtc aagaataatg gaaaattttg tcagatgaat actaagaatg
     1441 actaagaatg ctccttcata gaaaaaggtc agactctaaa aataaaacat ttttgaggct
     1501 ctgg
//
