LOCUS       NM_001107375            2327 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus peroxisomal biogenesis factor 19 (Pex19),
            transcript variant 1, mRNA.
ACCESSION   NM_001107375 XM_001057306 XM_001057359 XM_001057414 XM_225711
VERSION     NM_001107375.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2327)
  AUTHORS   Kinoshita,N., Matsuura,A. and Fujiki,Y.
  TITLE     Peroxisome biogenesis: a novel inducible PEX19 splicing variant is
            involved in early stages of peroxisome proliferation
  JOURNAL   J Biochem 161 (3), 297-308 (2017)
   PUBMED   28391327
  REMARK    GeneRIF: The PEX19i most likely plays important roles involving the
            membrane formation at early stages, in prompt response to
            peroxisome proliferation. Similar types of PEX19 mRNA variants were
            also elevated in mouse regenerating liver.
REFERENCE   2  (bases 1 to 2327)
  AUTHORS   Bharti,P., Schliebs,W., Schievelbusch,T., Neuhaus,A., David,C.,
            Kock,K., Herrmann,C., Meyer,H.E., Wiese,S., Warscheid,B., Theiss,C.
            and Erdmann,R.
  TITLE     PEX14 is required for microtubule-based peroxisome motility in
            human cells
  JOURNAL   J Cell Sci 124 (Pt 10), 1759-1768 (2011)
   PUBMED   21525035
REFERENCE   3  (bases 1 to 2327)
  AUTHORS   Pinto,M.P., Grou,C.P., Fransen,M., Sa-Miranda,C. and Azevedo,J.E.
  TITLE     The cytosolic domain of PEX3, a protein involved in the biogenesis
            of peroxisomes, binds membrane lipids
  JOURNAL   Biochim Biophys Acta 1793 (11), 1669-1675 (2009)
   PUBMED   19715730
REFERENCE   4  (bases 1 to 2327)
  AUTHORS   Neufeld,C., Filipp,F.V., Simon,B., Neuhaus,A., Schuller,N.,
            David,C., Kooshapur,H., Madl,T., Erdmann,R., Schliebs,W.,
            Wilmanns,M. and Sattler,M.
  TITLE     Structural basis for competitive interactions of Pex14 with the
            import receptors Pex5 and Pex19
  JOURNAL   EMBO J 28 (6), 745-754 (2009)
   PUBMED   19197237
REFERENCE   5  (bases 1 to 2327)
  AUTHORS   Matsuzaki,T. and Fujiki,Y.
  TITLE     The peroxisomal membrane protein import receptor Pex3p is directly
            transported to peroxisomes by a novel Pex19p- and Pex16p-dependent
            pathway
  JOURNAL   J Cell Biol 183 (7), 1275-1286 (2008)
   PUBMED   19114594
REFERENCE   6  (bases 1 to 2327)
  AUTHORS   Biermanns,M. and Gartner,J.
  TITLE     Targeting elements in the amino-terminal part direct the human
            70-kDa peroxisomal integral membrane protein (PMP70) to peroxisomes
  JOURNAL   Biochem Biophys Res Commun 285 (3), 649-655 (2001)
   PUBMED   11453642
REFERENCE   7  (bases 1 to 2327)
  AUTHORS   Jones,J.M., Morrell,J.C. and Gould,S.J.
  TITLE     Multiple distinct targeting signals in integral peroxisomal
            membrane proteins
  JOURNAL   J Cell Biol 153 (6), 1141-1150 (2001)
   PUBMED   11402059
REFERENCE   8  (bases 1 to 2327)
  AUTHORS   Sacksteder,K.A., Jones,J.M., South,S.T., Li,X., Liu,Y. and
            Gould,S.J.
  TITLE     PEX19 binds multiple peroxisomal membrane proteins, is
            predominantly cytoplasmic, and is required for peroxisome membrane
            synthesis
  JOURNAL   J Cell Biol 148 (5), 931-944 (2000)
   PUBMED   10704444
REFERENCE   9  (bases 1 to 2327)
  AUTHORS   Matsuzono,Y., Kinoshita,N., Tamura,S., Shimozawa,N., Hamasaki,M.,
            Ghaedi,K., Wanders,R.J., Suzuki,Y., Kondo,N. and Fujiki,Y.
  TITLE     Human PEX19: cDNA cloning by functional complementation, mutation
            analysis in a patient with Zellweger syndrome, and potential role
            in peroxisomal membrane assembly
  JOURNAL   Proc Natl Acad Sci U S A 96 (5), 2116-2121 (1999)
   PUBMED   10051604
REFERENCE   10 (bases 1 to 2327)
  AUTHORS   Kammerer,S., Arnold,N., Gutensohn,W., Mewes,H.W., Kunau,W.H.,
            Hofler,G., Roscher,A.A. and Braun,A.
  TITLE     Genomic organization and molecular characterization of a gene
            encoding HsPXF, a human peroxisomal farnesylated protein
  JOURNAL   Genomics 45 (1), 200-210 (1997)
   PUBMED   9339377
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB718412.1, CK600534.1, CO573662.1, BF543157.1, AI712677.1 and
            CK838542.1.
            
            On Sep 5, 2008 this sequence version replaced NM_001107375.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FN802327.1, SRR8487231.156072.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                CB718412.1         14-33
            21-696              CK600534.1         15-690
            697-1350            CO573662.1         1-654
            1351-1556           BF543157.1         208-413
            1557-1918           AI712677.1         16-377              c
            1919-2327           CK838542.1         1-409               c
FEATURES             Location/Qualifiers
     source          1..2327
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..2327
                     /gene="Pex19"
                     /gene_synonym="PxF"
                     /note="peroxisomal biogenesis factor 19"
                     /db_xref="GeneID:289233"
                     /db_xref="RGD:1306913"
     exon            1..96
                     /gene="Pex19"
                     /gene_synonym="PxF"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..926
                     /gene="Pex19"
                     /gene_synonym="PxF"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peroxin-19; peroxisomal farnesylated protein; peroxisome
                     biogenesis factor 19"
                     /codon_start=1
                     /product="peroxisomal biogenesis factor 19 isoform 1"
                     /protein_id="NP_001100845.1"
                     /db_xref="GeneID:289233"
                     /db_xref="RGD:1306913"
                     /translation="MAAAEGGCGAGVEADRELEELLESALDDFDKAKPSPAPSPTISA
                     PDASGPQKRSPGDTAKDALFASQEKFFQELFDSELASQATAEFEKAMKELAEEEPHLV
                     EQFQKLSEAAGRVGSDASSQQEFTSCLKETLSGLAKNATDLQNAGMSEEELTKAMEGL
                     GMDEGDGEGNILPIMQSLMQNLLSKDVLYPSLKEITEKYPEWLQSHQESIPPEQFEKY
                     QQQHSVMGKICEQFEAETPTDSEATHRARFEAVLDLMQQLQDLGHPPKELAGEMPPGL
                     NFDLDALNLSGPPGANGEQCLIM"
     exon            97..206
                     /gene="Pex19"
                     /gene_synonym="PxF"
                     /inference="alignment:Splign:2.1.0"
     exon            207..372
                     /gene="Pex19"
                     /gene_synonym="PxF"
                     /inference="alignment:Splign:2.1.0"
     exon            373..458
                     /gene="Pex19"
                     /gene_synonym="PxF"
                     /inference="alignment:Splign:2.1.0"
     exon            459..620
                     /gene="Pex19"
                     /gene_synonym="PxF"
                     /inference="alignment:Splign:2.1.0"
     exon            621..797
                     /gene="Pex19"
                     /gene_synonym="PxF"
                     /inference="alignment:Splign:2.1.0"
     exon            798..842
                     /gene="Pex19"
                     /gene_synonym="PxF"
                     /inference="alignment:Splign:2.1.0"
     exon            843..2310
                     /gene="Pex19"
                     /gene_synonym="PxF"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcctacggca agtcggaggc agcaagatgg cggctgctga aggaggttgc ggtgctgggg
       61 tcgaagcgga ccgggaattg gaggagcttt tggaaagtgc tcttgatgat tttgataaag
      121 ccaaaccctc cccagcaccc tctcctacca tctcggcccc cgatgcttca gggccccaga
      181 agagatcgcc aggagacact gccaaagatg ctctctttgc ctcccaagag aaatttttcc
      241 aggaactgtt cgacagtgag ctggcttccc aagccaccgc agagtttgag aaggcaatga
      301 aggagctggc tgaggaagag ccccatctgg tggagcagtt ccagaagctc tcagaggcag
      361 ctgggagagt gggcagcgat gcaagttctc aacaagaatt tacttcttgc ctaaaggaga
      421 cattaagtgg gctagccaaa aatgccactg accttcagaa cgcaggcatg tctgaagaag
      481 aactgacaaa agccatggaa gggctgggca tggatgaagg agacggggaa gggaacattc
      541 tccccatcat gcagagcctc atgcagaacc tcttgtctaa ggatgtattg tatccatccc
      601 tgaaggagat caccgaaaag tatccagaat ggctacagag tcaccaggag tctattcccc
      661 cagagcagtt tgagaagtat cagcagcagc acagtgtcat gggcaaaatc tgcgagcagt
      721 tcgaggcaga gacgcccaca gacagcgagg ctactcacag ggctcgcttt gaggcggtac
      781 tcgatcttat gcagcagtta caggacttgg gccaccctcc gaaagagctg gctggggaga
      841 tgcctcctgg cctcaacttt gacctggatg ccctcaatct atcgggccca ccaggtgcta
      901 atggcgaaca gtgtctgatc atgtgaaaca caacacggtt tcctccctga gtcccagcca
      961 tggggaacat ctggaatcaa cagagtcact gggaactgag gcaggagtat catctgtggg
     1021 agctgctgcc ccacactctc tacatcccat tcaagactgt gccataccag ctgaggacct
     1081 gttgtaggcc ttttctatga gccctactcc attatggtgt ctgctgttag aaacgggcca
     1141 attatttgct aggtgaagga aggcatccct tgtggggcat tttacttctt cccactctcc
     1201 aaaataatgt tacatgtggt ggtactcatg ttccccttga ttcccaggga ctttgtgcct
     1261 tgtttctact ccctcccttg tgtctgggag caagagctaa gtcctaagac tgcgcttctc
     1321 ttaggcaggg cctctgggaa tgaggagaaa agtagcctgg gtggggctgg aggcttgtca
     1381 cagtatctgc tagccttctt ttggaattct ccgaagggaa aggaattttg cacttagtca
     1441 gcaggttgaa agcaaagcct tgggcatttc ctgtccttag gtgctgcgcc ctaattcccc
     1501 tttcctcctg agagctcaag ttgataccct ggttctttct acaactccat gatttagggg
     1561 accccccgct cttgactttg ctttgcccca tgactatcct tacctcctct ctttagagtc
     1621 ttatttattc tgctcttttt aactagggct gtgatggatg gaggctaatc ttgtttcctt
     1681 tcatctagta cctggaccat tctcactaga cccttctctg cctctttggc caacacatac
     1741 ttgtggtgtc agatctggta catgaatggc cattctaccc agatagattt tggtttattt
     1801 aagacatcag attccctaga atccttggtt caggaaggcg cttgggaaag gggtgtagcc
     1861 agattctttt ttttcctgca agccccatgg ggcagtgtcc aataaatatt ctgacgagcg
     1921 tgtgggctgt ttttcatcca ggtctattct actcttcctc agtttgtgta ggctgctagg
     1981 gaagagtgag agatgtcaga agagttgtgt gtggtggtga tgttaggtct gccacgaccc
     2041 agccctcccg ctcaggttgc actttcagca aaagaatact gtcttcatct ccttggtact
     2101 tcagtcttaa ctctttacaa gataattgat gctaatgata tattgttaac atgttttcta
     2161 aattacctaa ctttgaattg agctgccttt tcacagtggg gttaaggacc atggttgcca
     2221 tgtagtttat ggatattctt tttaggtcac ctagctgtcc tggttcacct ggaaaataac
     2281 gttttaaaaa tatatttttt atttatttta aaaaaaaaaa aaaaaaa
//
