LOCUS       NM_001012088            1236 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus peroxisomal biogenesis factor 16 (Pex16), mRNA.
ACCESSION   NM_001012088 XM_006234567 XM_242072
VERSION     NM_001012088.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1236)
  AUTHORS   Yonekawa,S., Furuno,A., Baba,T., Fujiki,Y., Ogasawara,Y.,
            Yamamoto,A., Tagaya,M. and Tani,K.
  TITLE     Sec16B is involved in the endoplasmic reticulum export of the
            peroxisomal membrane biogenesis factor peroxin 16 (Pex16) in
            mammalian cells
  JOURNAL   Proc Natl Acad Sci U S A 108 (31), 12746-12751 (2011)
   PUBMED   21768384
REFERENCE   2  (bases 1 to 1236)
  AUTHORS   Bharti,P., Schliebs,W., Schievelbusch,T., Neuhaus,A., David,C.,
            Kock,K., Herrmann,C., Meyer,H.E., Wiese,S., Warscheid,B., Theiss,C.
            and Erdmann,R.
  TITLE     PEX14 is required for microtubule-based peroxisome motility in
            human cells
  JOURNAL   J Cell Sci 124 (Pt 10), 1759-1768 (2011)
   PUBMED   21525035
REFERENCE   3  (bases 1 to 1236)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 1236)
  AUTHORS   Toro,A.A., Araya,C.A., Cordova,G.J., Arredondo,C.A., Cardenas,H.G.,
            Moreno,R.E., Venegas,A., Koenig,C.S., Cancino,J., Gonzalez,A. and
            Santos,M.J.
  TITLE     Pex3p-dependent peroxisomal biogenesis initiates in the endoplasmic
            reticulum of human fibroblasts
  JOURNAL   J Cell Biochem 107 (6), 1083-1096 (2009)
   PUBMED   19479899
REFERENCE   5  (bases 1 to 1236)
  AUTHORS   Matsuzaki,T. and Fujiki,Y.
  TITLE     The peroxisomal membrane protein import receptor Pex3p is directly
            transported to peroxisomes by a novel Pex19p- and Pex16p-dependent
            pathway
  JOURNAL   J Cell Biol 183 (7), 1275-1286 (2008)
   PUBMED   19114594
REFERENCE   6  (bases 1 to 1236)
  AUTHORS   Fransen,M., Vastiau,I., Brees,C., Brys,V., Mannaerts,G.P. and Van
            Veldhoven,P.P.
  TITLE     Analysis of human Pex19p's domain structure by pentapeptide
            scanning mutagenesis
  JOURNAL   J Mol Biol 346 (5), 1275-1286 (2005)
   PUBMED   15713480
REFERENCE   7  (bases 1 to 1236)
  AUTHORS   Kikuchi,M., Hatano,N., Yokota,S., Shimozawa,N., Imanaka,T. and
            Taniguchi,H.
  TITLE     Proteomic analysis of rat liver peroxisome: presence of
            peroxisome-specific isozyme of Lon protease
  JOURNAL   J Biol Chem 279 (1), 421-428 (2004)
   PUBMED   14561759
REFERENCE   8  (bases 1 to 1236)
  AUTHORS   Honsho,M., Hiroshige,T. and Fujiki,Y.
  TITLE     The membrane biogenesis peroxin Pex16p. Topogenesis and functional
            roles in peroxisomal membrane assembly
  JOURNAL   J Biol Chem 277 (46), 44513-44524 (2002)
   PUBMED   12223482
REFERENCE   9  (bases 1 to 1236)
  AUTHORS   South,S.T. and Gould,S.J.
  TITLE     Peroxisome synthesis in the absence of preexisting peroxisomes
  JOURNAL   J Cell Biol 144 (2), 255-266 (1999)
   PUBMED   9922452
REFERENCE   10 (bases 1 to 1236)
  AUTHORS   Honsho,M., Tamura,S., Shimozawa,N., Suzuki,Y., Kondo,N. and
            Fujiki,Y.
  TITLE     Mutation in PEX16 is causal in the peroxisome-deficient Zellweger
            syndrome of complementation group D
  JOURNAL   Am J Hum Genet 63 (6), 1622-1630 (1998)
   PUBMED   9837814
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On or before Dec 1, 2020 this sequence version replaced
            XM_006234567.3, NM_001012088.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.1715107.1,
                                           SRR22399481.480395.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               JAXUCZ010000003.1  98802745-98802952
            209-244             JAXUCZ010000003.1  98803148-98803183
            245-321             JAXUCZ010000003.1  98803915-98803991
            322-455             JAXUCZ010000003.1  98804328-98804461
            456-556             JAXUCZ010000003.1  98804592-98804692
            557-637             JAXUCZ010000003.1  98805478-98805558
            638-790             JAXUCZ010000003.1  98805681-98805833
            791-863             JAXUCZ010000003.1  98805919-98805991
            864-983             JAXUCZ010000003.1  98806117-98806236
            984-1048            JAXUCZ010000003.1  98807340-98807404
            1049-1236           JAXUCZ010000003.1  98807904-98808091
FEATURES             Location/Qualifiers
     source          1..1236
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..1236
                     /gene="Pex16"
                     /note="peroxisomal biogenesis factor 16"
                     /db_xref="GeneID:311203"
                     /db_xref="RGD:1311372"
     exon            1..208
                     /gene="Pex16"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1107
                     /gene="Pex16"
                     /note="peroxisome biogenesis factor 16"
                     /codon_start=1
                     /product="peroxisomal biogenesis factor 16"
                     /protein_id="NP_001012088.2"
                     /db_xref="GeneID:311203"
                     /db_xref="RGD:1311372"
                     /translation="MEKLRLLGLRYQEYVTRHPAATAQLETAVRGLSYLLAGRFSDSH
                     ELSELVYSASNLLVLLNDGILRKELRKKLPVSLSQQKLLTWLSVLECVEVFMEMGAAK
                     VWGEVGRWLVIALIQLAKAVLRMFLLIWFKTGIQTSPPIVPLDRETQAQPLDGDHNLG
                     SPEPSYVGKRSNRVVRTLQNSPSLHSRHWGAPQQREIRQKQQQEELSTPPTPLGLQET
                     IAESLYIARPLLHLLSLGLWGQRSWAPWLLSGVVDMTSLSLLSDRKNLTRRERLELRR
                     RTILLLYYLLRSPFYDRFSEAKILFLLQLLADHIPGIGLVARPLMDYLPSWQKIYFYS
                     WG"
     exon            209..244
                     /gene="Pex16"
                     /inference="alignment:Splign:2.1.0"
     exon            245..321
                     /gene="Pex16"
                     /inference="alignment:Splign:2.1.0"
     exon            322..455
                     /gene="Pex16"
                     /inference="alignment:Splign:2.1.0"
     exon            456..556
                     /gene="Pex16"
                     /inference="alignment:Splign:2.1.0"
     exon            557..637
                     /gene="Pex16"
                     /inference="alignment:Splign:2.1.0"
     exon            638..790
                     /gene="Pex16"
                     /inference="alignment:Splign:2.1.0"
     exon            791..863
                     /gene="Pex16"
                     /inference="alignment:Splign:2.1.0"
     exon            864..983
                     /gene="Pex16"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1048
                     /gene="Pex16"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1236
                     /gene="Pex16"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcctagggc cggaagcagg aaggagggct caggacgcag ggcgccgctg ccagcagtgc
       61 tgtcggccgg tgggacttgt cggtggccag agcaggatgg agaagctgcg gcttctgggc
      121 ctacgctacc aggagtacgt gactcgtcat ccagccgcca cggcccagct ggagacggct
      181 gtgcggggcc tcagttacct gctggcaggt cgcttctccg attcccacga gctgtctgag
      241 ttggtgtact ctgcctctaa cctgcttgtg ctgctcaatg acgggatcct tcggaaggag
      301 cttcgaaaaa agttgcctgt gtcgctgtcc cagcagaagt tgctgacatg gctgagtgta
      361 ctggaatgtg tggaggtgtt catggagatg ggggctgcca aggtgtgggg cgaagtaggc
      421 cgttggctcg tcattgctct catccagctg gccaaggcag tcctgcgcat gttcttgctg
      481 atctggttca agactggcat tcagacatca ccccccattg tgccactgga cagggagacc
      541 caggcacagc ccttggatgg cgaccacaat ctgggcagcc cggaaccgtc atatgtggga
      601 aaacggtcaa acagagtggt gcgaaccctc cagaacagcc catccctgca ctcgaggcac
      661 tggggagccc cccagcagcg ggaaattcgg cagaaacaac agcaggagga actgagcaca
      721 cccccaacac ctctgggact gcaggagacc attgcagagt ctttgtatat cgcccggccc
      781 ctgctgcact tgctcagcct gggcttatgg ggtcagcgat cgtgggcacc ctggctcctg
      841 tctggtgtgg tggatatgac tagcctgagt ctcctgagcg acaggaagaa cttgacccgg
      901 agggagcggc tggaactgag gcgccgcaca atcctgctgc tgtactacct attgcgctca
      961 ccgttctatg accgcttctc tgaagccaag atcctcttcc tgcttcagct gcttgcagac
     1021 cacatccctg gcattggcct ggtggcaagg ccactcatgg actacctgcc ctcctggcag
     1081 aaaatatatt tctacagttg gggctgacag gcacgcagga gctggtccag agtgggccac
     1141 gtggtgtgct ctgttgctct gagcagggcc tttctcagcc ctccaattcc cccccaggcc
     1201 cctcttctct aataaaagtg actctggtag tatcca
//
