LOCUS       NM_172063               1903 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus peroxisomal biogenesis factor 14 (Pex14), mRNA.
ACCESSION   NM_172063
VERSION     NM_172063.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1903)
  AUTHORS   Barros-Barbosa,A., Ferreira,M.J., Rodrigues,T.A., Pedrosa,A.G.,
            Grou,C.P., Pinto,M.P., Fransen,M., Francisco,T. and Azevedo,J.E.
  TITLE     Membrane topologies of PEX13 and PEX14 provide new insights on the
            mechanism of protein import into peroxisomes
  JOURNAL   FEBS J 286 (1), 205-222 (2019)
   PUBMED   30414318
  REMARK    GeneRIF: results indicate that PEX14 is a bona fide intrinsic
            membrane protein with a Nin -Cout topology, and that PEX13 adopts a
            Nout -Cin topology, thus exposing its carboxy-terminal Src homology
            3 [SH3] domain into the organelle matrix
REFERENCE   2  (bases 1 to 1903)
  AUTHORS   Freitas,M.O., Francisco,T., Rodrigues,T.A., Alencastre,I.S.,
            Pinto,M.P., Grou,C.P., Carvalho,A.F., Fransen,M., Sa-Miranda,C. and
            Azevedo,J.E.
  TITLE     PEX5 protein binds monomeric catalase blocking its tetramerization
            and releases it upon binding the N-terminal domain of PEX14
  JOURNAL   J Biol Chem 286 (47), 40509-40519 (2011)
   PUBMED   21976670
REFERENCE   3  (bases 1 to 1903)
  AUTHORS   Bharti,P., Schliebs,W., Schievelbusch,T., Neuhaus,A., David,C.,
            Kock,K., Herrmann,C., Meyer,H.E., Wiese,S., Warscheid,B., Theiss,C.
            and Erdmann,R.
  TITLE     PEX14 is required for microtubule-based peroxisome motility in
            human cells
  JOURNAL   J Cell Sci 124 (Pt 10), 1759-1768 (2011)
   PUBMED   21525035
REFERENCE   4  (bases 1 to 1903)
  AUTHORS   Williams,C.P., Schueller,N., Thompson,C.A., van den Berg,M., Van
            Haren,S.D., Erdmann,R., Bond,C.S., Distel,B., Schliebs,W.,
            Wilmanns,M. and Stanley,W.A.
  TITLE     The Peroxisomal Targeting Signal 1 in sterol carrier protein 2 is
            autonomous and essential for receptor recognition
  JOURNAL   BMC Biochem 12, 12 (2011)
   PUBMED   21375735
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1903)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 1903)
  AUTHORS   Gavva,N.R., Wen,S.C., Daftari,P., Moniwa,M., Yang,W.M.,
            Yang-Feng,L.P., Seto,E., Davie,J.R. and Shen,C.K.
  TITLE     NAPP2, a peroxisomal membrane protein, is also a transcriptional
            corepressor
  JOURNAL   Genomics 79 (3), 423-431 (2002)
   PUBMED   11863372
REFERENCE   7  (bases 1 to 1903)
  AUTHORS   Amery,L., Mannaerts,G.P., Subramani,S., Van Veldhoven,P.P. and
            Fransen,M.
  TITLE     Identification of a novel human peroxisomal 2,4-dienoyl-CoA
            reductase related protein using the M13 phage protein VI phage
            display technology
  JOURNAL   Comb Chem High Throughput Screen 4 (7), 545-552 (2001)
   PUBMED   11669066
REFERENCE   8  (bases 1 to 1903)
  AUTHORS   Reguenga,C., Oliveira,M.E., Gouveia,A.M., Sa-Miranda,C. and
            Azevedo,J.E.
  TITLE     Characterization of the mammalian peroxisomal import machinery:
            Pex2p, Pex5p, Pex12p, and Pex14p are subunits of the same protein
            assembly
  JOURNAL   J Biol Chem 276 (32), 29935-29942 (2001)
   PUBMED   11397814
  REMARK    Erratum:[J Biol Chem. 2005 Sep 23;280(38):33096]
REFERENCE   9  (bases 1 to 1903)
  AUTHORS   Shimizu,N., Itoh,R., Hirono,Y., Otera,H., Ghaedi,K., Tateishi,K.,
            Tamura,S., Okumoto,K., Harano,T., Mukai,S. and Fujiki,Y.
  TITLE     The peroxin Pex14p. cDNA cloning by functional complementation on a
            Chinese hamster ovary cell mutant, characterization, and functional
            analysis
  JOURNAL   J Biol Chem 274 (18), 12593-12604 (1999)
   PUBMED   10212238
REFERENCE   10 (bases 1 to 1903)
  AUTHORS   Will,G.K., Soukupova,M., Hong,X., Erdmann,K.S., Kiel,J.A., Dodt,G.,
            Kunau,W.H. and Erdmann,R.
  TITLE     Identification and characterization of the human orthologue of
            yeast Pex14p
  JOURNAL   Mol Cell Biol 19 (3), 2265-2277 (1999)
   PUBMED   10022913
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB017544.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB017544.1, BC081708.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760396, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1903
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1903
                     /gene="Pex14"
                     /note="peroxisomal biogenesis factor 14"
                     /db_xref="GeneID:64460"
                     /db_xref="RGD:68336"
     exon            1..52
                     /gene="Pex14"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1147
                     /gene="Pex14"
                     /note="peroxin-14; PTS1 receptor-docking protein;
                     peroxisomal membrane anchor protein PEX14"
                     /codon_start=1
                     /product="peroxisomal membrane protein PEX14"
                     /protein_id="NP_742060.1"
                     /db_xref="GeneID:64460"
                     /db_xref="RGD:68336"
                     /translation="MASSEQAEQPNQPSSSPGSENVVPREPLIATAVKFLQNSRVRQS
                     PLATRRAFLKKKGLTDEEIDLAFQQSGTASDEPSPVGPATPVVPVQPPHLISQPYSPG
                     GSRWRDYGALAIILAGIAFGFHQLYKKYLLPLILGGREDRKQLERMAASLSELSGSVA
                     QTVTQVQTTLASVQELLRQQQQKVQELAHELAAAKATTSTNWILESQNINELKSEINS
                     LKGLLLNRRQFPPSPSAPKIPSWQIPVKSPSPSSPAAVNHHSSSDISPVSNESPSSSP
                     GKDGHSPEGSTATYRLLGPQEEGEGVMDVKGQVRMEVQGEEEKREDEEGEEDEDDDVS
                     HVDEEDVLGVQREDRRGGDGQINEQVEKLRRPEGASNESERD"
     exon            53..100
                     /gene="Pex14"
                     /inference="alignment:Splign:2.1.0"
     exon            101..185
                     /gene="Pex14"
                     /inference="alignment:Splign:2.1.0"
     exon            186..314
                     /gene="Pex14"
                     /inference="alignment:Splign:2.1.0"
     exon            315..400
                     /gene="Pex14"
                     /inference="alignment:Splign:2.1.0"
     exon            401..503
                     /gene="Pex14"
                     /inference="alignment:Splign:2.1.0"
     exon            504..601
                     /gene="Pex14"
                     /inference="alignment:Splign:2.1.0"
     exon            602..693
                     /gene="Pex14"
                     /inference="alignment:Splign:2.1.0"
     exon            694..1903
                     /gene="Pex14"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1903
                     /gene="Pex14"
                     /note="18 a nucleotides"
ORIGIN      
        1 gtcaggcctg aggaagatgg cgtcctcgga gcaggcagag cagccgaacc agcccagctc
       61 ttctccagga agtgaaaatg tggtgcctcg agagcctctg attgccacag cagtgaagtt
      121 cctacagaac tctcgggtcc ggcagagccc acttgcgacc aggagagcat ttcttaagaa
      181 gaaagggctg acagatgaag agattgacct ggctttccag cagtcgggca ctgcttccga
      241 cgagccttca cccgtgggcc cagctacccc ggtggttcct gtccagcccc ctcacctcat
      301 ttcacagcca tacagccccg gaggttcccg atggcgagat tacggtgcct tggccatcat
      361 cctggcagga attgcatttg gcttccacca gctctacaag aagtacctgc tgcccctcat
      421 cctgggaggc cgagaggacc ggaagcagct ggagaggatg gcggcgagtc tctcggaact
      481 gagtggcagt gtggcccaga cagtgactca ggtacagaca acactggcct ctgtccagga
      541 gctactgaga cagcagcagc agaaggtcca ggagctagcc catgagctgg ccgctgccaa
      601 ggctaccaca tcaaccaact ggatcctgga gtcccagaat atcaatgagc tcaagtcaga
      661 aatcaactct ctgaaaggac ttcttctgaa tcggagacag ttccctccct ccccgtcagc
      721 cccgaagatc ccctcctggc agatcccagt gaagtctccg tcaccctcca gccccgcggc
      781 cgtgaaccac cacagcagca gtgacatctc ccctgtcagc aatgagtctc cgtcctcctc
      841 tccagggaag gacggccaca gccctgaggg ctccacagcc acataccgcc tgctggggcc
      901 tcaggaagag ggggaagggg tgatggacgt caagggccag gtgaggatgg aggtgcaagg
      961 ggaggaggag aagagggagg acgaggaggg cgaggaggat gaggatgatg acgtgagcca
     1021 cgtggatgaa gaggacgtcc tcggggtaca gagggaggac agacggggcg gcgatgggca
     1081 gatcaatgag caggtagaga agctgcggcg gccagagggc gccagcaatg agagtgagcg
     1141 agactagggc tggcgcttgg ttgcccgcct tcccagtgcc ccagggcctc agaggcgggt
     1201 gggcaagagt tgtggctctg cttccatgag gggggccgga aacccaggta ggggtggggc
     1261 cgtccttccg tgcagtgtgg gctgcgtttc ttttcaccag cctcccagac aggttcccag
     1321 ccccagccac gggcccaggc cgagaactcg ggagctctgc actccagccc cctccttgac
     1381 gggtgtcttg tctaggtgtg tcctctgagt accttgacca cctgacacca tgcatggcca
     1441 gagctcatgt catttcctgc ctctgtcacc tcagtgcagg ggaactatgg cccccctcgg
     1501 tcttgctgtc tcccccactg tgccctggcc tggcttgtgg cttcttcttt gcctgttcca
     1561 atagccaggg tgccagcccc gctcttcatc tctggggctg ccagccttcc cacagccagg
     1621 tcctggctga cagatgccgc ccttgggcgc ctgtccccag cccacctgcc cgttgttttt
     1681 tataccacac gagacgtcct cgcttgctgt gtcgtggttt agctactcag tggtgaggcg
     1741 tgcttctccc tcctgcggtg gaggaggcag cagggccttc ctgaccaaca gccatgtctg
     1801 tccttcccac tgagaaacac atgttcattt acgtgatcat gtatagattt cagactataa
     1861 gataagactg tacataatgt aataaatacg agttgccata ttt
//
