LOCUS       NM_001107242            1731 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus peroxisomal biogenesis factor 13 (Pex13), mRNA.
ACCESSION   NM_001107242 XM_001062825 XM_223684
VERSION     NM_001107242.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1731)
  AUTHORS   Barros-Barbosa,A., Ferreira,M.J., Rodrigues,T.A., Pedrosa,A.G.,
            Grou,C.P., Pinto,M.P., Fransen,M., Francisco,T. and Azevedo,J.E.
  TITLE     Membrane topologies of PEX13 and PEX14 provide new insights on the
            mechanism of protein import into peroxisomes
  JOURNAL   FEBS J 286 (1), 205-222 (2019)
   PUBMED   30414318
  REMARK    GeneRIF: results indicate that PEX14 is a bona fide intrinsic
            membrane protein with a Nin -Cout topology, and that PEX13 adopts a
            Nout -Cin topology, thus exposing its carboxy-terminal Src homology
            3 [SH3] domain into the organelle matrix
REFERENCE   2  (bases 1 to 1731)
  AUTHORS   Bharti,P., Schliebs,W., Schievelbusch,T., Neuhaus,A., David,C.,
            Kock,K., Herrmann,C., Meyer,H.E., Wiese,S., Warscheid,B., Theiss,C.
            and Erdmann,R.
  TITLE     PEX14 is required for microtubule-based peroxisome motility in
            human cells
  JOURNAL   J Cell Sci 124 (Pt 10), 1759-1768 (2011)
   PUBMED   21525035
REFERENCE   3  (bases 1 to 1731)
  AUTHORS   Kaczmarek,K., Studencka,M., Meinhardt,A., Wieczerzak,K., Thoms,S.,
            Engel,W. and Grzmil,P.
  TITLE     Overexpression of peroxisomal testis-specific 1 protein induces
            germ cell apoptosis and leads to infertility in male mice
  JOURNAL   Mol Biol Cell 22 (10), 1766-1779 (2011)
   PUBMED   21460186
REFERENCE   4  (bases 1 to 1731)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 1731)
  AUTHORS   Nenicu,A., Luers,G.H., Kovacs,W., David,M., Zimmer,A., Bergmann,M.
            and Baumgart-Vogt,E.
  TITLE     Peroxisomes in human and mouse testis: differential expression of
            peroxisomal proteins in germ cells and distinct somatic cell types
            of the testis
  JOURNAL   Biol Reprod 77 (6), 1060-1072 (2007)
   PUBMED   17881773
  REMARK    Erratum:[Biol Reprod. 2008 Feb;78(2):378. David, M [added]; Zimmer,
            Andreas [added]]
REFERENCE   6  (bases 1 to 1731)
  AUTHORS   Maxwell,M., Bjorkman,J., Nguyen,T., Sharp,P., Finnie,J.,
            Paterson,C., Tonks,I., Paton,B.C., Kay,G.F. and Crane,D.I.
  TITLE     Pex13 inactivation in the mouse disrupts peroxisome biogenesis and
            leads to a Zellweger syndrome phenotype
  JOURNAL   Mol Cell Biol 23 (16), 5947-5957 (2003)
   PUBMED   12897163
REFERENCE   7  (bases 1 to 1731)
  AUTHORS   Bjorkman,J., Gould,S.J. and Crane,D.I.
  TITLE     Pex13, the mouse ortholog of the human peroxisome biogenesis
            disorder PEX13 gene: gene structure, tissue expression, and
            localization of the protein to peroxisomes
  JOURNAL   Genomics 79 (2), 162-168 (2002)
   PUBMED   11829486
REFERENCE   8  (bases 1 to 1731)
  AUTHORS   Reguenga,C., Oliveira,M.E., Gouveia,A.M., Sa-Miranda,C. and
            Azevedo,J.E.
  TITLE     Characterization of the mammalian peroxisomal import machinery:
            Pex2p, Pex5p, Pex12p, and Pex14p are subunits of the same protein
            assembly
  JOURNAL   J Biol Chem 276 (32), 29935-29942 (2001)
   PUBMED   11397814
  REMARK    Erratum:[J Biol Chem. 2005 Sep 23;280(38):33096]
REFERENCE   9  (bases 1 to 1731)
  AUTHORS   Jones,J.M., Morrell,J.C. and Gould,S.J.
  TITLE     Multiple distinct targeting signals in integral peroxisomal
            membrane proteins
  JOURNAL   J Cell Biol 153 (6), 1141-1150 (2001)
   PUBMED   11402059
REFERENCE   10 (bases 1 to 1731)
  AUTHORS   Gould,S.J., Kalish,J.E., Morrell,J.C., Bjorkman,J., Urquhart,A.J.
            and Crane,D.I.
  TITLE     Pex13p is an SH3 protein of the peroxisome membrane and a docking
            factor for the predominantly cytoplasmic PTs1 receptor
  JOURNAL   J Cell Biol 135 (1), 85-95 (1996)
   PUBMED   8858165
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1 and FM088835.1.
            
            On Mar 22, 2013 this sequence version replaced NM_001107242.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.53042.1,
                                           SRR26360190.2732458.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760433,
                                           SAMEA5760475 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               JAXUCZ010000014.1  101822227-101822367 c
            142-351             JAXUCZ010000014.1  101812766-101812975 c
            352-1045            FM088835.1         1-694
            1046-1731           JAXUCZ010000014.1  101804673-101805358 c
FEATURES             Location/Qualifiers
     source          1..1731
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q22"
     gene            1..1731
                     /gene="Pex13"
                     /note="peroxisomal biogenesis factor 13"
                     /db_xref="GeneID:305581"
                     /db_xref="RGD:1310682"
     exon            1..141
                     /gene="Pex13"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1261
                     /gene="Pex13"
                     /note="peroxisome biogenesis factor 13; peroxin-13"
                     /codon_start=1
                     /product="peroxisomal membrane protein PEX13"
                     /protein_id="NP_001100712.1"
                     /db_xref="GeneID:305581"
                     /db_xref="RGD:1310682"
                     /translation="MASQPPPPPKPWETRRIPGAGPGPGPGPTFQSADLGPTLLTRPG
                     QPTLTRVPPPILPRPSQQTGGNNVNTFRPAYSSFSSGYGAYGNAFYGSYSPYSYGYNG
                     LGFNRLRVDDLPPSRFVQQAEESSRGAFQSIESIVHAFASVSMMMDATFSAVYNSFRA
                     VLDVANHFSRLKIHFTKVFSAFALVRTIRYLYRRLQWMMGLRRGSENEDLWAESEGTV
                     ACLGAEDQANNSAKSWPIFLFFAVILGGPYLIWKLLSTHSDEVTDSTNWANGEDDHVV
                     ARAEYDFAAVSDEEISFRAGDMLNLALKEQQPKVRGWLLASLDGQTTGLIPANYVKIL
                     GKRRGRKTVESSTMPKQQQSFTNPTSVKGVTTTNSLEEQEAAFESVFVETNKVAGTPD
                     STGKNGDKQDL"
     exon            142..836
                     /gene="Pex13"
                     /inference="alignment:Splign:2.1.0"
     exon            837..962
                     /gene="Pex13"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1731
                     /gene="Pex13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acccagccgt cgcagtcgct gtcctgagcc ggagcggagc aggcgagaca tggcctccca
       61 gccgccgccg cctcccaaac cctgggagac ccgccgaatt cccggggccg gccctgggcc
      121 gggccccggc cccactttcc aatctgctga cttgggccct actttattga caagacctgg
      181 acaaccaacg cttaccagag tgcctccacc tattcttccc aggccgtccc agcagacagg
      241 cggcaacaat gtgaacactt tcagacctgc ttacagttca ttctcatctg gatatggagc
      301 ctatggaaat gcgttctacg gaagctatag cccgtatagt tacggataca atggtttggg
      361 ctttaaccgc ctccgagtag atgatcttcc tcccagtagg tttgtccagc aagctgaaga
      421 aagcagcaga ggtgccttcc agtccattga gagcatcgtg catgcgtttg cctcggtcag
      481 catgatgatg gatgccactt tctcagccgt ctacaacagc ttcagggctg tcttggacgt
      541 agcaaaccac ttttcccggc taaagataca cttcaccaag gttttttcag cctttgcgtt
      601 agtgaggact ataagatatc tttatagacg gttacagtgg atgatgggtt taaggagagg
      661 ctctgagaac gaggacctat gggcagaaag tgaaggaact gtggcctgcc ttggtgccga
      721 ggaccaagca aataactcag caaaatcttg gccaatattc ctgttctttg ctgtcatcct
      781 tggtggtcct tatctcatct ggaaacttct gtctacacat agcgatgaag taacagacag
      841 caccaactgg gcaaacggtg aggacgacca tgtagttgct agagcagaat acgactttgc
      901 cgctgtgtct gatgaagaaa tttctttccg tgctggtgat atgctaaatc tagccctcaa
      961 agaacaacaa cccaaagtgc gtggctggct tctggctagt cttgacggtc aaacaacagg
     1021 acttatacct gcaaattatg tcaaaattct tggtaaaaga agaggcagaa aaacagtaga
     1081 atcgagtaca atgcccaagc agcaacagtc ttttaccaac ccaacatcag ttaaaggagt
     1141 cactaccacc aattctttgg aggaacagga agctgccttt gaatctgttt ttgttgaaac
     1201 taataaggtt gccggtacac ctgattctac agggaaaaat ggagacaaac aagacctttg
     1261 atgtgtttca tgtttgcggg caggtgaaca atattttaga gtatttttaa aattatttct
     1321 tacagaggaa ttaatttgcg gttgaatgaa agcatttgct catggctgtc ccgggcgttc
     1381 tgctgctaga agttatgtag tcacacgcta gttgctggtc aagtgatctg gctacacttg
     1441 attgtctctt ggaccatgag gacatttgtt tcacttagct tttaagattg tggagatagt
     1501 tgtcggctcc atcttatctc agtccccagg cttattggat caataaattt gatgaacaat
     1561 agaacacaca agttgcctca gaagggatca ctaatgcttt ttaaagttct gagttagttg
     1621 acgtgaagtc ttcaaaaatt gagtgataac aactacttat aagaacagac aaaagtctaa
     1681 atttttataa ccttataaag aaactaaata ataaaaattt tctgatctat a
//
