LOCUS       NM_053921               2347 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus peroxisomal biogenesis factor 12 (Pex12), mRNA.
ACCESSION   NM_053921
VERSION     NM_053921.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2347)
  AUTHORS   Bharti,P., Schliebs,W., Schievelbusch,T., Neuhaus,A., David,C.,
            Kock,K., Herrmann,C., Meyer,H.E., Wiese,S., Warscheid,B., Theiss,C.
            and Erdmann,R.
  TITLE     PEX14 is required for microtubule-based peroxisome motility in
            human cells
  JOURNAL   J Cell Sci 124 (Pt 10), 1759-1768 (2011)
   PUBMED   21525035
REFERENCE   2  (bases 1 to 2347)
  AUTHORS   Zeharia,A., Ebberink,M.S., Wanders,R.J.A., Waterham,H.R.,
            Gutman,A., Nissenkorn,A. and Korman,S.H.
  TITLE     A novel PEX12 mutation identified as the cause of a peroxisomal
            biogenesis disorder with mild clinical phenotype, mild biochemical
            abnormalities in fibroblasts and a mosaic catalase
            immunofluorescence pattern, even at 40 degrees C
  JOURNAL   J Hum Genet 52 (7), 599-606 (2007)
   PUBMED   17534573
REFERENCE   3  (bases 1 to 2347)
  AUTHORS   Mano,S., Nakamori,C., Nito,K., Kondo,M. and Nishimura,M.
  TITLE     The Arabidopsis pex12 and pex13 mutants are defective in both PTS1-
            and PTS2-dependent protein transport to peroxisomes
  JOURNAL   Plant J 47 (4), 604-618 (2006)
   PUBMED   16813573
REFERENCE   4  (bases 1 to 2347)
  AUTHORS   Kikuchi,M., Hatano,N., Yokota,S., Shimozawa,N., Imanaka,T. and
            Taniguchi,H.
  TITLE     Proteomic analysis of rat liver peroxisome: presence of
            peroxisome-specific isozyme of Lon protease
  JOURNAL   J Biol Chem 279 (1), 421-428 (2004)
   PUBMED   14561759
REFERENCE   5  (bases 1 to 2347)
  AUTHORS   Reguenga,C., Oliveira,M.E., Gouveia,A.M., Sa-Miranda,C. and
            Azevedo,J.E.
  TITLE     Characterization of the mammalian peroxisomal import machinery:
            Pex2p, Pex5p, Pex12p, and Pex14p are subunits of the same protein
            assembly
  JOURNAL   J Biol Chem 276 (32), 29935-29942 (2001)
   PUBMED   11397814
  REMARK    Erratum:[J Biol Chem. 2005 Sep 23;280(38):33096]
REFERENCE   6  (bases 1 to 2347)
  AUTHORS   Chang,C.C., Warren,D.S., Sacksteder,K.A. and Gould,S.J.
  TITLE     PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor
            docking in peroxisomal matrix protein import
  JOURNAL   J Cell Biol 147 (4), 761-774 (1999)
   PUBMED   10562279
REFERENCE   7  (bases 1 to 2347)
  AUTHORS   South,S.T. and Gould,S.J.
  TITLE     Peroxisome synthesis in the absence of preexisting peroxisomes
  JOURNAL   J Cell Biol 144 (2), 255-266 (1999)
   PUBMED   9922452
REFERENCE   8  (bases 1 to 2347)
  AUTHORS   Okumoto,K., Shimozawa,N., Kawai,A., Tamura,S., Tsukamoto,T.,
            Osumi,T., Moser,H., Wanders,R.J., Suzuki,Y., Kondo,N. and Fujiki,Y.
  TITLE     PEX12, the pathogenic gene of group III Zellweger syndrome: cDNA
            cloning by functional complementation on a CHO cell mutant, patient
            analysis, and characterization of PEX12p
  JOURNAL   Mol Cell Biol 18 (7), 4324-4336 (1998)
   PUBMED   9632816
REFERENCE   9  (bases 1 to 2347)
  AUTHORS   Okumoto,K. and Fujiki,Y.
  TITLE     PEX12 encodes an integral membrane protein of peroxisomes
  JOURNAL   Nat Genet 17 (3), 265-266 (1997)
   PUBMED   9354782
REFERENCE   10 (bases 1 to 2347)
  AUTHORS   Chang,C.C., Lee,W.H., Moser,H., Valle,D. and Gould,S.J.
  TITLE     Isolation of the human PEX12 gene, mutated in group 3 of the
            peroxisome biogenesis disorders
  JOURNAL   Nat Genet 15 (4), 385-388 (1997)
   PUBMED   9090384
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB002111.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB002111.1, BC072481.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMN12840119
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2347
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..2347
                     /gene="Pex12"
                     /note="peroxisomal biogenesis factor 12"
                     /db_xref="GeneID:116718"
                     /db_xref="RGD:620757"
     exon            1..216
                     /gene="Pex12"
                     /inference="alignment:Splign:2.1.0"
     exon            217..447
                     /gene="Pex12"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..1401
                     /gene="Pex12"
                     /note="PAF-3; peroxin-12; peroxisome assembly protein
                     12-like; peroxisome assembly factor 3"
                     /codon_start=1
                     /product="peroxisome assembly protein 12"
                     /protein_id="NP_446373.1"
                     /db_xref="GeneID:116718"
                     /db_xref="RGD:620757"
                     /translation="MAEHGAHITTASVADDQPSIFEVVAQDSLMTAVRPALQHVVKVL
                     AESNPAHYGFFWRWFDEIFTLLDFLLQQHYLSRTSASFSEHFYGLKRIVAGSSPQLQR
                     PASAGLPKEHLWKSAMFLVLLPYLKVKLEKLASTLREEDEYSIHPPSSHWKRFYRVFL
                     AAYPFVTMTWEGWFLTQQLRYILGKAEHHSPLLKLAGVRLGRLTAQDIQAMEHRLVEA
                     SAMQEPVRSIGKKIKSALKKAVGGVALSLSTGLSVGVFFLQFLDWWYSSENQETIKSL
                     TALPTPPPPVHLDYNSDSPLLPKMKTVCPLCRKARVNDTVLATSGYVFCYRCVFNYVR
                     SHQACPITGYPTEVQHLIKLYSPEN"
     exon            448..1001
                     /gene="Pex12"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..2347
                     /gene="Pex12"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2347
                     /gene="Pex12"
                     /note="18 a nucleotides"
ORIGIN      
        1 ggagcttctg tttccgggta cggtttctgt cacaaagccg agccctcctt tcgcaggtgg
       61 cgtcacgggt cctctgctcc gtgcccgagg tcagcaagca aggacgggcg cttcccagcc
      121 agccaccgga gccgggcctc gcagctctgg gactgcagct cgagcgacac gttccttggc
      181 ccacacctat ctccgagtca cgctctgccc tgtgaggtgc catgcagaag gactaagact
      241 cagcacccgt ttgatacaaa acaagttcat gctccctaga gtgttcgtgg gaaaagtaaa
      301 tcccagtaca cacaagacac tatggctgag catggggctc atatcacaac tgcttcggtg
      361 gcggacgacc agccatccat ctttgaggtg gtagcacagg acagtttaat gacagcagtg
      421 agacccgctc ttcagcatgt ggtcaaggtt cttgcagaat caaatcctgc gcactatggc
      481 ttcttttgga ggtggtttga tgaaatcttc actctgctag actttctgct ccagcagcat
      541 tatctttcta gaactagtgc ctcattttct gaacactttt atgggttaaa gcggattgta
      601 gcggggagct cgccgcagct tcagagacca gccagtgctg gcctccccaa ggaacacctc
      661 tggaaatccg ctatgttcct tgttcttctt ccctatctga aagtgaagct ggagaagctg
      721 gcttctacct tgagagaaga agacgaatac tctattcacc ccccttcttc tcactggaaa
      781 cgattctaca gagtcttcct ggctgcctac ccgtttgtta ccatgacctg ggaaggctgg
      841 ttccttacac aacaacttcg gtacatattg ggaaaagctg agcatcactc tcccctgctg
      901 aaactggctg gagttcggct aggtcgactg acagctcagg acatacaagc tatggaacac
      961 agactggttg aagccagtgc aatgcaggag cccgtcagaa gcattggtaa gaagataaag
     1021 tcagcactga agaaagctgt gggaggtgtt gccttatccc tctctactgg cctctctgtg
     1081 ggtgtattct tcctgcagtt tcttgactgg tggtactctt ctgagaacca agagaccatc
     1141 aagtcactga ctgccctgcc cactccacca ccacctgtgc acctcgacta caactctgat
     1201 tctcccctct tacccaaaat gaaaacagtg tgcccactgt gtcgtaaagc tcgggtcaat
     1261 gatacggttc ttgccacctc tggctatgta ttctgttacc gctgtgtgtt taattatgtg
     1321 agaagtcacc aagcctgtcc cattacaggg tatccaacgg aagtccagca tctaattaaa
     1381 ctctactctc cagagaactg aaagagagat tagtgtattc tctcacagct caagttctat
     1441 actataggac cacaagatgg ttttagtatg gcaatcaaca atgattcata actacattaa
     1501 cttttagtag ttatatggat ttctttaaaa ggatatatcc acttggtcct aaccttatgg
     1561 tttgctctct accaagctgt ttaagcagga gaatcaggat tgtaggtggt gtgagggccc
     1621 atgtggaggt gggttataaa agaccacctc acttaagagt aaggttttaa gttgtggtag
     1681 tgtagtgtca gcactctgga gatggaggcg ggagtttgag ttcaaggcca ccaaaggggg
     1741 agtgtcaaaa gtaaaatgaa agtaagagac tgattaagag ggataaaata gcataggaaa
     1801 ccccaggtta gatcttacaa agcaagtggt ttgggaagca ggccttctct ttagaaaaca
     1861 tttctctact tttgaagtag aggctttatc agacacggac tttctcttta tagaaatatc
     1921 tataaaccct ttagagaaaa gccccctcca tctatcatga cttactaaca tctaccacag
     1981 tttatcagta tttgaagatt tccttcatga tccatacctg cctgtctagg gaagggtttg
     2041 tttatggggc ggagtctgga aatttcaata tgaataaaaa ctagcaatgg tgagatgcag
     2101 taaaatcttt atctaatgtt tacctgatgc ctacctaata gatatctaat gagtaaaagc
     2161 tttctgcttg ctcttatgag tttgctcagt tgataggaat catgctaggt attatgaaag
     2221 tttctatgaa acatttaatt aaattttaac aatacatgat tctaggaaag aattgttcca
     2281 tgctgtcatg attatgtgga aactcaaaag atcacttcag gagtttaaat aaatttttat
     2341 tcagatc
//
