LOCUS       NM_001109220            4310 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus peroxisomal biogenesis factor 1 (Pex1), mRNA.
ACCESSION   NM_001109220 XM_001068563 XM_575360
VERSION     NM_001109220.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4310)
  AUTHORS   Berendse K, Boek M, Gijbels M, Van der Wel NN, Klouwer FC, van den
            Bergh-Weerman MA, Shinde AB, Ofman R, Poll-The BT, Houten SM, Baes
            M, Wanders RJA and Waterham HR.
  TITLE     Liver disease predominates in a mouse model for mild human
            Zellweger spectrum disorder
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1865 (10), 2774-2787 (2019)
   PUBMED   31207289
REFERENCE   2  (bases 1 to 4310)
  AUTHORS   Jurado Acosta A, Rysa J, Szabo Z, Moilanen AM, Komati H, Nemer M
            and Ruskoaho H.
  TITLE     Transcription factor PEX1 modulates extracellular matrix turnover
            through regulation of MMP-9 expression
  JOURNAL   Cell Tissue Res 367 (2), 369-385 (2017)
   PUBMED   27826738
  REMARK    GeneRIF: PEX1 activation of the MMP-9 promoter triggers the
            pro-fibrotic response directed by PEX1.
REFERENCE   3  (bases 1 to 4310)
  AUTHORS   Hiebler S, Masuda T, Hacia JG, Moser AB, Faust PL, Liu A, Chowdhury
            N, Huang N, Lauer A, Bennett J, Watkins PA, Zack DJ, Braverman NE,
            Raymond GV and Steinberg SJ.
  TITLE     The Pex1-G844D mouse: a model for mild human Zellweger spectrum
            disorder
  JOURNAL   Mol Genet Metab 111 (4), 522-532 (2014)
   PUBMED   24503136
REFERENCE   4  (bases 1 to 4310)
  AUTHORS   Bharti P, Schliebs W, Schievelbusch T, Neuhaus A, David C, Kock K,
            Herrmann C, Meyer HE, Wiese S, Warscheid B, Theiss C and Erdmann R.
  TITLE     PEX14 is required for microtubule-based peroxisome motility in
            human cells
  JOURNAL   J Cell Sci 124 (Pt 10), 1759-1768 (2011)
   PUBMED   21525035
REFERENCE   5  (bases 1 to 4310)
  AUTHORS   Kang D, Oh S, Ahn SM, Lee BH and Moon MH.
  TITLE     Proteomic analysis of exosomes from human neural stem cells by flow
            field-flow fractionation and nanoflow liquid chromatography-tandem
            mass spectrometry
  JOURNAL   J Proteome Res 7 (8), 3475-3480 (2008)
   PUBMED   18570454
REFERENCE   6  (bases 1 to 4310)
  AUTHORS   Nguyen T, Bjorkman J, Paton BC and Crane DI.
  TITLE     Failure of microtubule-mediated peroxisome division and trafficking
            in disorders with reduced peroxisome abundance
  JOURNAL   J Cell Sci 119 (Pt 4), 636-645 (2006)
   PUBMED   16449325
REFERENCE   7  (bases 1 to 4310)
  AUTHORS   Kikuchi M, Hatano N, Yokota S, Shimozawa N, Imanaka T and Taniguchi
            H.
  TITLE     Proteomic analysis of rat liver peroxisome: presence of
            peroxisome-specific isozyme of Lon protease
  JOURNAL   J Biol Chem 279 (1), 421-428 (2004)
   PUBMED   14561759
REFERENCE   8  (bases 1 to 4310)
  AUTHORS   Tamura S, Matsumoto N, Imamura A, Shimozawa N, Suzuki Y, Kondo N
            and Fujiki Y.
  TITLE     Phenotype-genotype relationships in peroxisome biogenesis disorders
            of PEX1-defective complementation group 1 are defined by
            Pex1p-Pex6p interaction
  JOURNAL   Biochem J 357 (Pt 2), 417-426 (2001)
   PUBMED   11439091
REFERENCE   9  (bases 1 to 4310)
  AUTHORS   Tamura S, Shimozawa N, Suzuki Y, Tsukamoto T, Osumi T and Fujiki Y.
  TITLE     A cytoplasmic AAA family peroxin, Pex1p, interacts with Pex6p
  JOURNAL   Biochem Biophys Res Commun 245 (3), 883-886 (1998)
   PUBMED   9588209
REFERENCE   10 (bases 1 to 4310)
  AUTHORS   Reuber BE, Germain-Lee E, Collins CS, Morrell JC, Ameritunga R,
            Moser HW, Valle D and Gould SJ.
  TITLE     Mutations in PEX1 are the most common cause of peroxisome
            biogenesis disorders
  JOURNAL   Nat Genet 17 (4), 445-448 (1997)
   PUBMED   9398847
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474013.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001068563.1, XM_575360.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4310
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q13"
     gene            1..4310
                     /gene="Pex1"
                     /gene_synonym="RGD1559939"
                     /note="peroxisomal biogenesis factor 1"
                     /db_xref="GeneID:500006"
                     /db_xref="RGD:1559939"
     CDS             1..3852
                     /gene="Pex1"
                     /gene_synonym="RGD1559939"
                     /note="peroxisome biogenesis factor 1"
                     /codon_start=1
                     /product="peroxisomal ATPase PEX1"
                     /protein_id="NP_001102690.1"
                     /db_xref="GeneID:500006"
                     /db_xref="RGD:1559939"
                     /translation="MWSSDRLAGAGSGGAVVTVAFTNARDCFLHLPRHLVAQLHLLQN
                     QAIEVTGDHQPTYLSWVEGRHFNDQSENVAEINRQVGQKLGLSSGDQVFLRPCSHVVS
                     CQQVEVEPLSADDWEILELHAISLEEHLLDQIRIVFPKAIVPIWVDQQTYIFIQIVAL
                     MPTAPYGRLETNTKLLIQPKTRQAKESTFPKEGDARGQAHNYGREQKGTVKELQTKQL
                     HKNTEAVPVSNGRNPEVPGDSVKPRWWAVLGSMFSFGPDNKQESAWGSLELGAFKNMQ
                     SQTVPLDSIFRVCQVQPPSVHNTPANSVFHKHCTVHVFPWDQEYFDVEPSFTVVYGKL
                     VKLHSPKQQQDKSKQGVLLPEKEKQLSQSPGHKRIGSDGSEEAAETCVLKVVWNGLEE
                     LKNATEFTKSLEPLHHGKVWIPADLRKRLNIEMHAVVRITPLETTPVIPRALRLQPAE
                     NLPRDVSEEEVKAVFSSWLQESATTMFPLIISKQECIKLEIKDGLKEFSLSIVHSQEK
                     EKEQGRTVFVLSPILLQKISVQVLLEPMIGEHSEEIDILLPSLTLSSLGGVSSLSVSA
                     MEHITHSLLGRPLSRQLMALVAGLRNGALLITGGKGSGKSTLAKAICKEAHDALDAHV
                     EMVDCKALRGKRLESIQKALEVAFSEAAWRQPSVILLDDLDLIAGLPSTPEHEHSPEA
                     VQSQRLAHALNNMIKEFVSMGSLVALIATSQLQHSLHPSLVSAQGVHTFQCIQHIQPP
                     DQEQRCEILHSVVKNKLGCDISKSPDLDLKCIAKETEAFVARDFTVLVDRAIHSSLSR
                     QQNPTREGLTLTTADFQKALRGFLPASLRNVNLHKPRDLGWDKIGGLHEVRQILMDTI
                     QLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVVARESGMNFISIQGPELLSKY
                     IGASEQAVRDVFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTDRVVNQLLTQLDGVE
                     GLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILTVLSKSLPLADDV
                     DLQHVASVTESFTGADLKALLYNAQLEALQGRLLPGGLHDGGSSSDSDLSLSSMVFLN
                     HSSGSDDSAGDGECGLDQSLVSLEMSEILPDESKFNMYRLYFGSSYESELGNGASCDL
                     SSHCLSAPSSMTQDLPATPGKDPLFTQHPVFRTPSQEGSQDLTQEQRDQLRADISIIK
                     GRYQSQSGEDESLNQPGPIKTSFAISQAHLMTALAHTRPSINEDEGKEFAELYENFQN
                     PKKRKNQSGTVFRTGQKVTLA"
     exon            1..129
                     /gene="Pex1"
                     /gene_synonym="RGD1559939"
                     /inference="alignment:Splign:2.1.0"
     exon            130..273
                     /gene="Pex1"
                     /gene_synonym="RGD1559939"
                     /inference="alignment:Splign:2.1.0"
     exon            274..357
                     /gene="Pex1"
                     /gene_synonym="RGD1559939"
                     /inference="alignment:Splign:2.1.0"
     exon            358..472
                     /gene="Pex1"
                     /gene_synonym="RGD1559939"
                     /inference="alignment:Splign:2.1.0"
     exon            473..1236
                     /gene="Pex1"
                     /gene_synonym="RGD1559939"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1356
                     /gene="Pex1"
                     /gene_synonym="RGD1559939"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1480
                     /gene="Pex1"
                     /gene_synonym="RGD1559939"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1590
                     /gene="Pex1"
                     /gene_synonym="RGD1559939"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1670
                     /gene="Pex1"
                     /gene_synonym="RGD1559939"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1803
                     /gene="Pex1"
                     /gene_synonym="RGD1559939"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1900
                     /gene="Pex1"
                     /gene_synonym="RGD1559939"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2071
                     /gene="Pex1"
                     /gene_synonym="RGD1559939"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2226
                     /gene="Pex1"
                     /gene_synonym="RGD1559939"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2416
                     /gene="Pex1"
                     /gene_synonym="RGD1559939"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2583
                     /gene="Pex1"
                     /gene_synonym="RGD1559939"
                     /inference="alignment:Splign:2.1.0"
     exon            2584..2718
                     /gene="Pex1"
                     /gene_synonym="RGD1559939"
                     /inference="alignment:Splign:2.1.0"
     exon            2719..2783
                     /gene="Pex1"
                     /gene_synonym="RGD1559939"
                     /inference="alignment:Splign:2.1.0"
     exon            2784..2926
                     /gene="Pex1"
                     /gene_synonym="RGD1559939"
                     /inference="alignment:Splign:2.1.0"
     exon            2927..3030
                     /gene="Pex1"
                     /gene_synonym="RGD1559939"
                     /inference="alignment:Splign:2.1.0"
     exon            3031..3207
                     /gene="Pex1"
                     /gene_synonym="RGD1559939"
                     /inference="alignment:Splign:2.1.0"
     exon            3208..3438
                     /gene="Pex1"
                     /gene_synonym="RGD1559939"
                     /inference="alignment:Splign:2.1.0"
     exon            3439..3636
                     /gene="Pex1"
                     /gene_synonym="RGD1559939"
                     /inference="alignment:Splign:2.1.0"
     exon            3637..3767
                     /gene="Pex1"
                     /gene_synonym="RGD1559939"
                     /inference="alignment:Splign:2.1.0"
     exon            3768..4310
                     /gene="Pex1"
                     /gene_synonym="RGD1559939"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtggagca gtgatcgctt agccggtgcg gggtctggtg gggcggtcgt gacggtggcc
       61 ttcacgaatg ctcgggactg cttcctccat ctgccacggc acctcgtggc ccagcttcac
      121 ctgctgcaga atcaagctat agaagtaacc ggggatcacc agcctaccta cttgagctgg
      181 gtggaaggca ggcattttaa tgatcaaagt gaaaatgtgg cagaaattaa tagacaagtt
      241 ggccagaagc ttggactctc gagcggggat caggtgtttc tcaggccgtg ttcccatgtg
      301 gtctcatgcc agcaggttga ggtggagcct ctctcggcag acgactggga gatactggag
      361 ctgcacgcca tttcccttga agaacacctt ctagatcaga ttcgaatagt tttccctaaa
      421 gccatcgttc ccatctgggt tgaccagcag acctacatat ttatccaaat tgtcgctctg
      481 atgccaactg ccccttatgg aaggctagaa actaacacca aactccttat tcagccaaag
      541 acccgccaag ccaaagagag cacatttcca aaagaaggcg atgcacgtgg acaagctcat
      601 aattatgggc gagaacagaa aggaacggta aaggaattgc aaaccaagca gcttcataag
      661 aacacagagg ctgtccctgt atctaatgga agaaacccgg aagtcccagg tgactcagtg
      721 aagccacgct ggtgggctgt gctaggaagc atgttttcct ttgggcctga caacaaacaa
      781 gagtcagctt ggggctcatt ggaactcggt gctttcaaaa acatgcagtc acagactgtc
      841 cctctagaca gtattttcag agtgtgccaa gttcagcctc ctagtgtgca taacacccct
      901 gctaactccg tgtttcacaa acactgcacc gtccatgtat ttccatggga ccaagaatat
      961 tttgatgtgg agcccagctt tactgtggtc tatgggaaac tagttaagct acattctcca
     1021 aaacaacagc aggacaaaag taagcagggc gtcctgttac ctgaaaaaga gaagcaactg
     1081 tcccagtctc caggtcataa gcggatcggc tccgatggca gtgaggaagc tgctgagacc
     1141 tgtgtgctga aggtagtctg gaatggactg gaggagctga agaatgccac ggagttcacc
     1201 aaaagtctag agcctctcca ccatgggaaa gtctggattc cagctgacct gagaaagaga
     1261 ctcaacatag aaatgcatgc agtagtcagg ataactccac tggaaaccac ccctgtcatc
     1321 ccaagagccc tgagattaca acctgcagag aacttaccta gagacgtgag tgaagaagag
     1381 gtaaaagctg tgttctcatc gtggctacag gagtctgcca ccaccatgtt tcctttgata
     1441 atatcaaagc aagaatgtat taagctggaa attaaagatg ggttgaaaga gttctctctg
     1501 agcatagttc attctcagga aaaagagaag gaacaaggaa gaactgtttt tgtgttgagt
     1561 cccattctgc tgcagaagat ctcagtacaa gtccttctag agcccatgat cggagaacac
     1621 agtgaggaaa ttgacattct tcttccctct ttaacactga gctctttggg cggtgtgagt
     1681 tccttaagtg tatctgccat ggaacacatc actcacagtc tcctgggacg ccctttgtct
     1741 cggcagctga tggccctcgt tgccggactg aggaatgggg ctcttttgat cactggagga
     1801 aagggaagcg ggaaatcaac gttagctaaa gccatctgta aggaagcaca tgacgctctg
     1861 gatgcccacg tggagatggt cgactgcaaa gctttacgag gaaaaaggct tgaaagcata
     1921 caaaaagccc tagaggtggc tttctcagag gcagcctgga ggcagccatc cgtcattctg
     1981 ctggatgacc tggacctcat tgctggatta ccgagcaccc cagagcatga gcacagccct
     2041 gaagcagtgc agagccaacg gcttgcacac gctttgaaca atatgatcaa agagtttgtt
     2101 tccatgggaa gcttggtcgc gctcatcgcc acgagccagc tccagcactc tctccatcct
     2161 tcccttgtct ctgctcaagg agtccacaca tttcagtgca tccagcacat ccagcctcct
     2221 gatcaggaac agagatgtga aattctgcat agtgttgtga agaataaact gggctgtgat
     2281 ataagcaagt cccctgactt ggacctgaag tgcatagcta aagagacgga ggcgtttgtg
     2341 gctcgagact ttacagttct cgtggaccga gccatacact cctctctctc tcgccagcag
     2401 aaccccacca gggaaggatt gactttaaca acagcagact tccaaaaggc tctccgtgga
     2461 tttcttcctg cttctctgcg aaatgtcaac ttgcataaac ctagagacct gggctgggac
     2521 aagatcggtg gattacatga agttcggcag atactcatgg atactatcca gttaccagcc
     2581 aagtacccag aattatttgc aaacttaccc atacgacaga ggacgggaat actgctttat
     2641 ggccctcctg ggacaggaaa aactttactc gctggggtgg ttgcaagaga gagtgggatg
     2701 aactttatta gtattcaggg accagagtta ctcagcaaat acattggagc aagtgagcaa
     2761 gctgttcgag atgtcttcat cagagcacag gctgcaaagc cctgtattct tttctttgat
     2821 gagtttgaat ccattgctcc tcgaagaggt catgacaaca caggggttac agaccgagta
     2881 gttaaccagt tgctgacaca gttagatgga gtagaaggct tacagggagt ttatgtgttg
     2941 gctgctacta gtcgccctga tttgattgac cccgccttgt tacggcccgg ccgactggat
     3001 aaatgtgtat actgccctcc tccagatcag gtgtctcgtc ttgagatttt aactgtcctc
     3061 agcaagtctc tacctctggc ggatgacgtg gaccttcagc acgtggcctc tgtcactgag
     3121 tccttcactg gagcggatct gaaagctctg ctgtacaatg cacagctgga ggccttgcag
     3181 ggacggctac tgcccggcgg gctccacgat ggaggatcca gctctgacag tgacctcagt
     3241 ctgtcttcaa tggtctttct taaccacagc agtggttccg acgactcagc tggagatgga
     3301 gaatgtggct tagatcaatc cctcgtttct ctcgagatgt cggagatcct tccagatgaa
     3361 tcaaaattca atatgtaccg gctgtacttt ggcagctcct atgaatcgga acttggaaac
     3421 ggagcctctt gtgacttgag ctcacactgt ctgtctgcac cgagctccat gactcaggac
     3481 ttacctgcca ctcctgggaa agacccattg tttacacagc atcctgtgtt caggacacct
     3541 tcccaagaag gctcccaaga ccttacacag gagcagagag accagctgag agcagacatc
     3601 agcatcatca aaggcagata ccagagccaa agtggagagg atgaatccct taaccagcct
     3661 ggaccaatca aaaccagttt tgctattagt caggcacatt taatgactgc gcttgcccac
     3721 acgagaccgt ccattaatga ggatgaaggc aaggaatttg ctgagctgta tgaaaacttt
     3781 caaaatccga agaagagaaa aaatcaaagt ggaacagtgt ttcgaactgg acagaaagta
     3841 acgttagcat aaaatacact tctgattttt ctagatgtgt ctgctctgat ggtctgtccc
     3901 taagttgtaa ctataagaac gatgtataga ttttaattta ataaatctgg ttaatctata
     3961 aaatcacaga atggtaagtg ctgtgattgc acaatgctca ggactatctg agatcaatag
     4021 tgcaggctaa atggggttat ttgtaagaga tggtgttttg tccctcagtc tgtattaagt
     4081 cctcaatggt cttatgtcag tggcagagct catttgctct ccttcagagg gatgcatttc
     4141 ttggcactca cagacccaga gtcactgttt ttctagctcc tggcagattg tatgccttgc
     4201 aacttcttga ctgttttgga aaaagatata ttctattatc ttcttttttt ttgtttttaa
     4261 tcagaacata acatttacac ataattcaaa taaatttaat cccttcaacc
//
