LOCUS       NP_001102690            1283 aa            linear   ROD 26-FEB-2024
DEFINITION  peroxisomal ATPase PEX1 [Rattus norvegicus].
ACCESSION   NP_001102690 XP_001068563 XP_575360
VERSION     NP_001102690.1
DBSOURCE    REFSEQ: accession NM_001109220.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1283)
  AUTHORS   Berendse K, Boek M, Gijbels M, Van der Wel NN, Klouwer FC, van den
            Bergh-Weerman MA, Shinde AB, Ofman R, Poll-The BT, Houten SM, Baes
            M, Wanders RJA and Waterham HR.
  TITLE     Liver disease predominates in a mouse model for mild human
            Zellweger spectrum disorder
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1865 (10), 2774-2787 (2019)
   PUBMED   31207289
REFERENCE   2  (residues 1 to 1283)
  AUTHORS   Jurado Acosta A, Rysa J, Szabo Z, Moilanen AM, Komati H, Nemer M
            and Ruskoaho H.
  TITLE     Transcription factor PEX1 modulates extracellular matrix turnover
            through regulation of MMP-9 expression
  JOURNAL   Cell Tissue Res 367 (2), 369-385 (2017)
   PUBMED   27826738
  REMARK    GeneRIF: PEX1 activation of the MMP-9 promoter triggers the
            pro-fibrotic response directed by PEX1.
REFERENCE   3  (residues 1 to 1283)
  AUTHORS   Hiebler S, Masuda T, Hacia JG, Moser AB, Faust PL, Liu A, Chowdhury
            N, Huang N, Lauer A, Bennett J, Watkins PA, Zack DJ, Braverman NE,
            Raymond GV and Steinberg SJ.
  TITLE     The Pex1-G844D mouse: a model for mild human Zellweger spectrum
            disorder
  JOURNAL   Mol Genet Metab 111 (4), 522-532 (2014)
   PUBMED   24503136
REFERENCE   4  (residues 1 to 1283)
  AUTHORS   Bharti P, Schliebs W, Schievelbusch T, Neuhaus A, David C, Kock K,
            Herrmann C, Meyer HE, Wiese S, Warscheid B, Theiss C and Erdmann R.
  TITLE     PEX14 is required for microtubule-based peroxisome motility in
            human cells
  JOURNAL   J Cell Sci 124 (Pt 10), 1759-1768 (2011)
   PUBMED   21525035
REFERENCE   5  (residues 1 to 1283)
  AUTHORS   Kang D, Oh S, Ahn SM, Lee BH and Moon MH.
  TITLE     Proteomic analysis of exosomes from human neural stem cells by flow
            field-flow fractionation and nanoflow liquid chromatography-tandem
            mass spectrometry
  JOURNAL   J Proteome Res 7 (8), 3475-3480 (2008)
   PUBMED   18570454
REFERENCE   6  (residues 1 to 1283)
  AUTHORS   Nguyen T, Bjorkman J, Paton BC and Crane DI.
  TITLE     Failure of microtubule-mediated peroxisome division and trafficking
            in disorders with reduced peroxisome abundance
  JOURNAL   J Cell Sci 119 (Pt 4), 636-645 (2006)
   PUBMED   16449325
REFERENCE   7  (residues 1 to 1283)
  AUTHORS   Kikuchi M, Hatano N, Yokota S, Shimozawa N, Imanaka T and Taniguchi
            H.
  TITLE     Proteomic analysis of rat liver peroxisome: presence of
            peroxisome-specific isozyme of Lon protease
  JOURNAL   J Biol Chem 279 (1), 421-428 (2004)
   PUBMED   14561759
REFERENCE   8  (residues 1 to 1283)
  AUTHORS   Tamura S, Matsumoto N, Imamura A, Shimozawa N, Suzuki Y, Kondo N
            and Fujiki Y.
  TITLE     Phenotype-genotype relationships in peroxisome biogenesis disorders
            of PEX1-defective complementation group 1 are defined by
            Pex1p-Pex6p interaction
  JOURNAL   Biochem J 357 (Pt 2), 417-426 (2001)
   PUBMED   11439091
REFERENCE   9  (residues 1 to 1283)
  AUTHORS   Tamura S, Shimozawa N, Suzuki Y, Tsukamoto T, Osumi T and Fujiki Y.
  TITLE     A cytoplasmic AAA family peroxin, Pex1p, interacts with Pex6p
  JOURNAL   Biochem Biophys Res Commun 245 (3), 883-886 (1998)
   PUBMED   9588209
REFERENCE   10 (residues 1 to 1283)
  AUTHORS   Reuber BE, Germain-Lee E, Collins CS, Morrell JC, Ameritunga R,
            Moser HW, Valle D and Gould SJ.
  TITLE     Mutations in PEX1 are the most common cause of peroxisome
            biogenesis disorders
  JOURNAL   Nat Genet 17 (4), 445-448 (1997)
   PUBMED   9398847
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474013.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_001068563.1, XP_575360.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1283
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q13"
     Protein         1..1283
                     /product="peroxisomal ATPase PEX1"
                     /note="peroxisome biogenesis factor 1"
                     /calculated_mol_wt=141269
     Region          17..98
                     /region_name="PEX-2N"
                     /note="Peroxisome biogenesis factor 1, N-terminal;
                     pfam09263"
                     /db_xref="CDD:462730"
     Region          104..179
                     /region_name="PEX-1N"
                     /note="Peroxisome biogenesis factor 1, N-terminal;
                     pfam09262"
                     /db_xref="CDD:462729"
     Region          418..>750
                     /region_name="NACHT"
                     /note="Predicted NTPase, NACHT family domain [Signal
                     transduction mechanisms]; COG5635"
                     /db_xref="CDD:444362"
     Region          <595..1060
                     /region_name="CDC48"
                     /note="AAA family ATPase, CDC48 subfamily; TIGR01243"
                     /db_xref="CDD:273521"
     CDS             1..1283
                     /gene="Pex1"
                     /gene_synonym="RGD1559939"
                     /coded_by="NM_001109220.1:1..3852"
                     /db_xref="GeneID:500006"
                     /db_xref="RGD:1559939"
ORIGIN      
        1 mwssdrlaga gsggavvtva ftnardcflh lprhlvaqlh llqnqaievt gdhqptylsw
       61 vegrhfndqs envaeinrqv gqklglssgd qvflrpcshv vscqqvevep lsaddweile
      121 lhaisleehl ldqirivfpk aivpiwvdqq tyifiqival mptapygrle tntklliqpk
      181 trqakestfp kegdargqah nygreqkgtv kelqtkqlhk nteavpvsng rnpevpgdsv
      241 kprwwavlgs mfsfgpdnkq esawgslelg afknmqsqtv pldsifrvcq vqppsvhntp
      301 ansvfhkhct vhvfpwdqey fdvepsftvv ygklvklhsp kqqqdkskqg vllpekekql
      361 sqspghkrig sdgseeaaet cvlkvvwngl eelknateft ksleplhhgk vwipadlrkr
      421 lniemhavvr itplettpvi pralrlqpae nlprdvseee vkavfsswlq esattmfpli
      481 iskqecikle ikdglkefsl sivhsqekek eqgrtvfvls pillqkisvq vllepmigeh
      541 seeidillps ltlsslggvs slsvsamehi thsllgrpls rqlmalvagl rngallitgg
      601 kgsgkstlak aickeahdal dahvemvdck alrgkrlesi qkalevafse aawrqpsvil
      661 lddldliagl pstpehehsp eavqsqrlah alnnmikefv smgslvalia tsqlqhslhp
      721 slvsaqgvht fqciqhiqpp dqeqrceilh svvknklgcd iskspdldlk ciaketeafv
      781 ardftvlvdr aihsslsrqq nptregltlt tadfqkalrg flpaslrnvn lhkprdlgwd
      841 kigglhevrq ilmdtiqlpa kypelfanlp irqrtgilly gppgtgktll agvvaresgm
      901 nfisiqgpel lskyigaseq avrdvfiraq aakpcilffd efesiaprrg hdntgvtdrv
      961 vnqlltqldg veglqgvyvl aatsrpdlid pallrpgrld kcvycpppdq vsrleiltvl
     1021 skslpladdv dlqhvasvte sftgadlkal lynaqlealq grllpgglhd ggsssdsdls
     1081 lssmvflnhs sgsddsagdg ecgldqslvs lemseilpde skfnmyrlyf gssyeselgn
     1141 gascdlsshc lsapssmtqd lpatpgkdpl ftqhpvfrtp sqegsqdltq eqrdqlradi
     1201 siikgryqsq sgedeslnqp gpiktsfais qahlmtalah trpsinedeg kefaelyenf
     1261 qnpkkrknqs gtvfrtgqkv tla
//
