LOCUS       NM_023978               3504 bp    mRNA    linear   ROD 03-JUL-2024
DEFINITION  Rattus norvegicus period circadian regulator 3 (Per3), mRNA.
ACCESSION   NM_023978
VERSION     NM_023978.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3504)
  AUTHORS   Banach,E., Pawlak,J., Kapelski,P., Szczepankiewicz,A.,
            Rajewska-Rager,A., Skibinska,M., Czerski,P., Twarowska-Hauser,J.
            and Dmitrzak-Weglarz,M.
  TITLE     Clock genes polymorphisms in male bipolar patients with comorbid
            alcohol abuse
  JOURNAL   J Affect Disord 241, 142-146 (2018)
   PUBMED   30121446
REFERENCE   2  (bases 1 to 3504)
  AUTHORS   Zhang,L., Hirano,A., Hsu,P.K., Jones,C.R., Sakai,N., Okuro,M.,
            McMahon,T., Yamazaki,M., Xu,Y., Saigoh,N., Saigoh,K., Lin,S.T.,
            Kaasik,K., Nishino,S., Ptacek,L.J. and Fu,Y.H.
  TITLE     A PERIOD3 variant causes a circadian phenotype and is associated
            with a seasonal mood trait
  JOURNAL   Proc Natl Acad Sci U S A 113 (11), E1536-E1544 (2016)
   PUBMED   26903630
REFERENCE   3  (bases 1 to 3504)
  AUTHORS   Hasan,S., van der Veen,D.R., Winsky-Sommerer,R., Hogben,A.,
            Laing,E.E., Koentgen,F., Dijk,D.J. and Archer,S.N.
  TITLE     A human sleep homeostasis phenotype in mice expressing a
            primate-specific PER3 variable-number tandem-repeat coding-region
            polymorphism
  JOURNAL   FASEB J 28 (6), 2441-2454 (2014)
   PUBMED   24577121
REFERENCE   4  (bases 1 to 3504)
  AUTHORS   Maire,M., Reichert,C.F., Gabel,V., Viola,A.U., Strobel,W.,
            Krebs,J., Landolt,H.P., Bachmann,V., Cajochen,C. and Schmidt,C.
  TITLE     Sleep ability mediates individual differences in the vulnerability
            to sleep loss: evidence from a PER3 polymorphism
  JOURNAL   Cortex 52, 47-59 (2014)
   PUBMED   24439663
REFERENCE   5  (bases 1 to 3504)
  AUTHORS   Hasan,S., van der Veen,D.R., Winsky-Sommerer,R., Dijk,D.J. and
            Archer,S.N.
  TITLE     Altered sleep and behavioral activity phenotypes in PER3-deficient
            mice
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 301 (6), R1821-R1830 (2011)
   PUBMED   21957163
REFERENCE   6  (bases 1 to 3504)
  AUTHORS   Barnes,J.W., Tischkau,S.A., Barnes,J.A., Mitchell,J.W.,
            Burgoon,P.W., Hickok,J.R. and Gillette,M.U.
  TITLE     Requirement of mammalian Timeless for circadian rhythmicity
  JOURNAL   Science 302 (5644), 439-442 (2003)
   PUBMED   14564007
  REMARK    Erratum:[Science. 2003 Nov 14;302(5648):1153]
REFERENCE   7  (bases 1 to 3504)
  AUTHORS   Dudley,C.A., Erbel-Sieler,C., Estill,S.J., Reick,M., Franken,P.,
            Pitts,S. and McKnight,S.L.
  TITLE     Altered patterns of sleep and behavioral adaptability in
            NPAS2-deficient mice
  JOURNAL   Science 301 (5631), 379-383 (2003)
   PUBMED   12843397
REFERENCE   8  (bases 1 to 3504)
  AUTHORS   Kita,Y., Shiozawa,M., Jin,W., Majewski,R.R., Besharse,J.C.,
            Greene,A.S. and Jacob,H.J.
  TITLE     Implications of circadian gene expression in kidney, liver and the
            effects of fasting on pharmacogenomic studies
  JOURNAL   Pharmacogenetics 12 (1), 55-65 (2002)
   PUBMED   11773865
REFERENCE   9  (bases 1 to 3504)
  AUTHORS   Ebisawa,T., Uchiyama,M., Kajimura,N., Mishima,K., Kamei,Y.,
            Katoh,M., Watanabe,T., Sekimoto,M., Shibui,K., Kim,K., Kudo,Y.,
            Ozeki,Y., Sugishita,M., Toyoshima,R., Inoue,Y., Yamada,N.,
            Nagase,T., Ozaki,N., Ohara,O., Ishida,N., Okawa,M., Takahashi,K.
            and Yamauchi,T.
  TITLE     Association of structural polymorphisms in the human period3 gene
            with delayed sleep phase syndrome
  JOURNAL   EMBO Rep 2 (4), 342-346 (2001)
   PUBMED   11306557
REFERENCE   10 (bases 1 to 3504)
  AUTHORS   Jin,X., Shearman,L.P., Weaver,D.R., Zylka,M.J., de Vries,G.J. and
            Reppert,S.M.
  TITLE     A molecular mechanism regulating rhythmic output from the
            suprachiasmatic circadian clock
  JOURNAL   Cell 96 (1), 57-68 (1999)
   PUBMED   9989497
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB092512.1 and JAXUCZ010000005.1.
            
            On Jan 29, 2008 this sequence version replaced NM_023978.1.
            
            Summary: This gene is a member of the Period family of genes and is
            expressed in a circadian pattern in the suprachiasmatic nucleus,
            the primary circadian pacemaker in the mammalian brain. Genes in
            this family encode components of the circadian rhythms of locomotor
            activity, metabolism, and behavior. This gene is upregulated by
            Clock/Arntl heterodimers but then represses this upregulation in a
            feedback loop using Per/Cry heterodimers to interact with
            Clock/Arntl. Polymorphisms in this gene have been linked to sleep
            disorders. [provided by RefSeq, Feb 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.25679.1,
                                           SRR26360190.789438.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1571              AB092512.1         1-1571
            1572-1698           JAXUCZ010000005.1  166754066-166754192 c
            1699-1905           AB092512.1         1573-1779
            1906-2032           JAXUCZ010000005.1  166754066-166754192 c
            2033-2260           AB092512.1         1907-2134
            2261-2952           JAXUCZ010000005.1  166748953-166749644 c
            2953-3055           JAXUCZ010000005.1  166747554-166747656 c
            3056-3239           JAXUCZ010000005.1  166746417-166746600 c
            3240-3390           JAXUCZ010000005.1  166745643-166745793 c
            3391-3630           JAXUCZ010000005.1  166743050-166743289 c
FEATURES             Location/Qualifiers
     source          1..3504
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3504
                     /gene="Per3"
                     /gene_synonym="period3; rper3"
                     /note="period circadian regulator 3"
                     /db_xref="GeneID:78962"
                     /db_xref="RGD:621581"
     CDS             1..3348
                     /gene="Per3"
                     /gene_synonym="period3; rper3"
                     /note="circadian clock protein PERIOD 3; period homolog 3;
                     period circadian clock 3"
                     /codon_start=1
                     /product="period circadian protein homolog 3"
                     /protein_id="NP_076468.2"
                     /db_xref="GeneID:78962"
                     /db_xref="RGD:621581"
                     /translation="MDPCGNPAVPGGDCPQTRGPGLQGSSGQEGPLQGICVDSSHSEH
                     EDRNRMSEELIMVVQEMKKYFPAERHTKPSTLDALNYALRCVHSVQANSEFFQSLSPR
                     GARQAEATVYNLEELTSLASEHTSKNTDTFVAVFSFLSGRLVHISEQAAWILNSKKGF
                     LKSLHFVDLLAPRDVRVFYAHTAPTQLPFWNTWTQRASQYECAPVKPFFCRICGGGDR
                     EQKRHYSPFRILPYLVHVHSPAQPEPEPCCLTLVEKIHSGYEAPRIPVDKRVFTTTHT
                     PGCVFLEVDERAVPLLGFLPQDLIGTSILTYLHPEDRPLMVAVHQKVLKYVGHPPFEH
                     SPIRFCTQNGDYVILDSSWSSFVNPWSRKVSFIIGRHKVRTSPLNEDVFATRIKKATS
                     HDEDITELQEQIHRLLLQPVHASASSGYGSLGSSGSQEQHISVTSSSESSGHCVEEAQ
                     QEQMTLQQVYASVNKIKNVGQQLYIESMARSSVKPVMETCTEPQGSDEQKDFSSSQTL
                     KNKSTDTGSGGDLRPEQHSSSYQQMNCIDSVIRYLTSYSFPALKRKCISCTNTSSSSE
                     EAKPNPEADGSLRDTEQLLDIPEQETTAPSADAEGGVARTLSTAALSMASGVSQCSCS
                     STTDHVPPLQSESVAGACEPWALRTKAHVTAEGFKPVGLTAAVLSAHTQKEEQNYVDR
                     FREKILTSPYGCYLQQEGRNHAKYACVVGAGATPKHSRCAGSERRKHKRKKLPTPVDS
                     SSSSAHLCPHVRGLLPDVQHWSASVTSPCATGLALPSALVVPSQTPYLLSSFPLQDMA
                     PQGVGDSAAWGAAAECPPLSAGPQPVSTFPSAYMGTFMTVLLHNSPLFPLWPASFSPY
                     PFLGATGPSQMAPLVPAMAPDLEPTPSDHGPRRVEENWETHSEEEHPFISSRSSSPLQ
                     LNLLQEEMPAPSEYADAVRRGACPDAKQLCVTGNSGSRSPPCATGELATASVQQESSS
                     AAASGSSASSVHGSGSDYTSEVSENGQRSQDRQRDRAFSGAAEESIWRMIERTPECVL
                     MTYQVPERGRDTVLREDLEKLHSMERQQPQFSSAQKEELAKVRSWIHSRPAPEERQLQ
                     SYVTCENRGSVGDTAEACEQCPAEDTS"
     exon            1..125
                     /gene="Per3"
                     /gene_synonym="period3; rper3"
                     /inference="alignment:Splign:2.1.0"
     exon            126..271
                     /gene="Per3"
                     /gene_synonym="period3; rper3"
                     /inference="alignment:Splign:2.1.0"
     exon            272..387
                     /gene="Per3"
                     /gene_synonym="period3; rper3"
                     /inference="alignment:Splign:2.1.0"
     exon            388..589
                     /gene="Per3"
                     /gene_synonym="period3; rper3"
                     /inference="alignment:Splign:2.1.0"
     exon            590..638
                     /gene="Per3"
                     /gene_synonym="period3; rper3"
                     /inference="alignment:Splign:2.1.0"
     exon            639..781
                     /gene="Per3"
                     /gene_synonym="period3; rper3"
                     /inference="alignment:Splign:2.1.0"
     exon            782..860
                     /gene="Per3"
                     /gene_synonym="period3; rper3"
                     /inference="alignment:Splign:2.1.0"
     exon            861..967
                     /gene="Per3"
                     /gene_synonym="period3; rper3"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1124
                     /gene="Per3"
                     /gene_synonym="period3; rper3"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1230
                     /gene="Per3"
                     /gene_synonym="period3; rper3"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1359
                     /gene="Per3"
                     /gene_synonym="period3; rper3"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1489
                     /gene="Per3"
                     /gene_synonym="period3; rper3"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1622
                     /gene="Per3"
                     /gene_synonym="period3; rper3"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1738
                     /gene="Per3"
                     /gene_synonym="period3; rper3"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1906
                     /gene="Per3"
                     /gene_synonym="period3; rper3"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2134
                     /gene="Per3"
                     /gene_synonym="period3; rper3"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2826
                     /gene="Per3"
                     /gene_synonym="period3; rper3"
                     /inference="alignment:Splign:2.1.0"
     exon            2827..2929
                     /gene="Per3"
                     /gene_synonym="period3; rper3"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..3113
                     /gene="Per3"
                     /gene_synonym="period3; rper3"
                     /inference="alignment:Splign:2.1.0"
     exon            3114..3264
                     /gene="Per3"
                     /gene_synonym="period3; rper3"
                     /inference="alignment:Splign:2.1.0"
     exon            3265..3504
                     /gene="Per3"
                     /gene_synonym="period3; rper3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggatccct gtggaaaccc ggcagtgcct ggtggcgact gtccccaaac taggggaccg
       61 gggctccaag ggtcgtctgg ccaggagggt cctctgcagg gcatttgcgt ggacagcagc
      121 cacagtgaac atgaagaccg aaacagaatg tctgaagagc ttataatggt tgtccaagaa
      181 atgaaaaagt atttcccagc cgagagacac actaaaccca gcaccctaga tgcccttaac
      241 tatgccctac gctgtgtaca tagtgtgcaa gcaaacagtg aatttttcca gagtctcagt
      301 ccacgtggag cacgtcaggc agaagcgact gtatataatc tcgaggagct gacctctctg
      361 gcttctgaac atacttccaa gaacacagat accttcgtgg cagtgttttc gtttctgtct
      421 ggaaggctgg tgcacatttc tgaacaggct gcttggatcc tgaattctaa gaaaggtttc
      481 ctcaagagct tgcacttcgt cgacctgctt gcccctcggg acgtgagggt gttctacgct
      541 cacaccgctc caactcaact ccctttctgg aacacctgga cccaaagagc ctcgcagtat
      601 gaatgcgcac cagtgaagcc ctttttctgc agaatctgtg gcggtggaga cagggagcag
      661 aagagacatt actccccatt ccggatcctc ccctacttgg ttcatgtaca cagccctgcc
      721 cagccagagc cagagccttg ctgtctaaca ctggttgaaa agattcactc tggttatgaa
      781 gctcctcgaa tccctgtaga taaaagagtt tttaccacaa cacacacgcc gggatgtgtg
      841 tttcttgaag tagatgaaag agcagtgcct ttgctgggtt tcctacctca ggatctgatt
      901 ggaacgtcga tcttaacgta cttgcaccca gaagatcggc ctctgatggt tgcagtacac
      961 caaaaagttt taaagtacgt gggccaccct ccatttgaac actcacccat aagattctgc
     1021 acgcagaatg gagattatgt cattctggat tccagctggt ccagctttgt gaacccctgg
     1081 agccggaagg tctccttcat cattggtcga cataaagtcc gaacgagccc gttaaatgaa
     1141 gatgtttttg ccaccagaat aaaaaaggca accagtcatg acgaagacat aacagaatta
     1201 caagaacaaa ttcacagact tctcttgcag ccggttcatg ccagtgcttc cagtggctac
     1261 gggagcctgg gcagcagtgg ctcgcaggag cagcacatca gcgtcacctc ttccagtgag
     1321 tcaagcggac actgtgtgga ggaagcccag caggagcaga tgaccctgca gcaggtctat
     1381 gccagtgtaa acaaaattaa gaatgtgggc caacagctct acatcgagtc gatggccaga
     1441 tcgtcggtga agccagtgat ggagacgtgc acggaaccgc agggtagtga tgagcagaag
     1501 gacttttctt cctctcagac actgaaaaat aaaagcacag ataccggctc tggaggcgat
     1561 ctgcggccag agcagcatag ctcgtcctat cagcagatga actgcatcga cagtgtcatc
     1621 aggtacctga caagctacag tttcccagcc ttgaaaagaa agtgcatctc ctgcacaaac
     1681 acgtcttcat cctcagagga agccaagcca aacccagagg cagacggcag cctgcgagac
     1741 accgaacagc tcctggacat tccagaacag gaaacaaccg caccatccgc agacgccgag
     1801 ggaggtgttg cacggaccct gtccactgcc gcactgagca tggcgtctgg cgtaagccag
     1861 tgcagctgca gcagcaccac ggaccacgtc ccccccctac agtcagaaag tgttgccgga
     1921 gcgtgtgagc cctgggccct gagaacgaag gctcacgtga ccgcagaagg attcaagccc
     1981 gtggggctca cagcggccgt cctctccgcg cacacgcaga aggaagagca gaactatgtt
     2041 gacaggttcc gggagaagat cctgacctcg ccctacggct gttatcttca gcaagaaggc
     2101 aggaaccatg ccaagtacgc ctgcgtcgtc ggagcagggg ccacccctaa gcacagcaga
     2161 tgtgctggaa gtgagagacg gaagcacaaa cggaagaagc tgccgacgcc tgtggacagc
     2221 agcagctcca gtgcccacct ctgtccccat gtcagaggac tccttccaga tgtgcagcac
     2281 tggagcgctt ccgttacctc tccctgtgct acaggcctag ctctcccctc agccctggtg
     2341 gttcccagcc agaccccgta tctcctctcc tcttttcccc ttcaagacat ggcccctcag
     2401 ggagtagggg actccgcagc ctggggtgct gcagccgagt gtccacctct gtccgctggt
     2461 ccccagcctg tttccacgtt cccttctgct tacatgggta ctttcatgac cgtcctcctg
     2521 cacaacagcc ctctctttcc tctgtggccg gcatcattct ctccatatcc attcctgggg
     2581 gccacaggtc cttctcaaat ggcaccctta gtaccagcaa tggctccaga cctggaacca
     2641 accccttcag accacggccc aaggagagtg gaggagaact gggagacaca cagcgaagaa
     2701 gagcatccgt ttattagctc acggagcagt tcaccattgc agttaaattt actccaggaa
     2761 gaaatgcctg caccatcaga gtatgcagat gcagtgagaa gaggcgcctg cccagacgct
     2821 aagcaactct gtgttacagg taacagtggc agtaggagcc ctccctgtgc cacaggtgag
     2881 ctggccacag catcagtaca gcaagaatct tcatccgcag ctgcctcagg aagcagtgcc
     2941 agcagtgtac acggcagtgg cagtgactac acttctgaag tctctgaaaa tggacagagg
     3001 tcacaggata gacagagaga cagagccttt tccggggcgg ctgaagaatc tatctggaga
     3061 atgatagaac ggacgccaga gtgtgttctc atgacatacc aggtgccgga gaggggtaga
     3121 gacacggtgc tgagggaaga cctggaaaaa cttcacagca tggagcggca gcagccccag
     3181 ttctcttctg cgcagaagga ggagctggcc aaggtgcggt cctggatcca cagccgccct
     3241 gcccctgagg aaagacagct ccaaagctat gtcacctgtg aaaacagagg ttcagttggt
     3301 gacactgcag aggcctgtga acagtgtcca gcagaagaca ccagttgagc agctgtgaag
     3361 atgtcccacc ctctccaggt catgtggaac acagagacgt gtgttacctc attacagtct
     3421 ctgaaatggc agtcatcaac attaagatct tccctggctt tgttctggtt tggttttggt
     3481 ttcagtggcg ctggggatca aacc
//
