LOCUS       NM_031678               5760 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Rattus norvegicus period circadian regulator 2 (Per2), mRNA.
ACCESSION   NM_031678
VERSION     NM_031678.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5760)
  AUTHORS   Jin,W., Tian,Y., Ding,Y., Zhou,D., Li,L., Yuan,M., Wu,Y., Ye,M.,
            Luan,J. and Yang,K.
  TITLE     Pers reverse angiotensin II -induced vascular smooth muscle cell
            proliferation by targeting cyclin E expression via inhibition of
            the MAPK signaling pathway
  JOURNAL   Chronobiol Int 40 (7), 903-917 (2023)
   PUBMED   37338051
  REMARK    GeneRIF: Pers reverse angiotensin II -induced vascular smooth
            muscle cell proliferation by targeting cyclin E expression via
            inhibition of the MAPK signaling pathway.
REFERENCE   2  (bases 1 to 5760)
  AUTHORS   Li,Y., Li,G., Li,J., Cai,X., Sun,Y., Zhang,B. and Zhao,H.
  TITLE     Depression-like behavior is associated with lower Per2 mRNA
            expression in the lateral habenula of rats
  JOURNAL   Genes Brain Behav 20 (4), e12702 (2021)
   PUBMED   32964673
  REMARK    GeneRIF: Depression-like behavior is associated with lower Per2
            mRNA expression in the lateral habenula of rats.
REFERENCE   3  (bases 1 to 5760)
  AUTHORS   Katary,M. and Abdel-Rahman,A.A.
  TITLE     Alcohol suppresses cardiovascular diurnal variations in male
            normotensive rats: Role of reduced PER2 expression and CYP2E1
            hyperactivity in the heart
  JOURNAL   Alcohol 89, 27-36 (2020)
   PUBMED   32777474
  REMARK    GeneRIF: Alcohol suppresses cardiovascular diurnal variations in
            male normotensive rats: Role of reduced PER2 expression and CYP2E1
            hyperactivity in the heart.
REFERENCE   4  (bases 1 to 5760)
  AUTHORS   Zhang,X.Y., Wang,L., Yan,W.J., Lu,X.T., Li,X.Y. and Sun,Y.Y.
  TITLE     Period 2-Induced Activation of Autophagy Improves Cardiac
            Remodeling After Myocardial Infarction
  JOURNAL   Hum Gene Ther 31 (1-2), 119-128 (2020)
   PUBMED   31822134
  REMARK    GeneRIF: Period 2-Induced Activation of Autophagy Improves Cardiac
            Remodeling After Myocardial Infarction.
REFERENCE   5  (bases 1 to 5760)
  AUTHORS   Sarkar,D.K., Gangisetty,O., Wozniak,J.R., Eckerle,J.K.,
            Georgieff,M.K., Foroud,T.M., Wetherill,L., Wertelecki,W.,
            Chambers,C.D., Riley,E., Zymak-Zakutnya,N. and Yevtushok,L.
  TITLE     Persistent Changes in Stress-Regulatory Genes in Pregnant Women or
            Children Exposed Prenatally to Alcohol
  JOURNAL   Alcohol Clin Exp Res 43 (9), 1887-1897 (2019)
   PUBMED   31329297
REFERENCE   6  (bases 1 to 5760)
  AUTHORS   Toh,K.L., Jones,C.R., He,Y., Eide,E.J., Hinz,W.A., Virshup,D.M.,
            Ptacek,L.J. and Fu,Y.H.
  TITLE     An hPer2 phosphorylation site mutation in familial advanced sleep
            phase syndrome
  JOURNAL   Science 291 (5506), 1040-1043 (2001)
   PUBMED   11232563
REFERENCE   7  (bases 1 to 5760)
  AUTHORS   Sakamoto,S., Miyazaki,K., Fukui,H., Oishi,K., Hayasaka,N.,
            Okada,M., Kamakura,M., Taniguchi,T., Nagai,K. and Ishida,N.
  TITLE     Molecular characterization and nuclear localization of rat
            timeless-like gene product
  JOURNAL   Biochem Biophys Res Commun 279 (1), 131-138 (2000)
   PUBMED   11112428
REFERENCE   8  (bases 1 to 5760)
  AUTHORS   Jin,X., Shearman,L.P., Weaver,D.R., Zylka,M.J., de Vries,G.J. and
            Reppert,S.M.
  TITLE     A molecular mechanism regulating rhythmic output from the
            suprachiasmatic circadian clock
  JOURNAL   Cell 96 (1), 57-68 (1999)
   PUBMED   9989497
REFERENCE   9  (bases 1 to 5760)
  AUTHORS   Oishi,K., Sakamoto,K., Okada,T., Nagase,T. and Ishida,N.
  TITLE     Antiphase circadian expression between BMAL1 and period homologue
            mRNA in the suprachiasmatic nucleus and peripheral tissues of rats
  JOURNAL   Biochem Biophys Res Commun 253 (2), 199-203 (1998)
   PUBMED   9878515
REFERENCE   10 (bases 1 to 5760)
  AUTHORS   Sakamoto,K., Nagase,T., Fukui,H., Horikawa,K., Okada,T., Tanaka,H.,
            Sato,K., Miyake,Y., Ohara,O., Kako,K. and Ishida,N.
  TITLE     Multitissue circadian expression of rat period homolog (rPer2) mRNA
            is governed by the mammalian circadian clock, the suprachiasmatic
            nucleus in the brain
  JOURNAL   J Biol Chem 273 (42), 27039-27042 (1998)
   PUBMED   9765215
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031678.1.
            
            Summary: This gene is a member of the Period family of genes and is
            expressed in a circadian pattern in the suprachiasmatic nucleus,
            the primary circadian pacemaker in the mammalian brain. Genes in
            this family encode components of the circadian rhythms of locomotor
            activity, metabolism, and behavior. This gene is upregulated by
            Clock/Arntl heterodimers but then represses this upregulation in a
            feedback loop using Per/Cry heterodimers to interact with
            Clock/Arntl. Polymorphisms in this gene may increase the risk of
            getting certain cancers and have been linked to sleep disorders.
            [provided by RefSeq, Jan 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB016532.1, SRR26643294.37424.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                JAXUCZ010000009.1  99496909-99496993   c
            86-325              JAXUCZ010000009.1  99488107-99488346   c
            326-391             JAXUCZ010000009.1  99487330-99487395   c
            392-546             JAXUCZ010000009.1  99486282-99486436   c
            547-668             JAXUCZ010000009.1  99483673-99483794   c
            669-870             JAXUCZ010000009.1  99482741-99482942   c
            871-922             JAXUCZ010000009.1  99478936-99478987   c
            923-1065            JAXUCZ010000009.1  99478005-99478147   c
            1066-1144           JAXUCZ010000009.1  99476524-99476602   c
            1145-1251           JAXUCZ010000009.1  99473924-99474030   c
            1252-1405           JAXUCZ010000009.1  99473293-99473446   c
            1406-1514           JAXUCZ010000009.1  99472901-99473009   c
            1515-1640           JAXUCZ010000009.1  99471580-99471705   c
            1641-1725           JAXUCZ010000009.1  99470983-99471067   c
            1726-1888           JAXUCZ010000009.1  99468900-99469062   c
            1889-1995           JAXUCZ010000009.1  99468703-99468809   c
            1996-2160           JAXUCZ010000009.1  99467077-99467241   c
            2161-2400           JAXUCZ010000009.1  99465334-99465573   c
            2401-3197           JAXUCZ010000009.1  99461428-99462224   c
            3198-3384           JAXUCZ010000009.1  99459843-99460029   c
            3385-3577           JAXUCZ010000009.1  99458986-99459178   c
            3578-3728           JAXUCZ010000009.1  99457953-99458103   c
            3729-5760           JAXUCZ010000009.1  99454830-99456861   c
FEATURES             Location/Qualifiers
     source          1..5760
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q36"
     gene            1..5760
                     /gene="Per2"
                     /gene_synonym="rPER2"
                     /note="period circadian regulator 2"
                     /db_xref="GeneID:63840"
                     /db_xref="RGD:61945"
     exon            1..85
                     /gene="Per2"
                     /gene_synonym="rPER2"
                     /inference="alignment:Splign:2.1.0"
     exon            86..325
                     /gene="Per2"
                     /gene_synonym="rPER2"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..3878
                     /gene="Per2"
                     /gene_synonym="rPER2"
                     /note="circadian clock protein PERIOD 2; period circadian
                     clock 2"
                     /codon_start=1
                     /product="period circadian protein homolog 2"
                     /protein_id="NP_113866.1"
                     /db_xref="GeneID:63840"
                     /db_xref="RGD:61945"
                     /translation="MNGYVDFSPSPTSPTQEPGEPQPTQAVLQEDVDMSSGSSGNENC
                     STGRDSQGSDCDDSGKELRMLVESSNTHPSPDDTFRLMMTEAEHNPSTSGCSSEQSAK
                     ADAHKELIRTLRELKVHLPADKKAKGKASTLATLKYALRSVKQVKANEEYYQLLMSSE
                     SQPCSVDVPSYTMEQVEGITSEYIVKNSDMFAVAVSLVSGKILYISNQVAPIFHCKKD
                     AFSDAKFVEFLAPHDVSVFHSYTTPYKLPPWSVSSGLDSFTQECMEEKSFFCRVSVGK
                     HHENEIRYQPFRMTPYLVKVQEQKGAASQLCCLLLAERVHSGYEAPRIPPEKRIFTTT
                     HTPNCLFQDVDERAVPLLGYLPQDLIETPVLVQLHPSDRPLMLAIHKKILQASGQPFD
                     YSPIRFRTRNGEYITLDTSWSSFINPWSRKISFIIGRHKVRVGPLNEDVFAASPCPEE
                     KTPHPSVQELTEQIHRLLMQPVPHSGSSGYGSLGSNGSHEHLMSQTSSSDSNGQEESH
                     WRRSGIFKTSGKSQSKSHFSPESGGQKEASVAEMQSSPPAQVRSVTTMERDSSGASLP
                     KASFPEELTYKSQPPCSYQQISCLDSVIRYLESCNEAATLKRKCEFPANIPSRKATVS
                     PGLHSGEAARSSKVTSHTEVSAHLSSLALPGKAESVVSLTSQCSYSSTIVHVGDKKPQ
                     PELETVEDVASGPESQDDAAGGLSQEKGSLQKLGLTKEVLAAHTQREEQGFLQRFREV
                     SRLGALQAHCQNYLQERSRAPASDRGLRNASGIESSWKKTGKNRKLKSKRVKTRDSSE
                     STGSGGPVSHRPPLVGLNATAWSPSDTSQSSCPSAPFPAPVPAYPLPVFPAPGIVSTP
                     GTVVAPPAAAHTGFTMPVVPMGTQPEFAVQPLPFAAPLAPVMAFMLPSYPFPPATPNL
                     PQAFFPSQPHFPAHPTLASEITPASQAEFPSRTSMLRQPCACPVTPPAGTVALGRASP
                     PLFQSRGSSPLQLNLLQLEEAPESSTGAAGTLGTTGTAASGLDCTSGASRDRQPKAPP
                     TCSEPSDTQNSDAISTSSDLLNLLLGEDLCSATGSALSRSGASATSDSLGSSSLGCDT
                     SRSGAGSSDTSHTSKYFGSIDSSENNHKAKMITDTEESEQFIKYVLQDPIWLLMANTD
                     DNIMMTYQLPSRDLQAVLKEDQEKLKLLQRSQPHFTEGQRRELREVHPWVHTGGLPTA
                     IDVTGCVYCESEEKGNLCLPYEEDSPSLGLCDTSEAKEEESGQLANPRKEAQT"
     exon            326..391
                     /gene="Per2"
                     /gene_synonym="rPER2"
                     /inference="alignment:Splign:2.1.0"
     exon            392..546
                     /gene="Per2"
                     /gene_synonym="rPER2"
                     /inference="alignment:Splign:2.1.0"
     exon            547..668
                     /gene="Per2"
                     /gene_synonym="rPER2"
                     /inference="alignment:Splign:2.1.0"
     exon            669..870
                     /gene="Per2"
                     /gene_synonym="rPER2"
                     /inference="alignment:Splign:2.1.0"
     exon            871..922
                     /gene="Per2"
                     /gene_synonym="rPER2"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1065
                     /gene="Per2"
                     /gene_synonym="rPER2"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1144
                     /gene="Per2"
                     /gene_synonym="rPER2"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1251
                     /gene="Per2"
                     /gene_synonym="rPER2"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1405
                     /gene="Per2"
                     /gene_synonym="rPER2"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1514
                     /gene="Per2"
                     /gene_synonym="rPER2"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1640
                     /gene="Per2"
                     /gene_synonym="rPER2"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1725
                     /gene="Per2"
                     /gene_synonym="rPER2"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1888
                     /gene="Per2"
                     /gene_synonym="rPER2"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..1995
                     /gene="Per2"
                     /gene_synonym="rPER2"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2160
                     /gene="Per2"
                     /gene_synonym="rPER2"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2400
                     /gene="Per2"
                     /gene_synonym="rPER2"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..3197
                     /gene="Per2"
                     /gene_synonym="rPER2"
                     /inference="alignment:Splign:2.1.0"
     exon            3198..3384
                     /gene="Per2"
                     /gene_synonym="rPER2"
                     /inference="alignment:Splign:2.1.0"
     exon            3385..3577
                     /gene="Per2"
                     /gene_synonym="rPER2"
                     /inference="alignment:Splign:2.1.0"
     exon            3578..3728
                     /gene="Per2"
                     /gene_synonym="rPER2"
                     /inference="alignment:Splign:2.1.0"
     exon            3729..5760
                     /gene="Per2"
                     /gene_synonym="rPER2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctccgggc ggctgcggcg caggccgagc gcaccaagtg acgggtcgag caaaggaccg
       61 acgcgcgggt ggacgctgcg aagcgcctca ttccagagcc cgacatgaat ggatatgtgg
      121 acttttcccc aagtcccacc agccccaccc aagagccagg ggagcctcaa cccacccagg
      181 ctgtgctcca ggaagacgtg gacatgagca gcggctccag cggaaatgaa aactgctcca
      241 cggggcggga ctctcagggc agtgactgtg acgacagtgg aaaggagctg cggatgttag
      301 tggaatcgtc caacactcac cccagccctg acgatacctt cagactcatg atgacagagg
      361 cggagcataa cccctccaca agcggctgca gtagtgagca gtctgccaaa gctgacgcac
      421 acaaagagct gataaggacc ctgagggagc tgaaggtcca cctccctgca gacaagaagg
      481 ccaaggggaa ggccagcacg ctggcaacct tgaagtacgc tctgcggagc gtgaagcagg
      541 tgaaggctaa tgaggagtac taccagctgc taatgtccag tgagagccag ccctgcagcg
      601 tggatgtgcc ttcctacacc atggagcagg ttgagggcat tacctccgag tatattgtga
      661 agaactcgga catgtttgct gtggctgtgt ccctggtctc tgggaagatc ctgtacatct
      721 ccaaccaagt cgcccccatc tttcactgta agaaggacgc cttcagtgat gccaagtttg
      781 tggagttcct ggctccccat gacgtcagtg tgttccacag ctacaccacc ccttacaagc
      841 ttccgccctg gagtgtgagc agtggcttag attctttcac tcaggagtgc atggaggaga
      901 aatctttttt ctgccgtgtc agtgttggga aacaccacga gaatgagatt cgctaccagc
      961 ccttccgcat gacaccctac ctggtcaagg tgcaagagca gaagggcgct gcgagccagc
     1021 tctgctgcct gctgctagca gagagggtac actcaggcta tgaagctcct agaattcctc
     1081 ccgagaagag aattttcaca acaacccaca caccaaactg cctgttccag gatgtggacg
     1141 aaagggcggt ccccctcctg ggctatctac ctcaggatct gatcgagacc cctgtgctcg
     1201 tgcagctcca ccccagcgac cggcccttga tgctcgccat ccacaagaag atcctacagg
     1261 ccagtgggca gcctttcgat tattctccca ttcgattccg cacacgcaac ggggagtaca
     1321 tcacactgga cactagctgg tccagcttca tcaacccgtg gagcaggaag atatccttca
     1381 tcatcgggag gcacaaagtc agggtaggcc ctttgaatga ggatgtgttc gcagcctccc
     1441 cttgcccaga ggagaagact ccgcacccca gcgttcagga gctcacagag caaatccacc
     1501 ggctactgat gcaacctgtc ccccacagcg gctccagtgg ctatgggagc ctgggcagta
     1561 acggatccca cgaacacctc atgagccaga catcatccag cgacagcaat ggtcaagagg
     1621 agtctcactg gaggagatcc ggaattttta aaaccagtgg caagagtcaa agcaaaagtc
     1681 acttttctcc tgagtctgga ggacaaaagg aagcctctgt tgcagaaatg caaagtagtc
     1741 ctccagctca ggtgaggtct gtcaccacca tggaaaggga cagctcgggg gccagcctac
     1801 ccaaggctag ctttccagag gaactaacct ataagagcca gcctccttgc tcctaccagc
     1861 agatcagctg cctggacagt gtcatcaggt acctggagag ctgcaacgag gcagccaccc
     1921 tgaaaagaaa gtgcgagttc ccagccaaca tcccatcccg gaaggccacg gtcagccctg
     1981 ggctgcactc tggagaggca gcgcggtcct ccaaggtgac cagccacacg gaggtcagtg
     2041 ctcacttgag ctccttggcg ttgccgggca aggccgagag tgtggtgtcc ctcaccagcc
     2101 agtgcagcta cagcagcacc atcgtgcacg tgggcgacaa aaagccacag cctgaactag
     2161 agacagtaga agatgtggcc agtgggcctg agtcccagga tgatgcagct ggtggcctca
     2221 gccaagaaaa ggggtctctg cagaagctag gcctcaccaa ggaagttctg gctgcacata
     2281 cccagagaga ggaacagggc ttcctgcaga ggttcaggga agtgagcagg ctcggtgccc
     2341 tgcaggctca ctgccagaac tatctccagg agcggtcccg agccccagca agtgatcgag
     2401 gactaagaaa tgcttctgga atagaatcat cttggaaaaa aactggaaag aacaggaaac
     2461 tgaagtccaa gcgtgtcaag actcgagact cttctgagag cacagggtct gggggacccg
     2521 tgtcccaccg acctcccctc gtgggcctga atgccacagc ctggtcgccc tctgacacat
     2581 cccagtctag ctgtccctct gcaccattcc ctgctccagt gccagcttac ccactacctg
     2641 tgttcccggc acctggaata gtatccacac cagggacggt ggtggcacca cctgcagccg
     2701 cccacaccgg cttcaccatg cctgttgtgc ctatgggcac ccagcctgaa ttcgcagtgc
     2761 agcccctgcc gttcgctgcc cccttggctc cggtcatggc cttcatgcta cccagctacc
     2821 cgtttccacc agcaacccca aacctgcctc aggccttctt ccccagccag cctcactttc
     2881 cggcccatcc cacacttgcc tctgaaataa ctcctgcctc ccaggctgag ttccctagtc
     2941 ggacctcgat gctcaggcag ccatgtgctt gcccagtcac ccccccggct ggcacagtgg
     3001 ccttgggcag agcctccccg ccactcttcc agtcccgagg cagcagtccc ctacagctta
     3061 acctgcttca gctagaggaa gcacctgaaa gtagtactgg agctgcaggg accttgggga
     3121 ccacggggac agcagcttct ggtctggact gcacatctgg cgcatctcgg gaccggcagc
     3181 caaaggcacc tccaacatgc agtgagccct cagacaccca gaacagtgat gccatctcca
     3241 cctccagtga cctgctcaac ctcctcctgg gcgaggacct ctgctcagcc accggctcag
     3301 cactgtcgag aagcggggca tctgccacct cagactcact gggctccagc tccctgggct
     3361 gtgacacatc ccggagtggg gcaggcagca gtgatacaag tcacaccagc aaatactttg
     3421 gaagcattga ctcttcagag aataatcaca aagcaaaaat gatcacagac acggaggaga
     3481 gtgaacagtt cattaagtac gtcttgcagg accccatctg gctgctgatg gccaacacag
     3541 acgacaatat catgatgaca taccagctgc cctcccggga tctccaggcg gtcttgaaag
     3601 aggaccagga gaagctgaag ctgctgcaga ggtcccagcc ccacttcacg gagggccaga
     3661 ggcgagagct tcgagaggtt catccgtggg tccacaccgg gggtctgcct accgccatcg
     3721 acgtaacagg gtgtgtttac tgtgaaagtg aggagaaagg caacctttgt ctgccatatg
     3781 aggaagacag tccttccctg ggactctgtg atacctcaga agccaaagag gaggagagcg
     3841 gacagctggc caatcctagg aaggaggccc agacgtaacc ccgtccccgg ccagaagtct
     3901 acattagacg gtgctcggaa gaggtggaag agcttgtgtt tctaacgaaa tggacccata
     3961 ccttcactgc ttcttttgtt ttagaaaaaa aaacaaaaca ccatagtttt ctgaaggtgg
     4021 aacagagctg tggggaggtt taggaggaaa tacgtttttg tattaaaata gaaatatgga
     4081 atttggggga tggggtgaga ttcgtcattg gacttgagga gactgagacc atctgtgtgt
     4141 catctggagg tcagaagtcc ctgacctcca tgagacctct ttccagtgta ccagtgtcct
     4201 cttacccctg gggattgtcc tgaaacatca ggatgtttca gatcaccagg atgtgacata
     4261 taacggggaa gccacatgag gctcagccaa gggcctgctt tctggaactt tcccatggtg
     4321 tggttgtatc agatcctatc tcccaagcag agagaccacc cctcctgaca tcctctcagt
     4381 gcgttccctt atgtggtttg gagcatggtg tggcagcttt tgcttcaggt cctgtggtgg
     4441 ccagcattcc agtcggacct ggcttcagtt catcaacaga gttgaaatgc ctactctgga
     4501 ctgatggagc ttagtggtgt ctgtgaccga tgccatcaga ctagcaccca cactgtacgt
     4561 ttctgtgccg ttcttggatc ctttttagac catcatggcc agtgtgcaga gagagctgtg
     4621 gcttcagcca tgtcaccctg tctgtttggt ggcctctgca agccaagctt tgttgctgct
     4681 ggggacgcgg tcatatattt gttctttggt tggactctca gatttcagct tccagcagaa
     4741 agcagccact gaacatgggg agagggcacc cacactgtca ccctgagctc ttcagtttgc
     4801 agggagctca gcctcccact atatatatat atatattcct agctcctgtg gctttggttc
     4861 tctgtcacat ctgtctgtgc tgctggtcct cagaccaccg gaacccatgg agagaagggg
     4921 acctctctgc ccagctctac aaaaccttat gctgcatcag acatccaaag attgttccga
     4981 catgcttcct ggtgacccct ggtggaatga gacatcacca gtgaggaact gttagactta
     5041 aaacatggac aaagtctgga gcagaggaag cagactttcc tgagtctaaa gcggctacta
     5101 gaaaggtgtt cctactatag ctggttttca tgggaaagcc atctgatgcc tgaatatcac
     5161 ccctattttt cataaagaca agaaatctat ttttattatt attattatta aagcaacacc
     5221 acctttcaca atgatcaggt agtagccatg ttttaaagga aattcaatgt tacagacagc
     5281 tgcctctgac cagtcagagc ctaagagtag atagatggtg gtctaagcct acgcttgtta
     5341 cttaaacaca aaactgccaa aaccttctct ctactatctt gaatgtttac catcagcatt
     5401 attttatgat tatttaatat atattccttg attgttaact gctaagaagt tgacttccta
     5461 ggataatttt gtgaatctgt ttacaagatg ccaagcatcc agtcctgttt tctttagaat
     5521 gtgtgcttac acgggtgtcc tgagactttc tctatttgaa actgagcctt ctttgtaatg
     5581 taaataagct ctcagagttt gtgcgatgat ttgtgagcct tgccggacaa gcggtttgtt
     5641 catgcgcaaa ccaaacgtac cttcacccag tgcaatatat ttgtgtgact gcttgtgtct
     5701 ttttatgact tttttgcctt ttagaaaatt gttaaataaa gcaagtatat ttttattttc
//
