LOCUS       NM_001034125            4001 bp    mRNA    linear   ROD 19-AUG-2024
DEFINITION  Rattus norvegicus period circadian regulator 1 (Per1), mRNA.
ACCESSION   NM_001034125 XM_340822
VERSION     NM_001034125.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4001)
  AUTHORS   Wei,J., Wang,Y., Tu,S., Zhang,S., Feng,Y., Hou,Y., Ai,H. and
            Chen,Z.
  TITLE     Circadian rhythm disruption upregulating Per1 in mandibular
            condylar chondrocytes mediating temporomandibular joint
            osteoarthritis via GSK3beta/beta-CATENIN pathway
  JOURNAL   J Transl Med 22 (1), 662 (2024)
   PUBMED   39010104
  REMARK    GeneRIF: Circadian rhythm disruption upregulating Per1 in
            mandibular condylar chondrocytes mediating temporomandibular joint
            osteoarthritis via GSK3beta/beta-CATENIN pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4001)
  AUTHORS   Wei,J.M., Tu,S.Q., Wang,Y.X., Zhang,S., Feng,Y., Ai,H. and Chen,Z.
  TITLE     Clock gene Per1 regulates rat temporomandibular osteoarthritis
            through NF-kappaB pathway: an in vitro and in vivo study
  JOURNAL   J Orthop Surg Res 18 (1), 817 (2023)
   PUBMED   37907921
  REMARK    GeneRIF: Clock gene Per1 regulates rat temporomandibular
            osteoarthritis through NF-kappaB pathway: an in vitro and in vivo
            study.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4001)
  AUTHORS   Jin,W., Tian,Y., Ding,Y., Zhou,D., Li,L., Yuan,M., Wu,Y., Ye,M.,
            Luan,J. and Yang,K.
  TITLE     Pers reverse angiotensin II -induced vascular smooth muscle cell
            proliferation by targeting cyclin E expression via inhibition of
            the MAPK signaling pathway
  JOURNAL   Chronobiol Int 40 (7), 903-917 (2023)
   PUBMED   37338051
  REMARK    GeneRIF: Pers reverse angiotensin II -induced vascular smooth
            muscle cell proliferation by targeting cyclin E expression via
            inhibition of the MAPK signaling pathway.
REFERENCE   4  (bases 1 to 4001)
  AUTHORS   Costello,H.M., Juffre,A., Cheng,K.Y., Bratanatawira,P.,
            Crislip,G.R., Zietara,A., Spires,D.R., Staruschenko,A., Douma,L.G.
            and Gumz,M.L.
  TITLE     The circadian clock protein PER1 is important in maintaining
            endothelin axis regulation in Dahl salt-sensitive rats
  JOURNAL   Can J Physiol Pharmacol 101 (3), 136-146 (2023)
   PUBMED   36450128
  REMARK    GeneRIF: The circadian clock protein PER1 is important in
            maintaining endothelin axis regulation in Dahl salt-sensitive rats.
REFERENCE   5  (bases 1 to 4001)
  AUTHORS   Zietara,A., Spires,D.R., Juffre,A., Costello,H.M., Crislip,G.R.,
            Douma,L.G., Levchenko,V., Dissanayake,L.V., Klemens,C.A.,
            Nikolaienko,O., Geurts,A.M., Gumz,M.L. and Staruschenko,A.
  TITLE     Knockout of the Circadian Clock Protein PER1 (Period1) Exacerbates
            Hypertension and Increases Kidney Injury in Dahl Salt-Sensitive
            Rats
  JOURNAL   Hypertension 79 (11), 2519-2529 (2022)
   PUBMED   36093781
  REMARK    GeneRIF: Knockout of the Circadian Clock Protein PER1 (Period1)
            Exacerbates Hypertension and Increases Kidney Injury in Dahl
            Salt-Sensitive Rats.
REFERENCE   6  (bases 1 to 4001)
  AUTHORS   Takekida,S., Yan,L., Maywood,E.S., Hastings,M.H. and Okamura,H.
  TITLE     Differential adrenergic regulation of the circadian expression of
            the clock genes Period1 and Period2 in the rat pineal gland
  JOURNAL   Eur J Neurosci 12 (12), 4557-4561 (2000)
   PUBMED   11122368
REFERENCE   7  (bases 1 to 4001)
  AUTHORS   Masubuchi,S., Honma,S., Abe,H., Ishizaki,K., Namihira,M., Ikeda,M.
            and Honma,K.
  TITLE     Clock genes outside the suprachiasmatic nucleus involved in
            manifestation of locomotor activity rhythm in rats
  JOURNAL   Eur J Neurosci 12 (12), 4206-4214 (2000)
   PUBMED   11122332
REFERENCE   8  (bases 1 to 4001)
  AUTHORS   Jin,X., Shearman,L.P., Weaver,D.R., Zylka,M.J., de Vries,G.J. and
            Reppert,S.M.
  TITLE     A molecular mechanism regulating rhythmic output from the
            suprachiasmatic circadian clock
  JOURNAL   Cell 96 (1), 57-68 (1999)
   PUBMED   9989497
REFERENCE   9  (bases 1 to 4001)
  AUTHORS   Sangoram,A.M., Saez,L., Antoch,M.P., Gekakis,N., Staknis,D.,
            Whiteley,A., Fruechte,E.M., Vitaterna,M.H., Shimomura,K.,
            King,D.P., Young,M.W., Weitz,C.J. and Takahashi,J.S.
  TITLE     Mammalian circadian autoregulatory loop: a timeless ortholog and
            mPer1 interact and negatively regulate CLOCK-BMAL1-induced
            transcription
  JOURNAL   Neuron 21 (5), 1101-1113 (1998)
   PUBMED   9856465
REFERENCE   10 (bases 1 to 4001)
  AUTHORS   Balsalobre,A., Damiola,F. and Schibler,U.
  TITLE     A serum shock induces circadian gene expression in mammalian tissue
            culture cells
  JOURNAL   Cell 93 (6), 929-937 (1998)
   PUBMED   9635423
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY903229.1.
            
            On Feb 6, 2006 this sequence version replaced XM_340822.2.
            
            Summary: This gene is a member of the Period family of genes and is
            expressed in a circadian pattern in the suprachiasmatic nucleus,
            the primary circadian pacemaker in the mammalian brain. Genes in
            this family encode components of the circadian rhythms of locomotor
            activity, metabolism, and behavior. This gene is upregulated by
            Clock/Arntl heterodimers but then represses this upregulation in a
            feedback loop using Per/Cry heterodimers to interact with
            Clock/Arntl. Polymorphisms in this gene may increase the risk of
            getting certain cancers. [provided by RefSeq, Jan 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY903229.1, AY903230.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4001
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="SHR/OlaIpcv"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..4001
                     /gene="Per1"
                     /gene_synonym="rper1"
                     /note="period circadian regulator 1"
                     /db_xref="GeneID:287422"
                     /db_xref="RGD:727863"
     exon            1..332
                     /gene="Per1"
                     /gene_synonym="rper1"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..3939
                     /gene="Per1"
                     /gene_synonym="rper1"
                     /note="circadian clock protein PERIOD 1; period 1; period
                     homolog 1; period circadian clock 1"
                     /codon_start=1
                     /product="period circadian protein homolog 1"
                     /protein_id="NP_001029297.1"
                     /db_xref="GeneID:287422"
                     /db_xref="RGD:727863"
                     /translation="MSGPLEGADGGGDPRPGEPFCPGGVPSPGAPQHRPCPGPSLADD
                     TDANSNGSSGNESNGHESRGASQRSSHSSSSGNGKDSALLETTESSKSTNSQSPSPPS
                     SSIAYSLLSASSEQDNPSTSGCSSEQSARARTQKELMTALRELKLRLPPERRGKGRSG
                     TLATLQYALACVKQVQANQEYYQQWSLEEGEPCAMDMSTYTLEELEHITSEYTLRNQD
                     TFSVAVSFLTGRIVYISEQAGVLLRCKRDVFRGARFSELLAPQDVGVFYGSTTPSRLP
                     TWGTGTSAGSGLKDFTQEKSVFCRIRGGPDRDPGPRYQPFRLTPYVTKIRVSDGAPAQ
                     PCCLLIAERIHSGYEAPRIPPDKRIFTTRHTPSCLFQDVDERAAPLLGYLPQDLLGAP
                     VLLFLHPEDRPLMLAIHKKILQLAGQPFDHSPIRFCARNGEYVTMDTSWAGFVHPWSR
                     KVAFVLGRHKVRTAPLNEDVFTPPVPSPAPSLDSDIQELSEQIHRLLLQPVHSSSTTG
                     LCGVGPLMSPGPLHSPGSSSDSNGGDAEGPGPPAPVTFQQICKDVHLVKHQGQQLFIE
                     SRAKPPPRPRLLATGTFKAKVLPCQSPNPELEVAPAPDQASLALAPEEPERKESSGCS
                     YQQINCLDSILRYLESCNIPNTTKRKCASSSCTASSASDDDKQRAGPVPVGAKKDTSS
                     AVLSGEGATPRKEPVVGGTLSPLALANKAESVVSVTSQCSFSSTIVHVGDKKPPESDI
                     IMMEDLPGLAPGPAPSPAPSPTVAPDPAPDAYRPVGLTKAVLSLHTQKEEQAFLSRFR
                     DLGRLRGLDTSSVAPSAPGCHHGPIPSGRRHHCRSKAKRSRHHQTPRPETPCYVSHPS
                     PVPSSGPWPPPPATTPFPAVVQPYPLPVFSPRGGPQPLPPAPTSVSPATFPSPLVTPM
                     VALVLPNYLFPSPTSYPYGVSQAPVEGPPTPASHSPSPSLPPPPPSPPHRPDSPLFNS
                     RCSSPLQLNLLQLEESPRTEGGAAAGGPGSSAGPLPPSEESAEPEPRLVEVTESSNQD
                     ALSGSSDLLELLLQEDSRSGTGSAASGSLGSGLGSGSGSGSHEGGSTSASITRSSQSS
                     HTSKYFGSIDSSEAEAGAAQARTEPGDQVIKYVLQDPIWLLMANADQHVMMTYQVPSR
                     DAASVLKQDRERLRAMQKQQPRFSEDQRRELGAVHSWVRKGQLPQALDVTACVDCGSS
                     VQDPGHSDDPLFSELDGLGLEPMEEGGGEGGGVGGGGGGVGGGGGDGGEEAQTQIGTK
                     GSSSQDSAMEEEEQGGSSSSPALPAEENGTS"
     exon            333..431
                     /gene="Per1"
                     /gene_synonym="rper1"
                     /inference="alignment:Splign:2.1.0"
     exon            432..586
                     /gene="Per1"
                     /gene_synonym="rper1"
                     /inference="alignment:Splign:2.1.0"
     exon            587..708
                     /gene="Per1"
                     /gene_synonym="rper1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..910
                     /gene="Per1"
                     /gene_synonym="rper1"
                     /inference="alignment:Splign:2.1.0"
     exon            911..962
                     /gene="Per1"
                     /gene_synonym="rper1"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1105
                     /gene="Per1"
                     /gene_synonym="rper1"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1184
                     /gene="Per1"
                     /gene_synonym="rper1"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1291
                     /gene="Per1"
                     /gene_synonym="rper1"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1445
                     /gene="Per1"
                     /gene_synonym="rper1"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1554
                     /gene="Per1"
                     /gene_synonym="rper1"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1686
                     /gene="Per1"
                     /gene_synonym="rper1"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1792
                     /gene="Per1"
                     /gene_synonym="rper1"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1964
                     /gene="Per1"
                     /gene_synonym="rper1"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2092
                     /gene="Per1"
                     /gene_synonym="rper1"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2272
                     /gene="Per1"
                     /gene_synonym="rper1"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2506
                     /gene="Per1"
                     /gene_synonym="rper1"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..3117
                     /gene="Per1"
                     /gene_synonym="rper1"
                     /inference="alignment:Splign:2.1.0"
     exon            3118..3304
                     /gene="Per1"
                     /gene_synonym="rper1"
                     /inference="alignment:Splign:2.1.0"
     exon            3305..3494
                     /gene="Per1"
                     /gene_synonym="rper1"
                     /inference="alignment:Splign:2.1.0"
     exon            3495..3645
                     /gene="Per1"
                     /gene_synonym="rper1"
                     /inference="alignment:Splign:2.1.0"
     exon            3646..4001
                     /gene="Per1"
                     /gene_synonym="rper1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtacccgttg tggcctcttc accttccctg ttttgtcctc cactgcatgg cccagacatg
       61 agcggtcccc tagaaggggc tgatggggga ggagacccca ggcccggaga acctttttgt
      121 cctggaggag ttccatcccc tggggcccca cagcatcggc cttgtccagg ccctagcctg
      181 gctgatgaca ctgatgcaaa cagcaatggc tcaagtggca atgaatccaa tggacacgag
      241 tccaggggtg catctcagcg gagttctcac agttcatctt ctggcaatgg caaggactca
      301 gctctgctgg agaccactga gagcagcaag agtacaaact cacagagccc atccccaccc
      361 agcagctcca ttgcctatag tctcctgagt gcaagctcag agcaggacaa cccgtctacc
      421 agtggctgca gcagtgaaca gtcagctcga gccaggaccc agaaagaact catgaccgca
      481 cttcgggagc tcaaacttcg gctgccacca gagcgtcggg gaaagggccg ctctgggacc
      541 ctggccacac tccagtatgc tctggcctgt gtcaagcagg tgcaggctaa ccaggaatat
      601 taccagcagt ggagcctgga ggagggtgag ccctgtgcca tggacatgtc tacttacacc
      661 ctggaggaat tggagcatat cacatctgaa tacactctcc gcaaccagga taccttctcg
      721 gtggctgtgt ccttcctgac aggccggatt gtctatattt cggagcaggc aggtgtcttg
      781 ctgcgttgca aacgggatgt gtttcggggt gctcgcttct cagagctcct agctccccag
      841 gatgtgggtg tcttctatgg ctctactaca ccatctcgcc tgcccacctg gggcactggc
      901 acctctgcag gttcaggcct caaggacttc acccaggaaa agtctgtctt ctgccgaatc
      961 agaggagggc ctgaccggga tccagggcct cgctaccagc cattccgcct aaccccatat
     1021 gtgaccaaga ttcgtgtctc agatggggcc cctgcacagc cgtgctgcct gctcattgca
     1081 gagcgcatcc actctggtta tgaagctccc cggattcctc ctgacaagag gatcttcacc
     1141 acacggcaca caccaagttg cctcttccag gatgtagatg aaagggctgc cccactgctg
     1201 ggttacctac cccaggatct cctgggggct ccggtacttc tctttctaca tcctgaggac
     1261 cgacctctca tgctggccat tcataagaag attctgcagt tggcaggcca gccctttgac
     1321 cactccccta ttcgattttg tgctcggaat ggggaatatg tcaccatgga taccagctgg
     1381 gccggctttg tgcacccctg gagccgcaag gtggctttcg tgctgggccg ccataaagtg
     1441 cgcacggcac ccctgaatga ggacgtcttc acacccccag ttcccagtcc agctccgtcc
     1501 ctggactctg atatccagga gctctcagag cagatccatc gattgctgct gcagccagtg
     1561 cacagctcca gcaccacggg gctctgtgga gttggccctc tgatgtcccc tggtcctctc
     1621 cacagccctg gctcctccag tgatagcaat gggggtgatg ctgaggggcc tgggcctcct
     1681 gctccagtga ctttccagca gatctgtaag gatgtgcatc tggtaaagca ccagggacaa
     1741 cagctcttca ttgagtcccg ggccaagcct ccgccccggc cccgcctcct tgctacaggt
     1801 acattcaagg ccaaagtcct tccctgccag tccccaaacc cggaactgga ggtggcccct
     1861 gctcctgacc aagcctcatt agcattggcc cctgaggagc cagagaggaa agagtcctct
     1921 ggctgctcct accagcaaat caactgcctg gacagcatcc tcaggtattt ggaaagctgc
     1981 aacattccta acacaaccaa gcgtaaatgt gcctcctctt cctgcacggc ctcttcagcc
     2041 tctgatgatg acaagcagag ggcgggtcca gttcctgtgg gggccaagaa agatacgtcg
     2101 tcagcagtgc tgtctgggga gggggcaact cctcggaagg agccagtggt gggaggcacc
     2161 ctgagcccgc tcgccctggc caataaggca gagagcgtgg tgtccgtcac cagtcagtgt
     2221 agcttcagct ccaccatcgt ccatgtggga gacaagaagc ccccggagtc ggacatcatc
     2281 atgatggaag acctgcctgg cctggcccct ggtccagccc ccagtccagc ccccagcccc
     2341 acagtagccc ctgacccagc cccagatgct tatcgcccag tgggtctgac caaggccgtg
     2401 ctgtccctgc acacccagaa ggaagagcaa gccttcctca gccgcttcag agacctcggc
     2461 aggcttcgtg ggcttgacac ctcttctgtg gcgccttcag cccctggttg ccaccatggc
     2521 cccattccct ctggtcgccg acaccactgc cgatctaaag caaagcgttc tcgccaccac
     2581 cagacccccc gacccgaaac cccctgctat gtgtctcatc cttcacctgt gccctcttct
     2641 ggaccctggc cacccccacc agccactacc cccttcccag cagtggtcca gccctaccca
     2701 ctcccagtgt tctcccctcg aggaggaccc cagccgcttc ctcctgcccc cacatctgtg
     2761 tcacctgcta ccttcccttc tcccttagtg accccaatgg tggccttggt gctccctaac
     2821 tatttattcc cttccccaac tagttaccca tatggggtat cccaggctcc tgttgagggg
     2881 ccacctacac ctgcttccca ctcaccttct ccatccctac ccccaccacc tcccagcccc
     2941 ccccaccgcc cagactcccc actgttcaac tcaagatgca gttccccact ccagctcaat
     3001 ctgctgcagc ttgaggagtc cccccgcact gaagggggtg ctgctgcagg aggccccgga
     3061 agtagtgctg ggcccctgcc tcccagtgag gagtctgctg agccagagcc cagactggtg
     3121 gaggtcacgg agtcatccaa tcaggatgca ctttcaggct ccagtgacct gctagagtta
     3181 ctgctccagg aggactctcg ctctggcaca ggctccgcag cctcgggctc cctgggctcc
     3241 ggcctgggct ctgggtctgg ttcgggatcc cacgaagggg gaagcacctc agccagcatc
     3301 actcgcagca gtcagagcag ccatacaagc aagtactttg gcagcatcga ctcttcagag
     3361 gctgaagctg gagctgctca ggccaggact gagcctgggg accaggtcat taagtatgtg
     3421 ctccaggatc ccatctggct gctcatggcc aacgctgacc agcatgtcat gatgacctac
     3481 caggtgccgt ccagggatgc agcgtctgtg ctgaagcaag accgggagag gctccgggcc
     3541 atgcagaaac aacagccacg gttctcagag gaccagcggc gggaactggg tgctgtgcac
     3601 tcctgggtcc ggaagggcca gctgcctcag gccctcgatg taacggcttg tgtggactgt
     3661 ggtagcagtg ttcaagatcc tggccactcg gacgaccctc tcttctcaga actggatgga
     3721 ttggggctgg agcctatgga agagggtgga ggcgagggag gtggtgttgg cgggggtgga
     3781 ggtggtgttg gcgggggtgg gggtgatggt ggtgaggagg cccagaccca aattgggact
     3841 aagggctcaa gctctcagga ctctgccatg gaggaagaag aacaaggtgg gagctcttcc
     3901 agtccagctt tacctgcaga agagaatggc accagctaga ctccatttgg gcgccactta
     3961 cagcagtcta atgagaggct tcctttgaac catgttggga t
//
